Clinical trials: Movement Abnormalities
Pantothenate Kinase-Associated Neurodegeneration
Long-term Deferiprone Treatment in Patients With Pantothenate Kinase-Associated Neurodegeneration
Patients with PKAN will be treated with the iron chelator deferiprone for 18 months. Only patients who have completed the earlier study TIRCON2012V1 (NCT01741532), a double-blind placebo-controlled trial in which participants…
- Trial name
- TIRCON-EXT (NCT02174848)
- Testing
- Deferiprone oral solution
- Where
- 4 sites in United States, Germany and 2 more
- Volunteers
- 68 people
- Sponsor
- ApoPharma
Ataxia Telangiectasia
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside
Study design: Single arm open-label clinical trial in ataxia-telangiectasia to test the effects of nicotinamide riboside on ataxia scales, immune function, and neurofilament light chain.
- Trial name
- ATNAD (NCT06324877)
- Testing
- Nicotinamide riboside
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- The University of Queensland
Ataxia, Cerebrovascular Accident
PET Scan to Study Brain Control of Human Movement
Positron Emission Tomography (PET) is a technique used to investigate activity in areas of the brain. The PET technique allows researchers to study the normal processes in the brain (central nervous system) of normal individuals…
- Conditions
- Ataxia, Cerebrovascular Accident, Healthy, Movement Disorder
- Trial name
- NCT00001324
- Where
- United States
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Obstructive Sleep Apnea, Sleep Apnea, Obstructive
Orthognathic Surgery and Obstructive Sleep Apnea Assessed by Mandibular Jaw Movement Monitoring (SUNRISE-ORTHO)
Orthognathic surgery changes the skeletal framework of the upper airway, but its functional effect on sleep-disordered breathing remains poorly documented, particularly with respect to respiratory effort.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Obstructive, Dentofacial Deformities
- Trial name
- SUNRISE-ORTHO (NCT07910461)
- Testing
- Orthognathic surgery (BSSO with or without Le Fort I osteotomy), Sunrise mandibular jaw movement monitoring, Facial multidetector CT in natural head position
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- CHR Sambre et Meuse Site Meuse
Alzheimer Disease, Early Onset, Lewy Body Disease
Patients With Alzheimer's Disease or Related Youth Disease
This study aims to determine factors related to diagnosis delay for patients with young onset dementia (first symptoms before 60 years old) who live in North of France.
- Conditions
- Alzheimer Disease, Early Onset, Lewy Body Disease, Frontotemporal Lobar Degeneration
- Trial name
- PARMAAJJ (NCT03508024)
- Where
- France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Lille
Parkinsons Disease (PD)
Transcranial Direct Current Stimulation for Motor Function and Fatigue in PD
The investigators hypothesize that multi-session anodal tDCS (atDCS) of the left primary motor cortex (M1) will induce long-lasting effects in improving motor function and reducing motor fatigue and fatigability in PD patients.
- Trial name
- tDCS (NCT06883266)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Sanford Health
Huntington's Disease
Child to Adult Neurodevelopment in Gene Expanded Huntington's Disease
Huntington's Disease (HD) is an autosomal dominant disease manifested in a triad of cognitive, psychiatric, and motor signs and symptoms. HD is caused by a triplet repeat (CAG)expansion in the gene Huntingtin (HTT).
- Trial name
- ChANGE HD (NCT01860339)
- Where
- 6 sites in United States
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Peggy C Nopoulos
Tourette's Syndrome
Aripiprazole in the Treatment of Tourette's Syndrome
This is an open-label, flexible dose study designed to evaluate the safety and efficacy of aripiprazole in TS (or chronic tic disorder) subjects with or without associated OC symptoms and with or without ADHD symptoms.
- Trial name
- NCT00282139
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Florida
Parkinson Disease, Stroke
Sonification Techniques for Gait Training
Music therapy is widely used in relational and rehabilitation settings. In addition to Neurologic Music Therapy and other music-based techniques, "sonification" approaches were recently introduced in the field of rehabilitation.
- Conditions
- Parkinson Disease, Stroke, Multiple Sclerosis
- Trial name
- SonicWalk (NCT04876339)
- Testing
- Gait rehabilitation with "sonification", Standard gait rehabilitation (without sonification)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Postural Kyphosis, Postural Lordosis
Investigating Association Between Spine, Scapular, Shoulder and Core in Swimmers
The aim of this observational study is to investigate relationship between cervical, thoracic, lumbar and thoracolumbar spine posture, spine movement, isometric and eccentric shoulder strength, scapular dyskinesis and core muscle…
- Conditions
- Postural Kyphosis, Postural Lordosis, Movement, Abnormal, Spine Injury
- Trial name
- NCT06326177
- Testing
- Spine Posture Assessment, Spine Movement Assessment, Core Muscle Endurance Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
REM Behavior Disorder, Parkinsonism
Efficacy and Tolerability of Ramelteon in Patients With Rapid Eye Movement (REM) Behavior Disorder and Parkinsonism
Parkinson's disease (PD) is the second most common neurodegenerative disorder of the elderly that affects a million patients in US. Sleep dysfunction impacts up to 90% of PD patients.
- Trial name
- NCT00745030
- Testing
- Rozerem
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Parkinson Disease
Strength Training and Different Subtypes of Parkinson´s Disease
The aim of this randomized controlled trial was to assess the impact of progressive resistance exercise (PRE) in PD patients with akinesia and rigidity (AR-subtype).
- Trial name
- NCT02966600
- Testing
- Progressive resistance exercise, Physical Activity
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- University of Oviedo
Parkinson Disease, Parkinson Disease, Secondary
Accelerated Temporal Interference Stimulation on Bilateral Subthalamic Nucleus for Parkinson's Disease and Secondary Parkinson's Syndrome
This clinical trial will evaluate the efficacy of accelerated Temporal Interference Stimulation (TIS) as a therapeutic intervention for individuals diagnosed with Parkinson's disease or secondary Parkinson's syndrome.
- Trial name
- NCT07568067
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ke Dong, MD
Parkinson's Disease
Effects of Probiotics on Peripheral Immunity in Parkinson's Disease
Parkinson's Disease (PD) is a common neurodegenerative disease, with no disease-modifying treatment available, therapy is therefore only symptomatic.
- Trial name
- NCT05173701
- Testing
- Probiotics
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Franca Marino
Encephalopathy, Psychosis
Neuroimmunology Registry and Biobank
A variety of antineuronal antibodies have been detected in the cerebrospinal fluid (CSF) of patients with neurological diseases.
- Conditions
- Encephalopathy, Psychosis, Impaired Consciousness, Epilepsy
- Trial name
- NCT06958341
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Response to Levodopa, Motor Outcomes
Effects of Helicobacter Pylori Infection Eradication in Patients With Parkinson's Disease
A higher prevalence of Helicobacter pylori infection rate has been demonstrated among PD patients compared to controls. As H. pylori infection is known to interfere with levodopa absorption, we embarked on this is a study to…
- Conditions
- Response to Levodopa, Motor Outcomes, Quality of Life Outcomes
- Trial name
- NCT02112812
- Testing
- Eradication therapy for H.pylori infection, Eradication of Helcobacter Pylori, Eradication therapy for Helicobacter pylori
- Where
- Malaysia
- Volunteers
- 82 people
- Sponsor
- National University of Malaysia
Nursing Education
PechaKucha Versus PowerPoint for Parkinson's Disease Education in Nurses
This study compared the effects of PechaKucha and traditional PowerPoint presentation techniques used for Parkinson's disease education on nurses' knowledge and awareness levels.
- Trial name
- NCT07800312
- Testing
- PechaKucha-Based Parkinson's Disease Education, PowerPoint-Based Parkinson's Disease Education
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Angelman Syndrome
Study on Tolerability of Levodopa/Carbidopa in Children With Angelman Syndrome
This study is designed to determine the highest dose of levodopa/carbidopa that can be tolerated without any serious side effects by children with Angelman syndrome.
- Trial name
- NCT00829439
- Testing
- Levodopa/Carbidopa (4:1)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Boston Children's Hospital
Parkinson's Disease
Use and Misuse of Domperidone in Parkinson's Disease in France - Dump Investigation
Parkinson disease is the second most frequent neurodegenerative disease after Alzheimer disease and affect 1% of the population over 60 years. The treatment of PD is based on dopamine replacement therapies (DRT).
- Trial name
- DUMP-invest (NCT03837067)
- Where
- France
- Volunteers
- 2,300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson's Disease (PD), Anxiety
Blood Flow Restriction Aerobic Exercise for Balance and Anxiety in Parkinson's Disease
Reducing balance problems and anxiety severity are the top two research uncertainties for people with Parkinson's disease (PD). Besides having a mutually aggravating relationship between postural impairment and anxiety severity…
- Conditions
- Parkinson's Disease (PD), Anxiety, Postural Balance
- Trial name
- NCT07831980
- Testing
- Aerobic Exercise with Blood Flow Restriction, Aerobic Exercise without Blood Flow Restriction
- Volunteers
- 54 people
- Sponsor
- National Cheng-Kung University Hospital