Clinical trials: Norepinephrine
Postural Tachycardia Syndrome
POTS NET mRNA Functional Correlation With NET Activity
DNA Acetylation can be responsible for significant down-regulation of transcription of the Norepinephrine Transporter (NET). NET is an important clearance transporter that removes norepinephrine (NE) from sympathetic neuronal…
- Trial name
- NCT03218761
- Testing
- NET mRNA level, Plasma catechols, Urine Catechols
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Overtraining Syndrome
Changes in the Hormonal and Inflammatory Profile of Young Sprint- and Endurance-trained Athletes.
One essential element of athlete training is conditioning camps, where athletes undergo a rigorous and targeted training schedule to prepare for upcoming sporting events.
- Trial name
- CHIPYA (NCT06150105)
- Testing
- Exercise training
- Where
- Poland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Ephedrine, Norepinephrine
Postoperative Delirium After Intraoperative Ephedrine Versus Norepinephrine
This retrospective study aims to investigate the effects of norepinephrine compared to ephedrine, administered on the day of surgery, on the incidence of postoperative delirium.
- Conditions
- Ephedrine, Norepinephrine, Postoperative Delirium (POD)
- Trial name
- NCT06844201
- Testing
- Ephedrine, Norepinephrine
- Volunteers
- 10,000 people
- Sponsor
- Riverside University Health System Medical Center
Anesthesia, Pediatrics
Norepinephrine for Prevention of Intraoperative Hypotension in Infants Undergoing Kasai Portoenterostomy
This study aims to assess the efficacy and safety of prophylactic intraoperative norepinephrine infusion versus the standard technique on decreasing the incidence of intraoperative hypotension in infants undergoing Kasai…
- Conditions
- Anesthesia, Pediatrics, Biliary Atresia
- Trial name
- NCT05521152
- Testing
- Norepinephrine Bitartrate
- Where
- Egypt
- Volunteers
- 31 people
- Sponsor
- Kasr El Aini Hospital
Primary Fibromyalgia
Long-Term Safety and Efficacy Study of Milnacipran in Pediatric Patients With Primary Fibromyalgia
The purpose of this study is to evaluate the long-term safety and efficacy of milnacipran in pediatric patients aged 13 to 17 years with primary fibromyalgia.
- Trial name
- MyFi (NCT01331109)
- Testing
- Milnacipran
- Where
- 31 sites in United States
- Volunteers
- 57 people
- Sponsor
- Forest Laboratories
Attention Deficit Hyperactivity Disorder
Methylphenidate Treatment Response Study of Genetic Polymorphism in Attention Deficit Hyperactivity Disorder(ADHD)
The purpose of this study is to determine whether norepinephrine gene polymorphism affect to treatment response in ADHD
- Trial name
- NCT00862108
- Testing
- Methylphenidate
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Neuroblastoma, Pheochromocytoma
18F-mFBG Expression in Neural Crest Tumors and Organs Innervated by the Sympathetic Nervous System
This is a prospective Phase 2 study being performed to document the relationship between 18F-mIBG positron emission tomography (PET) findings in subjects, and expression of the norepinephrine transporter.
- Conditions
- Neuroblastoma, Pheochromocytoma, Paraganglioma
- Trial name
- NCT06233903
- Testing
- 18F-mFBG
- Where
- United States
- Sponsor
- Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC)
Autonomic Nervous System Disease, Healthy
Study of Norepinephrine Levels and Sympathetic Nervous System Activity
Brain and nerve cells communicate with each other by releasing and picking up chemicals called neurotransmitters. Norepinephrine is a neurotransmitter used by part of the nervous system activated during stress called the…
- Conditions
- Autonomic Nervous System Disease, Healthy, Hypertension
- Trial name
- NCT00001329
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Oral Cancer, Head and Neck Cancer
Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery
Following surgery to remove tumours of the head and neck, patients undergo reconstruction with free flaps - tissue that is taken from elsewhere in the body and given a new blood supply by attaching it to vessels in the neck.
- Conditions
- Oral Cancer, Head and Neck Cancer, Free Flap, Hypotension
- Trial name
- Free4Flow (NCT01418118)
- Testing
- Epinephrine, Norepinephrine, Dobutamine
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Oxford University Hospitals NHS Trust
Septic Shock, Sepsis
The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock
The complexity of pediatric septic shock arise from its varied pathophysiology, which includes systemic inflammation, cardiovascular collapse, and multiple organ dysfunction.
- Trial name
- NCT06461390
- Testing
- Norepinephrine, Ringer's Lactate
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Indonesia
Primary Fibromyalgia
Safety and Efficacy of Milnacipran in Pediatric Patients With Primary Fibromyalgia
The purpose of this study is to evaluate the safety, tolerability, efficacy, and pharmacokinetics of milnacipran in pediatric patients aged 13 to 17 years with primary fibromyalgia.
- Trial name
- MyFi (NCT01328002)
- Testing
- Milnacipran
- Where
- 47 sites in United States
- Volunteers
- 116 people
- Sponsor
- Forest Laboratories
Syncope
Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance
This study will examine the effectiveness of the drug propranolol in preventing fainting in patients with sympathoadrenal imbalance (SAI).
- Trial name
- NCT00093860
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Depression, Acute Kidney Injury
Serotonin-norepinephrine Reuptake Inhibitors and Acute Kidney Injury
The purpose of this study is to determine if there is an excess risk of acute kidney injury (AKI) with Serotonin-norepinephrine reuptake inhibitors (SNRIs) as compared to Selective serotonin reuptake inhibitors (SSRIs), two…
- Trial name
- SNRI-AKI (NCT02320240)
- Testing
- Duloxetine, Venlafaxine, Desvenlafaxine
- Where
- Canada
- Volunteers
- 3,255,526 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Attention Deficit Disorder With Hyperactivity, Methylphenidate
Pharmacogenetic Study of Methylphenidate in Attention Deficit/Hyperactivity Disorder(ADHD)
The noradrenergic system plays a known role in attentional systems and suspected causal role in attention deficit/hyperactivity disorder(ADHD).Methylphenidate also has been suspected as a inhibitor of norepinephrine…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Methylphenidate, Pharmacogenetics
- Trial name
- NETADHD (NCT00757029)
- Testing
- norepinephrine transporter polymorphism,
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Hallym University Medical Center
HSAN Type IV
A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis
The aim of this study is to increase norepinephrine levels in a population of young adults where NE levels are very low or undetectable. In order to achieve this, the optimal dose will be determined in a titration step.
- Trial name
- NCT02624310
- Testing
- Droxidopa (L-DOPS)
- Sponsor
- NYU Langone Health
Maternal Hypotension Syndrome, Cesarean
Norepinephrine Versus Ephedrin for Prevention of Post Spinal Anesthesia in Cesarean Section
Spinal anesthesia is still the gold standard anesthetic method for elective and urgent cesarean section, the post spinal hypotension remains the most frequent complication of this procedure and is still responsible of…
- Trial name
- NCT03719625
- Testing
- Ephedrine, Norepinephrine
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mongi Slim Hospital
Anxiety Disorders, Panic Disorder
Initial Severity and Antidepressant Efficacy for Anxiety Disorders: an Individual Patient Data Meta-analysis
Anxiety disorders are common disorders, which pose a major burden to society and the individual. An anxiety disorder may be treated with medication, in particular with antidepressants such as the selective serotonin reuptake…
- Conditions
- Anxiety Disorders, Panic Disorder, Obsessive-compulsive Disorder, Post-traumatic Stress Disorder
- Trial name
- NCT02476136
- Testing
- paroxetine, duloxetine, fluoxetine or venlafaxine
- Volunteers
- 8,800 people
- Sponsor
- prof. Peter de Jonge