Clinical trials: Non-invasive
Pediatric Pulmonary Hypertension
Actigraphy in Pediatric Pulmonary Hypertension
Physical activity is an important factor in understanding how diseases can affect a child. Decreases in physical activity are sometimes the first thing that happens before a child is diagnosed with a disease.
- Trial name
- NCT02909608
- Testing
- No interventions / observations only
- Where
- 2 sites in United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Mucopolysaccharidosis, Fabry Disease
Non-invasive Assessment of Intraocular Pressure in MPS by Use of the Ocular Response Analyzer.
The aim of the present study is to compare intraocular pressure (IOP) values assessed with Ocular Response Analyzer to the classical gold standard of IOP measurement, to Goldmann applanation tonometry by mucopolysacchyridosis…
- Trial name
- MPSORA (NCT01695161)
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Hemoglobin Level Measurement, Hemoglobin Level Estimation
Non-Invasive Estimation of Hemoglobin Levels in Blood Using Combined Deep Learning Methods
Hemoglobin is an important protein that gives the blood its red color and helps transport oxygen to organs. There are quite a lot of people in the world who need to have their hemoglobin levels checked regularly, especially…
- Trial name
- NCT04865224
- Testing
- hemoglobin estimation
- Where
- Turkey (Türkiye)
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Liver Transplant Rejection, Liver Transplant Failure and Rejection
Cytokeratin 18 Non-invasive Biomarker for Rejection in Liver Transplant Patients
Liver transplantation is a lifesaving procedure; however, there are chances that the body may reject the organ following liver transplantation, and this remains a significant concern.
- Trial name
- NCT06153641
- Testing
- N/A-Observational Study
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Non-Invasive Blood Pressure
SuperSTAT Noninvasive Blood Pressure Monitor Evaluation
The accuracy and/or performance of the GE DINAMAP noninvasive blood pressure (NIBP) monitors may be improved with modifications in software and/or hardware monitoring techniques and/or accessories.
- Trial name
- NCT00603486
- Testing
- GE DINAMAP with SuperSTAT algorithm monitor
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Fetal Distress With Antenatal Problem, Fetal Growth Retardation
Validation of Sensors for Long-term Non-Invasive Fetal Monitoring
A multidisciplinary team of a doctor and engineers have developed a new sensor that will be able to detect mothers' and babies' heartbeat and babies movements in late pregnancy.
- Trial name
- NCT06952777
- Testing
- Non-adhesive capacitively-coupled sensors
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Renal Insufficiency, Chronic
Explore New Magnetic Resonance Technology in Assessment of Renal Dysfunction
Currently, renal biopsy is the gold standard for evaluating renal pathology and renal fibrosis, but it is invasive and carries the risk of serious complications; and the sampled tissue is only a small part of the kidney, which is…
- Trial name
- NCT06366529
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Zhen Li
Brain Edema
Non-invasive Monitoring and Serum Marker Study in Children With Cerebral Edema
Purpose of the study：This study aimed to evaluate the clinical significance of serum SUR1, TRPM4 and MMP-9 in the diagnosis of cerebral edema in children with cerebral edema admitted to PICU by comparing them with CT results and…
- Trial name
- NCT06017635
- Testing
- Exposure factors
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Intracranial Pressure Increase
Non-Invasive and Non-Contact Intracranial Pressure Waveform Recording Using Dynamic Video Ophthalmoscopy
This study will test the use of video ophthalmoscope to provide information about intracranial pressure without the use of invasive methods, anesthesia or contact with the eye.
- Trial name
- ICP Waveform (NCT04046523)
- Testing
- Video ophthalmoscope
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Trisomy 13, Trisomy 18
Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial
This prospective blinded study will assess the diagnostic capability of an informatics enhanced SNP based technology (Parental Support) to identify pregnant women who are carrying a fetus with an aneuploidy from fee floating DNA…
- Conditions
- Trisomy 13, Trisomy 18, Trisomy 21, Aneuploidy
- Trial name
- PreNATUS (NCT01545674)
- Testing
- Blood Draw
- Where
- 29 sites in United States, Canada and 4 more
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
COPD, Non Invasive Ventilation
Prospective Cohort of Respiratory Insufficiency Outcome
The Respiratory Insufficiency Outcome (RIO) project consists in a french multicenter prospective cohort of patients with chronic obstructive pulmonary disease (COPD) undergoing domiciliary noninvasive positive pressure…
- Trial name
- RIO (NCT01192451)
- Where
- 4 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Phenylketonurias
PKU Skin Stripping
PURPOSE OF STUDY: To determine if a non-invasive skin stripping technique can be used to detect individuals with phenylalanine abnormalities, and to monitor dietary and/or drug effects over time.
- Trial name
- NCT04368624
- Testing
- Skin Tape, Blood Draw
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Healthy, Pediatrics
Accelerating Motor Learning in Pediatrics
Non-invasive brain stimulation can both study and potentially treat neurological disorders. Transcranial direct-current stimulation (tDCS) is an emerging safe and tolerability form of stimulation and has been used increasingly…
- Trial name
- AMPED (NCT03193580)
- Testing
- Anodal Conventional tDCS, Anodal High Definition tDCS
- Where
- 2 sites in Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Neonates, Respiratory Distress
Non-invasive Secondary Respiratory Support in Late Preterm and Term Infants
The aim of the present work is to compare between various modes of non-invasive respiratory support (including NCPAP, NIPPV, and NHFOV) as secondary respiratory support modes in late preterm and term neonates as regards the need…
- Conditions
- Neonates, Respiratory Distress, Non- Invasive Ventilation
- Trial name
- NCT07000071
- Testing
- NCPAP, NIPPV, NHFOV
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Irritable Bowel Syndrome (IBS), Sucrase Isomaltase Deficiency
Genetic Carbohydrate Maldigestion as a Model to Study Food Hypersensitivity
Irritable bowel syndrome (IBS) affects one in seven people with gastrointestinal (GI) symptoms. IBS strongly impacts quality of life, is a leading cause of work absenteeism, and consumes 0.5% of the healthcare annual budget.
- Trial name
- GenMalCarb (NCT05795049)
- Testing
- Stool and saliva sample collection, Questionnaire completion
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Dyslexia
taVNS for Letter Learning in Dyslexia
This is a pilot study to establish feasibility of transcutaneous auricular vagus nerve stimulation (taVNS) for improving letter-learning in adolescents with dyslexia.
- Trial name
- NCT06127550
- Testing
- active taVNS
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Florida
Heart Failure
Developing a Non-invasive Cardiac Functional Health Status Measurement Device
This is a single-center, non-randomized study.Enrolled patients will be placed on a tilt table and a stress test will be performed in a total of 4 different positions. Their blood pressure will be measured at each position.
- Trial name
- NCT01877343
- Testing
- CVInsight(TM)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Florida
Apnea, Hypoxia
Effects of Automated Adjustment of Inspired Oxygen With Combined Adaptive Mechanical Backup Ventilation as Compared to Automated Oxygen Adjustment Alone in Preterm Infants With Intermittent Hypoxemic Events During Non-invasive Ventilatory Support
In this 2-phase cross-over study the investigators test the hypothesis that automated adjustment of the inspired oxygen with the combined use of synchronized noninvasive SpO2-sensitive and apnea-sensitive backup-ventilation…
- Trial name
- NCT02774408
- Testing
- Saturation sensitive backup ventilation
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Diabetic Foot, Type 2 Diabetes Mellitus With Established Diabetic Nephropathy
The Effectiveness of Improving Self-care After Counseling for the Diabetics Mellitus Foots Around Chiayi Region
Objectives: Preventing diabetic foot problems (DFP) and associated consequences, such as amputation, is a critical in rural regions.
- Trial name
- NCT01299246
- Testing
- Michigan Neuropathy Screening Instrument
- Where
- Taiwan
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Healthy Volunteers
MRCP: A Reliable, Non Invasive Method for Staging Chronic Pancreatitis in Pediatrics
The goal of this research study is to learn more about the pancreas. The investigators want to use Magnetic Resonance Cholangiopancreatography (MRCP) to learn more about the size of a normal pancreas.
- Trial name
- NCT02869893
- Testing
- Secretin
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati