Clinical trials: Lymphoedema
Lymphedema
Safety Study of Bevacizumab to Treat Women With a History of Breast Cancer and Suffering From Upper Extremity Lymphedema
The purpose of this study is to determine the safety and side effects of bevacizumab in subjects with lymphedema who will initially receive bevacizumab alone and then in combination with standard manual lymphatic drainage (MLD)…
- Trial name
- NCT00318513
- Testing
- Bevacizumab
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Premiere Oncology of Arizona
Primary Lymphedema
Out-of Pocket Payments in Patients With Lymphedema
Primary lymphedema is a chronic condition posing a high burden on patients. Clinical guidelines emphasize the role of compression therapy by prescription medical devices.
- Trial name
- Lymphorac2 (NCT02988479)
- Testing
- Out of pocket payments in patients
- Where
- France
- Volunteers
- 108 people
- Sponsor
- University Hospital, Montpellier
Lymphatic Filariasis
Death to Onchocerciasis and Lymphatic Filariasis (DOLF) Triple Drug Therapy for Lymphatic Filariasis
The DOLF Triple Drug Therapy for Lymphatic Filariasis study will determine the frequency, type and severity of adverse events following triple-drug therapy (IVM+DEC+ALB, IDA) compared to the standard two-drug treatment (DEC+ALB…
- Trial name
- NCT02899936
- Testing
- 3 drug dose - IDA, 2 drug dose - DA
- Where
- 4 sites in Haiti, India and 2 more
- Volunteers
- 23,789 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Lymphedema of Upper Limb
Effects of Physiotherapy in the Treatment of Lymphedema After Breast Cancer
Lymphedema related to breast cancer is one of the main complications after breast cancer treatment. Manual lymphatic drainage appears as a technique which could be applied in the treatment of lymphedema along with other…
- Trial name
- NCT05037708
- Testing
- Manual lymphatic drainage
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- University of Vigo
Lymphedema, Lymphatic Disorders
Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders
The purpose of this study is to demonstrate the feasibility of near-infrared fluorescence imaging in subjects with acquired or hereditary lymphedema, in subjects with lipidema and other lymphovascular disorders and in normal…
- Conditions
- Lymphedema, Lymphatic Disorders, Lipedema, Vascular Malformation
- Trial name
- NCT00833599
- Testing
- NIRFLI with ICG
- Where
- 3 sites in United States
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Lymphedema, Lymphatic Filariasis
A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka
Current lymphedema management protocols are based on the use of simple measures of hygiene (regular washing with soap and water, skin and nail care), use of topical antibiotics or antifungal agents, exercise and footwear.
- Conditions
- Lymphedema, Lymphatic Filariasis, Filariasis
- Trial name
- LeDoxy-SL (NCT02929134)
- Testing
- Doxycycline
- Where
- Sri Lanka
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- The Task Force for Global Health
Lymphatic Diseases, Lymphatic Abnormalities
A Prospective Natural History Study of Lymphatic Anomalies
Background: The lymphatic system is a network of vessels that carry a clear fluid called lymph through the body. Problems in the lymphatic system can cause pain, fluid buildup, and issues with immunity.
- Trial name
- NCT05731141
- Where
- 2 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Lymphedema Primary
Inelastic Compression Use in Primary Lymphedema
Primary lymphedema in children is a rare, chronic condition caused by congenital or inherited developmental abnormalities in the lymphatic system that lead to persistent fluid buildup and swelling.
- Trial name
- Primary LE (NCT07866599)
- Testing
- Compression device with medium pressure (23-32 mmHg)
- Volunteers
- 30 people
- Sponsor
- University School of Physical Education, Krakow, Poland
Lymphedema, Breast Cancer
An Integrated Algorithm for Surgical Intervention in Chronic Lymphedema After Breast Cancer Treatment: The Basel Lymphedema Protocol
The primary objective of the investigators is to develop an integrated algorithm for surgical treatment of chronic lymphedema after breast cancer surgery.
- Trial name
- NCT06374745
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- University Hospital, Basel, Switzerland
Breast Cancer, Lymphedema
Flexitouch Lymphedema System in Treating Stage II Lymphedema in Patients With Breast Cancer
RATIONALE: The Flexitouch lymphedema system may lessen lymphedema caused by treatment for breast cancer. It is not yet known whether the Flexitouch lymphedema system is more effective than complex decongestive therapy in treating…
- Trial name
- NCT01019512
- Testing
- questionnaire administration, lymphedema management
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Lymphedema, Lymphatic Filariasis
A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India
Current lymphedema management protocols are based on the use of simple measures of hygiene (regular washing with soap and water, skin and nail care), use of topical antibiotics or antifungal agents, exercise and footwear.
- Conditions
- Lymphedema, Lymphatic Filariasis, Filariasis
- Trial name
- LeDoxy-India (NCT02929121)
- Testing
- Doxycycline
- Where
- India
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- The Task Force for Global Health
Lymphedema
Evaluation of Pressure Applying Efficiency in Multi-Layer Bandaging
Lymphedema is a condition characterized by excess accumulation of protein rich tissue fluid in interstitial spaces. It is a progressive chronic disease and without appropriate management may result in serious complications.
- Trial name
- NCT02857621
- Where
- Israel
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Assuta Hospital Systems
Trachoma, Lymphatic Filariases
Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin
Cluster-randomised trial comparing co-administration of Azithromycin/Ivermectin/Albendazole with separate administration of Azithromycin and Ivermectin/Albendazole.
- Trial name
- NCT03570814
- Testing
- Administration of Albendazole on Day 1, Administration of Ivermectin on Day 1, Administration of Azithromycin on Day 1
- Where
- Ethiopia
- Volunteers
- 13,511 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Lymphatic Filariasis
Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study
The purpose of this study is to determine whether repeated ivermectin mass drug administrations to Burkinabé villagers, performed in three week intervals over the rainy-season, is well-tolerated and safe, and also effective in…
- Trial name
- RIMDAMAL (NCT02509481)
- Testing
- Ivermectin, Albendazole
- Where
- 2 sites in United States, Burkina Faso
- Volunteers
- 2,712 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Lymphedema of Upper Arm
Study of the Change of Breast Cancer Patients' Upper Limb Lymphatic Drainage Pathway After Operation
Lymphoscintigraphy is a noninvasive，accurate and effective imaging modality. In this study, it is used to investigate the imaging characteristics of patients'upper limb lymphatic drainage before operation, and the influence of…
- Trial name
- NCT02691624
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Primary Body Region (Arranged Most Common to Least), Lumbar/SI
ATI Evidence-based Guide Investigating Clinical Services
The goal of this study is to evaluate how standard-of-care outpatient rehabilitation is delivered and how variation in care delivery mechanisms relates to clinical outcomes, service utilization, and value in patients receiving…
- Conditions
- Primary Body Region (Arranged Most Common to Least), Lumbar/SI, Knee, Shoulder
- Trial name
- AEGIS (NCT02285868)
- Where
- United States
- Volunteers
- 4,000,000 people, healthy volunteers welcome
- Sponsor
- ATI Holdings, LLC
Lymphedema, Lymphatic Filariasis
A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali
Current lymphedema management protocols are based on the use of simple measures of hygiene (regular washing with soap and water, skin and nail care), use of topical antibiotics or antifungal agents, exercise and footwear.
- Conditions
- Lymphedema, Lymphatic Filariasis, Filariasis
- Trial name
- LeDoxy-Mali (NCT02927496)
- Testing
- Doxycycline
- Where
- Mali
- Volunteers
- 220 people
- Sponsor
- The Task Force for Global Health
Mastectomy Related Lymphedema, Breast Reconstruction
A Comparison of Dermal Autograft to AlloDerm in Breast Reconstruction
Breast Cancer affects about 1 out of 8 American women. Twenty percent of breast cancer patients undergo some form of breast reconstruction. Several types of reconstructive procedures are available for appropriate patients.
- Conditions
- Mastectomy Related Lymphedema, Breast Reconstruction, Breast Cancer
- Trial name
- NCT01561287
- Testing
- Dermal Autograft, AlloDerm
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Kentucky
Trachoma, Lymphatic Filariasis
Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis
Trachoma and lymphatic filariasis (LF) are two 'Neglected Tropical Diseases' (NTDs), infectious diseases that affect millions of poor people in countries in the developing world.
- Trial name
- AZIVAL2 (NCT01903057)
- Testing
- azithromycin, ivermectin, albendazole
- Where
- Mozambique
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Lymphatic Filariases, Onchocerciasis
Prevalence of LF Infection in Districts Not Included in LF Control Activities
Lymphatic filariasis is a neglected tropical disease earmarked for elimination as a public health problem by the year 2020. Since the year 2000, the Global Program for the Elimination of LF has together with endemic countries…
- Trial name
- NCT03131401
- Testing
- Diagnosis of lymphatic filariasis, Diagnosis of lymphatic Filariasis and onchocerciasis, DEC Patch
- Where
- Ghana
- Volunteers
- 3,736 people
- Sponsor
- Noguchi Memorial Institute for Medical Research