Clinical trials: Infection Control
HIV Infection
Phase I Study to Evaluate the Safety and Immunogenicity of HIV-1 Immunogen in Children With HIV-1 Infection
This is a single dose, phase I study to evaluate the safety/tolerance and the immunogenicity of HIV-1 Immunogen, gp120-depleted inactivated HIV-1 preparation in Incomplete Freund's Adjuvant (IFA), in children with HIV-1…
- Trial name
- NCT00001445
- Testing
- HIV-1 Immunogen
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- National Cancer Institute (NCI)
Bronchiolitis
Epinephrine, Dexamethasone and Hypertonic Saline in Bronchiolitis
Bronchiolitis is one of the main reasons for consultation in primary care and emergency services, as well as the leading cause of hospitalization for lower respiratory tract infection in children under two years.
- Trial name
- NCT02585531
- Testing
- Hypertonic Saline 3%, Epinephrine and Dexamethasone
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Hospital General Naval de Alta Especialidad - Escuela Medico Naval
Poliomyelitis
An Immunogenicity and Safety Study of Sabin Inactivated Poliovirus Vaccine (Vero Cell) in 2-month-old Infants
The purpose of this phase III study is to evaluate the immunogenicity and safety of Sabin Inactivated Poliovirus Vaccine (Vero cell) in 2-month-old infants.
- Trial name
- NCT03526978
- Testing
- Investigational sIPV, Control IPV
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Syphilis, Congenital
Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates
The Investigator hypothesize that the treatment efficacy will be similar in both study arms. Secondary outcomes and endpoints will characterize safety by comparing adverse events (AEs), tolerability, and adherence to therapy in…
- Trial name
- NCT07457385
- Testing
- Benzathine Penicillin, Amoxicillin
- Where
- 11 sites in United States
- Volunteers
- 374 people
- Sponsor
- University of Alabama at Birmingham
Hepatitis E
A Clinical Trial to Evaluate a Recombinant Hepatitis E Vaccine in Healthy Adults
Hepatitis E is characteristic by sporadic and local epidemic around the world, and mainly infects adults aged 15 to 40 years old, resulting in the infection rate ranged from 1% to 15%.
- Trial name
- NCT02603055
- Testing
- 30μg/0.5ml Hepatitis E vaccine, 30μg/0.5ml Recombinant Hepatitis E vaccine
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Schistosomiasis, Anaemia
Schistosomiasis in Women of Reproductive Age in Burkina Faso: Implications for Control
Cross-sectional study of prevalence and intensity of schistosome infection in pregnant women, follow-up into postpartum, and the association of schistosome infection with haemoglobin concentration, compared to a group of…
- Conditions
- Schistosomiasis, Anaemia, Pregnancy
- Trial name
- NCT00463632
- Where
- 2 sites in Burkina Faso
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development
Hemodynamic Response, Acute Appendicitis
Lidocaine VS Hemodynamic, Metabolic and Hormonal Response
Intravenous lidocaine - a potent local anesthetic with analgesic and anti- inflammatory properties has been shown to be an effective adjunct that reduces intra and postoperative opioid consumption and facilitates pain management…
- Conditions
- Hemodynamic Response, Acute Appendicitis, Complication of Treatment, Opioid Consumption
- Trial name
- NCT05238506
- Testing
- Intravenous lidocaine, Normal saline infusion
- Where
- Poland
- Volunteers
- 132 people
- Sponsor
- Medical University of Warsaw
Wheezy Bronchitis
Intravenous Magnesium in Wheezy Bronchitis
In infants and toddlers wheezy bronchitis is a common viral disease. To relieve wheezing symptoms bronchodilators or corticosteroids are commonly used but the efficacy is not always satisfactory.
- Trial name
- NCT01383655
- Testing
- Magnesium Sulfate
- Where
- Finland
- Volunteers
- 61 people
- Sponsor
- University of Oulu
Onychomycosis
Efficacy, Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail
This study is designed to assess the efficacy, safety and tolerability of a topical formulation of terbinafine solution applied daily in patients with toenail fungus.
- Trial name
- NCT00443898
- Testing
- terbinafine
- Where
- 22 sites in United States, Canada and 1 more
- Volunteers
- 518 people
- Sponsor
- Novartis Pharmaceuticals
Severe Sepsis, Acute Lung Injury
Citrulline in Severe Sepsis
This is a randomized, double-blind, placebo-controlled, phase 2 study to evaluate biochemical, clinical, and safety effects of 2 doses of intravenous L-citrulline compared to placebo in patients with severe sepsis at risk for or…
- Trial name
- NCT01474863
- Testing
- High Dose Citrulline, Low Dose Citrulline
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Vanderbilt University
Stress, COVID-19 Pandemic
Effects of an Immersive Virtual Reality Intervention Combined With Mindfulness-based Stress Reduction
Mindfulness-based stress reduction (MBSR), a widely used method to improve mental state and sleep quality, was developed by Kabat-Zinn in 1970.
- Conditions
- Stress, COVID-19 Pandemic, Nurse's Role
- Trial name
- NCT05517148
- Testing
- Therapeutic VR
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Trachoma
Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania
After single, yearly, mass treatment of communities with azithromycin for active trachoma, what is the added effectiveness for reduction of trachoma and ocular C.
- Trial name
- NCT00347607
- Testing
- community surveillance and re-treatment
- Where
- 2 sites in United States, Tanzania
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Onchocerciasis, Ascaris Lumbricoides Infection
Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases
This clinical trial compares two treatments - ivermectin and moxidectin - to learn which is better at reducing the proportion of people with onchocerciasis (river blindness) when given through mass drug administration (MDA) in…
- Conditions
- Onchocerciasis, Ascaris Lumbricoides Infection, Trichuris Trichiura; Infection, Hookworm Infections
- Trial name
- EKAIO (NCT07145736)
- Testing
- Moxidectin, Ivermectin
- Where
- Angola
- Volunteers
- 52,000 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
COVID-19
A Study of Immune System Proteins in Participants With Mild to Moderate COVID-19 Illness
The purpose of this study is to measure how well monoclonal antibodies work, either alone or in combination, against the virus that causes COVID-19. Study drug(s) will be given to participants with early symptoms of COVID-19.
- Trial name
- BLAZE-4 (NCT04634409)
- Testing
- Bamlanivimab, Etesevimab, VIR-7831
- Where
- 141 sites in United States, Argentina and 1 more
- Volunteers
- 1,755 people
- Sponsor
- Eli Lilly and Company
Feeding Intolerance, Necrotizing Enterocolitis
Bovine Colostrum as a Human Milk Fortifier for Preterm Infants
Very preterm infants (<32 weeks gestation) show the immaturity of organs and have high nutrient requirements for growth and development.
- Conditions
- Feeding Intolerance, Necrotizing Enterocolitis, Postnatal Growth, Late-Onset Neonatal Sepsis
- Trial name
- FortiColos-Ⅱ (NCT03822104)
- Testing
- Bovine Colostrum, FM85
- Where
- 2 sites in China
- Volunteers
- 139 people
- Sponsor
- Per Torp Sangild
Respiratory Tract Infection Viral
Echinacea Junior vs Vitamin C in Children 4-12 Years Old
Aim of this study is to investigate efficacy and safety of Echinaforce Junior Tablets (250mg) in comparison with Vitamin C tablets in the prevention of acute viral respiratory tract infections.
- Trial name
- NCT02971384
- Testing
- Echinaforce
- Where
- Switzerland
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- A. Vogel AG
Virus Diseases, Hepatitis B
Study of the Immunogenicity and Safety of a Challenge Dose of HBVAXPRO in Healthy Children Vaccinated 10 Years Ago With 3 Doses of HEXAVAC or INFANRIX HEXA
To evaluate the immune response to Hepatitis B virus in children who have been primed with HEXAVAC or INFANRIX HEXA 10 years ago.
- Trial name
- NCT02012998
- Testing
- HBVAXPRO 5µg
- Where
- 10 sites in Italy
- Volunteers
- 751 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Head and Neck Neoplasms, Wound Infection
Role of Prophylactic Antibiotics in New Introducer PEG-Gastropexy
Peristomal infections are the commonest complications of PEG despite prophylactic antibiotics which may result in emergence of resistant micro-organisms like Methicillin resistant Staphylococcus aureus (MRSA).
- Trial name
- NCT00375414
- Testing
- PEG-Gastropexy
- Where
- Germany
- Volunteers
- 97 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Upper Respiratory Tract Infections, Lower Respiratory Tract Infections
Maternal Vitamin D for Acute Respiratory Infections in Infancy
There is a growing body of data suggesting that vitamin D modulates the host's immune response to acute respiratory infection (ARI).
- Trial name
- MDARI (NCT02388516)
- Testing
- Vitamin D3
- Where
- Bangladesh
- Volunteers
- 1,214 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Meningococcal Disease, Infections, Meningococcal
Safety and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' Meningococcal B Recombinant Vaccine When Administered Concomitantly With Routine Vaccines to Healthy Infants of 2 Months of Age and Older, in Taiwan.
Assess the safety and immunogenicity of a 3-dose schedule (at 2, 4, 6 months) of GSK Biologicals' Meningococcal B recombinant vaccine followed by a booster at 12 months when concomitantly administered with routine vaccines in…
- Trial name
- NCT02173704
- Testing
- Bexsero®, Routine vaccines
- Where
- 2 sites in Taiwan
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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