Clinical trials: Necrosis, Femur Head
Osteochondritis of the Femoral Head
Mesenchymal Stem Cell for Osteonecrosis of the Femoral Head
Mesenchymal Stem Cells (MSCs) have been shown to have immunosuppressive and repairing properties. Bone marrow mononuclear cells (BMMNCs) have revascularization properties and complimentary effects to MSCs.
- Trial name
- NCT00813267
- Testing
- mesenchymal stem cell infusion, bone marrow mononuclear cell infusion
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Jianming Tan
Osteoarthritis, Arthritis
A Multi-centre, Prospective Surveillance to Assess Mid-term Performance of the Mpact Cup
This is a multi-centre, prospective post marketing surveillance study to assess mid-term performance of the Mpact cup in subjects requiring primary total hip arthroplasty.
- Conditions
- Osteoarthritis, Arthritis, Avascular Necrosis, Fracture of the Femoral Neck or Head
- Trial name
- NCT02196818
- Testing
- Mpact Acetabular Shell
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Medacta International SA
Legg Calve Perthes Disease
Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease
Legg-Calvé-Perthes disease is a childhood hip disorder which is common enough to be a significant public health problem (affects 1 in 740 boys between ages 0-14), but uncommon enough to have a sufficient number of patients from a…
- Trial name
- IPSG1 (NCT02040714)
- Testing
- Osteotomy + Long Term Non-Weight Bearing, Osteotomy + Short Term Non-Weight Bearing, Nonoperative Observation
- Where
- 46 sites in United States, Australia and 13 more
- Volunteers
- 1,500 people
- Sponsor
- Texas Scottish Rite Hospital for Children
Osteonecrosis
Core Decompression With or Without Cement Packing for ONFH
Osteonecrosis of the femoral head (ONFH) is difficult to treat as collapse frequently occurs after core decompression (CD). This may be due to the failure to provide structural support during revascularization and healing.
- Trial name
- NCT04233125
- Testing
- Core Decompression, PMMA augmentation
- Volunteers
- 37 people
- Sponsor
- University of Minnesota
Legg-Calve-Perthes Disease
Kineesiotaping for Patients With LCPD
Kinesiotaping is increasingly being used as a complement to musculoskeletal pain management. This study aimed to evaluate the immediate clinical efficacy of kinesiotaping on pain and pain-related symptoms of Legg-Calvé-Perthes…
- Trial name
- NCT05840146
- Testing
- Kinesiotaping
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University - Cerrahpasa
Avascular Necrosis of the Femoral Head
Outcome After Avascular Necrosis of the Femoral Head in Young Patients
1. The course of AVN between Initial diagnosis and total hip replacement (THA) is analysed. The impact of early interventions versus conservative therapy in AVN before THA will be evaluated. 2.
- Trial name
- AVN (NCT03753282)
- Testing
- questionnaires for patient reported outcome, questionnaire for course of the disease
- Sponsor
- University Hospital, Basel, Switzerland
Femur Head Necrosis
Examine the Possible Association of Hepatic CYP3A Activity and the Susceptibility to Femur Head Necrosis
The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.
- Trial name
- NCT00244400
- Where
- Japan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Osaka City University
Hip Dislocation, Femur Head Necrosis
Investigation of the Femoral Shortening Osteotomy in the Developmental Dislocation of the Hip (FSODDH)
Although older children and high dislocations may be more likely to require a femoral shortening osteotomy, the ultimate decision about whether or not to shorten a given femur should depend on the ease of femoral head reduction…
- Trial name
- FSODDH (NCT02633904)
- Testing
- Osteotomy, Non-osteotomy
- Volunteers
- 200 people
- Sponsor
- He Jin Peng
Osteoarthritis, Arthritis
AMIStem Primary Hip System Prospective Post-marketing Multi-centre Surveillance Study
This is a multicentre post-marketing prospective study to evaluate performance and clinical outcomes of AMIIStem primary hip system.
- Conditions
- Osteoarthritis, Arthritis, Avascular Necrosis, Fracture of the Femoral Neck or Head
- Trial name
- NCT01107340
- Testing
- AMIStem Hip System
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 500 people
- Sponsor
- Medacta International SA
Developmental Dysplasia of the Hip
Intraoperative Contrast-Enhanced Ultrasound Evaluation of Blood Flow at the Time of Surgical Hip Reduction for DDH
This study evaluates the feasibility and utility of contrast-enhanced ultrasound to provide real-time assessment of blood flow to the femoral head in infants undergoing surgical reduction for developmental dysplasia of the hip.
- Trial name
- NCT03107520
- Testing
- Intraoperative contrast-enhanced ultrasound (CEUS), Lumason
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Children's Hospital of Philadelphia
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Osteoarthritis, Hip, Femoroacetabular Impingement
Early Feasibility Study of Cartilage Defect Repair
Any patient aged 14 or older up to 64 years of age with hip disease, resulting in loss of articular cartilage integrity on the femoral head (e.g., femoroacetabular impingement or other structural deformity), has failed…
- Conditions
- Osteoarthritis, Hip, Femoroacetabular Impingement, Osteonecrosis, Legg-Calvé-Perthes Disease
- Trial name
- NCT06823089
- Testing
- ReNew Hip Implant
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cytex Therapeutics, Inc.
Legg-Calvé-Perthes Disease
The Long Term Outcome of Varus Derotational Osteotomy for Legg-Calvé-Perthes' Disease
Background: Varus derotation osteotomy (VDRO) is one of the most popular surgical treatments for Legg-Calvé-Perthes disease yet its long term results have not been assessed.
- Trial name
- NCT02676271
- Testing
- Proximal varus derotational osteotomy
- Where
- Israel
- Volunteers
- 35 people
- Sponsor
- Assaf-Harofeh Medical Center
Perthes' Disease
The Effect of Perthes' Disease on Hip Cartilage
The purpose of this study is to determine whether Perthes' disease has caused detectable hip cartilage damage in young people who have reached the healed stage of the disease.
- Trial name
- NCT00958464
- Testing
- MRI
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Osteoarthritis, Arthritis
Periprosthetic Bone Mineral Density After Total Hip Arthroplasty Performed Through a Minimally Invasive Anterior Approach (AMIS) With Either an AMIStem or a Quadra Femoral Component
This is a monocentric, prospective, randomized clinical survey to verify if the periprosthetic remodelling brought about either the AMIStem or the Quadra femoral component is equivalent.
- Conditions
- Osteoarthritis, Arthritis, Avascular Necrosis, Fracture of the Femoral Neck or Head
- Trial name
- NCT01285843
- Testing
- Anterior Minimally Invasive Approach (AMIS)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Medacta International SA
Legg-Calve Perthes Disease
Intraarticular Corticosteroid Therapy in Perthes Disease.
Legg-Calve-Perthes disease (LCP) represents the loss of blood flow to the head of the femur, resulting in significant hip pain and potential long term disability.
- Trial name
- NCT01026909
- Testing
- Aristospan 20mg
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Seattle Children's Hospital
Osteonecrosis of Femoral Head
The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-ONFH)
The purposes of the study is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cells (hUC-MSC) in treating osteonecrosis of femoral head patients.
- Trial name
- NCT03180463
- Testing
- Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#), core decompression
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sclnow Biotechnology Co., Ltd.
Osteonecrosis
Mononuclear Cells, Platelets and Zoledronic Acid for Preventing Collapse of the Femoral Head in Osteonecrosis
This study was mainly aimed to evaluate the efficacy of local administration of enriched bone marrow mononuclear cells, platelets and zoledronic acid for the clinical prevention of collapse of the early-stage osteonecrotic…
- Trial name
- NCT02721940
- Testing
- Control group, Mononuclear Cells, Platelets
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Femoral Head Avascular Necrosis
The Use of Bisphosphonates in the Treatment of Avascular Necrosis of the Femoral Head
To determine the safety and effectiveness of pamidronate in patients with radiographically proven avascular necrosis which are the result of unstable (acute) slipped capital femoral epiphysis, traumatic proximal femur fractures…
- Trial name
- NCT02007915
- Testing
- Pamidronate Disodium
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Legg-Calvé-Perthes Disease
WOMAC Hip Score in Children and Adolescents With Perthes Disease
Patient oriented clinical outcomes have increased in use and popularity and provide a comprehensive assessment of the level of symptoms and function experienced by a patient.
- Trial name
- WOMAC (NCT02795494)
- Testing
- WOMAC questionnaire at baseline, ASK-P questionnaire at baseline, WOMAC questionnaire at 2 weeks
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- British Columbia Children's Hospital