Clinical trials: Ketamine
Procedural Sedation
INK Feasibility Study
The trial (Intranasal ketamine for procedural sedation in children: a randomized controlled non-inferiority multicenter trial or INK; ReDA 5496; CTO 1545) is being scheduled for launch in Spring 2019.
- Trial name
- NCT05783492
- Testing
- Intranasal ketamine
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Esketamine, ECT
Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study
The study design was a randomized, double blind, parallel controlled trial.The goal of this clinical trial is to learn if esketamine-assisted modified electroconvulsive therapy (ESK-MECT) works to treat severe depression in…
- Conditions
- Esketamine, ECT, Depression, Adolescent
- Trial name
- NCT07247968
- Testing
- Esketamine injection group (0.25 mg/kg), Saline injection group (Consistent with esketamine injection volume)
- Where
- 2 sites in China
- Volunteers
- 220 people
- Sponsor
- Min Su
Bone Fracture
IN Sub-Dissociative Ketamine vs IN Fentanyl
This single center, randomized control, double blind trial will prospectively examine the feasibility of intranasal, sub-dissociative (IN) ketamine versus intranasal fentanyl for pain control in the pediatric emergency department…
- Trial name
- NCT02521415
- Testing
- ketamine, fentanyl, ibuprofen or acetaminophen
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Wake Forest University Health Sciences
Pain, Procedural, Minor Laceration
Ketamine as a Supplement to Local Anesthesia for Minor Procedures
This trial is a double-blind randomized controlled clinical trial of adults and children (ages 7 to less than 70 years). Patients who present to the ED and who undergo minor bedside procedures that require local anesthesia will…
- Conditions
- Pain, Procedural, Minor Laceration, Abscess
- Trial name
- INK-MP (NCT06284473)
- Testing
- Ketamine, Saline
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Loyola University
Sickle Cell Disease
Pilot Study on the Effects of Intravenous Ketamine on Acute Pain Crisis in Patients With Sickle Cell Disease
The purpose of this pilot study is to provide a preliminary assessment of the feasibility and efficacy of intravenous ketamine in controlling pain in patients with sickle cell disease (who are admitted to the hospital with…
- Trial name
- NCT00252122
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Children's Hospital of Philadelphia
Trauma Injury, Pain
Ketamine for Acute Pain Management After Trauma
The purpose of this study is to compare the effectiveness of Ketamine drip along with usual care and usual care alone on trauma patients and to longitudinally quantify the pain experience of patients during hospitalization.
- Conditions
- Trauma Injury, Pain, Opioid Use
- Trial name
- KAPT (NCT04129086)
- Testing
- Ketamine plus usual care, Usual Care
- Where
- United States
- Volunteers
- 305 people
- Sponsor
- The University of Texas Health Science Center, Houston
Recovery Period, Hypoxemia
Efficacy of Propofol-Ketamine and Sevoflurane in Children Undergoing Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is becoming increasingly important in the diagnosis and follow-up of pediatric diseases. However, successful MRI requires complete and prolonged immobility, which can be challenging for young…
- Conditions
- Recovery Period, Hypoxemia, Patient Safety
- Trial name
- NCT06832683
- Testing
- Sevoflurane, Propofol, Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people
- Sponsor
- Kocaeli City Hospital
Adverse Respiratory Events, Hypoxemia
Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric Gastroscopy
Gastroscopy is important for diagnosing and treating upper gastrointestinal diseases in children. To ensure the procedure is safe and smooth, most children require sedation.
- Conditions
- Adverse Respiratory Events, Hypoxemia, Children, Gastroscopy
- Trial name
- NCT07748884
- Testing
- Fentanyl and Propofol, Esketamine and remimazolam
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Pediatric Sedation, Clonidine Sedation
Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery.
Aim of the work Is to compare between oral ketamine and oral clonidine regarding the level of sedation pre and postoperatively in addition the need of opioids administration intraoperative in children undergoing elective lower…
- Conditions
- Pediatric Sedation, Clonidine Sedation, Ketamine Sedation
- Trial name
- NCT07461376
- Testing
- Oral Clonidine (OC)
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain, Intranasal Ketamine
Intranasal Ketamine Effectiveness in Reducing Intramuscular Injection Pain Before Sedation Among Children
Hypothesis: Intranasal administration of ketamine would reduce the intramuscular pain of ketamine injection in children who undergo procedural sedation and analgesia in the emergency department.
- Trial name
- NCT06139380
- Testing
- Ketamine, Sterile water
- Where
- Iran
- Volunteers
- 84 people
- Sponsor
- Tehran University of Medical Sciences
Forearm Fracture
Hematoma Block as an Adjunct to Procedural Sedation for Forearm Fracture Reduction
The purpose of our study is to determine if the use of a hematoma block together with intravenous sedation and analgesia is an effective means of managing forearm fractures in the Emergency Department.
- Trial name
- NCT00763880
- Testing
- Lidocaine, Saline
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Pain
Nasal Ketamine for Minor Procedures in Children
Nasal Ketamine has previously been tested in children for deep sedation or preoperative anxiolysis. The investigators intend to test the efficacy of low dose nasal Ketamine in children undergoing minor procedures in the emergency…
- Trial name
- NCT02839928
- Testing
- Intranasal ketamine, Intranasal atomizer, EMLA
- Volunteers
- 20 people
- Sponsor
- Kaplan Medical Center
Moderate, Deep Sedation
Optimal Dosing of Ketamine for Procedural Sedation and Analgesia in Children
There is a wide variation of published IV ketamine dosing regimens used for procedural sedation in children in the Emergency Department (ED).
- Trial name
- NCT02519595
- Testing
- Ketamine IV 1mg/kg, Ketamine IV 1.5mg/kg, Ketamine IV 2mg/kg
- Volunteers
- 182 people
- Sponsor
- Children's Hospital of Michigan
Lacertaions
A Clinical Trial of Oral Midazolam Plus Oral Ketamine for Sedation During Laceration Repair
Background: Sedation is often needed for young children undergoing minor procedures in the emergency department (ED). Oral midazolam is one of the most commonly used regimens for children undergoing laceration repair but its…
- Trial name
- NCT01470157
- Testing
- Ketamine, Normal Saline
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Assaf-Harofeh Medical Center
Postoperative Analgesia, S-ketamine
Analgesic Effects of Caudal S-ketamine for Supplementation of Ropivacaine Caudal Analgesia in Children With Hypospadias
Caudal analgesia with ropivacaine is commonly used in sub-umbilical pediatric surgery. However, increasing the dosage of ropivacaine has not been found to prolong the action significantly while complications will be serious.
- Conditions
- Postoperative Analgesia, S-ketamine, Pediatrics, Caudal Block
- Trial name
- NCT05922605
- Testing
- S-ketamine & Ropivacaine, Ropivacaine
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Tao Zhang
Respiratory Distress Syndrome, Prematurity of Fetus
Intranasal Midazolam Versus Intranasal Ketamine to Sedate Newborns for Intubation in Delivery Room
Anesthesia is rarely used to intubate newborns in delivery room because of the very difficulty of accessing veins. The investigators hypothesized that intranasal administration of sedative would be an effective alternative.
- Trial name
- NCT01517828
- Testing
- Sedation by ketamine, Sedation with Midazolam
- Where
- 3 sites in France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Montpellier
Epilepsy, Brain Tumor
Effect of Different Anesthetic Drugs on Electrocorticography (ECOG).
Prospective, double-blind, randomized-controlled study for pediatric cases scheduled for brain tumor excision with the aid of electrocorticography (ECOG).
- Trial name
- ECOG-Anaes (NCT07165262)
- Testing
- Fentanyl (IV), Ketamine (0.5 mg/kg)
- Where
- 2 sites in Egypt
- Volunteers
- 88 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Retinopathy
Anesthesia for Retinopathy of Prematurity
Premature infants experience more respiratory problems after surgical procedures. The investigators aimed to compare general anesthesia with sedation on the need for post-operative mechanical ventilation in infants undergoing…
- Trial name
- NCT01955135
- Testing
- Ketamine, Sevoflurane, propofol
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Traumatology, Wounds and Injury
Sufentanil Versus Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children.
Pain is one of the most common reasons for children to attend emergency departments, particularly following traumatic injuries such as fractures, sprains, or contusions.
- Conditions
- Traumatology, Wounds and Injury, Fractures Bone, Analgesia
- Trial name
- SUF-KET-PED (NCT06968546)
- Testing
- Intranasal Sufentanil, Intranasal Ketamine (IN)
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Fondation Lenval
Emergence Delirium
Dexmedetomidine-Midazolam vs. Ketamine-Midazolam on Emergence Delirium
Fifty children undergoing heart catheterization without local anesthesia in the skin will be randomly divided into two groups. Group DM (Dexmedetomidine + Midazolam) and Group KM (Ketamine + Midazolam)
- Trial name
- NCT07427446
- Testing
- Dexmedetomidine and Midazolam, Ketamine and Midazolam
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital