Clinical trials: Infiltration
Brain Tumor, Brain Metastases
TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and Meningiomas
This Phase I/II study evaluates the safety and efficacy of autologous tumor-infiltrating lymphocytes (TIL) therapy combined with Pembrolizumab (Keytruda) immunotherapy in patients with Advanced Brain Cancer including Gliomas and…
- Conditions
- Brain Tumor, Brain Metastases, Brain Cancer, Glioma
- Trial name
- BAH2472 (NCT06640582)
- Testing
- Tumor Infiltrating Lymphocytes (TIL), Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Essen Biotech
Anesthesia, Local
Efficiency of Single Buccal Infiltration Versus Buccal and Intrapapillary Infiltration
Everyday practice in dentistry is based on giving the painless injection and achieving adequate local anesthesia. Various techniques of reducing injection pain in children can be broadly categorized as psychological and physical.
- Trial name
- NCT04458142
- Testing
- Single buccal infiltration
- Volunteers
- 25 people
- Sponsor
- Cairo University
Stage IIIA Ovarian Cancer, Stage IIIB Ovarian Cancer
Study of Tumor Tissue Samples From Patients Who Have Undergone Surgery for Advanced Stage III or Stage IV Ovarian Epithelial Cancer
This research study is looking at tumor tissue samples from patients who have undergone surgery for advanced stage III or stage IV ovarian epithelial cancer.
- Conditions
- Stage IIIA Ovarian Cancer, Stage IIIB Ovarian Cancer, Stage IIIC Ovarian Cancer, Stage IV Ovarian Cancer
- Trial name
- NCT01000259
- Testing
- Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Gynecologic Oncology Group
Posterior Fossa Tumors
The Effects of Scalp Block on Haemodynamic Response and Postoperative Pain in Posterior Fossa Surgery
This study evaluate the effects of scalp block versus local infiltration on haemodynamic response to head pin replacement and skin incision and postoperative analgesia in posterior fossa surgery
- Trial name
- NCT02852382
- Testing
- Bupivacaine, morphine patient controlled analgesia
- Volunteers
- 45 people
- Sponsor
- Istanbul University
Molar Incisor Hypomineralization
Clinical Evaluation of Resin Infiltration Treatment of MIH-affected Teeth in Pediatric Patients
The goal of this clinical trial is to examine the clinical success of different pre-treatments in resin infiltration therapy applied to the incisors of pediatric patients with Molar Incisor Hypomineralization (MIH) and to…
- Trial name
- NCT07469124
- Testing
- Resin Infiltration, Microabrasion Followed by Resin Infiltration, Air Abrasion Followed by Resin Infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Inonu University
Pediatric Anesthesia, Local Anesthesia
The Effect of Needle-free Injection System During Palatal Anesthesia
Needle-free injection systems can contribute to the prevention of needle-related pain during palatal infiltration anesthesia (PIA) in children.
- Trial name
- NCT05166291
- Testing
- Comfort-in injection system, traditional anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Okan University
Molar Incisor Hypomineralization
Resin Infiltration Treatment Versus a Combined Treatment With Microabrasion for the Management of MIH Affected Incisors
The prevalence of molar incisor hypomineralization is relatively high. It has been reported that MIH-affected children experience a wide range of negative impacts because of having visible enamel opacities on their incisors…
- Trial name
- NCT04471571
- Testing
- Resin infiltration and microabrasion for MIH-affected incisors, Resin infiltration for MIH-affected incisors
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Anesthesia, Dental, Pain, Postoperative
Articaine vs Lidocaine for Pediatric Dental Procedures
The purpose of this study is to compare the efficacy of two types of local anesthesia (articaine and lidocaine) for infiltration anesthesia during restorative dental procedures on lower teeth in pediatric patients.
- Trial name
- NCT03318952
- Testing
- lidocaine, articaine
- Where
- United States
- Sponsor
- Boston University
Mesothelioma
Cryoablation for the Promotion of Local Tumor Infiltration in Patients With Mesothelioma
This trial evaluates if cryoablation will stimulate a local immune response by cluster of differentiation 8 positive (CD8+) cells which are not present in ablation naive regions of the tumors in patients with mesothelioma.
- Trial name
- NCT04429204
- Testing
- Biospecimen Collection, Cryosurgery
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Infiltration Facet Joint
Predictability of the Effects of Facet Joint Infiltration in the Degenerate Lumbar Spine When Assessing MRI Scans
Fifty MRI scans of patients with chronic lumbar back pain were graded radiologically using a wide range of classification and measurement systems.
- Trial name
- NCT03308149
- Testing
- infiltration with triamcinolone and bupivacaine
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Tuebingen
Postoperative Pain
Caudal Block v/s Local Wound Infiltration for Pain Control in Pediatric Patients After Operation for Inguinal Hernia
This randomized controlled trial aims to compare the analgesic efficacy of local wound infiltration with Ropivacaine versus Caudal Block with Ropivacaine in pediatric patients undergoing surgery for inguinal hernia
- Trial name
- NCT07747038
- Testing
- Caudal Block with Ropivacaine Intervention, Local Wound Infiltration with Ropivacaine Intervention, Intravenous Paracetamol Suspension Intervention
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Fatima Memorial Hospital
Anesthesia
Comparison of Articaine Mandibular Infiltration to Lidocaine Inferior Alveolar Nerve Block in Pediatric Patients
This is a prospective, single-blind, parallel-design randomized controlled clinical trial that aims compare the effectiveness of articaine local infiltration to lidocaine inferior alveolar nerve block (IANB) for restorative…
- Trial name
- NCT04865848
- Testing
- Dental local anesthesia
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Soft Tissue Sarcoma, Primary Central Nervous System Carcinoma
Study of Autologous Tumor-Infiltrating Lymphocytes in Pediatric, Adolescent, and Young Adult Participants
This study is planned to test the safety and tolerability of the TIL regimen. The study will also test how well TIL fights cancer.
- Conditions
- Soft Tissue Sarcoma, Primary Central Nervous System Carcinoma, Melanoma, Rhabdomyosarcoma
- Trial name
- NCT06566092
- Testing
- LN-145/LN-144
- Where
- 5 sites in United States
- Volunteers
- 5 people
- Sponsor
- Iovance Biotherapeutics, Inc.
Melanoma
Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma
Objectives: The primary objective will be to determine whether patients receiving the combination of dendritic cells and high dose IL-2 (Cohort A) have sustained persistence of infused T cells compared to patients treated with T…
- Trial name
- NCT00338377
- Testing
- Dendritic Cell Immunization, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 1,230 people
- Sponsor
- M.D. Anderson Cancer Center
Obesity, Morbid, Pain, Postoperative
Efficacy of CPPLAI in Laparoscopic Sleeve Gastrectomy Patients
The high demand for bariatric surgery due to the increasing prevalence of obesity worldwide necessitate evidence-based clinical pathway such as Enhanced Recovery After Bariatric Surgery (ERABS).
- Trial name
- CPPLAI (NCT04680923)
- Testing
- CPPLAI, Bupivacaine 0.25%
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- King Khalid University Hospital
Inguinal Hernia
Comparison of Regional Block, Wound Infiltration and Caudal Block for Pain Management in Children
Comparison of regional block, wound infiltration and caudal block for post operative pain management in participants undergoing inguinal herniotomy.
- Trial name
- RCT (NCT05969613)
- Testing
- Regional block, Wound infiltration, Caudal block
- Where
- Pakistan
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University
Breast Cancer
Combination Chemotherapy With or Without Trastuzumab Followed By an Autologous Stem Cell Transplant and Radiation Therapy in Treating Patients With Stage III or Stage IV Breast Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00182793
- Testing
- trastuzumab, carboplatin, cyclophosphamide
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- City of Hope Medical Center
Local Anesthetic Infiltration, Topical Anesthesia
Topical Cryoanesthesia Versus Benzocaine in Pediatric Dentistry
This clinical study tested and compared two ways (cold-base technique or "cryoanesthesia" and conventional benzocaine gel) to reduce pain from dental injections in children.
- Conditions
- Local Anesthetic Infiltration, Topical Anesthesia, Pain Perception
- Trial name
- No acronym (NCT07351383)
- Testing
- Local Anesthesia (lidocaine hydrochloride)
- Where
- Mexico
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Esophageal Squamous Cell Carcinoma
Prediction of Lymph Node Status in Stage T1 Esophageal Squamous Cell Carcinoma（RENMIN-237）
Accurate assessment of lymph node status in superficial esophageal squamous cell carcinoma is of great significance for preventing undertreatment and overtreatment.
- Trial name
- NCT05980403
- Testing
- no intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Yongshun Chen
Pain
Comparison of Intraosseous Anesthesia Osteocentral With Electronic Assistance to Injection With Conventional Anesthesia
Anesthesia systems with electronic injection assistance for slow injection pressure-limiting drips (especially for intraosseous anaesthesia) are offered to limit pain.
- Trial name
- SLEEPER-ONE (NCT04629924)
- Testing
- sleeper one, conventional technis
- Where
- 5 sites in France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Nice