Clinical trials: Metastases
Liver Diseases, Liver Cancer
CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection
This early-phase clinical trial will assess the use of ex vivo CRISPR-Cas9 genome editing on donor liver grafts to reduce immunogenicity before transplantation.
- Conditions
- Liver Diseases, Liver Cancer, Liver Cirrhosis, Liver Failure
- Trial name
- NCT07053488
- Testing
- Ex Vivo CRISPR-Cas9 Gene Editing of Donor Liver
- Where
- China
- Volunteers
- 90 people
- Sponsor
- AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC
Neuroblastoma (NB), Prognosis
Risk Model for Metastasis Detection of Neuroblastoma
Neuroblastoma (NB) is the most common extracranial solid tumor in children, accounting for about 15% of tumor-related mortality.
- Conditions
- Neuroblastoma (NB), Prognosis, Bone Marrow Metastasis, Bone Metastases
- Trial name
- NB (NCT06703944)
- Testing
- risk model in diagnosis and prognosis
- Where
- 3 sites in China
- Volunteers
- 500 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Surgery, Brain Tumor
Neurosurgical Transitional Care Programme
Readmissions increasingly serve as a metric of hospital performance, inviting quality improvement initiatives in both medicine and surgery.
- Conditions
- Surgery, Brain Tumor, Brain Tumor, Recurrent, Brain Pathology
- Trial name
- TCP (NCT03593330)
- Testing
- Transitional Care Programme
- Where
- United Kingdom
- Volunteers
- 242 people
- Sponsor
- Barts & The London NHS Trust
Bone Metastases, Radiotherapy
Pain Relief in Symptomatic Bone Metastases With Adjuvant Hyperthermia MR Guided HIFU
Metastatic disease to the bone is a common cause of pain. External beam radiation therapy (EBRT) is the standard palliative treatment BUT pain improvement is observed in 60% to 80%.
- Conditions
- Bone Metastases, Radiotherapy, Pain, MRI
- Trial name
- BM-RT-HIFU (NCT05167669)
- Testing
- HIFU-MRI guided
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Sana Boudabbous
Pathologic Fracture, Bone Metastases
Metastatic Pathologic Fractures, Short Term Results
This is a single center prospective study to compare the short term results of prosthesis, nail and plate-screw surgeries for metastatic pathologic fractures.
- Conditions
- Pathologic Fracture, Bone Metastases, Metastatic Cancer
- Trial name
- NCT05825456
- Testing
- endoprosthetic reconstruction, Intramedullary nailing, Open reduction internal fixation with plate and screws
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Ankara University
Adult Rhabdomyosarcoma, Lung Metastases
Intensity-Modulated Radiation Therapy in Treating Younger Patients With Lung Metastases
This pilot clinical trial studies intensity-modulated radiation therapy (IMRT) in treating younger patients with lung metastases.
- Conditions
- Adult Rhabdomyosarcoma, Lung Metastases, Metastatic Ewing Sarcoma, Previously Treated Childhood Rhabdomyosarcoma
- Trial name
- NCT01586104
- Testing
- intensity-modulated radiation therapy
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Solid Tumors, Soft Tissue Sarcoma
A Pilot Study of Thermodox and MR-HIFU for Treatment of Relapsed Solid Tumors
This is a pilot study of LTLD with MR-HIFU hyperthermia followed by ablation in subjects with refractory/relapsed solid tumors.
- Conditions
- Solid Tumors, Soft Tissue Sarcoma, Ewing Sarcoma, Malignant Epithelial Neoplasm
- Trial name
- NCT04791228
- Testing
- Magnetic Resonance-Guided High Intensity Focused Ultrasound, Lyso-thermosensitive Liposomal Doxorubicin
- Where
- United States
- Sponsor
- Children's National Research Institute
Brain Tumor, Brain Metastases
TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and Meningiomas
This Phase I/II study evaluates the safety and efficacy of autologous tumor-infiltrating lymphocytes (TIL) therapy combined with Pembrolizumab (Keytruda) immunotherapy in patients with Advanced Brain Cancer including Gliomas and…
- Conditions
- Brain Tumor, Brain Metastases, Brain Cancer, Glioma
- Trial name
- BAH2472 (NCT06640582)
- Testing
- Tumor Infiltrating Lymphocytes (TIL), Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Essen Biotech
Colorectal Neoplasms, Neoplasm Metastases
Screening for Synchronous Metastases in Colorectal Cancer With DW-MRI (SERENADE)
Eligible patients with high risk colorectal malignancy (T3/4, spread greater than 5mm, EMVI positive) will have additional surveillance of breath hold T1, T2 and DW-MRIs (no IV contrast) post surgery six monthly for three years.
- Conditions
- Colorectal Neoplasms, Neoplasm Metastases, Hepatic Neoplasms
- Trial name
- SERENADE (NCT02246634)
- Testing
- Diffusion Weighted MRI scan
- Where
- 13 sites in United Kingdom
- Volunteers
- 282 people
- Sponsor
- Imperial College London
Esophageal Neoplasms, Esophagectomy
Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC)
Esophagectomy is the cornerstone of the curative treatment of esophageal carcinoma. Despite this treatment, patients can suffer from locoregional or distant metastatic disease and only a very selected group of patients can be…
- Conditions
- Esophageal Neoplasms, Esophagectomy, Brain Metastases
- Trial name
- METABREC (NCT04654975)
- Testing
- Esophagectomy for esophageal cancer
- Where
- 8 sites in United States, Belgium and 4 more
- Volunteers
- 10,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bone Metastases, Pain
MRI Guided HIFU for Palliation of Painful Skeletal Metastases in Children
The Philips Sonalleve MR-HIFU system is expected to be effective in reducing pain intensity and/or reducing analgesic use in patients with painful uncomplicated bone metastases.
- Trial name
- NCT02616016
- Testing
- MRI Guided High Intensity Focused Ultrasound
- Where
- Canada
- Sponsor
- The Hospital for Sick Children
Brain Metastases, Adult, Stereotactic Radiotherapy
a Feasibility Study of iHD-SRT for BM
Brain metastasis is the most challenging disease in the field of tumor treatment, with a median overall survival of only 1-2 months for untreated patients.
- Trial name
- NCT06231186
- Testing
- iHD-SRT
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Ruijin Hospital
Neuroblastoma, CNS Metastases
131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases
Children with a neuroblastoma diagnose and central nervous system (CNS)/leptomeningeal metastases will be given up to 2 rounds of intracerebroventricular treatment with a radiolabelled monoclonal antibody, 131I-omburtamab to…
- Conditions
- Neuroblastoma, CNS Metastases, Leptomeningeal Metastases
- Trial name
- NCT03275402
- Testing
- 131I-omburtamab
- Where
- 8 sites in United States, Denmark and 2 more
- Volunteers
- 52 people
- Sponsor
- Y-mAbs Therapeutics
Metastases to Bone
Tranexamic Acid After Pathological Fracture Treated With Modular Arthroplasty
This study assesses the safety and efficacy of TXA for patients treated for pathological femur fractures using modular prosthetics.
- Trial name
- NCT06244498
- Testing
- Tranexamic acid injection
- Where
- Poland
- Volunteers
- 110 people
- Sponsor
- Piotr Biega
Papillary Thyroid Carcinoma; Molecular Heterogeneity; Multi-model Analysis; Artificial Intelligence; Lymph Node Metastases; Disease-free Survival
AI-Based Multimodal Multi-tasks Analysis Reveals Tumor Molecular Heterogeneity, Predicts Preoperative Lymph Node Metastasis and Prognosis in Papillary Thyroid Carcinoma
This study involved a comprehensive analysis of 256 PTC patients from Sun Yat-sen Memorial Hospital of Sun Yat-sen University (SYSMH) and 499 patients from The Cancer Genome Atlas.
- Trial name
- NCT06241092
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Peritoneal Metastases
Single-Cell Transcriptomics of the Peritoneal Microenvironment of Colorectal PC
Single cell transcriptomics of CRC PC samples
- Trial name
- SingleCell (NCT05676372)
- Testing
- CRC+HIPEC
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Ghent
Vertebral Compression Fracture, Myeloma
The Value of Systematic Biopsies During Vertebroplasty for the Treatment of Osteoporotic Vertebral Fractures
Background : Vertebral fracture is the most common complication of osteoporosis. Vertebroplasty is a widespread treatment modality for osteoporotic vertebral fractures, providing consolidation, rapid pain relief and preventing…
- Conditions
- Vertebral Compression Fracture, Myeloma, Bone Metastases, Malignant Bone Tumour
- Trial name
- NCT06153576
- Where
- France
- Volunteers
- 1,120 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Osteosarcoma, Pulmonary Metastases
Pulmonary Resectable Metastases of Osteosarcoma With Anti-angiogenics and CHemotherapy
The aim of this study is to evaluate the efficacy and safety of Second-line chemotherapy combined with Apatinib for the patients with resectable pulmonary metastasis of osteosarcoma.
- Conditions
- Osteosarcoma, Pulmonary Metastases, Apatinib
- Trial name
- PROACH (NCT03742193)
- Testing
- Apatinib, GD regimen
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Ruijin Hospital
Recurrent Colon Cancer, Liver Metastases
Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the Liver
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving them in different ways may kill more tumor cells.
- Conditions
- Recurrent Colon Cancer, Liver Metastases, Stage IV Rectal Cancer, Recurrent Rectal Cancer
- Trial name
- NCT00019760
- Testing
- floxuridine, leucovorin calcium, melphalan
- Where
- United States
- Sponsor
- National Institutes of Health Clinical Center (CC)
Lung Metastases, Osteosarcoma
Circulating Exosome RNA in Lung Metastases of Primary High-Grade Osteosarcoma
The purpose of this study is to learn whether the profile of RNA from circulating exosomes can be used as a biomarker for lung metastases of primary high-grade osteosarcoma.
- Trial name
- NCT03108677
- Testing
- Blood samples
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Ruijin Hospital