Clinical trials: Nitrates
Heavy Drinking
Study of Nitrate-Rich Juice on Cognitive Function in Heavy Alcohol Drinkers: a Two-Stage Adaptive Design Real-World Clinical Trial
It is known that alcohol consumption can lead to cognitive impairment and dysregulation of inflammatory responses. A preliminary randomized controlled trial conducted by our research team has suggested that nitrate may improve…
- Trial name
- NCT06777459
- Testing
- Nitrate-rich beetroot juice
- Volunteers
- 43 people
- Sponsor
- Peking University Sixth Hospital
Pulp Disease, Dental
Potassium Nitrate in Polycarboxylate as a Direct Pulp Capping
The study aimed to compare potassium nitrate in polycarboxylate cement to mineral trioxide aggregate as a direct pulp capping material of young permanent teeth in patients from 7 to 10 ears
- Trial name
- NCT05912907
- Testing
- potassium nitrate in polycarboxilate cement
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Minia University
Early Childhood Caries
The Caries-arresting Effect of Incorporating fTCP to NaF Varnish Applied Following AgNO3 in Preschool Children
The objective of this study is to compare the effectiveness of 25% AgNO3 solution plus 5% NaF varnish and 25% AgNO3 solution plus 5% NaF varnish with fTCP when applied semi-annually over 30 months in arresting dentine caries of…
- Trial name
- NCT03423797
- Testing
- 25% AgNO3 solution followed by 5% NaF, 25% AgNO3 solution followed by 5% NaF with fTCP
- Where
- China
- Volunteers
- 408 people
- Sponsor
- The University of Hong Kong
Becker Muscular Dystrophy
Effects of Sodium Nitrate on Blood Flow in Becker Muscular Dystrophy
This study is intended to build on a growing body of literature showing a blood flow abnormality in patients with Becker muscular dystrophy.
- Trial name
- NCT02147639
- Testing
- Sodium Nitrate, Sodium Nitrate - double dose, Increased exercise intensity
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Cedars-Sinai Medical Center
Hypertension, Pregnancy
Effects of Dietary Nitrate in Hypertensive Pregnant Women
High blood pressure in pregnancy affects around 10% of pregnancies, and is associated with serious adverse outcomes for both mother and baby.
- Trial name
- NCT02520687
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- University of Manchester
Other Abnormal Granulation Tissue Nos
Granulation Tissue Treatment: Silver Nitrate vs Kenalog vs Washcloth Abrasion
Granulation tissue, or excess tissue, forms around gastrostomy tube sites and is a common problem seen in the pediatric surgery population.
- Trial name
- NCT02519738
- Testing
- Silver Nitrate, Kenalog (Triamcinolone), Washcloth Abrasion
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Hypersensitivity Dentin
Potassium Nitrate Gel and Diode Laser for Dentinal Hypersensitivity
The goal of this randomized clinical trial is to evaluate whether combining a potassium nitrate gel with diode laser therapy is more effective in treating dentinal hypersensitivity compared to using the gel alone.
- Trial name
- NCT06746558
- Testing
- Potassium Nitrate Gel and Diode Laser Therapy, Potassium Nitrate Gel Alone
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- University of Modena and Reggio Emilia
Burn
Study of the Treatment of Burn Wounds With Antimicrobial Topical Soaks
Determine effectiveness of various antimicrobial solutions on burn wounds (infections, wound healing, length of hospital stay).
- Trial name
- Soaks (NCT00675922)
- Testing
- Sulfamylon 5% and Silver Nitrate Soaks
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Vital Pulp Therapies, Pulpotomy
Clinical and Radiographic Evaluation of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate in Vital Pulpotomy in Primary Molars
The purpose of this RCT is to compare the clinical/radiographic outcomes of Potassium nitrate in polycarboxylate cement and MTA as pulpotomy biomaterials used for asymptomatic vital primary lower second molar and this will help…
- Conditions
- Vital Pulp Therapies, Pulpotomy, Pulp Disease, Dental, Pulpotomies Primary Teeth
- Trial name
- NCT06871709
- Testing
- Potassium Nitrate in Polycarboxylate cement, MTA-Anglus
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Umbilical Granuloma
Double Ligation and Topical Silver Nitrate
To study and compare the efficacy and safety of Double Ligation and Topical Silver Nitrate Solution while treating children with Umbilical Granulomas
- Trial name
- RCT (NCT04248101)
- Testing
- Double Ligation, Topical Silver Nitrate
- Volunteers
- 176 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Gestational Hypertension
Role of the Oral Microbiome in Blood Pressure Regulation in Pregnancy
High blood pressure in pregnancy is associated with poor outcomes for both mum and baby, increasing the risk of pregnancy complications including pre-eclampsia, fetal growth restriction and preterm birth.
- Trial name
- NCT03930693
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Tinea
Clinical Assessment of Oxiconazole Nitrate Solid Lipid Nanoparticles Loaded Gel
Clinical study for the developed oxiconazole nitrate solid lipid nanoparticles (SLNs) gel system compared to the corresponding marketed product was conducted on 28 patients with different types of tinea fungal infection.
- Trial name
- NCT03823040
- Testing
- Oxiconazole Nitrate Cream 1%, Oxiconazole nitrate SLNs loaded gel.
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Minia University
Becker Muscular Dystrophy
Sodium Nitrate to Improve Blood Flow
Investigators recently showed that tadalafil restores functional sympatholysis in patients with Becker muscular dystrophy (BMD).
- Trial name
- NCT02847975
- Testing
- Sodium nitrate
- Where
- 2 sites in United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Fontan
Nitrate Effect on Exercise Capacitance
The investigators will investigate the safety and preliminary efficacy of ISDN therapy to reduce venous congestion and improve exercise tolerance in children and adults after the Fontan operation.
- Trial name
- NEET (NCT04297241)
- Testing
- Isosorbide Dinitrate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Becker Muscular Dystrophy
Sodium Nitrate for Muscular Dystrophy
The investigators' previous work in males with Becker Muscular Dystrophy shows that functional sympatholysis is restored by acute inorganic nitrate supplementation.
- Trial name
- NCT02434627
- Testing
- Sodium Nitrate
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Cedars-Sinai Medical Center
Early Childhood Caries
Effectiveness of Dental Caries Arrest Treatment in Primary Teeth Using AgNO3 Followed by NaF Varnish
Aim: This randomised controlled trial will systematically compare the efficacy of a 25% AgNO3 solution followed by 5% NaF varnish with that of a 38% SDF solution in arresting caries teeth among preschool children when applied at…
- Trial name
- NCT02019160
- Testing
- 25% AgNO3 solution followed by 5% NaF varnish
- Where
- China
- Volunteers
- 1,070 people
- Sponsor
- The University of Hong Kong
Tinea Pedis
A Therapeutic Equivalence Study of Two Oxiconazole Nitrate Topical Cream Treatments for Patients With Tinea Pedis
The objective of this study is to demonstrate that Oxiconazole nitrate 1% topical cream is effective for the treatment of patients with moderate to severe Tinea pedis.
- Trial name
- NCT01519752
- Testing
- Oxiconazole Nitrate Cream 1%, Oxiconazole Nitrate Cream 1% (Oxistat®)
- Volunteers
- 661 people
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Dentin Sensitivity
Nano-hydroxyapatite With Potassium Nitrate in the Therapy of the Dental Sensitivity
The chief aim of this study is to evaluate the difference in tooth sensitivity after having used a gel containing nano - hydroxyapatite and potassium nitrate This randomized double-blind clinical study is designed to compare the…
- Trial name
- NCT02895321
- Testing
- Cavex Bite&White ExSense, Colgate, Protection Caries
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Università degli Studi di Sassari
Brain and Central Nervous System Tumors, Lymphoma
Gallium Nitrate in Treating Children With Brain Tumor, Neuroblastoma, Rhabdomyosarcoma, Non-Hodgkin's Lymphoma, or Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: : Phase I trial to study the effectiveness of gallium nitrate in young patients who have malignant…
- Conditions
- Brain and Central Nervous System Tumors, Lymphoma, Neuroblastoma, Sarcoma
- Trial name
- NCT00002543
- Testing
- gallium nitrate
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Medical College of Wisconsin
Sleep Apnea Syndromes
Sleep Apnea and Oxidative Stress and Nitric Oxide
Background: Previous studies present contradictory data concerning obstructive sleep apnea syndrome (OSAS), lipid oxidation and nitric oxide (NO) bioavailability.
- Trial name
- NCT00547937
- Testing
- nasal continuous positive airway pressure (CPAP) therapy
- Where
- Spain
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica