Clinical trials: Hirschsprung Disease
Probiotics, Hirschsprung's Disease Associated Enterocolitis
A Trial on Probiotics in Preventing Hirschsprung's Disease Associated Entercolitis
Enterocolitis(EC) is the most common and serious postoperative complication of Hirschsprung's disease(HD) with high morbidity and mortality.
- Trial name
- NCT01934959
- Testing
- Bifico
- Volunteers
- 60 people
- Sponsor
- Tongji Hospital
Hirschsprung Disease
Laparoscopic Assisted Pull-through Versus Other Surgical Procedures for Treatment of Hirschsprung Disease
To evaluate the outcomes of laparoscopic pull-through concerning constipation, incontinence and enterocolitis in comparison of other surgical procedures for treatment of Hirschsprung disease.
- Trial name
- NCT03269812
- Testing
- laparoscopic assisted pull-through oeration
- Volunteers
- 60 people
- Sponsor
- Assiut University
Hirschsprung Disease
Translation and Validation of a Disease-specific Questionnaire for Hirschsprung's Disease in Danish Patients
The Hirschsprung and anorectal malformation quality of life (HAQL) questionnaire is a disease-specific quality of life questionnaire with 5 different elements (3 questionnaires for patients (categories: age 8-11, 12-16, and >17…
- Trial name
- NCT04730128
- Where
- Denmark
- Volunteers
- 173 people
- Sponsor
- University of Southern Denmark
Surgery
Fast-track Surgery in the Treatment of Hirschsprung's Disease
To evaluate the safety and efficacy of Hirschsprung's disease
- Trial name
- Fast-track (NCT02350088)
- Testing
- probiotics
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
NEC, Gastroschisis
Neokare Safety and Tolerability Assessment in Neonates With GI Problems
With an increasing body of evidence to support a causal link between drinking milk that contain cow's milk protein (CMP) and the development of gastrointestinal disturbance in infants, many clinicians avoid the use of CMP…
- Conditions
- NEC, Gastroschisis, Intestinal Perforation, Atresia, Intestinal
- Trial name
- NCT05293353
- Testing
- NeoKare Breast Milk Fortifier
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Constipation
Comparison of Circular(Soave) and Heart-shaped Anastomosis in Hirschsprung's Disease
Comparison of Circular(Soave)and Heart-shaped Anastomosis in Hirschsprung's disease.
- Trial name
- NCT02234219
- Testing
- Heart-shape anastomosis, Soave anastomosis
- Where
- China
- Volunteers
- 177 people
- Sponsor
- Tongji Hospital
Surgery, Pediatric ALL
Analysis of the Causes of Redo Pull-through for Recurrent Constipation and the Risk Factors Affecting the Prognosis of the Hirschsprung's Disease and Allied Disorders
The goal of this observational study is to conducted a comprehensive analysis of the factors contributing to redo- Pull-through surgery for constipation recurrence in Children who are suffering from Hirschsprun' s disease (HSCR)…
- Trial name
- NCT06175598
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Feng Jiexiong
Analgesia
Could Peri-anal Block be Effective as Caudal Block in Trans-anal Pull-through Surgery ??.
IN pediatric patient population pain is considered one of the most misunderstood; under diagnosed and under treated medical problems.
- Trial name
- NCT04367818
- Testing
- Peri-anal local anaesthetic infiltration, Caudal anaesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation
Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)
Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic and respiratory regulation that frequently alters oxygen delivery to the brain.
- Conditions
- Congenital Central Hypoventilation Syndrome, Congenital Central Hypoventilation, CCHS, CCHS With Hirschsprung Disease
- Trial name
- NCT03568669
- Testing
- NIH Toolbox Cognition Battery
- Where
- 4 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Ilya Khaytin
Hirschsprungs Disease
Electrophysiological Activity of the Anorectum in Children Suspected of Hirschsprung Disease
Children with chronic constipation, suspected of having hirschsprungs disease, who are admitted for rectal biopsy will be included in the study.
- Trial name
- NCT02342457
- Testing
- Child suspected of Hirschsprung disease
- Volunteers
- 20 people
- Sponsor
- Rabin Medical Center
Hirschprung's Disease, Hirschsprung Disease
Babies With Enterocolitis - A Study of Faecal Calprotectin in Hirschsprung Disease (The BEACH Study)
Babies with Hirschsprung's Disease are born without normal nerves to the end of their bowel which means they cannot poo properly, and are at high risk of infection of the bowel, called enterocolitis.
- Conditions
- Hirschprung's Disease, Hirschsprung Disease, Hirschsprung's Disease Associated Enterocolitis
- Trial name
- BEACH (NCT06592534)
- Volunteers
- 50 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Pathology
Different Clinicopathological Features of Non-Elderly Sigmoid Volvulus Patients
Sigmoid volvulus is frequently seen in male patients over 60 years old. In the sigmoid volvulus <60 age groups, the male/female ratio is close to each other.
- Trial name
- NCT04360525
- Testing
- Reasons
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Dr. Ersin Arslan Education and Training Hospital
Hirschsprung Disease
Full Thickness vs. Rectal Suction Biopsy in the Diagnosis of Hirschsprungs Disease
The objective of this prospective study is to compare the diagnostic accuracy of rectal suction biopsy (RSB) compared to full thickness rectal biopsy (FTB) in the diagnosis of Hirschsprungs Disease (HD) in children.
- Trial name
- BIOPSY (NCT05307419)
- Testing
- Rectal suction biopsy., Full-thickness rectal biopsy.
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- University of Southern Denmark
Hirschsprung Disease
Scintigraphic Defecography for Evaluation of Functional Outcome in an Adult Hirschsprung Population
This study aims to investigate long term outcomes of surgical intervention for Hirschsprung's disease and to explore the relation between scintigraphic defecography, type of surgery performed and symptoms as evaluated by a…
- Trial name
- NCT04957667
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- University of Southern Denmark
Total Colonic Aganglionosis, Hirschsprung Disease
Robot/Laparoscopic-Assisted Transanal Transection Duhamel Versus Modified Soave Pull-Through for TCA
Total colonic Hirschsprung disease (TCA) is the most severe form of Hirschsprung disease and is commonly managed with neonatal enterostomy followed by delayed definitive pull-through.
- Conditions
- Total Colonic Aganglionosis, Hirschsprung Disease, Duhamel, Soave
- Trial name
- NCT07343622
- Testing
- Transanal Transection Duhamel operation, Modified Soave Pull-Through
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zunyi Medical College
Bowel Dysfunction, Dysmotility
Comparison of a New Non-invasive Device With the Invasive Gold-standard Investigation to Assess Function of the Large Bowel in Children
The goal of this clinical trial is to learn if the new non-invasive device (Body Surface Colonic Mapping) works to accurately assess colonic movement and function in children.The main questions it aims to answer are: Are Body…
- Conditions
- Bowel Dysfunction, Dysmotility, Hirschsprung Disease, Anorectal Malformations
- Trial name
- NCT07789782
- Testing
- Body Surface Colonic Mapping
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Murdoch Childrens Research Institute
Hirschsprung Disease
Minimally Invasive Surgical Intervention for Hirschsprung Disease
Hirschsprung's disease (HD) is one of the most common congenital conditions, with a global incidence of 1/5000 newborns; the prevalence in the Vietnamese population is even higher.
- Trial name
- NCT06880666
- Testing
- Minimally invasive laparoscopic pull-through surgery
- Where
- Vietnam
- Volunteers
- 23 people
- Sponsor
- National Children's Hospital, Vietnam
Hirschsprung Disease
Hirschsprung Disease Genetic Study
Hirschsprung disease is a genetic condition caused by lack of nerve cells in varying lengths of the intestines. This study will investigate the complex genetic basis of the disease, which involves multiple interacting genetic…
- Trial name
- NCT00478712
- Testing
- Identification of genetic causes of Hirschsprung Disease
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Necrotizing Enterocolitis, Intestinal Atresia
Pattern And Outcome Of Neonatal Gastrointestinal Emergencies In Assiut University Children Hospital
This prospective observational study aims to evaluate the pattern, clinical presentation, complications, and short-term outcomes of neonates admitted with gastrointestinal emergencies to the NICU at Assiut University Children…
- Conditions
- Necrotizing Enterocolitis, Intestinal Atresia, Malrotation, Hirschsprung Disease
- Trial name
- NCT07526636
- Volunteers
- 120 people
- Sponsor
- Assiut University
Constipation, Hirschsprung Disease
Endoscopic Mucosal Resection for the Diagnosis of a-Ganglionosis, a Controlled Prospective Trial (EDGE Trial)
Patients undergoing routine rectal suction biopsy will undergo as part of the study an additional Endoscopic mucosal resection. The biopsy results will also be correlated with patient's clinical data including clinical history…
- Trial name
- EDGE (NCT01515501)
- Testing
- Endoscopic mucosal resection (EMR)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital