Clinical trials: Magnetic Resonance Spectroscopy
Brain Cancer, Brain Neoplasms
(1)H-Nuclear Magnetic Resonance Spectroscopic Imaging of the Brain in Patients Who Receive Neurotoxic Therapy
Central nervous system toxicity is a recognized side effect of certain therapies for cancers, particularly cranial irradiation, intrathecal therapy or systemic high-dose chemotherapy.
- Trial name
- NCT00001807
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Major Depressive Disorder
Creatine Treatment for Female Adolescents With Depression Who Are Non-Responders to Fluoxetine or Escitalopram
The purpose of this study is to see if creatine, which is a naturally occurring chemical in the body, is effective for treating Major Depressive Disorder (MDD) in female teenagers.
- Trial name
- NCT00851006
- Testing
- Creatine Monohydrate
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Utah
Autism Spectrum Disorders
Magnetic Resonance Spectroscopic and Diffusion Tensor Imaging of Adolescents with Autism Spectrum Disorders
The primary objective of this study is to conduct magnetic resonance spectroscopic (MRS) and imaging (MRI) scans to assess the structural and neurochemical profile of the brain in 20 children and adolescents, 6-17 years old with…
- Trial name
- NCT01361503
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Preterm Birth
Cerebral Magnetic Resonance Spectroscopy at Term Corrected Age and Dysexecutive Syndrome in Very Preterm Children at 5.5-years-old
Background: Compared to term-born peers, very preterm children generally perform poorly in executive functions, with a significant impact on learning at school and quality of life.
- Trial name
- Spectro5-5 (NCT06055062)
- Volunteers
- 39 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Bipolar Disorder
Oral Uridine for Treatment of Bipolar Depression in Adolescents
The purpose of the study is to see if the investigational medication uridine reduces depression symptoms in adolescents with bipolar disorder. Uridine is a naturally occurring chemical that is made by the human liver.
- Trial name
- NCT00841269
- Testing
- Uridine
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Utah
Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Autoimmune Encephalitis
Developing Advanced Neuroimaging for Clinical Evaluation of Autoimmune Encephalitis
Autoimmune encephalitis is brain inflammation caused by the immune system mistakenly reacting against proteins in the brain. The commonest form is called NMDAR-antibody encephalitis (N-methyl-D-aspartate receptor antibody…
- Trial name
- DANCE-AE (NCT05280600)
- Testing
- Not applicable - non-interventional study
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- King's College London
Autism Disorder
MEG Study of Acute STX209 Effects in ASD
This is a single-site, randomized, acute dose-response study to determine whether STX209 produces a dose-dependent significant change in MEG target parameters compared to baseline as well as compared to placebo treatment.
- Trial name
- NCT02278328
- Testing
- STX209 (15mg), STX209 (30mg)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Timothy Roberts
Neonatal Encephalopathy, Hypothermia Neonatal
Optimising the Duration of Cooling in Mild Encephalopathy
Phase II randomised control trial of whole body cooling in mild neonatal encephalopathy.
- Conditions
- Neonatal Encephalopathy, Hypothermia Neonatal, Magnetic Resonance Spectroscopy
- Trial name
- COMET (NCT03409770)
- Testing
- Therapeutic hypothermia
- Where
- 8 sites in United States, Italy and 1 more
- Volunteers
- 140 people
- Sponsor
- Thayyil, Sudhin
Prostate Cancer
Multifunctional Magnetic Resonance (MR) for Radiotherapy Planning in Prostate Cancer
To determine if functional MRI methods will aid planning of a radiation dose boost within the prostate in patients with prostate cancer potentially improving safety and efficacy.
- Trial name
- NCT01006564
- Testing
- Imaging Investigations (not radiation), Other
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Kidney Transplantation, Urinary Calculi
Evaluation of Kidney Function by Multi-modal Magnetic Resonance Imaging and Spectroscopy
Multimodal functional magnetic resonance (MR) methods, including MR diffusion, Blood-Oxygenation Level Dependent (BOLD) imaging and MR spectroscopy may provide complementary information about the functional status of a kidney.
- Trial name
- NCT00575432
- Testing
- diffusion MRI, BOLD MRI, Clinical Outcome
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Friedreich's Ataxia, FRDA
GABA and GSH in FRDA
The goal of this study is to obtain gamma-aminobutyric acid (GABA) and glutathione (GSH) assessment derived from magnetic resonance spectroscopy (MRS), to be used as a potential biomarker in patients with Friedreich Ataxia (FRDA)…
- Trial name
- NCT07635030
- Testing
- MRI/ MRS (Magnetic Resonance Imaging /Magnetic Resonance Spectroscopy)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Philadelphia
Nonmalignant Neoplasm, Prostate Cancer
MRI and Magnetic Resonance Spectroscopy Imaging in Patients Receiving Dutasteride for Benign Prostatic Hypertrophy and Low-Risk Prostate Cancer
RATIONALE: Diagnostic procedures, such as MRI and magnetic resonance spectroscopy imaging, may help in learning how well dutasteride works in patients with benign prostatic hypertrophy and low-risk prostate cancer.
- Trial name
- NCT00706966
- Testing
- dutasteride
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Breast Feeding
Newborn Feeding and Infant Phenotype
Breast feeding is believed to be beneficial to long-term health but how these effects are mediated is unknown. I suggest that this may be through effects on body composition and metabolism.
- Trial name
- NCT02033005
- Where
- United Kingdom
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Ischemia
Trial of the Effects of Remote Preconditioning on the Tissue Metabolism During Exercise and Ischemia
Previously, the preconditioning signaling pathways have been studied on molecular level or in animal model. By using MR spectroscopy and imaging in a dynamic human model of preconditioning, we will have a better understanding how…
- Trial name
- NCT00791206
- Testing
- Real preconditioning
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Prostate Adenocarcinoma, PSA Level Greater Than Ten
Hyperpolarized Carbon C 13 Pyruvate Magnetic Resonance Spectroscopic Imaging in Predicting Treatment Response in Patients With Prostate Cancer
This phase II trial studies how well hyperpolarized carbon C 13 pyruvate magnetic resonance spectroscopic imaging works in predicting treatment response in patients with prostate cancer.
- Conditions
- Prostate Adenocarcinoma, PSA Level Greater Than Ten, Stage IIB Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8
- Trial name
- NCT03581500
- Testing
- Hyperpolarized Carbon C 13 Pyruvate, Magnetic Resonance Spectroscopic Imaging
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Non-Alcoholic Fatty Liver Disease
Measuring Fatty Liver With Ultrasound and MRS in Children With Overweight or Obesity
Obesity is associated with a variety of comorbidities, amongst which non-alcoholic fatty liver disease (NAFLD). A recent meta-analysis has shown that the prevalence of NAFLD in obese pediatric populations is around 35%, compared…
- Trial name
- NCT03787108
- Testing
- Magnetic resonance spectroscopy measurement
- Where
- Netherlands
- Volunteers
- 53 people
- Sponsor
- Maastricht University Medical Center
Autism Spectrum Disorder
Biomarker-Driven Pharmacological Treatment of Adolescents With Autism Spectrum Disorder With Gabapentin
The social cognitive deficits associated with autism spectrum disorder (ASD) are related to an imbalance in excitatory and inhibitory neurotransmission, specifically a deficit in the inhibitory neurotransmitter GABA.
- Trial name
- NCT05063656
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- David Cochran
Autism Spectrum Disorder (ASD)
Brain Stimulation and Sensory Integration in Children With ASD
The goal of this clinical trial is to find out if brain stimulation can help improve sensory integration in children ages 6 to 12 with autism spectrum disorder (ASD).
- Trial name
- NCT07182331
- Testing
- Continuous Theta Burst Stimulation to Bilateral DLPFC
- Where
- 2 sites in Kazakhstan
- Volunteers
- 40 people
- Sponsor
- Neurolab Plus
Ischemic Stroke
Magnetic Resonance Imaging (MRI) Study of the Hippocampus After Infarction in the Territory of the Middle Cerebral Artery
The purpose of this study is to observe delayed neuronal death of hippocampus after middle cerebral artery infarction in human beings.
- Trial name
- NCT00867581
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Dementia, Alzheimer Type
Memantine Versus Donepezil in Early Stages of Alzheimer's Disease
It is well known that in the brain of the patients with Alzheimer's disease there is a glutamatergic hyperstimulation leading to neuronal death. Memantine is a low affinity antagonist of NMDA glutamate receptors.
- Trial name
- NCT00505167
- Testing
- Memantine, Donepezil
- Where
- 3 sites in Spain
- Volunteers
- 64 people
- Sponsor
- Hospital Miguel Servet