Clinical trials: Modification
Allergic Rhinitis
Sublingual Immunotherapy in Children With Allergic Rhinitis
The purpose of this study is to evaluate the clinical efficacy and mucosal/systemic antibody response changes after SLIT using house dust mite allergen with or without bacterial extracts in mite-allergic children.
- Trial name
- SLIT (NCT01506843)
- Where
- Brazil
- Volunteers
- 122 people
- Sponsor
- Federal University of Uberlandia
Obesity
Healthy Kids-Houston: A Community Childhood Obesity Intervention Program
The collaborative study is to determine the effectiveness of an after-school community-based program to prevent obesity among minority children.
- Trial name
- HKH (NCT00994084)
- Testing
- Healthy Kids-Houston program, Control
- Where
- United States
- Volunteers
- 1,094 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Premature Loss of Primary Molars
Chewing Pattern Changes Before and After Space Maintainer Placement in Children
This prospective observational study aims to evaluate changes in chewing patterns and chewing performance in children before and after placement of a unilateral fixed band-and-loop space maintainer.
- Trial name
- NCT07828158
- Testing
- Band-and-Loop Space Maintainer
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Marmara University
Diet, Food, and Nutrition, Healthy Eating
Mitigating and Preventing Disordered Eating in Transitioning Service Members
Despite documented evidence of disordered eating (DE) among Active Duty (AD) Service Members (SM) and Veterans, DE has not been assessed in SM undergoing the transition from AD to Veterans status (AD-VS).
- Conditions
- Diet, Food, and Nutrition, Healthy Eating, Eating Habit, Mindfulness
- Trial name
- NCT05074108
- Testing
- Pilot study
- Volunteers
- healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Dietary Modification
Medical College Students' Responds to Menu Labeling
The purpose of this study is to evaluate whether exposure to nutrition information with or without nutrition education would influence college students' dietary choices and improved the previous photographs-based dietary…
- Trial name
- NCT02574052
- Testing
- participants' food choices, menu labelling without nutrition education, menu labelling with nutrition education
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Necrotizing Enterocolitis
Therapeutic Controlled Hypothermia in the Treatment of Neonates With Severe Necrotizing Enterocolitis
Hypothesis: Controlled hypothermia to 33.5C for 48 hours reduces the severity of critical illness in neonates with severe necrotizing enterocolitis.
- Trial name
- CoolNEC (NCT01330576)
- Testing
- cooling blanket/mattress, Standard treatment of care at normothermia
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Children With Liver Transplant
VIRTUAL REALITY GLASSES, CHILDREN WITH LIVER TRANSPLANTATION
The aim of the study is to determine the effect of SGG application on pain, anxiety/anxiety, fear and physiological variables during dressing in children aged 4-10 years with liver transplantation.
- Trial name
- NCT05420025
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Firat University
Obesity
Vitamin D Supplementation in Vitamin D Deficient Obese Children During Weight-loss Program
1. Analyze the influence of vitamin D supplementation in obese children during weight-loss program on BMI, body composition and bone mineral density. 2.
- Trial name
- NCT02828228
- Testing
- Vitamin D 1200 IU
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- University Clinical Centre, Gdansk
Childhood Obesity
Role of Carbohydrate Modification in Weight Management Among Obese Children
The purpose of this study is to test the hypothesis that a low-carbohydrate diet and a low-glycemic load diet will improve body mass index and result in more body fat loss than a control diet among overweight children ages 7 to…
- Trial name
- NCT00215111
- Testing
- Low carbohydrate, reduced glycemic load, and a control diet
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Diabetic Macular Edema
The Effects of Intravitreal Ozurdex Implant in DME
Intravitreal Ozurdex implant therapy improves visual outcome and OCT findings. The purpose of this study is that these results are correlated with the change of cytokine level known to be increased in DME patients.
- Trial name
- NCT03475407
- Testing
- Ozurdex intravitreal injection
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Nune Eye Hospital, Seoul, Korea
Growth and Development
fMRI Study to Investigate Hemodynamic Changes in Brain Resulting From Supplementation of Bacopa Monnieri Extract and Multiple Micronutrient Supplementation.
The study will aim to compare the effects of a beverage powder fortified with multiple micronutrients and Bacopa monnieri extract (test product) to a non-fortified isocaloric beverage powder (control product) on cognitive…
- Trial name
- NCT02345187
- Testing
- Beverage powder fortified with Bacopa Monnieri Extract and Multiple Micronutrient supplementation, Non-fortified isocaloric beverage powder
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Mental Health Help-Seeking, Mental Health Difficulties
Changes in Children and Young People's Well-being and Parental Stress While Seeking Help at CAMHS in Denmark. How Does Waiting Affect CYP and Their Parents Before, During and After CAMHS Assessments.
Questionnaire-based longitudinal cohort study. Families on the waiting list for an assessment with Child and Adolescent Mental Health Services (CAMHS) are invited to complete questionnaires including the Parental Stress Scale…
- Conditions
- Mental Health Help-Seeking, Mental Health Difficulties, Help-Seeking Behavior, Waiting Times, Patient Pathways, Effect of Lifestyle-related, Clinical and Demographic Parameters on Outcomes
- Trial name
- NCT07553104
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aalborg University Hospital
Microbiology, Blood Culture
Optimisation of the Blood Culture Pathway Utilising Behaviour Change
Blood culture (BC) is the gold standard for the definitive diagnosis of bacteraemia, providing the opportunity to recover and identify the causative organism, and optimize subsequent antimicrobial treatment.
- Trial name
- NCT07392684
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Hypothermia; Anesthesia
Comparison of Upper Body and Full Underbody Forced Air Blanket in Pediatric Patients
The aim of this study is to compare the underbody blanket and overbody blanket for forced air warming to maintain normothermia in pediatric patients undergoing cardiovascular interventions under general anesthesia.
- Trial name
- NCT05349734
- Testing
- upper body blanket, full underbody blanket
- Where
- South Korea
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
EFFECT OF TOPICAL APPLICATION OF TRANEXAMIC ACID ON WOUND DRAINAGE POST MODIFIED RADICAL MASTECTOMY
EFFECT OF TOPICAL APPLICATION OF TRANEXAMIC ACID ON WOUND DRAINAGE POST MODIFIED RADICAL MASTECTOMY
Objective: To compare efficacy of topical tranexamic acid versus standard postop care in reducing wound drainage following modified radical mastectomy (MRM). Study Design: Randomized controlled trial.
- Trial name
- NCT07800832
- Testing
- Tranexamic Acid (Topical Application in Mastectomy Wound)
- Where
- 2 sites in Pakistan
- Volunteers
- 60 people
- Sponsor
- Gulab Devi Hospital
Fetal Growth Retardation, Low Birth Weight
BEP Supplementation Research in Bangladesh (JiVitA-BEP-IR)
The primary aim of the study is to evaluate the effect of fortified balanced energy and protein (BEP) supplementation vs. control (multiple micronutrient supplement, MMS) without targeting and with targeting (either by low…
- Conditions
- Fetal Growth Retardation, Low Birth Weight, Preterm Birth, Gestational Weight Gain
- Trial name
- Target-BEP (NCT05576207)
- Testing
- Balanced energy and protein supplement for pregnant women, Multiple Micronutrient Supplement for pregnant women
- Where
- Bangladesh
- Volunteers
- 3,390 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Overweight and Obesity, Attention-Deficit Hyperactivity Disorder
Families, Responsibility, Education, Support, and Health for Executive Function
The pilot study will be a one group open-label treatment program and will be used to refine a parent-based behavioral treatment enhanced with executive-function training (PBT-EF) for children with comorbid overweight or obesity…
- Trial name
- FRESH-EF (NCT05165511)
- Testing
- PBT-EF
- Where
- United States
- Sponsor
- University of California, San Diego
Dental Caries
Injectable Bioactive Composites vs RMGI for Proximal Cavities in Primary Molars
This randomized clinical trial aims to evaluate and compare the clinical performance of injectable bioactive composite (Beautifil Flow Plus X, Shofu) versus Resin Modified Glass Ionomer (RMGI) in restoring proximal cavities…
- Trial name
- GIOMER-RCT (NCT07561216)
- Testing
- giomer, RMGI
- Volunteers
- 50 people
- Sponsor
- Cairo University
Cleft Lip and/or Palate, Speech Disorder
Neural Changes After Speech Therapy in Patients With Cleft Palate: A Brain Imaging Study
Cleft palate is one of the most common maxillofacial congenital malformations, which results in severe speech disorders. Compensatory articulation disorder, also known as non-oral articulation disorder (NOA), is considered as the…
- Conditions
- Cleft Lip and/or Palate, Speech Disorder, Speech Therapy, Brain
- Trial name
- fMRI-Speech-CP (NCT07330687)
- Testing
- Structured Speech Training for Decompensation
- Where
- China
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Shufan Zhao
Retinitis Pigmentosa
A Phase 3 Study Of OCU400 Gene Therapy for the Treatment Of Retinitis Pigmentosa
This is a Phase 3 study to Assess the Efficacy, Safety and Tolerability of OCU400 in patients with retinitis pigmentosa (RP) associated with RHO mutations and patients with any other RP associated mutation with a clinical…
- Trial name
- liMeliGhT (NCT06388200)
- Testing
- Sub-Retinal Administration of OCU400-301
- Where
- 17 sites in United States, Canada
- Volunteers
- 140 people
- Sponsor
- Ocugen
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