Clinical trials: Movement Abnormalities
Parkinson Disease
Strength Training and Different Subtypes of Parkinson´s Disease
The aim of this randomized controlled trial was to assess the impact of progressive resistance exercise (PRE) in PD patients with akinesia and rigidity (AR-subtype).
- Trial name
- NCT02966600
- Testing
- Progressive resistance exercise, Physical Activity
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- University of Oviedo
Parkinson Disease, Executive Dysfunction
Effect of Computer-based Cognitive Training on Attention and Executive Functions in Patients With Parkinson's Disease
The current study adresses the effect of two different computer-based cognitive trianing programmes on attention and executive functions in patients with Parkinson's disease.
- Trial name
- NCT03285347
- Testing
- Computer-based cognitive training
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Bispebjerg Hospital
Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic
Feasibility Study Assessing the Effect of Carbidopa/Levodopa Ratio on Orthostatic Hypotension in Multiple System Atrophy - Parkinsonian Type and Parkinson Disease.
This study is aimed at patients with multi-system atrophy - parkinsonian type (P-MSA) or Parkinson's disease (PD) receiving dopaminergic drugs and suffering from orthostatic hypotension (OH).
- Conditions
- Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic, Parkinson Disease
- Trial name
- CARBIDOH (NCT06831500)
- Testing
- Administration of Carbidopa/levodopa
- Where
- 2 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- Julien Bally
Huntington Disease
Open-label Extension Study to Evaluate the Safety and Tolerability of WVE-120101 in Patients With Huntington's Disease
WVE-HDSNP1-002 is an open-label extension (OLE) study to evaluate the safety, tolerability, PK, PD, and clinical effects of WVE-120101 in adult patients with early manifest HD who carry a targeted single nucleotide polymorphism…
- Trial name
- NCT04617847
- Testing
- WVE-120101
- Where
- 18 sites in Australia, Canada and 5 more
- Volunteers
- 27 people
- Sponsor
- Wave Life Sciences USA, Inc.
Tourette Syndrome
Sensory Processing in Tourette Syndrome
The purpose of this study is to learn more about how patients with Tourette Syndrome deal with sensory stimuli in their environment such as bright lights, loud noises, physical sensations such as shirt tags, etcetera.
- Trial name
- NCT02512406
- Testing
- The Sensory Profile, The Adult/Adolescent Sensory Profile, Children's Yale-Brown Obsessive Compulsive Scale
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Florida
Safety Issues
NOPARK Open Label Extension Study
This protocol describes the NOPARK Open Label Extension Study. The NOPARK Open Label Extension study is an optional extension of the clinical phase II NOPARK study.
- Trial name
- NCT05546567
- Testing
- Nicotinamide Riboside
- Where
- Norway
- Volunteers
- 400 people
- Sponsor
- Haukeland University Hospital
Functional Movement Disorder
Study of the Ability of a New Technique to Effectively Diagnose Movement Disorders
Sante Fe is an investigation of a new technique to distinguish between different types of movement disorders, specifically organic versus functional, by observing changes in involuntary movements in two different situations.
- Trial name
- Sante-Fe (NCT03661021)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Cleveland Clinic
Epilepsy; Seizure, Neuromuscular Diseases
North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2
The "North Carolina Clinical Genomic Evaluation by Next-gen Exome Sequencing, 2 (NCGENES 2)" study is part of a larger consortium project investigating the clinical utility, or net benefit of an intervention on patient and family…
- Conditions
- Epilepsy; Seizure, Neuromuscular Diseases, Brain Malformation, Intellectual Disability
- Trial name
- NCGENES2 (NCT03548779)
- Testing
- Pre-visit prep, usual care + exome seq
- Where
- 3 sites in United States
- Volunteers
- 548 people
- Sponsor
- University of North Carolina, Chapel Hill
Tourette Syndrome
D-cycloserine Augmented Treatment for Youth With Tic Disorders
This pilot study aims evaluate the feasibility and initial efficacy of behavior therapy augmented by d-cycloserine (DCS) compared to behavior therapy augmented by placebo.
- Trial name
- NCT04357951
- Testing
- d-cycloserine, Behavior Therapy
- Where
- United States
- Sponsor
- Johns Hopkins University
Cerebral Palsy
Early Remote At-risk Diagnosis for Cerebral Palsy in Follow-up Clinics for High-risk Infants
Cerebral Palsy (CP) is the most common motor dysfunction in childhood. Traditionally, diagnosis is set between 12 and 24 months of age.
- Trial name
- In-Motion (NCT04287166)
- Where
- 3 sites in Norway
- Volunteers
- 100 people
- Sponsor
- St. Olavs Hospital
Tic Disorder, Chronic Motor or Vocal, Tourette Syndrome in Children
Evaluation of a Cognitive Psychophysiological Treatment for Tourette Syndrome and Tic Disorders
It is a randomized controlled trial to compare two behavioural treatments, namely CBIT and CoPs. This study would be the first head-to-head randomized trial between two established treatments rather than supportive counseling or…
- Conditions
- Tic Disorder, Chronic Motor or Vocal, Tourette Syndrome in Children, Tourette Syndrome
- Trial name
- NCT03225430
- Testing
- Cognitive behavioural treatment for tics, Cognitive psychophysiological
- Where
- Canada
- Volunteers
- 144 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal
Tourette's Syndrome
Aripiprazole in the Treatment of Tourette's Syndrome
This is an open-label, flexible dose study designed to evaluate the safety and efficacy of aripiprazole in TS (or chronic tic disorder) subjects with or without associated OC symptoms and with or without ADHD symptoms.
- Trial name
- NCT00282139
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Florida
Parkinson Disease, Gait, Shuffling
Efficacy of Proprioceptive Focal Stimulation (EQUISTASI) on Gait Parameters in Parkinson. Italian Multicentric Study
It's already known the efficacy of Gait Analysis (GA) on evaluating gait modification on Parkinson's Disease (PD) Patients (1). On the other hand Proprioceptive Focal Stimulation seems be useful in symptoms amelioration in…
- Conditions
- Parkinson Disease, Gait, Shuffling, Effects of Vibration
- Trial name
- PAGE (NCT02641405)
- Testing
- Equistasi, Inactive Equistasi
- Where
- 6 sites in Italy
- Volunteers
- 126 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Achondroplasia, Hypochondroplasia
Prospective Longitudinal Multicentric Study to Measure Limb Movement in Patients With FGFR3-related Skeletal Dysplasia
The study aims to identify which Syde®-derived digital outcomes are reliable in FGFR3-related Skeletal Dysplasia. This requires to set-up a natural history study to measure limb movements in patients with ACH or HCH.
- Trial name
- SKY-MOT3 (NCT07388966)
- Where
- 4 sites in Belgium, France and 1 more
- Volunteers
- 140 people
- Sponsor
- SYSNAV
Tourette Syndrome
Behavioral Therapy for Tourette Syndrome
This research is being done to determine whether a home-based behavioral therapy can be successfully used to treat tics in children with Tourette syndrome (TS).
- Trial name
- BTTS:HBTA (NCT03019731)
- Testing
- Therapist-directed Behavioral Therapy, Home-based DVD Therapy
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Hallux Valgus
The Effect of Hallux Valgus Angle on Dynamic Knee Movement Pattern
Abstract Background/aim: Little is known about the relationship between hallux valgus and the alignment of proximal joints. Dynamic knee valgus is a movement pattern characterized by excessive knee abduction along with femoral…
- Trial name
- NCT06563037
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Parkinson Disease
Effects of Osteopathic Visceral Manipulation on the Autonomic Nervous System, Balance and Gastrointestinal Disturbances in Individuals With Parkinson's Disease
Introduction: Parkinson's disease (PD) is responsible for several changes in the body, such as balance, gastrointestinal and autonomic disorders and are associated with impairments in the clinical prognosis of these individuals.
- Trial name
- NCT05047796
- Testing
- Intervention Protocol
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Instituto Docusse de Osteopatia e Terapia Manual
Hyperkinetic Movement Disorders
Compassionate Use of Tetrabenazine in the Treatment of Abnormal Movements
Although the results of studies looking at tetrabenazine have shown its effectiveness in the management of hyperkinetic(too much) movement disorders, it has not been made available in the U.S.
- Trial name
- TBZ (NCT00642057)
- Testing
- tetrabenazine
- Sponsor
- Joseph Jankovic
Niemann Pick Diseases
Saccadic Eye Movements in Patients With Niemann-Pick Type C Disease
This study is done in conjunction with a trial, conducted at Columbia University College of Physicians and Surgeons in New York and the Royal Manchester Children's Hospital in England, to examine the effectiveness of a new drug…
- Trial name
- NCT00316498
- Testing
- OGT918
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 30 people
- Sponsor
- National Eye Institute (NEI)
Parkinson's Disease
Use and Misuse of Domperidone in Parkinson's Disease in France - Dump Investigation
Parkinson disease is the second most frequent neurodegenerative disease after Alzheimer disease and affect 1% of the population over 60 years. The treatment of PD is based on dopamine replacement therapies (DRT).
- Trial name
- DUMP-invest (NCT03837067)
- Where
- France
- Volunteers
- 2,300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris