Clinical trials: Inhalation Pneumonia
Nosocomial Pneumonia, Healthcare-Associated Pneumonia
Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients
Oropharyngeal bacteria play an important role in the pathogenesis of nosocomial pneumonia in critically ill patients. Oral cleansing with chlorhexidine has been shown to decrease incidence of pneumonia in patients undergoing open…
- Conditions
- Nosocomial Pneumonia, Healthcare-Associated Pneumonia, Aspiration Pneumonia, Ventilator-Associated Pneumonia
- Trial name
- NCT00610324
- Testing
- Chlorhexidine gluconate, Potassium permanganate
- Where
- India
- Volunteers
- 512 people
- Sponsor
- King Edward Memorial Hospital
Severe Pneumonia
Feasibility and Preliminary Efficacy of a Child Life-Based Breathing Exercise Program for Children Recovering From Severe Pneumonia: A Pilot Randomized Controlled Trial
The goal of this pilot randomized controlled trial is to evaluate the feasibility and preliminary efficacy of a child life-based breathing exercise program for children recovering from severe pneumonia.
- Trial name
- NCT07593989
- Testing
- routine health education + a Child Life-Based Breathing Exercise Program, routine health education
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Fudan University
Pneumonia, Tachypnea
Randomized Trial of Amoxicillin Versus Placebo for (Fast Breathing) Pneumonia
The relative benefits and risks of antibiotic therapy in WHO defined fast breathing pneumonia in pre-school children in resource limited settings are controversial both at an individual and public health level.
- Trial name
- RETAPP (NCT02372461)
- Testing
- Amoxicillin
- Where
- Pakistan
- Volunteers
- 4,000 people
- Sponsor
- Aga Khan University
Asthma, Heart Failure
The General Breathing Record Study
This study will test the use of a new handheld device (called the N-Tidal C), that measures a person's tidal breath carbon dioxide, in diagnosing the cause of someone's breathlessness.
- Conditions
- Asthma, Heart Failure, Pneumonia, Motor Neuron Disease
- Trial name
- GBRS (NCT03356288)
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- TidalSense
Covid19
Inhalation of KELEA Excellerated Water in Covid-19 Infected Individuals
Preliminary reports have been received from several sources that the periodic inhaling of the nebulized mist from water that has a heightened level of kinetic activity has quickly (less than 2 days) lessened the severity of…
- Trial name
- NCT04490824
- Testing
- KELEA Excellerated Water, Water Without an Elevated Level of KELEA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Institute of Progressive Medicine
SARS-CoV-2 Infection
Chronic Mouth Breathing and SARS-CoV-2 Positivity in the Pediatric Population
Numerous non-scientific articles on the internet assert the significance of nasal breathing in protecting against COVID-19. Although nasal breathing is anticipated to result in a reduced intake of bioparticles when compared to…
- Trial name
- BREATH-COV (NCT07063134)
- Where
- Turkey (Türkiye)
- Volunteers
- 173 people
- Sponsor
- Dokuz Eylul University
Motor Neuron Disease, Amyotrophic Lateral Sclerosis, ALS (Amyotrophic Lateral Sclerosis)
Music Therapy Protocol to Support Bulbar and Respiratory Functions in ALS
This study evaluates potential of music therapy treatment to support breathing, speech, swallow and cough of persons with amyotrophic lateral sclerosis (ALS).
- Conditions
- Motor Neuron Disease, Amyotrophic Lateral Sclerosis, ALS (Amyotrophic Lateral Sclerosis), Dysarthria, Flaccid, Dysarthria, Spastic
- Trial name
- NCT03604822
- Testing
- Music therapy
- Where
- 2 sites in Russia, United Kingdom
- Volunteers
- 8 people
- Sponsor
- Alisa Apreleva
Infant, Newborn, Hypertension, Pulmonary
Inhaled Nitric Oxide Study for Respiratory Failure in Newborns
Respiratory failure in term newborns is associated with increased rates of death and long-term neurodevelopmental problems. This large international multicenter trial randomized newborns who had failed to respond to intensive…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- NINOS (NCT00005776)
- Testing
- Inhaled nitric oxide
- Where
- 20 sites in United States, Canada
- Volunteers
- 235 people
- Sponsor
- NICHD Neonatal Research Network
Respiratory Syncytial Virus Infections
Ribavirin to Prevent RSV Pneumonia in Bone Marrow Transplant Patients
The purpose of this study is to test the safety and effectiveness of ribavirin, administered as an aerosol, in preventing progression of upper respiratory tract RSV infection to RSV pneumonia in bone marrow and peripheral blood…
- Trial name
- NCT00031473
- Testing
- Virazole (Ribavirin) Inhalation Solution
- Where
- 11 sites in United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bacterial Infection
Bacterial Pulmonary Infection in PICU
The purpose of this study is to develop a scoring system to allow doctors to accurately identify children on a mechanical ventilator who have bacterial pneumonia.
- Trial name
- NCT00271531
- Where
- 4 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19, Dysfunctional Breathing
Prognostic of Dysfunctional Breathing in Long Covid: a Follow up Study
Dysfunctional breathing might participate to dyspnoea in long COVID-19. This study investigate the prognosis of patients diagnosed with dysfunctional breathing after SARS-CoV-2 infection in our center.
- Trial name
- NCT05217875
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Hôpital du Valais
Pneumonia, Pneumocystis Carinii, HIV Infections
Aerosols in the Treatment of Asymptomatic Pneumocystis Pneumonia: A Pilot Study Assessing the Effectiveness of Aerosolized Pentamidine as Treatment of Subclinical Pneumocystis Infection in Patients With No Clinical Symptoms
To confirm the ability of pulmonary (lung) function testing (PFT) to detect Pneumocystis carinii pneumonia (PCP) before the development of clinical symptoms and to determine if pentamidine (PEN), a drug used in treating PCP, can…
- Trial name
- NCT00000707
- Testing
- Pentamidine isethionate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumonia, Pneumocystis Carinii, HIV Infections
A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral/Oral Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia in AIDS
To compare the safety and effectiveness of drug therapy with aerosolized pentamidine (PEN) with that of conventional therapy, sulfamethoxazole plus trimethoprim (SMX/TMP) in the treatment of Pneumocystis carinii pneumonia (PCP)…
- Trial name
- NCT00000715
- Testing
- Pentamidine isethionate, Sulfamethoxazole-Trimethoprim
- Where
- 9 sites in United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bacterial Pneumonia, Viral Pneumonia
Inhaled Corticosteroids in U-5 Children With Acute Respiratory Infection in Uganda: A Randomised Trial
The purpose of this study is to find out whether adjunct treatment with inhaled corticosteroids lead to faster improvement and reduce mortality of children under 5 years of age admitted to hospital with ALRI.
- Conditions
- Bacterial Pneumonia, Viral Pneumonia, Acute Asthma
- Trial name
- ICS (NCT01868113)
- Testing
- Inhaled corticosteroid
- Where
- Uganda
- Volunteers
- 1,010 people
- Sponsor
- Makerere University
Pneumonia, Pneumocystis Carinii, HIV Infections
A Study of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia
To evaluate and compare 3 anti-pneumocystis regimens plus zidovudine (AZT) in persons with advanced HIV disease and T4 cell count < 200 cells/mm3.
- Trial name
- NCT00001003
- Testing
- Pentamidine isethionate, Zidovudine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Clinical Infection, Outcome
Efficacy and Safety of Ethanol Inhalation on COVID-19 Treatment (a Clinical Trial Study)
Cytokine storm is the cause of many deaths in COVID -19. The antiviral in-vitro effects of ethanol with solving the fat layer and destroying the glycoprotein of coronavirus have already been established.
- Conditions
- Clinical Infection, Outcome, Morality
- Trial name
- COVID-19 (NCT05268419)
- Testing
- Ethanol, Water Distilled
- Where
- Iran
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ali Amoushahi
Ventilator Acquired Pneumonia, Catheter Related Blood Stream Infections
Ontario ICU Clinical Best Practices Demonstration Project
The pragmatic issue at hand how to get physicians and nurses to use best practices… and how to measure consequences of their implementation.
- Conditions
- Ventilator Acquired Pneumonia, Catheter Related Blood Stream Infections, Pressure Ulcer Prophylaxis, DVT Prophylaxis
- Trial name
- NCT00332982
- Testing
- Focused knowledge translation strategies
- Where
- Canada
- Sponsor
- Sunnybrook Health Sciences Centre
Gastrostomy, Aspiration Pneumonia
The Effect of Semi-solid Feeding After Percutaneous Endoscopic Gastrostomy (PEG) on the Incidence of Aspiration Pneumonia and Postoperative Length of Stay
Percutaneous endoscopic gastrostomy (PEG) is a minimally invasive procedure for long-term enteral tube feeding in patients with insufficient oral intake.
- Trial name
- NCT02858596
- Testing
- Semi-solid feed (Terumo PG soft), Liquid feed (Meibalance)
- Volunteers
- 136 people
- Sponsor
- Hiroshima Kyoritsu Hospital
Esophageal Motility Disorders, Gastric Motor Dysfunction
Gastrointestinal Dysmotility on Aspiration Risk
The hypothesis of this study is that esophageal and gastric dysmotility increase the risk of developing aspiration-associated symptoms in children with neurologic impairment.
- Conditions
- Esophageal Motility Disorders, Gastric Motor Dysfunction, Aspiration Pneumonia, Gastro Esophageal Reflux
- Trial name
- NCT05455359
- Testing
- Prucalopride, Famotidine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Boston Children's Hospital
Pneumonia
3 Days Amoxicillin Versus Placebo for Fast Breathing Childhood Pneumonia in Malawi
The purpose of this study to assess the effectiveness of no antibiotic treatment for fast breathing, community-acquired childhood pneumonia in a malaria-endemic region of Malawi.
- Trial name
- NCT02760420
- Testing
- Amoxicillin
- Where
- 2 sites in Malawi
- Volunteers
- 1,126 people
- Sponsor
- Save the Children