Clinical trials: Hypertonic Disorder
Allergic Rhinitis
Effect of Hypertonic Solutions on Allergic Rhinitis Patients
The purpose of this study is to assess the effectivity of using hypertonic nasal solutions alone on the symptom scores and nasal eosinophil levels of allergic rhinitis patients, retrospectively.
- Trial name
- hypertonic (NCT02233426)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Namik Kemal University
Rectal Prolapse
Comparison of Cow Milk and 15% Hypertonic Saline in the Treatment of Rectal Prolapse in Children
To see the outcome of results of Cow Milk \& Hypertonic Saline in the treatment of Rectal Prolapse in Children
- Trial name
- NCT06174584
- Testing
- Hypertonic saline, Cow Milk
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Cystic Fibrosis
Positive Expiratory Pressure During Inhalation of Hypertonic Saline in Patients With Cystic Fibrosis
This trial aims to analyze whether the inhalation of hypertonic saline combined with a positive expiratory pressure (PEP) device increases the amount of sputum expectorated during the chest physiotherapy session ( inhalation +…
- Trial name
- NCT02303808
- Testing
- INHALATION WITH PEP DEVICE (Acapella Duet)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Universidad San Jorge
Neuromuscular Diseases
Nebulised Hypertonic Saline in Children and Young People With Neuromuscular Disease and Cerebral Palsy
Pneumonia, respiratory exacerbations, and chronic pulmonary infection are important causes of emergency admissions, hospitalisations and death in children with Neuromuscular disorders and Cerebral Palsy.
- Trial name
- NCT03623698
- Testing
- Nebulised hypertonic saline
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Imperial College London
Bronchiolitis
Efficacy and Safety of 3% Hypertonic Saline Inhalation (24h vs 72h) to Treat Acute Bronchiolitis in Hospitalized Infants
Efficacy/Safety of 3% hypertonic saline inhalation (24H vs 72H) to treat acute bronchiolitis in infants.
- Trial name
- BRONDUSAL (NCT02538458)
- Testing
- 3 % hypertonic saline up to 72H, 3 % hypertonic saline up to 24H
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
TMJ Disc Disorder
Therapeutic Effect of Proliferative Therapy (Prolotherapy) on Pain Using Injectable Hypertonic Dextrose 25% Versus Injectable Dextrose 10% in Retrodiscal Tissues in Patients With Anterior Disc Displacement With Reduction: A Randomized Clinical Trial .
prolotherapy is an injection-based treatment method used to alleviate pain, particularly musculoskeletal pain associated with chronic ligament and tendon injuries.
- Trial name
- NCT06859034
- Testing
- injection of dextrose 10% in retrodiscal tissues, injection of dextrose 25% in retrodiscal tissues
- Volunteers
- 24 people
- Sponsor
- Cairo University
Allergic Rhinitis
Efficacy of Buffered Hypertonic Saline(BHS)Nasal Irrigation in Allergic Rhinitis (AR) Children
The purpose of this study is to investigate whether buffered hypertonic saline (BHS) is superior to normal saline (NSS) for improving mucociliary function and relief nasal symptoms in children with allergic rhinitis.
- Trial name
- NCT01441778
- Testing
- NSS nasal irrigation salt, BHS nasal irrigation salt
- Where
- Thailand
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Cerebral Palsy
"DOES MYOBLOC™ IMPROVE FUNCTIONAL HAND USE IN YOUNG CHILDREN WITH A HYPERTONIC UPPER EXTREMITY?"
In children with cerebral palsy, stiffness of the arm can develop early and delay or prevent the acquisition of normal hand skills.
- Trial name
- NCT00238641
- Testing
- Botulinum Toxin type B
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Bronchiolitis
The Effectiveness of Nebulized Hypertonic Saline Solution for Acute Bronchiolitis
This study evaluates the effectiveness of nebulized 3% hypertonic saline solution with salbutamol in the treatment of children under 2 years, hospitalised for acute viral bronchiolitis.
- Trial name
- NHSAB (NCT02760719)
- Testing
- nebulized 3% hypertonic solution
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Viral Bronchiolitis
Hypertonic Saline to Reduce Hospital Admissions in Bronchiolitis
Inhaled 3% hypertonic saline (HS) administered every 2-8 hours to infants admitted to hospital with viral bronchiolitis has been shown to improve airway clearance and reduces length of stay.
- Trial name
- NCT00677729
- Testing
- solution contains 1 mg salbutamol plus 3% hypertonic saline, solution contains 1 mg salbutamol plus 0.9% saline
- Where
- 3 sites in Canada
- Volunteers
- 81 people
- Sponsor
- Queen's University
BRONCHIOLITIS
Comparison of 3% Hypertonic Saline and Salbutamol in Children With Bronchiolitis
Bronchiolitis is a common lower respiratory tract infection that often leads to hospitalization in infants. The use of nebulized 3% hypertonic saline for treating bronchiolitis is being explored as an alternative to Salbutamol.
- Trial name
- NCT06665711
- Testing
- 3% Hypertonic Saline, Intervention: Salbutamol (Ventolin)
- Volunteers
- 100 people
- Sponsor
- University of Health Sciences Lahore
Acute Viral Bronchiolitis
High Flow Therapy vs Hypertonic Saline in Bronchiolitis
The purpose of this study is to demonstrate that heated, humidified, high-flow nasal cannula (HHHFNC) is superior to hypertonic saline solution (HSS) in the treatment of moderate acute viral bronchiolitis in infants in improving…
- Trial name
- NCT01873144
- Testing
- Epinephrine 1/1000, HSS 3%, HHHFNC
- Where
- 2 sites in Spain
- Volunteers
- 75 people
- Sponsor
- Ministry of Health, Spain
Melanoma (Skin)
Effect of Topical Application of Hypertonic Saline on Melanoma on Its Sizes and Number.
This study evaluates the effectiveness of applying Hypertonic Saline solution directly on the Melanomas in reducing their sizes and/or number.
- Trial name
- NCT05854589
- Testing
- Sodium Chloride Granules, Water
- Volunteers
- 20 people
- Sponsor
- Rafik Batroussy
Cystic Fibrosis
Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis
The purpose of this research study is to determine whether the combination of inhaled amiloride and a concentrated salt solution is better than the salt solution itself for cystic fibrosis (CF) patients.
- Trial name
- NCT00274391
- Testing
- 7% NaCl, Amiloride HCl
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina
Cystic Fibrosis
PEP and O-PEP Device for Nebulization in Cystic Fibrosis
Physiotherapy is an essential element in the comprehensive treatment of patients with cystic fibrosis. In symptomatic individuals, from a respiratory system perspective, it should be performed regularly, as it directly…
- Trial name
- NCT06964074
- Testing
- Nebulization with OPEP device, Nebulization with PEP device, Nebulization with Pari LC Sprint
- Where
- 2 sites in Poland
- Volunteers
- 70 people
- Sponsor
- National Institute for Tuberculosis and Lung Diseases, Poland
Bronchiolitis
Nebulized Hypertonic Saline Treatment in Hospitalized Children With Moderate to Severe Viral Bronchiolitis
The purpose of this study is planned to investigate whether frequently inhaled hypertonic saline (HS) can relieve symptoms and signs faster than normal saline (NS) and shorten length of stay (LOS) significantly for moderately to…
- Trial name
- NCT01120496
- Testing
- 3% hypertonic saline, normal saline
- Volunteers
- 135 people
- Sponsor
- Chongqing Medical University
Brain Injuries, Disorder of Consciousness
Long Term Effects of Soft Splints on Stroke Patients and Patients With Disorders of Consciousness
The purpose of this study is to assess the effects on upper limb spasticity of soft splints worn during three weeks three hours a day by patients with stroke or disorders of consciousness.
- Conditions
- Brain Injuries, Disorder of Consciousness, Stroke, Spasticity as Sequela of Stroke
- Trial name
- NCT03008486
- Testing
- Real soft splint (6 cm)
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Géraldine Martens
Bronchiolitis, Wheezing
Nebulized 3% Hypertonic Saline Solution Treatment of Bronchiolitis in Infants
Determine the efficacy of nebulized salbutamol/hypertonic saline combination in moderate to severe bronchiolitis.
- Trial name
- NCT02233985
- Testing
- 0.9% Sodium Chloride, 3% Sodium Chloride
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Common Cold, Upper Respiratory Tract Infections
Hypertonic Saline Nasal Irrigation and Gargling for the Common Cold.
Viral upper respiratory tract infections (URTI), one of the commonest infection faced by humans, have a significant impact on individuals, families, health service and economy.
- Trial name
- ELVIS (NCT02438579)
- Testing
- Nasal Irrigation & Gargling
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- NHS Lothian
Cystic Fibrosis (CF)
Rethinking Early Airway Clearence Therapies
The REACT trial consists of two parallel, randomized studies; the Hypertonic Saline Study and the Dornase Alfa Study. Health outcomes among people with cystic fibrosis (CF) have been steadily improving, most recently with the…
- Trial name
- REACT (NCT07696338)
- Testing
- As-needed hypertonic saline (HS), Twice daily hypertonic saline (HS), As-needed dornase alfa (DA)
- Where
- 39 sites in United States, Canada
- Volunteers
- 405 people
- Sponsor
- Nicole Hamblett