Clinical trials: Local Anesthesia
Regional Anesthesia Morbidity
Does Use of Ultrasound Reduce the Rate of Sham Caudal Block in Children
Caudal blocks are one of the most commonly performed regional anesthetics in children and are performed daily for a host of infra-umbilical surgical procedures.
- Trial name
- NCT03283865
- Testing
- Ultrasound guidance for caudal block
- Where
- United States
- Sponsor
- Baylor College of Medicine
Procedural Pain
A Combined 2% Lidocaine Anesthetic Technique for Mandibular Molar Procedures Without Inferior Alveolar Nerve Block
This prospective single-arm pilot study evaluated the clinical effectiveness of a combined local anesthetic technique using 2% lidocaine with 1:100,000 epinephrine for dental procedures involving mandibular molars.
- Trial name
- NCT07771452
- Testing
- Lidocaine 2% with 1:100 000 epinephrine
- Where
- Afghanistan
- Volunteers
- 60 people
- Sponsor
- Herat University
Analgesia, Topical Anesthetic
Ametop Compared to Ametop With Pain Ease Spray
The investigators propose to examine if Pain Ease spray, used as an adjunct to the topical anesthetic Ametop Gel, can improve the percentage of pain-free IV starts.
- Trial name
- NCT03749915
- Testing
- Pain Ease Cold Spray, Ametop
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- University of British Columbia
Anesthesia, Local
Subconjunctival Bupivacaine in Strabismus Surgery
This study aimed to assess the effectiveness of the Subconjunctival bupivacaine on postoperative pain in Strabismus surgery under general anaesthesia.
- Trial name
- NCT04782960
- Testing
- Iocal anaesthetic bupivacaine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Anesthesia, Local
A Study of Safety and the Local Anesthetic Effect of AG-920 Ophthalmic Solution in a Pediatric Population
A Phase 3, randomized, active-controlled, study in pediatric subjects. It is designed to evaluate the safety and anesthetic efficacy of one dose of AG-920 ophthalmic solution compared to Proparacaine Hydrochloride Ophthalmic…
- Trial name
- NCT05325853
- Testing
- AG-920, Proparacaine Ophthalmic
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Laparoscopic Cholecystectomy Surgery, Analgeisa
Pain Relief Following Laparoscopic Cholecystectomy While Comparing Intra Abdominal Versus Sub Cutaneous Local Anesthetic Administration
Laparoscopic cholecystectomy involves removal of gallbladder through small incision ports resulting in faster recovery. Small incisions are less painful and hence local anesthesis administered can be effective for pain…
- Conditions
- Laparoscopic Cholecystectomy Surgery, Analgeisa, Local Anesthetic Infiltration
- Trial name
- NCT07409688
- Testing
- Intraoperitoneal local anesthetic administration, Sub cutaneous administration of local anesthetic
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Anxiety, Pain
A Novel Approach in Reducing Dental Pain and Anxiety of Pediatric Patient During Local Anesthesia.
The aim of this study is to determine the efficacy of sweet in compare to virtual reality (VR) device in reducing injection pain and anxiety associated with local anesthesia in pediatric dental patients.
- Trial name
- NCT04585061
- Testing
- Lidocaine Hydrochloride, Virtual reality device (Harga Miniso Vr Glass 3d terbaru), Xylitol
- Where
- Saudi Arabia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Regional Anesthesia, Postoperative Pain
Pudendal Block Versus Penian Block For Circumcision In Children
The authors study the efficacy of the pudendal versus penile block for the relief of postoperative pain in children receiving ambulatory circumcision.
- Conditions
- Regional Anesthesia, Postoperative Pain, Circumcision
- Trial name
- NCT03046290
- Testing
- circumcision, Lidocaine, Ropivacaine
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Université Libre de Bruxelles
Stroke, TIA
A New Oxygen Mask for Carotid Endarterectomy Under Local Anaesthesia
The purpose of this study is to determine the effectiveness of oxygenation and patient-acceptability of a novel oxygen face mask in patients undergoing carotid endarterectomies (CEAs).
- Conditions
- Stroke, TIA, Surgery, Anaesthesia
- Trial name
- NCT01064908
- Testing
- OxyMask
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Clubfoot
Clubfoot Tenotomy Trial
Infants undergoing Ponseti treatment for idiopathic clubfoot often require percutaneous tendoachilles lengthening (TAL) after serial casting.
- Trial name
- ClubTT (NCT04766684)
- Testing
- Jet injection of 1% lidocaine, 4% liposomal lidocaine cream
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Vanderbilt University Medical Center
Adductor Canal Block, Postoperative Pain
Comparison of Combination of Proximal ACB and iPACK With Large-Volume Distal ACB for Early Mobilization After TKR
Large-volume distal ACB is not superior to combination of proximal ACB and iPACK in facilitating early mobilization after TKR. Block performing time of distal ACB was significantly shorter compared to the combination of proximal…
- Conditions
- Adductor Canal Block, Postoperative Pain, Regional Anesthesia
- Trial name
- NCT06525493
- Testing
- Regional Anesthesia
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Universitas Indonesia
Analgesia After Pacemaker, AICDS Implantation Pediatrics
Truncal Ultrasound Guided Regional Anesthesia for Implantation and Revision of Automatic Implantable Cardioverter Defibrillators (AICDs) and Pacemakers in Pediatric Patients
The purpose of this study is to determine the efficacy and safety of truncal blocks for pacemaker and Automatic Implantable Cardioverter Defibrillator implantation in children and to prospectively evaluate whether there is a…
- Trial name
- NCT04184349
- Testing
- LA group, B Group
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pain, Postoperative
Transversus Abdominis Plane Block Versus Quadratus Lumborum Block in The Pediatric Population Undergoing Orchiopexy
Transversus abdominis plane (TAP) and Quadratus lumborum (QL) blocks are used for the management of acute pain treatment, especially after the lower and upper abdominal surgeries.
- Trial name
- NCT03969316
- Testing
- Transversus abdominis plane block, Quadratus lumborum block
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Istanbul University - Cerrahpasa
Anesthesia, Local
Diode Laser on the Reversal of Inferior Alveolar Nerve Block Anesthesia in Children
Inevitable problems were reported following the injection of local anesthesia in pediatric dental procedures, which can last until the elimination of soft tissue anesthesia.
- Trial name
- NCT05648981
- Testing
- Inferior Alveolar Nerve Block administration with laser irradiation, Inferior Alveolar Nerve Block administration
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Hams Hamed Abdelrahman
Molar-Incisor Hypomineralization
Evaluation of Different Anesthesias in Children With Molar Incisor Hypomineralization
In children with molar-incisor hypomineralization (MIH), insufficient depth of anesthesia can lead to increased anxiety and behavior management problems, which may negatively affect the quality of restorations.
- Trial name
- NCT07268157
- Testing
- Computer-controlled anesthesia device (SleeperOne), Conventional injection technique
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Canan Bayraktar Nahir
Sevoflurane Consumption
Pre-emptive Local Anesthesia and Sevoflurane Consumption in Pediatric Dental Anesthesia
This study will evaluate whether pre-emptive local anesthesia reduces sevoflurane consumption during pediatric day-case dental treatment performed under general anesthesia.
- Trial name
- PEDSEVOLA (NCT07608900)
- Testing
- Pre-emptive Local Anesthesia, Articaine With Epinephrine, Sevoflurane
- Volunteers
- 80 people
- Sponsor
- TC Erciyes University
Knee Osteoarthritis, Hip Osteoarthritis
Regional Anesthesia in Total Hip and Knee Arthroplasty
The purpose of this study is to test whether the use of Ropivacaine and Mepivacaine are better in terms of effectiveness, cost, and safety than Bupivacaine as regional anesthetics in elective hip or knee replacement surgery.
- Trial name
- NCT04257682
- Testing
- Bupivacaine, Ropivacaine, Mepivacaine
- Volunteers
- 135 people
- Sponsor
- Ottawa Hospital Research Institute
Pain, Local Infiltration
Pain Perception With a Comfort-ın Jet Injection and Conventional Dental Injection
The investigators aimed to compare the effectiveness of the Comfort-in system, which is a jet injection type, and infiltrative anesthesia with a traditional injector, and to measure the effect of children's anxiety on the…
- Conditions
- Pain, Local Infiltration, Anesthesia, Fear
- Trial name
- NCT04682080
- Testing
- Needle-free injection
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Anesthesia, Local
Compare the Efficacy of Various Pain Alleviating Methods in Reducing Pain in Children During Intraoral Local Anaesthetic Injections
The aim of study is to compare the efficacy of various pain alleviating methods by application of Emla gel, TENS, and topical cooling of injection sites compared with 20% benzocaine gel in reducing pain in children requiring…
- Trial name
- NCT05564442
- Testing
- 20% benzocaine gel, Transcutaneous electric nerve stimuli, Emla gel
- Where
- Egypt
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Minia University
Anesthesia, Local
Comparison of The Effectiveness of Intraligamentary and Mandibular Anesthesia on Mandibular Molar Teeth
This study aimed to compare the effects of mandibular and intraligamentary anesthesia techniques on pain scores during restorative treatment of permanent mandibular molars in pediatric patients.
- Trial name
- NCT05115773
- Testing
- Intraligamentary anaesthesia, Mandibular anaesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University