Clinical trials: Laboratory Procedure Development and Validation
Vision Disorder
A Novel Acuity Testing Method
The purpose of this protocol is to develop a valid, reliable, better standardized, and more efficient test of visual acuity (ability to see fine details) for use in clinical trials.
- Trial name
- NCT00013936
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Eye Institute (NEI)
Cerebral Palsy (CP), Developmental Coordination Disorder (DCD)
Experimental Validation of the Virtual Eggs Test (VET) in the Pediatric Population
This study aims to investigate the validity of the Virtual Egg Test (VET) for the assessment of manual dexterity in children and adolescents with cerebral palsy and developmental coordination disorder (experimental group)…
- Trial name
- VET-PED (NCT07793032)
- Testing
- Virtual Eggs Test (VET)
- Where
- Italy
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Cystic Fibrosis
The iStep Study: Development and Validation of an Incremental Exercise Step Test for Children With Cystic Fibrosis
The progression of lung disease in cystic fibrosis (CF) results inevitably in a reduction in exercise capacity. The assessment of fitness and exercise capacity in CF is an important measure of the impact of the disease process…
- Trial name
- NCT02199340
- Testing
- iStep exercise test, CPET exercise test
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Chronic Urticaria
Validation of an Urticaria Control Test
The aim of this study is to validate a previously developed patient reported outcome instrument (in project UCT-D) to assess disease control in chronic urticaria patients (Urticaria Control Test - UCT) of age 12 and older.
- Trial name
- UCT-V (NCT01614834)
- Where
- 2 sites in Germany
- Volunteers
- 120 people
- Sponsor
- Charite University, Berlin, Germany
Dengue
Dengue - Sample Collection Study Pakistan
The objective of this study is to collect well-characterized serum and plasma specimens from confirmed dengue positive and dengue negative subjects to support dengue diagnostic products development.
- Trial name
- NCT07203183
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Abbott Rapid Dx
Child Development, Child Development Disorder
The Indonesian Version of Ages and Stages Questionnaire III Accuracy Compared to Bayley Scales of Infant Development III
This study aimed to evaluate the concurrent validity information of the 24-, 30-, and 36-month Indonesian ASQ-3 with the Bayley Scales of Infant and Toddler Development 3rd Edition (BSID-III) in Indonesian children.
- Conditions
- Child Development, Child Development Disorder, Development Delay, Developmental Delay
- Trial name
- NCT05408351
- Where
- Indonesia
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Asphyxia Neonatorum
Biomarkers And Neurological Outcome in Neonates (BANON)
Validation of biomarkers in a human population for their ability to diagnose the severity of neonatal asphyxia. These biomarkers linked to asphyxia have been identified in animal studies and a preliminary human study.
- Trial name
- NCT03357250
- Where
- 11 sites in Germany
- Volunteers
- 553 people, healthy volunteers welcome
- Sponsor
- Life Science Inkubator
Cancer
Development and Validation of the EFT for Adolescents With Cancer
There is increasing evidence of interventions shown to be effective to promote physical activity in adolescents with cancer. Nevertheless, adolescents with cancer become physically inactive after the end of the interventions.
- Trial name
- NCT05304988
- Testing
- Testing of the EFT
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- The Hong Kong Polytechnic University
Validity-evidence for a Simulator-based Test, Virtual Simulation
Development and Validation of a Simulator-based Test in Transurethral Resection of Bladder Tumors
Bladder cancer (BC) is the seventh most common cancer in men worldwide and fourth most common cancer among Danish men. BC is estimated to be the most cost expensive cancer pr. patient life.
- Conditions
- Validity-evidence for a Simulator-based Test, Virtual Simulation, Bladder Cancer, Surgical Skill Training
- Trial name
- NCT03863028
- Testing
- Simulation training
- Where
- 2 sites in Denmark
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pectus Excavatum
Field-test and Psychometric Validation of the Pectus Excavatum Evaluation Questionnaire in the Dutch Pectus Excavatum Population
A questionnaire that can measure disease severity from the patients perspective in patients with pectus excavatum already exists in English (Pectus Excavatum Evaluation Questionnaire; PEEQ).
- Trial name
- TRANSLATE (NCT06918392)
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Erik de Loos
Autism Spectrum Disorder, Developmental Delay
Validation of a Salivary miRNA Diagnostic Test for ASD
This study involves sample collection to identify biomarkers relating to Autism Spectrum Disorder(ASD) in the saliva of children who are between the ages of 18 months to 6 years and 11 months.
- Trial name
- NCT05418023
- Testing
- Salivary Collection, Adaptive Assessment, Medical and Demographic questionnaire
- Where
- 16 sites in United States
- Volunteers
- 6,604 people
- Sponsor
- Quadrant Biosciences Inc.
Asphyxia Neonatorum
Biomarkers And Neurological Outcome in Neonates 2
Follow-up of participants of BANON1 study at age of at least 2 years. BANON1 (ClinicalTrials.gov ID: NCT03357250): Validation of biomarkers based on 24 months neuro-developmental outcome data in a human population for their…
- Trial name
- BANON2 (NCT04714775)
- Where
- 13 sites in Germany, Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- InfanDx AG
Autism Spectrum Disorder, Developmental Delay
A Salivary miRNA Diagnostic Test for Autism
The goal of this study is to validate a panel of miRNAs that distinguish children with autism spectrum disorder (ASD) from their non-ASD peers with a positive MCHAT-R.
- Trial name
- NCT02832557
- Testing
- Salivary collection, Vineland Adaptive Behavior Scale-III Assessment, Medical history questionaire
- Where
- United States
- Volunteers
- 998 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Congenital Heart Defect, Respiratory Distress Syndrome in Premature Infant
Neonatal Cardio-Pulmonary Outcome Measure
Neonatal Cardio-Pulmonary outcome measure (N-COM) will be used to assess the overall status of pulmonary and cardiac vascular system of neonates in Neonatal Intensive Care Unit (NICU).
- Trial name
- N-COM (NCT04324957)
- Testing
- Neonatal cardio-pulmonary outcome measure used to assess cardio-pulmonary status
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Asir John Samuel
Healthy Nurses, Educational Activities
The Study Focuses on Training Newly Employed Nurses With Two Groups Interventional (Simulation Training) & Control (Brochure) Group Using BLS -AHA 2020 Using Simulation, the Test Includes Pre-test & 2 Post-test Surveys to Assess Knowledge, Practice & Confidence Level.
The general objective of this study is to develop, validate and evaluate the effectiveness of simulation in basic life support training (SBLST) among newly employed nurses in Jordanian governmental hospitals; the study design is…
- Trial name
- BLS-NEN-HCP (NCT06001879)
- Testing
- Simulation in basic life support training (SBLST), standard treatment by using an AHA-BLS 2020 brochure
- Where
- Jordan
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- yousef Shukry Mohammad Abu-Wardeh
Aminoglycoside Toxicity, Aminoglycoside-Induced Hearing Loss
Video Game Hearing Tests for Remote Monitoring of Ototoxicity
The reason for this clinical trial is to test different ways of carrying out hearing tests to be able to detect for hearing loss within the hospital and at home.
- Conditions
- Aminoglycoside Toxicity, Aminoglycoside-Induced Hearing Loss, Hearing Loss, Video Games
- Trial name
- VAROT (NCT05847556)
- Testing
- video game hearing tests, Audio-training
- Where
- 2 sites in United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Imperial College London