Clinical trials: Intestinal Infection
Influenza
The Interaction Between Mucosal Microbiota Colonization and the Immune Response to an Intranasal Influenza Live Attenuated Vaccine
This is a single-center, randomized, open-label trial designed to explore the interaction between mucosal microbiota colonization in the nasal cavity and gut and the immune response to an intranasal live attenuated influenza…
- Trial name
- NCT06609811
- Testing
- Intranasal Influenza Live Attenuated Vaccine
- Where
- China
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Inflammatory Bowel Diseases, Hepatitis C Virus Infection
Evaluation of the Safety and Effectiveness of Direct-acting Antiviral Drugs in the Treatment of Hepatitis C in Patients With Inflammatory Bowel Disease: National Multicenter Study
The prevalence of hepatitis C virus infection (HCV) in patients with inflammatory bowel disease (IBD) ranges from 1-6%. Direct-acting antivirals (DAAs), with cure rates >90%, represent a radical change from interferon-based…
- Trial name
- MIC project (NCT05452187)
- Testing
- Assess the effectiveness and safety of DAAs in patients with IBD., Evaluate the interaction of DAAs with IBD drugs, particularly immunosuppressants and/or biologics., Assessment of the impact of DAAs on the course of IBD.
- Where
- Spain
- Volunteers
- 79 people
- Sponsor
- Hospital Mutua de Terrassa
Appendicitis
The Hospital Volume Relationship in Appendicectomy Outcomes
Background Appendicitis is a common condition which represents a significant resource burden for the Scottish National Health Service (NHS).
- Trial name
- NCT02018016
- Where
- United Kingdom
- Volunteers
- 40,000 people
- Sponsor
- University of Edinburgh
Pregnancy Related, Pregnancy Loss
Microbiome and Malnutrition in Pregnancy
This study is being conducted to investigate how a mother's nutritional status and her gut microbiome during pregnancy contribute to the birth outcomes and health of her baby.
- Conditions
- Pregnancy Related, Pregnancy Loss, Pregnancy Complications, Pregnancy; Parasitic Disease
- Trial name
- MMIP (NCT04992104)
- Where
- 2 sites in Canada
- Volunteers
- 800 people
- Sponsor
- The Hospital for Sick Children
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Stem Cell Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy and radiation therapy used to kill tumor cells.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00004904
- Testing
- anti-thymocyte globulin, filgrastim, cladribine
- Where
- United States
- Sponsor
- Northwestern University
Cholera, Inflammatory Bowel Diseases
Immunogenicity of Cholera Vaccine in Children With IBD
Assessment of the immunogenicity and safety of immunization against cholera in children with inflammatory bowel disease.
- Trial name
- NCT03998449
- Testing
- Vaccination against cholera
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Warsaw
Schistosomiasis
Repeated Doses of Praziquantel in Schistosomiasis Treatment (RePST)
An open label, randomized controlled trial of single vs. multiple treatments of praziquantel in intestinal African schistosomiasis in Côte d'Ivoire This study aims to determine the efficacy of repeated (up to four times)…
- Trial name
- RePST (NCT02868385)
- Testing
- 4x Praziquantel, 1x Praziquantel
- Where
- Côte d’Ivoire
- Volunteers
- 167 people
- Sponsor
- Leiden University Medical Center
Proctitis, Ulcerative, Sexually Transmitted Disease (STD)
The Prevalence of Chlamydia Trachomatis and Neisseria Gonorrhoeae in Patients Suspected of Hemorrhagic Proctosigmoiditis
Background Chlamydia trachomatis and Neisseria gonorrhoeae can cause infectious proctitis, which macroscopically cannot be distinguished from haemorrhagic proctosigmoiditis (HP) caused by inflammatory bowel disease.
- Conditions
- Proctitis, Ulcerative, Sexually Transmitted Disease (STD), Ulcerative Proctosigmoiditis
- Trial name
- SOSProctitis (NCT07061899)
- Testing
- Anal swap for Chlamydia and Gonorrhoea
- Where
- 5 sites in Denmark
- Volunteers
- 214 people
- Sponsor
- University of Aarhus
Necrotizing Enterocolitis, Intraventricular Hemorrhage
PUFAs in Preterm Infants
The research endeavors to examine the critical composition of Polyunsaturated Fatty Acids (PUFAs) in premature infants across different gestational stages and under varying disease conditions, and delineate the metabolic…
- Conditions
- Necrotizing Enterocolitis, Intraventricular Hemorrhage, BPD - Bronchopulmonary Dysplasia, Sepsis
- Trial name
- PIPI (NCT06045130)
- Volunteers
- 600 people
- Sponsor
- The First Hospital of Jilin University
Typhoid Fever, Intestinal Perforation
TyVECO: Surveillance Protocol
In Kisantu Health Zone, approximate population 200,000, fever surveillance will be implemented in 8 health centers and 1 tertiary hospital.
- Trial name
- TyVECO (NCT05562102)
- Testing
- Typbar-TCV, Bharat Biotech
- Where
- 9 sites in Democratic Republic of the Congo
- Volunteers
- 48,000 people
- Sponsor
- International Vaccine Institute
Organic, Including Symptomatic, Mental Disorders, Substance Use
Exploring the Comorbidity Between Mental Disorders and General Medical Conditions
Mental disorders have been shown to be associated with a number of general medical conditions (also referred to as somatic or physical conditions).
- Conditions
- Organic, Including Symptomatic, Mental Disorders, Substance Use, Schizophrenia, Mood [Affective] Disorders
- Trial name
- COMO-GMC (NCT03847753)
- Testing
- Organic Disorders, Substance Use Disorders, Schizophrenia Disorders
- Volunteers
- 5,940,299 people
- Sponsor
- University of Aarhus
Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma
Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant
This clinical trial studies personalized dose monitoring of busulfan and combination chemotherapy in treating patients with Hodgkin or non-Hodgkin lymphoma undergoing stem cell transplant.
- Conditions
- Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma
- Trial name
- NCT01959477
- Testing
- busulfan, etoposide, cyclophosphamide
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Case Comprehensive Cancer Center
Inflammatory Bowel Diseases, Crohn's Disease
Intertriginous/Periorificial Dermatoses in Patients With IBD on Anti-TNFα: Relative Abundance of Staphylococcus Aureus Within the Lesion Microbiota and Clinical Correlation (micSPIDER).
The main objective of this study is to evaluate the change in the relative abundance of S. aureus within the lesion-site skin microbiota in SPIDER patients (change between inclusion and 6 months), and to assess whether this…
- Conditions
- Inflammatory Bowel Diseases, Crohn's Disease, Skin Diseases, Dermatitis
- Trial name
- micSPIDER (NCT07812675)
- Where
- 5 sites in France
- Volunteers
- 82 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Schistosomiasis
Evaluation of Strategies for Improved Uptake of Preventive Treatment for Intestinal Schistosomiasis
Previous research undertaken among adults in high endemic districts of Busia, Adjumani, Moyo and Nebbi reported unwillingness to take preventive treatment.
- Trial name
- ESIUPT (NCT01869465)
- Testing
- Pre-treatment snack, Education arm
- Where
- Uganda
- Volunteers
- 1,277 people
- Sponsor
- Makerere University
Acute Appendicitis
Single Incision Versus Conventional Laparoscopic Appendectomy
This is a randomized prospective study comparing single incision versus conventional laparoscopic appendectomy for management of acute appendicitis.
- Trial name
- NCT01424631
- Testing
- single incision laparoscopic appendectomy, conventional laparoscopic appendectomy
- Volunteers
- 2 people
- Sponsor
- Mansoura University
Necrotizing Enterocolitis, Sepsis
The Role of Lactobacillus Reuteri in Preventing Necrotizing Enterocolitis (NEC) in Pre-term Infants
The purpose of this study is to compare the effectiveness of L. Reuteri with placebo in prevention of NEC in children, as according to my knowledge, there is limited work is done nationally and internationally.
- Trial name
- NEC (NCT04541771)
- Testing
- Lactobacillus Reuteri DSM 17938
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital and Institute of Child Health, Multan
Fecal Calprotectin in Intestinal Protozoa
Fecal Calprotectin in Patients Infected with Intestinal Protozoan Infections
Calprotectin extracted from stool can be detected easily using ELISA. Numerous studies have shown that fecal calprotectin concentrations demonstrate a good correlation with intestinal inflammation This study aims to detect the…
- Trial name
- NCT06890455
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sohag University
Complicated Appendicitis, Acute Appendicitis
Antibiotic Instillation in Appendicitis
Appendicitis (inflammation of the wall of the appendix, causing pain and tenderness in the abdomen) has a range of severity that goes from simple to complicated.
- Trial name
- NCT05470517
- Testing
- Ceftriaxone, Intra-peritoneal Fluid Aspiration
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Johns Hopkins All Children's Hospital
Severe Infection and Non-injury Death
SEPSIS Observational Cohort Study in Young Infants in Bangladesh
Globally, infectious diseases such as sepsis, meningitis and pneumonia are among the leading causes of neonatal deaths. A recent observational study in South Asia highlighted the contribution of both bacterial and viral…
- Trial name
- NCT04012190
- Where
- 2 sites in Bangladesh
- Volunteers
- 2,083 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Acne, Acne Vulgaris
A Pilot Study to Explore the Role of Gut Flora in Acne
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Acne, Acne Vulgaris, Acne Keloidalis, Acne Keloid
- Trial name
- NCT04214483
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome