Clinical trials: Muscle Damage
Cerebral Palsy
Effect of TENS in Children With Spastic Cerebral Palsy
TENS is cheap and simple tool for physiotherapist, free of many side effects compared with other tools. so The aim of study was record the effect of TENS on calf muscle tone in spastic cerebral palsy children.
- Trial name
- NCT05649254
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Cairo University
Cerebral Palsy
Whole Body Vibration in Rehabilitation of Spastic Cerebral Palsy
Spasticity is one of the most common features in children with cerebral palsy (CP) and is evident in the majority of CP types such as hemiplegia, diplegia, quadriplegia, etc.
- Trial name
- WBV (NCT06077136)
- Testing
- whole body vibration, standard physical therapy
- Where
- Saudi Arabia
- Volunteers
- 56 people
- Sponsor
- University of Hail
Cerebral Palsy, Spina Bifida
A Peer E-mentoring Intervention to Improve Employment
Despite the strong business case of hiring people with disabilities, a significant proportion of youth with disabilities leave high school and neither work nor continue their education and are unprepared to meet the demands of a…
- Conditions
- Cerebral Palsy, Spina Bifida, Juvenile Arthritis, Spinal Cord Injury
- Trial name
- NCT02522507
- Testing
- Empowering youth towards employment
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Cerebral Palsy, Respiratory Function
Inspiratory Muscle Training in Children With Cerebral Palsy: Effects on Respiratory and Motor Functions
This study investigates the effect of inspiratory muscle training on respiratory parameters, trunk control, upper extremity function and swallowing in patients with cerebral palsy aged 5-18 years.
- Conditions
- Cerebral Palsy, Respiratory Function, Balance, Swallowing
- Trial name
- NCT07041593
- Testing
- Inspiratory muscle training and standard neurodevelopmental physiotherapy (SNP), Standard neurodevelopmental physiotherapy (SNP)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Sadık Emre ÇELEBİ
Pediatrics, Muscle Spasticity
BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity
This study will evaluate the long-term safety of BOTOX® (botulinum toxin Type A) for the treatment of pediatric upper limb spasticity.
- Conditions
- Pediatrics, Muscle Spasticity, Cerebral Palsy, Stroke
- Trial name
- NCT01603615
- Testing
- Botulinum Toxin Type A
- Where
- 48 sites in United States, Canada and 7 more
- Volunteers
- 220 people
- Sponsor
- Allergan
Cerebral Palsy
Effects of Multimodal Neuro Rehabilitation on Cortical Activity and Muscle Syenergy in Spastic Cerebral Palsy
To determine the effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on cortical activity and muscle synergy.
- Trial name
- NCT07574996
- Testing
- Active Anodal Transcranial Direct Current Stimulation (tDCS) + Task-Oriented Training, Active Anodal Transcranial Direct Current Stimulation + Virtual Reality, Conventional Physiotherapy
- Volunteers
- 150 people
- Sponsor
- Riphah International University
Spastic Cerebral Palsy
3D-Microscopic Muscle Architecture in Cerebral Palsy
The focus of this study is to understand and define the mechanisms of the altered muscle development and growth on a microscopic level within a long-term perspective in children with cerebral palsy and to relate these findings to…
- Trial name
- 3D-MMAP (NCT06584851)
- Where
- Belgium
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Idiopathic Toe Walking, Cerebral Palsy
The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children
Tight ankle muscles can produce ankle equinus (limited ability to pull the foot upward) and occur often in children, significantly impacting their ability to walk.
- Conditions
- Idiopathic Toe Walking, Cerebral Palsy, Hereditary Spastic Paraparesis, Traumatic Brain Injury
- Trial name
- Plantaris Sx (NCT07090057)
- Testing
- Tendoachilles (TA) lengthening or gastrocnemius (GN) recession, then Plantaris tenotomy, Plantaris tenotomy, then Tendoachilles (TA) lengthening or gastrocnemius (GN) recession
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University of Alberta
Cerebral Palsy, Muscle Spasticity
Dysport® Pediatric Lower Limb Spasticity Follow-on Study
The purpose of this research study was to determine the long term safety and efficacy of repeated treatments with Dysport® used in the treatment of lower limb spasticity in children with dynamic equinus foot deformity due to…
- Conditions
- Cerebral Palsy, Muscle Spasticity, Children
- Trial name
- NCT01251380
- Testing
- Botulinum toxin type A
- Where
- 27 sites in United States, Chile and 4 more
- Volunteers
- 216 people
- Sponsor
- Ipsen
Cerebral Palsy, Caregiver Burden
Awareness Levels of Caregivers of Disabled Children
Disability-or apology; It is the inability or incompleteness of individuals to fulfill their roles in life, such as age, gender, culture, social and psychological factors, due to their inadequacies.
- Conditions
- Cerebral Palsy, Caregiver Burden, Disabilities Multiple, Muscular Dystrophy
- Trial name
- caregivers (NCT05228405)
- Testing
- All of the disabled children's caregivers will answer the Questionnaire of Disease, Physiotherapy and Sports Awareness
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Cerebral Palsy
Early Intervention in Infants With Cerebral Palsy
Contractures are a frequent cause of reduced mobility in children with Cerebral palsy (CP) already at the age of 2-3 years. Reduced muscle use and muscle growth have been suggested as key factors in the development of…
- Trial name
- CONTRACT (NCT04250454)
- Testing
- CONTRACT
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- University of Copenhagen
Blepharospasm, Hemifacial Spasm
Post Marketing Surveillance Study of Dysport
The purpose of this study is to provide further information regarding the risks and benefits of Dysport in marketed indications.
- Conditions
- Blepharospasm, Hemifacial Spasm, Cervical Dystonia, Spasmodic Torticollis
- Trial name
- NCT00210431
- Where
- 36 sites in France, Germany and 1 more
- Volunteers
- 783 people
- Sponsor
- Ipsen
Cerebral Palsy, Muscle Disorder
A New Training to Enhance Physical Activity in Adolescents With Cerebral Palsy
The purpose of this research study is to test the feasibility and response of a new exercise protocol on improving physical activity in adolescents with cerebral palsy.
- Conditions
- Cerebral Palsy, Muscle Disorder, Physical Disability, Posture Disorders in Children
- Trial name
- FOLIC (NCT05865418)
- Testing
- Loaded high intensity training, High intensity circuit training (HICT)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Alabama at Birmingham
Sjogren-Larsson Syndrome
ADX-629 Therapy for Sjogren-Larsson Syndrome
This research study will determine whether orally administered ADX-629 is safe and has biochemical efficacy in participants with Sjögren-Larsson syndrome (SLS), a rare inherited disorder of fatty aldehyde metabolism The disease…
- Trial name
- NCT05443685
- Testing
- ADX-629
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Nebraska
Cerebral Palsy, Spastic, Diplegic
Potential Benefits of Home Based Exercise Programs in the Management of Spastic Cerebral Palsy
The study will be conducted to see the potential benefits of home based exercise program comprising routine physical therapy and traditional massage in the management of spastic cerebral palsy (CP).
- Trial name
- HEP&CP (NCT05111236)
- Testing
- Routine physical therapy, Traditional massage
- Where
- Pakistan
- Volunteers
- 86 people
- Sponsor
- National Institute of Rehabilitation Medicine, Islamabad, Pakistan
Duchenne Muscular Dystrophy, Cardiomyopathies
The Preventive Efficacy of Carvedilol on Cardiac Dysfunction in Duchenne Muscular Dystrophy
Purpose This cardiac dysfunction in patients with Duchenne muscular dystrophy is associated with minor cardiac damage as indicated by elevation of plasma cardiac troponin I (cTnI).
- Trial name
- NCT00606775
- Testing
- Carvedilol
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Suzuka Hospital
Spasticity, Cerebral Palsy
Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity
Oral baclofen is used commonly to treat spasticity in children with cerebral palsy. Although for adults there is dosing,safety and efficacy information in the package insert, this is not the case for children.
- Trial name
- Best PK/PD (NCT00607542)
- Testing
- baclofen
- Where
- 11 sites in United States
- Volunteers
- 61 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Cerebral Palsy
Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for the Treatment of Cerebral Palsy
This is an Individual Patient Expanded Access Protocol of Autologous HB-adMSCs for the Treatment of Cerebral Palsy (CP) with the primary goal of treating 1 individual with CP who has exhausted all treatment options, his condition…
- Trial name
- NCT04029896
- Testing
- HB-adMSCs
- Where
- United States
- Sponsor
- Hope Biosciences Research Foundation
Muscle Spasticity, Cerebral Palsy
Therapeutic Photobiomodulation and Tretament of Spasticity
Cerebral palsy is a non-progressive, permanent syndrome that occurs in childhood and is accompanied by motor, tônus and posture disorders.
- Conditions
- Muscle Spasticity, Cerebral Palsy, Photobiomodulation, Low-Level Laser Therapy
- Trial name
- NCT06536751
- Testing
- Photobiomodulation, Institution's Standard Physiotherapy
- Where
- 2 sites in Brazil
- Volunteers
- 12 people
- Sponsor
- University of Nove de Julho
Cerebral Palsy
Effects of Play Based Neural Mobilisation Activities on Hand Grip Strength and Dexterity in Cerebral Palsy Children
The study design will be a Randomized control trial. The data will be collected from Acme Medical complex and Rehab cure clinic. The study will be completed in 10 months after the approval of synopsis.
- Trial name
- NCT07428928
- Testing
- neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment., Regular physical therapy
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University