Clinical trials: LPS
Dental Caries on Pit and Fissure Surface
A Clinical Trial Comparing Isolite® vs. Cotton Roll Isolation in the Placement of Dental Sealants
The purpose of this split-mouth, randomized, controlled trial is to evaluate the retention rates of sealants placed under Isolite vs. cotton roll isolation.
- Trial name
- NCT02668874
- Testing
- Isolite System, Cotton Roll Technique
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Pit and Fissure Caries
Investigation of the Incidence of Caries in Pits and Fissures Sealed With Bioactive Sealant Compared to Fluoride Releasing Resin Based Pit and Fissure Sealant
This study will be conducted to investigate the incidence of caries in pits and fissures sealed with a bioactive sealant compared to a fluoride releasing resin based pits and fissures sealant in preventive treatment procedures in…
- Trial name
- NCT03628729
- Testing
- Embrace™ WetBond™ Pit & Fissure Sealant, Seal-Rite™ Pit & Fissure Sealant, Pulpdent Corportation, USA
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Dental Caries
Sealing Microcavitated Carious Lesions
This study aimed to test whether sealing microcavitated ICDAS 3 carious lesions in permanent molars may be arrested by sealing using two different types of materials; a glass ionomer and a resin sealant.
- Trial name
- SealCaries (NCT02849925)
- Testing
- Sealants to arrest microcavitated caries.
- Where
- Chile
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Talca
Dental Caries
Performance of Glass-ionomer Cements: 2-year Follow-up
The purpose of this randomized clinical trial was evaluate the performance of two conventional glass-ionomer cements in the pit and fissure sealing and atraumatic restorative treatment in high caries risk children.
- Trial name
- NCT02659917
- Testing
- Glass ionomer, Glass ionomer cement, -Glass ionomer-
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Fernanda Miori Pascon
Glass Ionomer Cement, Cost-effectiveness
Effectiveness and Economic Evaluation of Glass Ionomer Material Using as Dental Sealant
Eruption of the first permanent molar is the earliest in our oral cavity, leading to a high occurrence of dental caries in its pits and fissures.
- Conditions
- Glass Ionomer Cement, Cost-effectiveness, Pit and Fissure Caries (Disorder)
- Trial name
- NCT03034837
- Testing
- resin sealant, ART sealant
- Where
- 2 sites in China
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- Zhengzhou University
Recurrent Osteosarcoma
Single-Patient Expanded Access Protocol - RNA-LP in a Patient With Recurrent Osteosarcoma
Treatment of a patient with recurrent osteosarcoma with personalized pp65/tumor mRNA RNA-LP under an individual patient expanded access protocol.
- Trial name
- NCT07560709
- Testing
- pp65/tumor mRNA RNA-LP
- Where
- United States
- Sponsor
- University of Florida
Resin Infiltration, Pit and Fissure Sealant
Resin Infiltrate as Pit and Fissure Sealant in Permanent Molars
The aim of this study is to evaluate and compare the clinical effectiveness of ICON resin Infiltration versus conventional sealant and the microleakage and penetration depth of the two sealant materials.
- Conditions
- Resin Infiltration, Pit and Fissure Sealant, Permanent Molars
- Trial name
- NCT06729788
- Testing
- ICON resin infiltration Material group in vivo, Resin-based fissure sealant group in vivo, ICON resin infiltration in vitro
- Where
- Egypt
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Tanta University
Prematurity, Histologic Chorioamnionitis
Infant Immune Response to Bacterial Infection
This study will examine the response of white blood cells to bacterial infection in blood taken from the umbilical cords of newly delivered infants.
- Trial name
- NCT00546195
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Hypersensitive, Molar Incisor Hypomineralization
Effect of Glass-Ionomer Sealing Technique on Hypersensitive Teeth With Molar Incisor Hypomineralisation
This single armed cohort study is aimed to assess the acceptance, durability and efficiency of glass-Ionomer sealing technique on hypersensitive MIH molars (TNI-3 \& 4a/b/c) clinically shortly (15 minutes) after the application…
- Conditions
- Hypersensitive, Molar Incisor Hypomineralization, Pit and Fissure Sealants
- Trial name
- MIH_GIC (NCT05945381)
- Testing
- GIC on MIH
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Burns
Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Thermal Burns
This observational pilot study aims to identify criteria for evaluating the effectiveness of hemoadsorption with the Efferon LPS NEO device in pediatric burn injury.
