Clinical trials: Nitrous Oxide
Sickle Cell Disease
Prevalence of Problematic Use of Equimolar Mixture of Oxygen and Nitrous Oxide and Analgesics in the Sickle-cell Disease
The use of analgesics can lead to cases of drug abuse and dependence. It can also cause pseudo-addiction in patients suffering from pain.
- Trial name
- PHEDRE (NCT02580565)
- Testing
- telephone interview
- Where
- France
- Volunteers
- 1,004 people
- Sponsor
- Nantes University Hospital
Opioid-Related Disorders, Substance-Related Disorders
Effects of Combined Sevoflurane and Nitrous Oxide Inhalation - 14
The purpose of this study is to determine the effects of combined sevoflurane and nitrous oxide inhalation on mood, psychomotor performance, and the pain response in humans.
- Trial name
- NCT00000262
- Testing
- 30% Nitrous oxide, 0.4% Sevoflurane, 0.2% sevoflurane
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Mild to Moderate Dehydration
Nitrous Oxide for Analgesia During Nasogastric Tube Placement in Young Children
Since nitrous oxide/oxygen mixture is effective to reduce pain and anxiety induced by various painful procedures in children, the investigators hypothesized that its inhalation would reduce pain during nasogastric tube placement…
- Trial name
- SONGER (NCT04008628)
- Testing
- Nitrous Oxide
- Where
- 4 sites in France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Leukemia, Non Hodgkin Lymphoma
Evaluation of the Analgesy With Emla and/or Nitrous Oxide in Pediatric Patients for Lumbar Puncture
In this randomised controlled study the investigators intended to compare the analgesic effects of EMLA and\or nitrous oxide in children submitted to lumbar puncture.
- Trial name
- NCT00808171
- Testing
- Livopan, EMLA
- Where
- Brazil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Cornea, Anesthesia; Reaction
The Effects of Nitrogen Protoxide and Oxygen on Corneal Endothelial in Pediatric Patients
To evaluate the mean changes in Endothelial Cell and Corneal pachymetry in eyes that operated under N2O + sevoflurane and O2 + sevoflurane general anesthesia.
- Trial name
- NCT03006211
- Testing
- Nitrogen protoxide, Oxygen
- Volunteers
- 40 people
- Sponsor
- Inonu University
Conscious Sedation
Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children
The purpose of this study is to compare the safety and efficacy of sedation using orally administered midazolam and promethazine with nitrous oxide/oxygen in uncooperative children receiving dental treatments.
- Trial name
- NCT01118884
- Testing
- Promethazine
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Dental Anxiety
The Impact of Nitrous Oxide Sedation on Dental Fear and Anxiety Scores in Children Aged 6-10 Years
Dental anxiety (DA) is highly prevalent among children undergoing dental procedures, with 50-80% experiencing fear that disrupts treatment and exacerbates oral health outcomes.
- Trial name
- N₂O (NCT07384988)
- Testing
- Nitrous Oxide Sedation, psychological support
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shaoxing Maternity and Child Health Care Hospital
Brief Psychosocial Intervention
Psychosocial Support for Nitrous Oxide Misuse
Nitrous oxide (laughing gas, N₂O) is the third most commonly used recreational drug among young people in the UK. Although it may seem harmless, frequent use can damage the nerves and spinal cord.
- Trial name
- NCT07716293
- Testing
- Psychosocial intervention
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Queen Mary University of London
Labor Pain
Inhaled Nitrous Oxide and Labor Analgesia
Hypothesis: The administration of nitrous oxide for labor analgesia will decrease the labor epidural anesthesia rate by 15%. Specific Aim: To determine if nitrous oxide can be an effective alternative technique for the provision…
- Trial name
- NCT01738672
- Testing
- Inhaled nitrous oxide
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ya'aqov Abrams
Dental Anxiety, Pain
Nitrous Oxide Prior to Intranasal Midazolam for Moderate Dental Sedation in Pediatric Patients
The purpose of this study is to assess the effectiveness of nitrous oxide/oxygen administration in reducing the discomfort of intranasal midazolam administration for moderate sedation for dental procedures.
- Trial name
- NCT04083105
- Testing
- Nitrous Oxide, Midazolam
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Children's Hospital Colorado
Adult Disease
Time - Related Cuff Pressure and Volume of the Laryngeal Tube With the Use of Nitrous Oxide
The purpose of this study is to investigate the time-related intracuff pressure and volume change (which reflects the pharyngeal pressure) of the LT during anesthesia with N2O.
- Trial name
- NCT01346384
- Testing
- laryngeal tube (VBM Medizintechnik)
- Where
- Thailand
- Volunteers
- 75 people
- Sponsor
- Prince of Songkla University
Myelomeningocele, Prone Position
Cuff Pressure in Infants
The changes in the cuff pressure in the absence of nitrous oxide are less clear.In the current study, we aim to determine the changes in cuff pressure over time in infants undergoing myelomeningocele repair in prone position…
- Trial name
- NCT03088761
- Testing
- cuffed tracheal tube
- Volunteers
- 20 people
- Sponsor
- Istanbul Science University
Dental Anxiety
Effectiveness of Children Experiencing Nitrous Oxide/Oxygen Inhalation Sedation at an Assessment Visit Before Having Treatment.
The purpose of this study is to find out the effect of experience of dental sedation at assessment on children's anxiety before the actual treatment session.
- Trial name
- NCT06056492
- Testing
- Experience of nitrous oxide sedation at assessment
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dr Richard Balmer
Glaucoma, Intraocular Pressure
The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops
Pediatric glaucoma is a rare but potentially blinding condition where the pressure in the eye is too high. Diagnosis is based on intraocular pressure (IOP) and assessment of the optic nerve, cornea and other structures.
- Conditions
- Glaucoma, Intraocular Pressure, Anesthesia
- Trial name
- IOP (NCT01925391)
- Testing
- Tono-pen XL Applanation tonometer + Ocu-film +
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Miami
Pediatric Dentistry
Virtual Reality and Anxiety in Pediatric Dentistry
Two groups of pediatric patients between the ages of 4 to 12 years old will be examined in this study. The treatment group will receive dental treatment while wearing Virtual reality Headset.
- Trial name
- NCT04886141
- Testing
- Virtual Reality Headset
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Geisinger Clinic
Pain Alleviation, Dilatation and Evacuation
Use of Nitrous Oxide for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Dilatation and Evacuation
A randomised control study aiming to examine whether inhaled N2O/O2 during cervical preparation for second trimester dilatation and evacuation with osmotic dilators (laminaria) alleviates pain and is superior to placebo.
- Conditions
- Pain Alleviation, Dilatation and Evacuation, Laminaria Placement, Nitrous Oxide
- Trial name
- NCT05579288
- Testing
- Nitrous oxide (N2O/O2), Oxygen (O2)
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Alcohol-Related Disorders, Opioid-Related Disorders
Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide - 13
The purpose of this study is to evaluate the effects of alcohol history on the subjective and reinforcing effects of sevoflurane and nitrous oxide in healthy volunteers.
- Conditions
- Alcohol-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00000261
- Testing
- 30% Nitrous oxide, 0.2% sevoflurane, 0.4% sevoflurane
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Chicago
Respiratory Ilness, Children
Microbiote's Evolution After Use of Nitrous Oxide on Pediatric Patient Needing Airway Samples
The objective of this study is to determine whether the use of MEOPA alters the composition of respiratory microbiota collected by induced sputum in children requiring respiratory sampling for suspected lower respiratory tract…
- Trial name
- MicroNO (NCT07118644)
- Testing
- MEOPA, Standard induced sputum
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Brest
Anxiety
High-Concentration Nitrous Oxide for Dental Procedural Sedation in Children
The use of nitrous oxide as a sedative agent is very common in pediatric dentistry. In concentrations up to 50% it is considered as mild sedation and it is very safe.
- Trial name
- NCT02886351
- Testing
- Nitrous Oxide
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Behavior, Child, Anxiety, Dental
Virtual Reality in Pediatric Dentistry
Dental Fear and Anxiety is an emotional experiences affecting many children and adolescents which can lead to behavioral problems in the dental setting.
- Trial name
- NCT05585905
- Testing
- Virtual Reality, Basic Behavior Guidance Techniques
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern California