Clinical trials: Modification
Depression and Suicide Ideation, Anxiety
Culturally Adapted Psychological Support for Conflict-Affected Afghans: Study Protocol on Mental Health & Violence
This pilot study examines the feasibility and acceptability of a culturally adapted psychological intervention-Problem Management Plus with Emotional Processing (PM+ EP)-for young Afghans aged 16-30 experiencing high…
- Conditions
- Depression and Suicide Ideation, Anxiety, PTSD
- Trial name
- NCT06980441
- Testing
- Problem Management Plus with Emotional Processing module
- Where
- Afghanistan
- Volunteers
- 60 people
- Sponsor
- Peace of Mind Association (PoMA)
Non-Suicidal Self-Injury, Emotional Dysregulation
Integrated Motivational Interviewing and Rational Emotive Behavior Therapy Intervention for Non-Suicidal Self-Injury Among Malaysian Primary School Students: A Feasibility Trial Protocol
This study aims to evaluate the feasibility and preliminary effects of the MIND-SET Intervention Module, an integrated Motivational Interviewing and Rational Emotive Behavior Therapy (MI-REBT) intervention, among Malaysian…
- Trial name
- MIND-SET (NCT07627061)
- Testing
- MIND-SET Intervention Module, PRISMA Mental Health Module
- Where
- Malaysia
- Volunteers
- 105 people
- Sponsor
- Universiti Utara Malaysia
Impaired Glucose Tolerance, Prediabetes
CGM and Lifestyle Changes in Patients With Impaired Glucose Tolerance
The incidence of type 2 diabetes (T2D) in children is increasing, paralleling the rising incidence of obesity. Preventing children and adolescents from developing T2D is critical.
- Trial name
- NCT05387551
- Testing
- CGM
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nemours Children's Clinic
Malaria, Schistosomiasis
Artemisinin-based Combination Therapy-Intermittent Preventive Treatment (ACT-IPT) Trial Among Schoolchildren in Kassena-Nankana, Ghana
The purpose of this study is to determine if Artemisinin-based Combination Therapy, ACT,(artemether-lumefantrine) used as intermittent preventive treatment (IPT) alone or in combination with praziquantel, will have any effects on…
- Conditions
- Malaria, Schistosomiasis, Helminthiasis, Anemia
- Trial name
- ACTIPT (NCT01459146)
- Testing
- Artemether-lumefantrine combination plus albendazole, Artemether-lumefantrine plus Praziquantel plus Albendazole, Albendazole plus Praziquantel
- Where
- Ghana
- Volunteers
- 345 people
- Sponsor
- Navrongo Health Research Centre, Ghana
Genetic Screening, Adolescent
Engaging Adolescents in Decisions About Return of Genomic Research Results
Recent recommendations to return children's results for adult-onset conditions to parents anytime whole exome or genome sequencing is performed, as well as growing expectations to return research results to participants on a…
- Conditions
- Genetic Screening, Adolescent, Genetic Change, Shared Decision Making
- Trial name
- NCT04481061
- Testing
- Electronic Decision Tool
- Where
- 2 sites in United States
- Volunteers
- 787 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Obesity, Weight Loss
Hormonal Regulation of Body Weight Maintenance
The investigators here propose to perform a collaborative clinical research effort including a randomized controlled trial investigating the mechanisms of weight maintenance and their relation to a lifestyle intervention in…
- Conditions
- Obesity, Weight Loss, Weight Gain, Hormone Disturbance
- Trial name
- NCT00850629
- Testing
- multimodal lifestyle intervention
- Where
- Germany
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Healthy Subjects
Imaging of Electrical Properties by MRI: Investigation of Age-Related Changes
The goal of this study is to build a database of personalized EP (Electrical Properties) maps (accounting for age, anatomical location, and tissue complexity), obtained via MRI, to improve electromagnetic safety assessments…
- Trial name
- ELECTRA (NCT07415759)
- Testing
- Magnetic Resonance Imaging (MRI) examination
- Where
- 2 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Hematologic Changes
Effect of Blood Harvesting and Administration at End of CPB on Coagulation Profile
Blood transfusions after pediatric heart surgery is a relatively common practice occurring in up to 46% of patients, however its use has been associated with increased morbidity.
- Trial name
- NCT01958242
- Testing
- Preoperative blood harvesting
- Where
- Israel
- Sponsor
- Rabin Medical Center
Child Nutrition and Early Child Development
Engaging Fathers for Effective Child Nutrition and Development in Tanzania
This study aims to evaluate the independent and combined effectiveness of engaging both mothers and fathers in bundled parenting and nutrition behavior change packages on early child nutrition and development.
- Trial name
- EFFECTS (NCT03759821)
- Testing
- Nutrition, mothers, Nutrition, mothers and fathers, Nutrition+parenting, mothers
- Where
- Tanzania
- Volunteers
- 960 people
- Sponsor
- Project Concern International
Infant, Newborn
Investigating Changes in Vital Signs in Neonates
1 in 7 babies require neonatal care. During their time in hospital their vital signs (such as heart rate, breathing rate and oxygen saturation) are continuously monitored as part of standard care.
- Trial name
- Neo-vital (NCT06032494)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Oxford
Mobility Limitation
Does Dosage Matter: Ride-on Cars to Enhance Social-mobility Function and Motivation in Toddlers With Motor Disabilities
Modified ride-on toy cars (ROCs) have been viewed as one Maker Movement and become an innovative, alternative option to enhance independent mobility and socialization in young children with disabilities in the recent years.
- Trial name
- NCT04468451
- Testing
- A 48-hour ROC training program with a standing posture, A 24-hour ROC training program with a standing posture, A regular therapy program without receiving any ROC training
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- Chang Gung Memorial Hospital
Cervical Cancer
DNA Array Analysis of Patients With Cervical Cancer
The goal of this clinical research study is to find out if the expression of certain genes is linked with the response of cervical cancer to radiation.
- Trial name
- NCT00512551
- Testing
- Tumor Biopsies
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Crohn's Disease
Nutritional Therapy Study in Pediatric Crohn's Disease
The investigators are doing this research study to answer questions about a nutritional therapy called the Specific Carbohydrate Diet (SCD) for children with active Crohn's Disease (CD).
- Trial name
- NCT02610101
- Testing
- Traditional SCD Diet, Modified SCD Diet, Whole foods diet
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Seattle Children's Hospital
Upper Resp Tract Infection
Climate Change Trends and Their Impact on the Seasonal Upper Respiratory Tract Disease Burden
Investigators assume that global climate changes can influence upper respiratory tract infection peak prevalence, which may have significant clinical implication, for example, by adjusting seasonal Influenzas' vaccine timing.
- Trial name
- NCT07767019
- Testing
- No Intervention: Observational Cohort
- Where
- Israel
- Volunteers
- 5,000 people
- Sponsor
- Barzilai Medical Center
Obesity and Type 2 Diabetes, Diet Modification
Mobile Regulation of Craving Training (mROC-T) to Improve Dietary Intake in Rural Adolescent Girls
The goal of this clinical trial is to test if a regulation of craving training intervention in the form of a mobile phone app can increase fruit and vegetable intake in adolescent girls ages 14-18 years of age.
- Trial name
- ROC Teens! (NCT06723028)
- Testing
- Regulation of craving training
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Wyoming
Congenital Talipes Equinovarus
Clinical Effectiveness of the Modified WalkFlex DB Splint in Children With Congenital Talipes Equinovarus (CTEV)
This pilot study aims to evaluate the effectiveness of the Modified WalkFlex DB Splint in the maintenance phase of Congenital Talipes Equinovarus (CTEV) treatment following successful correction through the Ponseti method.
- Trial name
- NCT07055672
- Testing
- Modified WalkFlex DB Splint (Intervention Arm)
- Where
- Pakistan
- Volunteers
- 15 people
- Sponsor
- Superior University
Anxiety Disorders
Attention Bias Modification Treatment (ABMT) for Anxiety Disorders in Youth
Attention biases in threat processing have been assigned a prominent role in the etiology and maintenance of anxiety disorders. Attention Bias Modification Treatment (ABMT) utilizes computer-based protocols to implicitly modify…
- Trial name
- NCT02460536
- Testing
- Attention Bias Modification treatment (ABMT), Exposure only +ABMT, Attention training only +ABMT
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel Aviv University
Central Venous Catheterization, Vascular Access Devices
Anatomical Landmark Method for Paediatric Port Catheter Tip Positioning
This study looks at how to place port catheters safely and accurately in children who need long-term intravenous treatment. For these treatments to work well and to avoid problems such as heart rhythm issues, blood clots, or…
- Conditions
- Central Venous Catheterization, Vascular Access Devices, Pediatric Patients, Monitoring
- Trial name
- NCT07582107
- Testing
- Anatomical Landmark Method, Intracavitary Electrocardiography (IC-ECG)
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Ankara City Hospital Bilkent
Fever, Wheezing
Fever and Wheezing Events in Children After US Influenza Vaccines Using Text Messaging
Children 2-11 years of age who are given the influenza vaccine (inactivated influenza (IIV) or live attenuated influenza vaccine (LAIV)) as part of their routine care can enroll in this study if their parent has the ability to…
- Trial name
- NCT02295007
- Testing
- text message
- Where
- 3 sites in United States
- Volunteers
- 266 people
- Sponsor
- Columbia University
Mild Traumatic Brain Injury
A Prospective Study of Brain Network Activation (BNA) Changes in High School Athletes Following Concussion
The main purpose of this study is to prospectively examine changes in Brain Network Activation(BNA)following concussion in high school athletes.
- Trial name
- NCT01673464
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
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