- Trial name
- NCT07248930
- Testing
- Efferon LPS NEO
- Where
- 2 sites in Russia
- Sponsor
- Efferon JSC
Caries
Effectiveness of Two Sealant Materials Over 5 Years
The purpose of this study is to assess the effectiveness of a new hydrophilic sealant (Ultraseal XT Hydro) compared to the previously existing hydrophobic sealant materials (Ultraseal XT Plus) which requires prime and dry to dry…
- Trial name
- NCT01710865
- Testing
- Ultraseal Sealant
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pit and Fissure Sealants, Dental Caries Prevention
Dry-Shield vs Rubber Dam During Fissure Sealant Placement
This randomized clinical trial aims to evaluate the efficiency of the Dry-Shield isolation system compared with rubber dam isolation and cotton roll isolation during fissure sealant application in permanent molars among pediatric…
- Trial name
- DRY-SEAL (NCT07622173)
- Testing
- Pit and fissure sealant (Conseal F)
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Exercise Training
Effect of Aronia Supplementation on the LPS-CD14-TLR2/4 Axis in Football Players
This randomized, double-blind, placebo-controlled trial will investigate the effects of 8-week Aronia melanocarpa supplementation on exercise-induced activation of the LPS-LBP-CD14-TLR2/TLR4 axis in trained male football players.
- Trial name
- ARONIA-TLR (NCT07829523)
- Testing
- Aronia melanocarpa Extract
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hanna Dziewiecka
Dental Caries
Efficacy of Sealing Molars: Split-mouth Randomized Clinical Trial
The sealing of fossae and fissures is an effective procedure in preventing occlusal caries lesions. However, there are gaps regarding its efficacy in the treatment of initial enamel lesions.
- Trial name
- NCT03819868
- Testing
- High cost, Low Cost
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Faculty Sao Leopoldo Mandic Campinas
Cleft Lip and Cleft Palate
Detection of Single Nucleotide Polymorphism (SNP) Rs2235371 of IRF6 Gene in Egyptian Patients with Non-Syndromic Cleft Lip and Palate
The aim of this work is to study the relation between SNP rs2235371 of IRF 6 gene and Non-Syndromic Cleft Lip and Palate in Egyptian Patients in a prospective study
- Trial name
- NCT06730880
- Testing
- PCR
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pit and Fissure Sealant
Clinical Efficiency of Bioactive Pit and Fissure Sealant
This study will compare the performance of newly introduced bioactive resin based pits and fissure sealant versus fluoride releasing filled resin based pits and fissure sealant in posterior molars prone to carious lesions of…
- Trial name
- NCT06493942
- Testing
- BioCoat® by Premier®, UltraSeal XT™ plus by Ultradent
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries; Initial, Pit and Fissure Caries
Retention Rate of Self-etch Resin Based Sealant With and Without Prior Sandblasting
The aim of the study is to clinically assess the effect of sandblasting prior to self-etch resin based sealant on its retention after one year follow up.
- Trial name
- NCT04929327
- Testing
- Self etch Pit and fissure sealant application (prevent seal), Self etch Pit and fissure sealant application (prevent seal) with prior sandblasting, Total etch resin based sealant ultraseal xt
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Randomized Clinical Trial of Occlusal Sealant
This study assessed long-term impact of tooth Eruption Stages (ES) on sealant retention on occlusal surfaces previously coated with intermediary bonding layer and it determined caries incidence outcome evolved.
- Trial name
- NCT02589743
- Testing
- Sealant, Adhesive and Sealant
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Caries Prevention
Comparison of the Efficacy of Three Preventive Methods to Reduce the Incidence of Coronal Caries in Schoolchildren
The objective of this clinical trial is to compare the efficacy of three preventive methods in reducing the incidence of coronal caries in the first permanent molars of Mexican schoolchildren.
- Trial name
- NCT07131358
- Testing
- Glass ionomer pit and fissure sealant plus fluoride varnish, Pit and fissure sealant with Giomer® technology, Fluoride varnish
- Where
- 3 sites in Mexico
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico