Clinical trials: Genetic Polymorphism
Dyslipidemia, Type 2 Diabetes Mellitus
Postprandial Fatty Acids and FABP2 in Type 2 Diabetes Mellitus (DM)
This study will be conducted in type 2 diabetic patient's to evaluate the if there is a different response of serum lipids after a standard meal (rich in saturated fatty acids) in patients who have the presence of a genetic…
- Trial name
- NCT00634673
- Testing
- sandwich
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Breast Cancer
Markers for Breast Cancer
This study will analyze blood samples to identify substances that are associated with the development of breast cancer. It will determine if: Women who are diagnosed with a benign breast condition that is related to a…
- Trial name
- NCT00339248
- Where
- United States
- Volunteers
- 2,632 people
- Sponsor
- National Cancer Institute (NCI)
Bronchopulmonary Dysplasia
Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants
Despite considerable obstetric and neonatal advances in the care of very low birth weight (VLBW) neonates, bronchopulmonary dysplasia (BPD) continues to occur among 20 to 40% of surviving infants, and new ways for combatting this…
- Trial name
- GENBPD (NCT00904774)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Lupus Erythematosus, Systemic, Adverse Effects
Exploration of Genotype Based Personalized Prescription of Cyclophosphamide in Systemic Lupus Erythematosus Treatment
The purpose of this study is to investigate the relationship between the side effects of cyclophosphamide in the treatment of systemic lupus erythematosus (SLE) in Han Chinese and the genetic polymorphisms of drug metabolizing…
- Trial name
- NCT01060410
- Testing
- Polymorphism Analysis, Cyclophosphamide, Pharmacokinetic analysis
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Sun Yat-sen University
Polymorphism, Genetic, Bacterial Infections
The Association of Gene Polymorphisms With Invasive Bacterial Infections in Neonates and Young Infants
Invasive bacterial infections (IBIs) are globally significant, with high mortality rates, particularly within the critical 0-3 month age bracket.
- Conditions
- Polymorphism, Genetic, Bacterial Infections, Infant
- Trial name
- NCT06985160
- Testing
- Specific single nucleotide polymorphisms
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ege University
Pediatric Non-Hodgkin Lymphoma
A Retrospective Cohort Study: Influence of MTHFR C677T and A1298C Polymorphisms on the Survival of Pediatric Patients With Non-Hodgkin's Lymphoma
The primary purpose of this retrospective study was to investigate the influence of methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphism on the survival of pediatric patients with Non-Hodgkin lymphoma (NHL)…
- Trial name
- NCT04469543
- Where
- China
- Volunteers
- 374 people
- Sponsor
- Sun Yat-sen University
Aggressive Periodontitis
Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP
The aim of this study is to estimate genetic impact of MCP-1 -2518 and its receptor CCR2 -190 polymorphisms on AgP patients among Turkish individuals and whether MCP-1 genotype effects mRNA levels of Peripheral Blood Mononuclear…
- Trial name
- NCT02817568
- Testing
- Drawing Blood
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Cardiovascular Disease
Study of Inherited Changes of Receptors Located on Blood Vessels
The renin angiotensin system is a complex process involving hormones and enzymes that regulate blood volume and blood pressure. The hormone angiotensin II is responsible for making blood vessels narrow or constrict.
- Trial name
- NCT00001741
- Testing
- Losartan
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cleft Lip and Cleft Palate
Detection of Single Nucleotide Polymorphism (SNP) Rs2235371 of IRF6 Gene in Egyptian Patients with Non-Syndromic Cleft Lip and Palate
The aim of this work is to study the relation between SNP rs2235371 of IRF 6 gene and Non-Syndromic Cleft Lip and Palate in Egyptian Patients in a prospective study
- Trial name
- NCT06730880
- Testing
- PCR
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Arteriosclerosis, Cardiovascular Diseases
Apolipoprotein A-I Gene Polymorphism and Atherosclerosis
To further define the linkage of the Apo A-I gene polymorphism to genetic high density lipoprotein (HDL) deficiency and premature coronary artery disease.
- Conditions
- Coronary Arteriosclerosis, Cardiovascular Diseases, Heart Diseases, Atherosclerosis
- Trial name
- NCT00005183
- Sponsor
- Tufts University
Hemophilia A
Personalized Prediction of Tolerance and Immunogenicity in Hemophilia
This study is designed to accurately identify the pharmacogenetic determinants of risk of Factor VIII (FVIII) inhibitor development by focusing on only a select group of Hemophilia A (HA) patients who have: (i) received a…
- Trial name
- PPTIH (NCT01626105)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Victor J Marder, M.D.
Asthma
The Genetics of Severe Asthma in Children
Near fatal asthma exacerbations are one of the most common causes of critical illness in children, accounting for approximately ten thousand intensive care unit (ICU) admissions per year in the United States.
- Trial name
- NCT01238432
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Connecticut Children's Medical Center
Development, Child
The Relationship Between VDR Gene Polymorphism and Children's Physical and Intellectual Development
This study was used to determine the relationship between vitamin D receptor gene polymorphism and children's physical and intellectual development, further adjust the doses of vitamin D supplementation after birth, and provide…
- Trial name
- RVDRGPCPID (NCT03742310)
- Testing
- Vitamin D
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Androgenetic Alopecia
Association of Polymorphisms in the Androgen Receptor Gene and Finasteride Response in Women With Androgenetic Alopecia
Previous studies of finasteride treatment in women with hair loss have failed to show positive results, yet, some women have responded anecdotally.
- Trial name
- NCT01052870
- Testing
- Finasteride
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- HairDx, LLC
Sinus Arrhythmia
Identification of Gene Polymorphism in Patients With Sick Sinus Syndrome in Chinese Population in Taiwan
Background: Sinus node dysfunction is a major cause of bradycardia necessitating pacemaker implantation. Evidences of genetic study supported that some genes involved in the pacemaker current or renin-angiotensin system were…
- Trial name
- NCT00314223
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Day-3 Positive of Parasitaemia, Prevalence of Drug Resistance Gene Mutation
Molecular Assessment of Artemisinin Resistance Markers in Eastern and Western Border Areas of Myanmar
Artemisinin resistance have been documented in Myanmar and Myanmar artemisinin resistance containment measures have been launched since 2009-2010.
- Trial name
- NCT02198573
- Where
- Burma
- Volunteers
- 91 people
- Sponsor
- Myat Htut Nyunt
Psoriasis, Psoriatic Arthritis
IKBKB Gene Polymorphism (Single Nucleotide Polymorphism) (SNP) in Psoriatic and Psoriatic Arthritis Patients
Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema. It impairs patients' quality of life enormously. Psoriasis refers to a persistent inflammatory illness of the skin and joints.
- Trial name
- NCT06729463
- Testing
- Humira
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- South Valley University
Asthma
A Cohort Study of Smoking Prevention and Health Promotion for Middle School Students in Wuhan, China
We propose to add a collection of buccal cells to a school-based cohort of 7th graders in Wuhan, a large industrial city in China.
- Trial name
- NCT00341653
- Where
- China
- Volunteers
- 5,051 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Prostate Cancer
Study of a Polymorphism in Patients With Prostate Cancer
RATIONALE: Studying samples of blood from patients with cancer and from healthy participants in the laboratory may help doctors learn more about changes that may occur in DNA.
- Trial name
- NCT00900185
- Testing
- mutation analysis, polymerase chain reaction, polymorphism analysis
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)