Clinical trials: Neonates
Excipient Exposure, Neonatal
Safe Excipient Exposure in Neonates and Small ChildreN
The purpose of this study is to explore the quantity of excipient exposure in neonatal and young pediatric patients in a Danish Hospital.
- Conditions
- Excipient Exposure, Neonatal, Pediatric
- Trial name
- SEEN (NCT02545712)
- Testing
- Exposure to ethanol, Exposure to propylene glycol, Exposure to benzyl alcohol
- Volunteers
- 630 people
- Sponsor
- Bispebjerg Hospital
Hypoplastic Left Heart Syndrome, Atrioventricular Canal
Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle
Patients under the age of 5, with a diagnosis of hypoplastic left heart syndrome (HLHS), unbalanced atrioventricular canal (uAVC), or borderline left heart who are undergoing staged LV recruitment following bidirectional Glenn…
- Trial name
- NCT03079401
- Testing
- MPC; rexlemestrocel-L
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Boston Children's Hospital
Recessive Dystrophic Epidermolysis Bullosa
A Study of PTR-01 in Recessive Dystrophic Epidermolysis Bullosa
Protocol PTR-01-002 is a 3-part Phase 2, open-label study of PTR-01. While new patients will be enrolled, priority will be given to patients that satisfactorily completed study PTR-01-001.
- Trial name
- NCT04599881
- Testing
- PTR-01
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Phoenix Tissue Repair, Inc.
Diaper Dermatitis
Neonatal Intensive Care Unit (NICU) Diaper Dermatitis: Prevention and Treatment With Airtime
The purpose of this study is to investigate the use of 3-5 minutes air therapy for the prevention and treatment of diaper dermatitis in infants 30 weeks and older receiving care in the neonatal intensive care unit (NICU).
- Trial name
- NCT06958003
- Testing
- Air Therapy
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- TriHealth Inc.
Cleft Lip, Cleft Palate
Follow Ups of Parents With Infants With Cleft Lip and Palate
In Norway, 100-120 children are born with CLP (1.9 per 1,000 live births) each year. Parents of infants with CLP need information and support, especially with feeding immediately after birth. These needs are often not met.
- Trial name
- NCT02415361
- Testing
- Cleft lip and palate
- Where
- Norway
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Thalassemia in Children
Observational Study: Hetrombopag for Platelet Recovery in Haploidentical HSCT
The objective of this observational study is to investigate the long-term effects of Hetrombopag in promoting platelet engraftment during haploidentical hematopoietic stem cell transplantation (HSCT) in children with thalassemia…
- Trial name
- NCT07003269
- Testing
- Hetrombopag
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Haikou Affiliated Hospital of Central South University Xiangya School of Medicine
Maternal Health, Infant Health
Using Advanced Data Systems to Improve Health in Early Life in Rural Nepal
The goal of this cluster randomized controlled trial is to study the effect of a mobile-phone based application used by pregnant women on maternal and newborn health indicators.
- Conditions
- Maternal Health, Infant Health, Institutional Delivery, Birth Preparedness and Complication Readiness
- Trial name
- CITH (NCT05697822)
- Testing
- Mobile Phone and Cloud-based Electronic Contact and Recording System
- Where
- Nepal
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Amit Arjyal
Leigh Syndrome (Maternally Inherited, MILS), Leigh Syndrome (AR, AD, XR)
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells
In this project, the investigators are using iPSC lines derived from patients with Leigh syndrome that carry mutations in the mitochondrial (mtDNA) and in the nuclear DNA (nDNA) to reprogram them into neural progenitor cells and…
- Trial name
- cureMILS (NCT06967831)
- Testing
- skin biopsy, generation of iPSCs, blood drawing
- Where
- 2 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Gram-negative Bacterial Infection
Evaluation of Pharmacokinetics, Safety, and Tolerability of Ceftazidime-avibactam in Neonates and Infants.
This study will assess the pharmacokinetics, safety, and tolerability of single and multiple doses of intravenous ceftazidime-avibactam in hospitalized infants and neonates from 26 weeks gestation to 3 months of age.
- Trial name
- NOOR (NCT04126031)
- Testing
- Part A: Single Dose Ceftazidime-Avibactam, Cohorts 1-3, Part B: Multiple-dose Ceftazidime-Avibactam, Cohorts 1-3
- Where
- 18 sites in United States, Estonia and 6 more
- Volunteers
- 48 people
- Sponsor
- Pfizer
Cardiovascular Abnormalities
Thoracoscopic Vascular Rings Chart Review
The purpose of this study is to review the use of diverticulopexy, and collect data regarding the ease of the procedure and the overall outcome.
- Trial name
- NCT00229853
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Children's Healthcare of Atlanta
Stillbirth, Neonatal Death
Intermittent Auscultation Using Handheld Doppler: a Randomized Controlled Trial Comparing Perinatal Outcomes in Uganda
A novel handheld Doppler has been developed which is rugged and is powered only by a hand crank. This study aims to test the use of this Doppler versus the Pinard horn to monitor the fetal heart rate in labour in a hospital…
- Trial name
- NCT02273037
- Testing
- Fetal heart rate Doppler, Partograph
- Where
- 2 sites in Canada, Uganda
- Volunteers
- 1,987 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Thalassemia
Pharmacotherapy Prescribing Pattern and the Adherence Level to Iron Chelation Therapy in Thalassemia
Thalassemias are a heterogeneous grouping of genetic disorders that result in dysfunctional Hb, reduced RBC life span leading to chronic anemia . Thalassemia is endemic in the Middle East.
- Trial name
- NCT06210139
- Where
- Iraq
- Volunteers
- 199 people
- Sponsor
- Reem Ali Shaker
Alveolar Bone Grafting, Quality of Life
Effect of Alveolar Bone Grafting
This study included patients who underwent secondary alveolar bone grafting by harvesting graft from the anterior iliac crest, in Oral and Maxillofacial Department, Faculty of Dentistry, Ankara University, Turkey, during the…
- Trial name
- NCT03549039
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ankara University
Mediterranean Fever, Colchicine Resistance
Study of Colchicine Resistance in Familial Mediterranean Fever
Five to 10% of familial mediterranean patients are considered colchicine-resistant (i.e. patients with a persistent inflammatory syndrome, despite taking the maximum tolerated dose of colchicine daily).
- Trial name
- COLCHI-RESIST (NCT05418686)
- Testing
- Capillary colchicine dosage in colchicine-resistant Familial Mediterranean Fever patients.
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Maxillary Hypoplasia
Skeletal and Dental Changes with Hyrax-type Rapid Maxillary Expander Anchored to Permanent Versus Deciduous Molars
The aim of the study is to compare the skeletal and dental maxillary expansion obtained with an Hyrax tooth-borne expander anchored either on the 2nd deciduous molars (V) or on the 1st permanent molars (6)
- Trial name
- DENTHYRAX (NCT05773573)
- Testing
- Experimental group, Control group
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Montpellier
Congenital Bleeding Disorder, Haemophilia A
Observational Study on Safety of Room Temperature Stable NovoSeven® in Patients With Haemophilia A or B
This study is conducted in Europe and Asia. The aim of this observational study is to monitor antibody formation towards the room temperature stable formulation of NovoSeven® (activated recombinant human factor VII).
- Conditions
- Congenital Bleeding Disorder, Haemophilia A, Haemophilia B
- Trial name
- NCT01220141
- Testing
- activated recombinant human factor VII
- Where
- 14 sites in Argentina, Austria and 12 more
- Volunteers
- 51 people
- Sponsor
- Novo Nordisk A/S
Thalassemia Major
Study to Evaluate Efficacy and Safety of S303 Treated Red Blood Cells (RBCs)in Subjects With Thalassemia Major Requiring Chronic RBC Transfusion
To evaluate the efficacy and safety of S 303 treated red blood cells (RBCs) in subjects who require chronic transfusion support due to thalassemia major.
- Trial name
- NCT01740531
- Testing
- S-303 Treated Red Blood Cells (RBCs), Conventional, untreated Red Blood Cells
- Where
- 3 sites in Italy, Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Cerus Corporation
Infant, Premature, Diseases, Continuous Positive Airway Pressure
Routine Or Selective Application of a Face Mask for Preterm Infants at Birth: the ROSA Trial
International guidelines recommend giving positive pressure ventilation (PPV) by face mask to newborns who do not breathe or have a slow heart rate at birth.
- Conditions
- Infant, Premature, Diseases, Continuous Positive Airway Pressure, Positive-Pressure Respiration, Resuscitation
- Trial name
- ROSA (NCT04500353)
- Testing
- Face mask application for CPAP and/or PPV delivery
- Where
- Ireland
- Volunteers
- 201 people
- Sponsor
- University College Dublin
Sickle Cell Disease
Lung Ultrasound in Pediatric Acute Chest Syndrome
Sickle-cell disease is a common disease with serious complications, in particular acute chest syndrome (ACS), which can be life threatening.
- Trial name
- Lupacs (NCT06497153)
- Testing
- lung ultrasound
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hyperparathyroidism, Hypercalcemia
Studies of Elevated Parathyroid Activity
Observational Phase: Patients whose parathyroid activity is elevated above normal are referred to as having hyperparathyroidism.
- Conditions
- Hyperparathyroidism, Hypercalcemia, Parathyroid Neoplasm, Multiple Endocrine Neoplasia
- Trial name
- NCT00001277
- Testing
- 68Ga-Dotatate, 18F-DOPA
- Where
- United States
- Volunteers
- 1,553 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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