Clinical trials: Neurodevelopmental Conditions
Dyslexia
Study of Hierarchy of Afferents in Postural Control of Children With Dyslexia
The purpose is to determine the hierarchy of sensory afferents according to different forms of dyslexia in children. The secondary purpose is to determine sensitive and sufficiently specific posturographic indexes for standard…
- Trial name
- EQUIDYS (NCT02879786)
- Testing
- Posturographic tests, Questionnaire of motion sickness susceptibility
- Where
- France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Dravet Syndrome, Severe Myoclonic Epilepsy of Infancy
Treatment of Gait Disorders in Children With Dravet Syndrome
Dravet syndrome is a severe infantile onset epilepsy syndrome with a prevalence of 1/15.000 to 1/30.000. An infant with an apparently normal development presents around 6 months of age with a convulsive status epilepticus.
- Trial name
- T-GaiD (NCT03857451)
- Testing
- Clinical gait analysis
- Where
- 3 sites in Belgium
- Volunteers
- 50 people
- Sponsor
- Universiteit Antwerpen
Mucolipidosis Type IV
The Natural History of Mucolipidosis Type IV
The purpose of this study is to define the natural history of Mucolipidosis Type IV and identify potential clinical outcome measures.
- Trial name
- NCT01067742
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Baylor Research Institute
Autism Spectrum Disorder, Intellectual Disability
Transcranial Magnetic Stimulation Studies in Autism Spectrum Disorders
Autism Spectrum Disorder (ASD) is the most prevalent of the developmental disorders and their incidence is rising. However, the variability in the behavioral symptoms is large.
- Trial name
- NCT02591446
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Stress, Psychological, Inflammatory Bowel Diseases
Introduction of Microsystems in a Level 3 Neonatal Intensive Care Unit
The advancement in life-saving technologies and clinical expertise in the care of extremely premature infants, have resulted in the development of large neonatal intensive care units (NICU).
- Conditions
- Stress, Psychological, Inflammatory Bowel Diseases, Lung Diseases, Infant Nutrition Disorders
- Trial name
- NCT02912780
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- McMaster Children's Hospital
Chronic Troublesome Sialorrhea, Cerebral Palsy
Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability
The objective of this study is to investigate the efficacy and safety of NT 201 compared with placebo for the treatment of chronic troublesome sialorrhea associated with neurological disorders (e.g.
- Conditions
- Chronic Troublesome Sialorrhea, Cerebral Palsy, Stroke, Traumatic Brain Injury
- Trial name
- SIPEXI (NCT02270736)
- Testing
- NT 201
- Where
- 31 sites in Georgia, Hungary and 4 more
- Volunteers
- 256 people
- Sponsor
- Merz Pharmaceuticals GmbH
Swallowing Disorder, Perinatal Asphyxia
Effect of Non-nutritive Sucking on Transition to Oral Feeding in Infants With Asphyxia
The transition period to full oral feeding in infants with perinatal asphyxia is important in predicting long-term outcomes. The transition to independent oral feeding is accepted as a discharge criterion by the American Academy…
- Conditions
- Swallowing Disorder, Perinatal Asphyxia, Feeding; Difficult, Newborn, Feeding Disorder of Infancy or Early Childhood
- Trial name
- NCT05687708
- Testing
- Non-Nutritive Sucking
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medipol University
Sjogren-Larsson Syndrome (SLS)
Sjogren-Larsson Syndrome: Natural History, Clinical Variation and Evaluation of Biochemical Markers
Sjogren-Larsson syndrome (SLS) is a rare genetic disease in which patients typically exhibit ichthyosis (dry, scaly skin), intellectual disability, spasticity, seizures and a distinctive maculopathy.
- Trial name
- SLS (NCT01971957)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Tourette's Disorder, Tic Disorder
Study Evaluating the Safety and Efficacy of Fixed-dose Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder
The goal of the current trial is to determine efficacy and safety of Once-daily aripiprazole in reducing Total Tic Severity in children and adolescents with Tourette's Disorder.
- Trial name
- NCT01727700
- Testing
- Aripiprazole
- Where
- 75 sites in United States, Canada and 7 more
- Volunteers
- 133 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Developmental Language Disorder, Specific Language Impairment
Retrieval-Based Word Learning in Developmental Language Disorder During Book Reading
Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and…
- Conditions
- Developmental Language Disorder, Specific Language Impairment, Language Development
- Trial name
- NCT06026124
- Testing
- Retrieval-based word learning: Repeated Spaced Retrieval condition, Retrieval-based word learning: Repeated Study condition
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Purdue University
Neurodevelopmental Disorders, Autism
Early Life Anemia and Children's Risk of Neurodevelopmental Disorders: National and Regional Register-based Studies
The overall project aim is to study children's neurodevelopmental outcomes (including diagnoses of autism, ADHD, and intellectual disability) following exposure to maternal anemia during pregnancy or anemia during the first year…
- Conditions
- Neurodevelopmental Disorders, Autism, ADHD, Intellectual Disability
- Trial name
- NCT06199362
- Where
- Sweden
- Volunteers
- 2,400,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Attention Deficit Disorder With Hyperactivity, Autistic Disorder
Methylphenidate in Children and Adolescents With Pervasive Developmental Disorders
This study will evaluate the efficacy and safety of methylphenidate for treating hyperactivity, impulsiveness, and distractibility in 60 children and adolescents with Pervasive Developmental Disorders (PDD).
- Conditions
- Attention Deficit Disorder With Hyperactivity, Autistic Disorder, Pervasive Development Disorders
- Trial name
- NCT00025779
- Testing
- methylphenidate, guanfacine
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health (NIMH)
Adhd
Omega-3, Inflammation in ADHD With AI
This is a 12 week study to investigate the effects of omega-3 polyunsaturated fatty acids (PUFAs) in children with attention deficit hyperactivity disorder (ADHD).
- Trial name
- OmInADHDAI (NCT07348562)
- Testing
- Omega-3
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- China Medical University Hospital
Attention Deficit Disorder With Hyperactivity, Attention Deficit Disorder
Adverse Effect of Prolonged Methylphenidate Treatment on Cardiac Functions
The purpose of this study is to find out whether prolonged treatment with methylphenidate has any adverse effect on cardiac functions and measurements.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, Attention Deficit Disorders With Hyperactivity
- Trial name
- NCT00372359
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Ornit Cohen
Intellectual Disability, Epilepsy
MEHMO Natural History and Biomarkers
This observational natural history study will follow individuals with MEHMO (Mental disability, Epileptic seizure, Hypopituitarism/Hypogenitalism, Microcephaly, Obesity) syndrome or an eIF2-pathway related disorder, who have…
- Conditions
- Intellectual Disability, Epilepsy, Hypogonadisms, Microcephaly
- Trial name
- NCT06019182
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
EEG
Behavioural and Physiological Measures of Young Students With Dyslexia
The proposed is reading intervention study to track neural changes in the brain. Students with dyslexia will participate in a reading study.
- Trial name
- NCT05376696
- Testing
- Set For Variability, Current Best Practices
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University
Autism Spectrum Disorder
Assessing the Impact of Probiotic Supplementation in Children Diagnosed With Autism Spectrum Disorder: the PROBI-O-TISM Study
Children with autism spectrum disorder (ASD) present with stereotyped behaviors and often with comorbidities including gastrointestinal symptoms and sleep disturbances.
- Trial name
- (PROBI-O-TISM) (NCT06906068)
- Testing
- Three strains of Lactobacillus: L. acidophilus CL1285®, L. casei LBC80R® and L. rhamnosus CLR2®
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- Valérie Marcil
Dyslexia, Developmental
Developmental Dyslexia and Remediation Methods
At least, three theoretical frameworks are currently involved in therapeutic research in developmental dyslexia. Each theoretical framework relies on the type of underlying cognitive processes that is viewed as impaired: 1°)…
- Trial name
- DDMR (NCT04028310)
- Testing
- Phonological, Visual-attention
- Where
- France
- Volunteers
- 145 people
- Sponsor
- Fondation Lenval
Autism Spectrum Disorder, Intellectual Disability, Mild
Computer-Mediated Intervention to Enhance Emotional Competence in Children With Autism in Schools
Autism spectrum condition (ASC) is a neurodevelopmental disorder characterized fundamentally by social deficits. Emotional competence - the ability to express, recognize, understand, and regulate emotions - is a key aspect of…
- Trial name
- NCT05902832
- Testing
- EmotiPlay
- Where
- Israel
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Bar-Ilan University, Israel
Autism Spectrum Disorder, Catatonia
Use of MRI and cTBS for Catatonia in Autism
Despite the significant morbidity and mortality associated with catatonia in autism, no diagnostic research has attempted to identify biomarkers for catatonia.
- Conditions
- Autism Spectrum Disorder, Catatonia, Intellectual Disability
- Trial name
- NCT06016764
- Testing
- Continuous Theta Burst in Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Vanderbilt University Medical Center
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