Clinical trials: Modification
Inborn Errors of Metabolism, Epilepsy (Treatment Refractory)
Metabolites in Blood and Breath in Metabolic Conditions
In patients with inborn errors of metabolism (IEM) and in those requiring a ketogenic diet for the treatment of medical conditions, relevant biochemical analytes are routinely and regularly measured in venous or capillary blood…
- Trial name
- NCT07704606
- Testing
- Observational Study
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Nutritional Insufficiency
Food Energy Density in Eating Disorders
Nutritional insufficiency is defined as an inadequate amount of nutrition due to decreased food/caloric intake, often due to an eating disorder, such as anorexia nervosa or bulimia.
- Trial name
- NCT01095107
- Testing
- Low fat intake, Increased fat intake
- Sponsor
- The Cleveland Clinic
Dental Crowding, Passive Extraction Space
Comparison of Alignment Efficiency, Arch Dimensional Changes, and Passive Extraction Space Closure Between Self-Ligating and Conventional Brackets
Purpose: This study aims to compare two types of orthodontic braces - self-ligating brackets (SLBs) and conventional brackets (CBs) - to see which one aligns teeth faster, affects the width of the dental arch, and closes spaces…
- Conditions
- Dental Crowding, Passive Extraction Space, Intercanine Width, Intermolar Width
- Trial name
- SLBs CBs RCT (NCT07503314)
- Testing
- Self-Ligating Brackets (SLB), Conventional Bracket
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Saidu College of Dentistry
Invasive Fungal Disease, Fever and Neutropenia
Evaluation of NGS for Detection and Follow-up of Fungal Pathogens in Immunocompromised Pediatric Patients
The Sponsor hypothesize that Next-generation Sequencing (NGS) can identify fungal pathogens, is more accurate than other noninvasive options and can report fungal genomic load.
- Conditions
- Invasive Fungal Disease, Fever and Neutropenia, Invasive Fungal Infections, Immunocompromised
- Trial name
- NCT03262584
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Karius, Inc.
Emotional Regulation
Acceptability and Feasibility of an Adapted DBT-informed Skills Group for Gender Diverse Young People Co-delivered in a Charity Setting
Gender diverse (e.g. trans or non-binary) young people are at higher risk of self-harm and may be more likely to access support through gender-diverse-specific 3rd sector charities.
- Trial name
- NCT06237608
- Testing
- Dialectical behavioural therapy (DBT)-informed skills group
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- King's College London
Hypothermia
Preventing Inadvertent Hypothermia in Paediatric Neurosurgery in Malawi
The investigators wish to undertake a randomized controlled non-inferiority trial to evaluate the ability of a simple and low-cost method (Hibler´s method of wrapping the patient in multiple insulating layers) to prevent…
- Trial name
- NCT02975817
- Testing
- Hibler's, Warm Air
- Where
- Malawi
- Volunteers
- 76 people
- Sponsor
- Oslo University Hospital
Cognitive Change
Cognitive Effects of Music and Dance Training in Children
The study used a randomized controlled trial to test the efficacy of two interventions (dance and musical training) for typically developing children. Interventions were run for three weeks in local community locations.
- Trial name
- NCT03160391
- Testing
- Music Training, Dance Training
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- York University
Circadian Dysregulation
Maintaining Behavior Change: A 6-year Follow-up of Adolescent 'Night-owls'
A follow-up of a cohort of participants recruited for a prior study will be conducted. In the prior study, 10-18 years olds were provided one of two treatments to improve the sleep of adolescent night-owls.
- Trial name
- NCT05098782
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Cystic Fibrosis
Using MRI to Observe Lung Changes in Infants With CF Compared to Infants Without CF
Our research is comparing the lungs of babies and young children with CF (cystic fibrosis) to those without CF. We are looking at the blood flow in the lungs to help doctors better understand how CF damages lungs and how to…
- Trial name
- MRIinfantCF (NCT01832519)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Healthy Volunteers
Longitudinal Development of Behavior and Its Underlying Neural Correlates in Human Infants
The unique importance of human brain development during the first years of life is unquestionable. During an infant's first year, the brain undergoes its most dramatic structural and functional changes, with factors such as early…
- Trial name
- MultiLongDev (NCT05167565)
- Testing
- MRI/DTI, EEG, Eye Tracking
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Eating Disorders
Mindfulness and Eating Disorder Symptoms
This prospective one-arm study aims to examine short and long-term changes in dysfunctional eating among individuals who signed up for an 8-week, group based, low threshold, mindfulness-based intervention.
- Trial name
- NCT05539807
- Testing
- Mindful Eating Conscious Living
- Where
- Norway
- Volunteers
- 197 people
- Sponsor
- University of Bergen
Cognitive Change, Child Development
Conectar Jugando: Board Games in Rural Elementary Classrooms (6-12 Years Old) to Improve Executive Functions
The use of board games in classrooms has been increasing in recent years. Education and psychology professionals have found in the board game a way to train some key cognitive processes for good academic development: executive…
- Trial name
- CJ-Rural (NCT05267730)
- Testing
- Conectar Jugando Game Program
- Where
- Spain
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Brain In Game scientific-technical service
pH, Microbiome
Oral Changes With Caloric and no Caloric Sweeteners
The objective of this clinical trial is to compare the effect that the intake of beverages without sweeteners, added with non-caloric sweeteners (stevioside) and caloric sweeteners (sucrose) on oral pH and dental biofilm…
- Conditions
- pH, Microbiome, Dental Plaque
- Trial name
- NCT05852145
- Testing
- Stevioside, Sucrose, Natural water
- Where
- Mexico
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
HIV Infections, HIV Wasting Syndrome
A Comparison of Two Caloric Supplements in the Prevention of Weight Loss in Patients With AIDS Who Take Daily Multivitamin and Mineral Supplements
To compare a caloric supplement containing peptides and medium-chain triglycerides, a caloric supplement containing whole protein and long-chain triglycerides, and no caloric supplement for the prevention of weight loss in…
- Trial name
- NCT00001077
- Testing
- Multivitamin and mineral supplements, Peptamen, NuBasics
- Where
- 17 sites in United States
- Volunteers
- 536 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tracheal Stenosis, Airway Disease
Endotracheal Dilator to Improve Oxygenation
The purpose of the study is to prospectively assess the use of a modified tracheal balloon dilator in children (<13 years old) with subglottic or tracheal stenosis.
- Conditions
- Tracheal Stenosis, Airway Disease, Pediatric Respiratory Diseases
- Trial name
- EDITION2 (NCT03411928)
- Testing
- Tracheolator
- Where
- South Africa
- Volunteers
- 12 people
- Sponsor
- University of Cape Town
Obesity, Childhood
Changing Health and Lifestyle Behaviors of Offspring Following Maternal Bariatric Surgery
This is the Phase 2 pilot/feasibility randomized controlled trial of HALO (Health And Lifestyle Behaviors In Offspring), a parent-led behavioral intervention targeting a high-risk pediatric population (i.e., residing offspring…
- Trial name
- HALO-2 (NCT05350267)
- Testing
- HALO, Enhanced Standard of Care
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sickle Cell Disease, Sickle-Cell Disease With Crisis
Investigation Into the Use of BAH243 Lentiviral Vector for Gene Therapy in Treating Sickle Cell Disease
This study is an open-label, non-randomized, single-dose Phase 1/2 trial involving around 85 adult and pediatric participants aged between 2 and 50 years with sickle cell disease (SCD).
- Trial name
- BAH243 (NCT06399107)
- Testing
- Drug Product is administered by IV infusion following myeloablative conditioning with busulfan
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Essen Biotech
Pain, Postoperative, Periapical; Infection
Clinical and Radiographic Evaluation of Zinc Oxide-Propolis Mixture Versus Modified Triple Antibiotic Paste in LSTR
The aim of this study is to evaluate and compare the clinical effectiveness of zinc oxide-propolis mixture with triple antibiotic paste in LSTR as root canal filling material in necrotic primary molars.
- Trial name
- NCT06158451
- Testing
- Zinc oxide propolis, Modified triple antibiotic paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
CLASS II DIVISION 1 MALOCCLUSION, Class II Malocclusion
The Effectiveness of the Twin Block and Carriere Motion Appliances in Post-pubertal Patients and an Evaluation of the Impact of Class II Malocclusion and Its Correction on Oral Health-related Quality of Life
The investigators of this clinical trial aim to: Compare the effectiveness and efficiency of Clark's Twin Block Appliance (CTB) vs Carriere Motion Appliance (CMA) in correcting Class II malocclusion when used in post-pubertal…
- Conditions
- CLASS II DIVISION 1 MALOCCLUSION, Class II Malocclusion, Growth, Overjet
- Trial name
- NCT07292636
- Testing
- CTB, CMA
- Where
- Ireland
- Volunteers
- 88 people
- Sponsor
- Aslam Alkadhimi
Menstrual Symptoms
Body Composition and Sport Performance Among Young Female Soccer Players Using Subdermic Etonogestrel
The goal of this clinical trial study is to evaluate the effect of subdermic etonogestrel implant on body composition, sport performance parameters, quantify bleeding patters and quality of life parameters among young female…
- Trial name
- NCT06775626
- Testing
- Implanon NXT® subdermal implant, Etonogestrel 68mg implant
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maíta Poli de Araújo
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