Clinical trials: Local Anesthesia
Pain, Distress
Acupuncture for Pain During Injection of Local Anaesthetic
Stimulation of acupoint LI4 has been shown to result in analgesic effects in patients experiencing acute pain. We aimed to determine whether LI4 acupuncture could reduce pain and distress in children receiving an injection of a…
- Conditions
- Pain, Distress, Satisfaction
- Trial name
- AcuDent (NCT02197546)
- Testing
- Acupuncture & acupressure
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- University Medicine Greifswald
Lidocaine
Effect of Different Concentrations of Lidocaine in Relieving Pain in Wide Awake Hand Surgery Using Tumescence
Lidocaine has been used along with adrenaline in tumescent anesthesia for a variety of procedures. This has been quite popular especially in wide awake surgery of the hand with no tourniquet.
- Trial name
- NCT04692896
- Testing
- lidocaine
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- King Edward Medical University
Submucosal Resection of the Nasal Septum (SMR)
Four vs. Ten Local Anesthetic Injections for SMR
Submucosal resection of the nasal septum (SMR) could be performed under local anesthetic infiltration performed through ten injections in addition to general anesthesia which was associated with less postoperative pain and…
- Trial name
- NCT02463370
- Testing
- suprazygomatic maxillary area infiltration, non-suprazygomatic maxillary area infiltration
- Where
- Lebanon
- Volunteers
- 120 people
- Sponsor
- Makassed General Hospital
Trigger Thumb
Trigger Thumb Randomized Controlled Trial
We are conducting this study to determine if administration of local anesthetic to the thumb prior to surgery can reduce the amount of anesthetic gas given during the course of surgery.
- Trial name
- NCT03873480
- Testing
- Administration of Marcaine without Epinephrine prior to the start of surgery
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Children's Hospital of Philadelphia
Scoliosis
Effect of Regional Anesthesia or Intravenous Infusion of Lidocaine on Morphine Use After Scoliosis Repair Surgery
The goal of the surgical correction of scoliosis is to prevent progression of the curve or progression of restrictive lung disease. After scoliosis surgery, patients experience severe pain.
- Trial name
- NCT06451562
- Testing
- Lidocaine
- Where
- Israel
- Volunteers
- 105 people
- Sponsor
- Assaf-Harofeh Medical Center
Respiratory Depression
Observation of Respiration Following Regional Anaesthesia With Intrathecal Opioids for Caesarean Section
Spinal Administration of opioids offers segmental analgesia, but has side effects including pruritus, nausea and vomiting, urinary retention, hypotension, and respiratory depression, both early and delayed.
- Trial name
- NCT00544947
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- NHS Greater Clyde and Glasgow
Cerebral Oxygenation
Cerebral NIRS Monitoring During Anesthesia in Neonates and Infants
The brain is a very vulnerable organ, especially in premature babies, newborns and infants. However, during anesthesia, the oxygenation of the brain can only be monitored indirectly and insufficiently.
- Trial name
- NCT04132414
- Testing
- NIRS open
- Sponsor
- Medical University of Graz
Anesthesia, Local
Lidocaine Administration Using STAR Particles
This study is being done to answer the question: Do STAR particles (tiny pieces of ceramic with small spikes) help numbing gel (a gel that helps you feel less pain) work more quickly to provide local anesthesia or numbing in a…
- Trial name
- NCT06034340
- Testing
- LET Gel after STAR Particle Application (Right or Left Arm), LET Gel Application without STAR Particle Application (Contralateral Arm)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Emory University
Congenital Heart Defect, Congenital Heart Disease
Regional Anesthesia for Cardiothoracic Enhanced Recovery (RACER) Study
The erector spinae plane block is a novel regional anesthetic technique that allows for analgesia of the thorax and abdomen with a peripheral nerve block.
- Conditions
- Congenital Heart Defect, Congenital Heart Disease, Anesthesia, Local, Opioid Use
- Trial name
- NCT03611374
- Testing
- Bilateral Erector Spinae Plane Block (ESPB)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Stanford University
Cholelithiasis, Postoperative Pain, Laparoscopic Cholecystectomy
ESP vs Subcostal TAP Block for Analgesia After Laparoscopic Cholecystectomy
This prospective, randomized, double-blind study compares the analgesic efficacy of ultrasound-guided erector spinae plane (ESP) block and subcostal transversus abdominis plane (TAP) block in patients undergoing laparoscopic…
- Trial name
- ESP TAP (NCT07661693)
- Testing
- Erector Spinae Plane Block, Subcostal Transversus Abdominis Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Gaziantep City Hospital
Pain, Postoperative
Cesarean Delivery and Post-operative Pain Management With Local Anesthesia
The use of .5% Bupivacaine with epinephrine at the time of skin closure in cesarean deliveries will decrease post-op pain.
- Trial name
- NCT00298571
- Testing
- .5% bupivacaine with epinephrine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Anxiety, Fear
AI Avatar Video vs. Tell-Show-Do for Reducing Anxiety and Improving Cooperation in Children During Local Anesthesia
This randomized clinical trial aims to compare two behavior guidance techniques used to reduce anxiety in children during local anesthesia injections in dental treatment.
- Conditions
- Anxiety, Fear, Local Anesthesia, Pediatric Dentistry
- Trial name
- NCT07449884
- Testing
- AI Avatar-Based video, Tell-Show-Do Technique
- Where
- Lebanon
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Regional Anesthesia
Comparison of Caudal Block and Retrolaminar Block for Circumcision
Primary Outcome: Analgesic Efficiency: The primary outcome is the comparison of the analgesic efficacy of the retrolaminar block (RL) versus caudal block (CB) based on postoperative pain scores measured by the FLACC score.
- Trial name
- NCT06584292
- Testing
- caudal block, Retrolaminar block
- Where
- Turkey (Türkiye)
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Local Anesthetic Efficacy
Effectiveness of Nitrous Oxide 50% for Reducing Pain and Distress Associated with Needle-stick in Children
Venipuncture (puncturing of a vein) through the skin in order to insert a vein catheter (also know as cannula) is one of the most common needle-related medical procedures performed in children.
- Trial name
- NCT03342079
- Testing
- Local Anesthetics,(lidocaine 70 mg/tetracaine 70 mg topical patch; Synera)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Photobiomodulation Therapy
Reversal of Anaesthesia with Diode Laser
Background: After local anesthesia, which is frequently used in pediatric dentistry, long-term soft tissue numbness can cause various problems.
- Trial name
- NCT06841120
- Testing
- Actual laser application
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Injection Pain, Local Anesthesia Infiltration
Clinical Trial Comparing Pain Perception in Children Using Two Different Local Anesthesia Tools
The goal of this clinical study is to learn whether the Super Pen (SP) device can reduce pain during local anesthesia (LA) infiltration for primary teeth compared to the conventional syringe (CS) in children aged 6-12 years.
- Conditions
- Injection Pain, Local Anesthesia Infiltration, Pediatric Patient
- Trial name
- NCT07292194
- Testing
- super pen
- Where
- Jordan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Lamis D. Rajab
Dental Phobia, Dental Anxiety
"Study of Pain Perception Using Computer-Controlled Versus Conventional Local Anaesthesia in Children Undergoing Molar Extraction
This clinical trial aims to compare pain perception in children during dental procedures when using a computer-controlled local anesthesia device versus a traditional syringe.
- Conditions
- Dental Phobia, Dental Anxiety, Dental Anesthesia, Dental Anesthesia Efficacy
- Trial name
- CCLAD-Pain (NCT07056101)
- Testing
- A conventional dental syringe, GENI High-Speed Injection, GENI Moderate-Speed Injection
- Where
- Egypt
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Tarek MHD kher al saka amini
Anesthesia, Local
Cold Vibratory Stimuli on Pain Perception Governing Infiltration Anesthesia in in Children
Local anesthesia injections are sometimes painful, resulting in antagonistic cooperation, fear, and anxiety in children. This study aims to investigate the effectiveness of vibratory and cold stimulation before the injection to…
- Trial name
- NCT05857033
- Testing
- Buccal and direct palatal injection with the aid of Buzzy, Buccal and indirect palatal injection with the aid of Buzzy, Buccal and direct palatal injection without Buzzy
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Alexandria University
Pain, Tooth Extraction
Rofecoxib and Bupivacaine to Prevent Pain After Third Molar (Wisdom Tooth) Extraction
This study will evaluate the ability of the drugs rofecoxib and bupivacaine to prevent pain following third molar (wisdom tooth) extraction. Rofecoxib is approved to treat pain of arthritis and menstrual cramps.
- Trial name
- NCT00050362
- Testing
- Rofecoxib and Bupivacaine
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Anesthesia, Local
Changes in Tissue Oxygenation Following Regional Anesthesia
Adequate tissue oxygenation is required for effective white blood cell function and bactericidal activity. Decreased tissue oxygenation is a risk factor for perioperative wound infections.
- Trial name
- NCT01418690
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Nationwide Children's Hospital