Clinical trials: Intensity-modulated Radiotherapy
Prostate Cancer
Intensity-Modulated Radiation Therapy in Treating Patients With Prostate Cancer
RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
- Trial name
- NCT00946543
- Testing
- hypofractionated radiation therapy, intensity-modulated radiation therapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 198 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Nasopharyngeal Cancer Recurrent
Intensity Modulated Radiotherapy in Recurrent T1-2 Nasopharyngeal Carcinoma
The hypothesis of the study is to address the efficacy and toxicity profile of aforementioned four modalities for rT1-2 NPC. Characters of the patients: list item one: 168 patients, median age 48 years (range 16-75 years） proven…
- Trial name
- NCT02113423
- Testing
- 3D-CRT, IMRT, BT, BT combined 3D-CRT or IMRT
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Fujian Cancer Hospital
Craniopharyngioma
A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection
Craniopharyngioma is a rare brain tumor that affects both children and adults. It arises in a region of the brain near the pituitary gland, visual pathways, and central blood vessels.
- Trial name
- NCT02792582
- Testing
- Proton Therapy, Surgery
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- St. Jude Children's Research Hospital
Diffuse Intrinsic Pontine Gliomas (DIPG)
IMPT Versus IMRT for Diffuse Intrinsic Pontine Glioma
This is a prospective, open-label, multicenter, phase III randomized controlled trial comparing intensity-modulated proton therapy (IMPT) with intensity-modulated radiation therapy (IMRT) in participants aged 3-18 years with…
- Trial name
- NCT07869524
- Testing
- Intensity-Modulated Proton Therapy (IMPT), Intensity-Modulated Radiation Therapy (IMRT)
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Shandong Cancer Hospital and Institute
Breast Neoplasms
A Clinical Trial to Reduce Skin Burn Induced by Breast Radiotherapy Using Intensity Modulated Radiation Therapy (IMRT)
The purpose of this study is to determine whether the use of a 3D missing tissue compensation radiation technique during a standard adjuvant breast radiotherapy delivering a dose of 50Gy in 25 treatments could reduce…
- Trial name
- NCT00187343
- Testing
- Breast IMRT
- Where
- 2 sites in Canada
- Volunteers
- 340 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prostate Cancer
Biological Imaging for Optimising Clinical Target Volume (CTV) and Gross Tumour Volume (GTV) Contouring in Prostate Cancer to Improve the Possibilities for Intensity Modulated RadioTherapy (IMRT) Dose Escalation
The clinical outcome after external beam irradiation for prostate cancer is disappointing in the advanced tumor stages. There are indications that an increase in radiation dose to the tumor will improve outcome significantly…
- Trial name
- NCT00122252
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Alberta Health services
Head and Neck Cancer, Radiotherapy
A New Delineation Approach for Oral Cavity, Oropharynx, Larynx and Hypopharynx in IMRT for Head and Neck Cancer
The investigators tries a new method to delineating the oral cavity, oropharynx, larynx and hypopharynx, and use the head-and-neck region to test whether the method can to create a good IMRT plan, and alleviate the oral radiation…
- Conditions
- Head and Neck Cancer, Radiotherapy, Oropharynx Abnormality, Radiotherapy; Adverse Effect
- Trial name
- NCT05539144
- Testing
- "Oropharyngeal mucosa", oropharynx, oropharynx and "oropharyngeal mucosa"
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Hebei Provincial Hospital of Traditional Chinese Medicine
Acute Leukemia, Myelodysplastic Syndrome
TBI Using IMRT (VMAT or Tomotherapy) for the Prevention of Pul Toxicities in Patients Undergoing Donor SCT
This trial studies how well radiation therapy techniques, volumetric modulated arc therapy (VMAT) and tomotherapy, work to reduce doses to the lung compared to standard total body irradiation methods to prevent pulmonary…
- Trial name
- NCT04281199
- Testing
- Hematopoietic Cell Transplantation, Intensity-Modulated Radiation Therapy, Tomotherapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Prostate Cancer
Radiation Therapy With or Without Bicalutamide and Goserelin in Treating Patients With Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Bicalutamide and goserelin may fight prostate cancer by reducing the production of testosterone.
- Trial name
- NCT00021450
- Testing
- bicalutamide, goserelin acetate, adjuvant therapy
- Where
- 20 sites in Belgium, Cyprus and 9 more
- Volunteers
- 819 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Anal Cancer, Quality of Life
Prospective Cohort on Quality of Sexual Life Among Men Who Have Sex With Men Treated for Anal Cancer With Concurrent Chemotherapy and Intensity-modulated Radiotherapy
Treatment of anal cancer has been always linked to quality of life. Recently, with development on radiotherapy technique, toxicities have been lowered with the maintenance of adequate rates of disease control.
- Trial name
- NCT02949596
- Testing
- Quality of life and quality of sexual life questionnaires
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Palliative Radiotherapy, Radiotherapy, Intensity-Modulated
Advanced Techniques for Single-fraction Palliative Radiotherapy Versus ASPIRE-single
One third of patients treated in the radiation oncology departments are treated with palliative intent. These patients can be unwell due to their advanced disease and suffering from pain and other symptoms related to metastases.
- Trial name
- ASPIRE single (NCT04658537)
- Testing
- Radiation Therapy
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Royal North Shore Hospital
Prostate Cancer
Intraprostatic MAXimal Simultaneous Boost
This trial uses a type of radiotherapy called intensity modulated radiotherapy (IMRT), which is able to deliver the radiation to the prostate while delivering less dose to the surrounding normal organs compared with standard 3D…
- Trial name
- NCT00798837
- Testing
- Intraprostatic maximal simultaneous boost
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- British Columbia Cancer Agency
Adult Supratentorial Primitive Neuroectodermal Tumor (PNET), Ewing Sarcoma of Bone
Whole-Body Radiation Therapy, Systemic Chemotherapy, and High-Dose Chemotherapy Followed By Stem Cell Rescue in Treating Patients With Poor-Risk Ewing Sarcoma
This pilot clinical trial studies whole-body radiation therapy, systemic chemotherapy, and high-dose chemotherapy followed by stem cell rescue in treating patients with poor-risk Ewing sarcoma.
- Conditions
- Adult Supratentorial Primitive Neuroectodermal Tumor (PNET), Ewing Sarcoma of Bone, Extraosseous Ewing Sarcoma, Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
- Trial name
- NCT01795430
- Testing
- etoposide, ifosfamide, intensity-modulated radiation therapy
- Where
- United States
- Sponsor
- City of Hope Medical Center
Sarcoma
IMRT Lower Limb Soft Tissue Sarcoma
Intensity-modulated radiation therapy may make wound healing problems less likely by 1)precisely shaping the region of high radiation dose to the shape of the tissue which harbours tumour cells, and 2) precisely shaping the…
- Trial name
- NCT00188175
- Testing
- Intensity Modulated Radiation Therapy
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- University Health Network, Toronto
Uterine Cancer, Cervical Cancer
Intensity Modulated Radiotherapy (IMRT) for the Pelvis Post-Hysterectomy
The goal of this clinical research study is to use CT scans to find any changes in position of the vagina and pelvic lymph node areas during the course of IMRT radiation therapy.
- Conditions
- Uterine Cancer, Cervical Cancer, Endometrial Cancer
- Trial name
- NCT00508703
- Testing
- Intensity Modulated Radiotherapy (IMRT), CT Scan
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Neoplasm Metastasis, Pain
Volumetric Intensity Modulated Arc Therapy vs. Conventional Radiotherapy for Cancer Pain
This study compares the use of conventional radiotherapy technique with volumetric intensity-modulated radiotherapy (VMAT) in the treatment of painful cancer metastases.
- Conditions
- Neoplasm Metastasis, Pain, Radiotherapy Side Effect, Quality of Life
- Trial name
- NCT03374592
- Testing
- Volumetric Intensity-Modulated Arc Therapy, Conventional Radiotherapy
- Volunteers
- 73 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Malignant Tumor, Benign Neoplasm
Twenty-five Years of Advanced RadioTherapy at San Raffaele Hospital
This retrospective observational study aims to evaluate the efficacy and toxicity of advanced radiotherapy (ART) techniques, including intensity-modulated radiotherapy (IMRT), image-guided radiotherapy (IGRT), and stereotactic…
- Conditions
- Malignant Tumor, Benign Neoplasm, Parkinson Disease, Trigeminal Neuralgia
- Trial name
- 25-ART-HSR (NCT07894900)
- Testing
- Advanced radiotherapy techniques
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS San Raffaele
Adenocarcinoma of the Prostate
High Dose-Rate Brachytherapy and/or Intensity Modulated External Beam Radiation Therapy for Prostate Cancer
The principal objective of this study is to demonstrate that patients can safely receive combined High Dose Rate brachytherapy and Intensity-Modulated Radiation Therapy without experiencing a treatment limiting toxicity.
- Trial name
- NCT00243321
- Testing
- high dose-rate brachytherapy, intensity-modulated radiation therapy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Virginia Commonwealth University
NPC
IMRT vs 2DRT for NPC Patients
Irradiation of the parotid gland with subsequent long-term xerostomia is a well-recognized complication after radiotherapy for head and neck (HAN) cancers.
- Trial name
- NCT03352778
- Testing
- IMRT, 2DRT
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Non-small Cell Lung Cancer
Gated Intensity Modulated Radiation Therapy and Concurrent Chemotherapy for Inoperable NSCLC
Radiation therapy technology that allows increased radiation dose to the tumor while sparing healthy tissue will improve the balance between complications and cure.
- Trial name
- NCT00692380
- Testing
- Fractionated radiation therapy followed by chemotherapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Virginia Commonwealth University