Clinical trials: Necrosis, Femur Head
Non Traumatic Osteonecrosis of the Femoral Head (Hip)
Controlled Study of Stage 3 Osteonecrosis Treatment by Bone Marrow
In stage 3 Osteonecrosis (ON) of the femoral head, a beneficial effect of bone marrow grafting was reported with a reduction of the functional evolution and the necessity of a total prosthesis placement in a non-controlled…
- Trial name
- NCT01544712
- Testing
- core decompression with autologous bone marrow implantation, core decompression of the femoral head
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University of Liege
Non-inflammatory Degenerative Joint Disease, Osteoarthritis
Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement
This study is intended to gather medium (5- to 7-years) and long-term (minimum 8- to 10-years) information regarding the performance and safety of the commercially available 36mm CERAMAX® Ceramic on Ceramic (COC) Total Hip System…
- Conditions
- Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-Traumatic Osteoarthritis of Hip
- Trial name
- COC36mmPAS (NCT02096198)
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- DePuy Orthopaedics
Avascular Necrosis, Osteonecrosis
The Use of Genex in the Management of Early-Stage Osteonecrosis of the Femoral Head
The purpose of this study is to assess the clinical and x-ray results of patients who are treated with core decompression of the hip and the injection of a bone marrow concentrate and the use of the Bone Graft Substitute Genex®.
- Trial name
- Genex (NCT05706909)
- Testing
- Genex with ABMC
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Osteoarthritis, Hip, Femoroacetabular Impingement
Early Feasibility Study of Cartilage Defect Repair
Any patient aged 14 or older up to 64 years of age with hip disease, resulting in loss of articular cartilage integrity on the femoral head (e.g., femoroacetabular impingement or other structural deformity), has failed…
- Conditions
- Osteoarthritis, Hip, Femoroacetabular Impingement, Osteonecrosis, Legg-Calvé-Perthes Disease
- Trial name
- NCT06823089
- Testing
- ReNew Hip Implant
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cytex Therapeutics, Inc.
Osteonecrosis of the Femoral Head
Screening for Biomarkers of Osteonecrosis of the Femoral Head
Osteonecrosis of the femoral head (ONFH) presents a rapidly progressive natural disease course. Femoral head collapse may occur within two years, ultimately necessitating total hip arthroplasty and imposing a heavy medical and…
- Trial name
- NCT07545616
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Necrosis of Femoral Head, Knee Osteoarthritis
MRI Maker of Perioperative Neurocognitive Disorder
Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear.
- Conditions
- Necrosis of Femoral Head, Knee Osteoarthritis, Fracture of Lower Limb
- Trial name
- MRIPND (NCT03773627)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Bone Marrow, Femoral Neck Fractures
Bone Marrow Injection in Fracture of Femoral Neck
Objectives: Primary objective : To investigate the predisposing factors for femoral neck fractures, including age, sex, and associated comorbidities.
- Trial name
- NCT07808294
- Testing
- Anatomical reduction and fixation with bone marrow injection, Anatomical reduction with Fixation
- Where
- Syria
- Volunteers
- 32 people
- Sponsor
- Yaser Alkanash
Degenerative Hip Joint Disease, Post-traumatic Osteoarthritis
Safety and Performance Assessment of the SYMBOL Range of Medical Devices in Patients Underlying Total Hip Arthroplasty
The purpose of this post-market clinical follow up study is to assess the safety and effectiveness of the SYMBOL range of medical devices.
- Conditions
- Degenerative Hip Joint Disease, Post-traumatic Osteoarthritis, Hip Arthritis, Femoral Neck Fractures
- Trial name
- NCT05227924
- Testing
- Total hip arthroplasty (primary or revision)
- Where
- 9 sites in France
- Volunteers
- 747 people
- Sponsor
- Dedienne Sante S.A.S.
Arthroplasty, Replacement, Hip
A Post Market Clinical Follow-up Study With the aneXys Cup
The purpose of the study is the evaluation of the clinical and radiological short- to long-term safety and performance of the aneXys cup. The data will be used for an ongoing evaluation of the product safety and performance.
- Trial name
- NCT03274830
- Testing
- aneXys
- Where
- 3 sites in Germany
- Volunteers
- 102 people
- Sponsor
- Mathys Ltd Bettlach
Osteoarthritis, Hip, Avascular Necrosis of Hip
Avenir Complete Post-Market Clinical Follow-Up Study
The main objectives of this study are to confirm the long-term safety, performance and clinical benefits the Avenir Complete femoral stem and its instrumentation when used in primary total, hemi, and revision hip arthroplasty.
- Conditions
- Osteoarthritis, Hip, Avascular Necrosis of Hip, Avascular Necrosis of the Femoral Head, Post-traumatic; Arthrosis
- Trial name
- NCT04731077
- Testing
- Avenir Complete Femoral Stem
- Where
- 9 sites in United States, Denmark and 4 more
- Volunteers
- 275 people
- Sponsor
- Zimmer Biomet
Avascular Necrosis of Femur Head
Investigation of the Effect of Hyperbaric Oxygen Therapy in Patients With Avascular Necrosis
Avascular necrosis is a condition that occurs when bone tissue loses sufficient blood flow. This condition causes bone cells to die and, as a result, bone structure to deteriorate.
- Trial name
- NCT07142018
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Hip Osteoarthritis, Acute Traumatic Fracture of the Femoral Head or Neck
Z1 Hip System: Post-Market Clinical Follow Up Study
The objectives of this study are to confirm the early to mid- term safety, performance, and clinical benefits of the Z1 Femoral Hip System in hemi- and primary total hip arthroplasty.
- Conditions
- Hip Osteoarthritis, Acute Traumatic Fracture of the Femoral Head or Neck, Avascular Necrosis of the Femoral Head
- Trial name
- NCT07104279
- Testing
- Z1 Femoral Hip System
- Where
- 5 sites in United States
- Volunteers
- 300 people
- Sponsor
- Zimmer Biomet
Hip Arthropathy, Osteoarthritis, Hip
PROMIS Evaluation Study
A total of 250 total hip arthroplasties (THA) are performed at the Bezirkskrankenhaus St. Johann. In a majority of those, implants from the company Falcon Medical (Austria) are used.
- Conditions
- Hip Arthropathy, Osteoarthritis, Hip, Perthes Disease, Osteonecrosis
- Trial name
- NCT05734651
- Testing
- PROMIS Stem
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Bezirkskrankenhaus St. Johann in Tirol
Avascular Necrosis of Femoral Head, Degenerative Arthritis of Hip
Rotational Thromboelastography Study in Tranexamic Acid and Colloid Infusion
Colloid solution is generally used to maintain intravascular volume. It is reported to impair blood coagulation in vivo and in vitro more than crystalloid does by prolonging coagulation time and decreasing clot strength.
- Trial name
- NCT02146456
- Testing
- Tranexamic Acid
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Bundang Hospital
Osteonecrosis of the Femoral Head
Triple-Modal Therapy in Early-Stage Femoral Head Osteonecrosis (TM-ONFH)
This retrospective observational study evaluates the clinical and radiological outcomes of patients with early-stage osteonecrosis of the femoral head treated with a combination of core decompression, stromal vascular fraction…
- Trial name
- TM-ONFH (NCT07560163)
- Testing
- Core decompression, stromal vascular fraction (SVF), Hyperbaric Oxygen Therapy (HBOT)
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara City Hospital Bilkent
AVN
Hyperbaric Oxygen Therapy Versus Core Decompression Augmented With Bone Substitute in Pre Collapse of Avascular Necrosis of Femoral Head
Introduction: osteonecrosis of the femoral head is a potentially crippling disorder, which mainly affects the young adults. Core decompression has been used for the treatment of the osteonecrosis of the femur head since was…
- Trial name
- NCT04657653
- Testing
- core decompression
- Where
- Qatar
- Volunteers
- 19 people
- Sponsor
- Hamad Medical Corporation
Hip Necrosis, Hip Injuries
The Treatment of Initial Stage of Hip Osteonecrosis: the Core Decompression
This retrospective study evaluates 52 cases of avascular necrosis of femoral head (AVN) treated by core decompression, bone chips allograft, fibrin platelet rich-plasma (PRF) and concentrated autologous mesenchymal stromal cells…
- Trial name
- NEC15 (NCT04210440)
- Testing
- Core decompression procedure
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Dante Dallari, MD
Arthrosis, Traumatic Arthritis
The Medacta International AMIStem-P Post-Marketing Surveillance Study
This is a Post-Market Surveillance study of AMIStem-P femoral stem prosthesis
- Conditions
- Arthrosis, Traumatic Arthritis, Rheumatoid Polyarthritis, Congenital Hip Dysplasia
- Trial name
- NCT04997005
- Testing
- AMIStem-P
- Where
- 5 sites in France
- Volunteers
- 550 people
- Sponsor
- Medacta International SA
Perthes' Disease
The Effect of Perthes' Disease on Hip Cartilage
The purpose of this study is to determine whether Perthes' disease has caused detectable hip cartilage damage in young people who have reached the healed stage of the disease.
- Trial name
- NCT00958464
- Testing
- MRI
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Osteoarthritis, Hip, Femur Head Necrosis
Prospective Clinical 5-year Follow-up of the LINK® SP-CL® Hip Prosthesis Stem
The objective of this PMCF is to collect clinical and radiographic outcome information on Total Hip Arthroplasty (THA) performed with LINK® SP-CL® Hip Prosthesis Stem under routine conditions.
- Conditions
- Osteoarthritis, Hip, Femur Head Necrosis, Femoral Neck Fractures
- Trial name
- NCT02288117
- Where
- 4 sites in Germany, Italy and 1 more
- Volunteers
- 240 people
- Sponsor
- Waldemar Link GmbH & Co. KG