Clinical trials: Ocular Pathologies
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Haploidentical Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancer
This phase II trial studies how well giving fludarabine phosphate, cyclophosphamide, tacrolimus, mycophenolate mofetil and total-body irradiation together with a donor bone marrow transplant works in treating patients with…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT00049504
- Testing
- cyclophosphamide, fludarabine phosphate, tacrolimus
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Fred Hutchinson Cancer Center
Blepharoptosis, Ptosis, Eyelid
Clinical Trial Comparing Two Non-Surgical Treatments for Severe Blepharoptosis
This clinical trial will evaluate two non-surgical devices designed to improve eye lid opening for patients with severe Blepharoptosis (incomplete opening of the eyelids).
- Conditions
- Blepharoptosis, Ptosis, Eyelid, Myasthenia Gravis, Stroke
- Trial name
- NCT04678115
- Testing
- Magnetic Levator Prosthesis (MLP), Kinesiotape Frontalis Sling (KTFS)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Amblyopia, Amblyopia Unilateral
A Comparative Study of the Efficacy of AR Based Amblyopia Training Therapy and Occlusion Therapy in Older Children and Adults With Amblyopia
The goal of this clinical trial is to investigate the efficacy and safety of dichoptic treatment based on Augmented Reality (AR) technology in treating monocular amblyopia aged 12 to 55 years, and compare dichoptic AR treatment…
- Trial name
- NCT07622576
- Testing
- Augmented Reality glasses, Eye patch
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Amblyopia
5 Years of Eye Screening for ARF in Children Aged <3 Years in Flanders
Researchers will investigate the distribution and evolution of amblyopia risk factors and other refractive errors in children younger than 3 years of age.
- Trial name
- NCT05612568
- Where
- Belgium
- Volunteers
- 250,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Vision, Low, Child
CREATE - Children Reading With Electronic Assistance To Educate
This pilot randomized controlled trial (RCT) will test the methodology for a full RCT of assistive technologies for children/young people with low vision/blindness.
- Conditions
- Vision, Low, Child, Adolescent Development
- Trial name
- CREATE (NCT02798848)
- Testing
- Tablet computer
- Where
- 3 sites in India, United Kingdom
- Volunteers
- 40 people
- Sponsor
- University College, London
Cystinosis
Randomized Study of New Formulation Ophthalmic Cysteamine Hydrochloride for Corneal Cystine Accumulation in Patients With Cystinosis
OBJECTIVES: I. Determine the proportion of patients with cystinosis who experience a serious adverse effect when treated with a new formulation of cysteamine hydrochloride for corneal cystine accumulation. II.
- Trial name
- NCT00010426
- Testing
- cysteamine hydrochloride
- Volunteers
- 30 people
- Sponsor
- FDA Office of Orphan Products Development
Helicobacter Infections
Helicobacter Pylori and Dry Eye
This study will examine whether infection with Helicobacter pylori bacteria may cause inflammation of the eye's surface. Although most people who are infected with H.
- Trial name
- NCT00083291
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Eye Institute (NEI)
Leber Congenital Amaurosis 10, Blindness
An Open-label, Dose Escalation and Double-masked, Randomized, Controlled Trial Evaluating Safety and Tolerability of Sepofarsen in Children (<8 Years of Age) With LCA10 Caused by Mutations in the CEP290 Gene.
PQ-110-005 (BRIGHTEN) is an open-label, dose escalation and double-masked, randomized, controlled study evaluating safety and tolerability of sepofarsen administered via intravitreal (IVT) injection in pediatric subjects (<8…
- Conditions
- Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Vision Disorders
- Trial name
- BRIGHTEN (NCT04855045)
- Testing
- sepofarsen
- Where
- 9 sites in Belgium, Brazil and 5 more
- Volunteers
- 15 people
- Sponsor
- ProQR Therapeutics
Cataract
Dynamic Light Scattering for Studying Lens Aging and Cataract Formation
This study will use dynamic light scattering (DLS) technology to study normal lens aging and early cataract formation. Cataract is a clouding of the lens that interferes with the passage of light to the retina, impairing visual…
- Trial name
- NCT00081991
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Diabetic Retinopathy, Blindness
Diabetic Retinopathy Study (DRS)
To determine whether photocoagulation helps prevent severe visual loss from proliferative diabetic retinopathy. To determine whether a difference exists in the efficacy and safety of argon versus xenon photocoagulation for…
- Trial name
- NCT00000160
- Testing
- Xenon Photocoagulation, Argon Photocoagulation, Photocoagulation
- Sponsor
- National Eye Institute (NEI)
Apgar; 0-3 at 1 Minute, Metabolic Acidosis
Autologous Stem Cells in Newborns With Oxygen Deprivation
The purpose of this study is to determine whether the plasticity of autologous intravenous application of cord blood stem cells would improve the clinical course of asphyxiated newborns.
- Conditions
- Apgar; 0-3 at 1 Minute, Metabolic Acidosis, Hypoxia, Brain, Multiple Organ Failure
- Trial name
- NCT01506258
- Testing
- Application of Stem Cells, Observation
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Obesity, Myopia
Beijing (Peking)---Myopia and Obesity Comorbidity Intervention (BMOCI)
Based on the RE-AIM framework, this project intends to integrate the prevention and control measures of myopia and obesity, and establish a set of key suitable technical packages and guarantee systems for the…
- Trial name
- NCT05275959
- Testing
- A cluster randomized trial of a comprehensive intervention nesting family and clinic into school centered implementation to reduce myopia and obesity among children and adolescents in Beijing, China
- Where
- 3 sites in China
- Volunteers
- 3,963 people, healthy volunteers welcome
- Sponsor
- Peking University
Cycloplegia, Refractive Errors
Cycloplegic Refraction in Pediatric Patients With Esotropia
The primary outcome of this study is to compare cyclopentolate 1% and tropicamide 1% for cycloplegic refractions in pediatric populations with esotropia.
- Conditions
- Cycloplegia, Refractive Errors, Esotropia, Vision Disorders
- Trial name
- NCT06077682
- Testing
- Cyclopentolate, Tropicamide
- Where
- 2 sites in Jordan, Qatar
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Islamic Hospital, Jordan
Retinopathy of Prematurity (ROP)
The Effect of Two Non-Pharmacological Methods on Pain During Retinopathy Examination
The goal of this randomized controlled trial is to determine the effect of reverse kangaroo care position and ROP (Retinopathy of Prematurity) position applied during ROP examination in premature infants on pain.
- Trial name
- NCT06694103
- Testing
- Reverse Kangaroo Care Position, ROP Position
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Sinem Basdemir
Metastatic Ocular Melanoma, Metastatic Uveal Melanoma
Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Ocular Melanoma
Background: The National Cancer Institute (NCI) Surgery Branch has developed an experimental therapy that involves taking white blood cells from patients' tumors, growing them in the laboratory in large numbers, and then giving…
- Trial name
- NCT01814046
- Testing
- Aldesleukin, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Amblyopia
Augmenting Atropine Treatment for Amblyopia in Children 3 to < 8 Years Old
This study is designed to evaluate the effectiveness of adding a plano lens to weekend atropine after visual acuity has stabilized with weekend atropine but amblyopia is still present.
- Trial name
- ATS16 (NCT00944710)
- Testing
- Atropine, Plano lens
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- Jaeb Center for Health Research
Diabetic Retinopathy, Macular Degeneration
Diabetic Retinopathy and Visual Function Study
The purpose of this study is to evaluate possible mechanisms of central visual loss in patients with diabetes mellitus. The visual loss of interest to be investigated is that associated with macular edema (prior to and following…
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Vision, Subnormal
- Trial name
- NCT00001346
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Eye Institute (NEI)
Myopia
Efficacy and Safety of MiSight ® Contact Lenses in Reducing the Progression of Childhood Myopia.
The purpose of the study is to quantify the effectiveness of CooperVision MiSight® (omafilcon A) soft (hydrophilic) contact lens in slowing the rate of progression of juvenile-onset myopia.
- Trial name
- NCT01917110
- Testing
- omafilcon A, Spectacle
- Where
- Spain
- Volunteers
- 79 people
- Sponsor
- CooperVision, Inc.
Emergence Delirium, Strabismus
KETODEX for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery
Strabismus surgery for children is a very common procedure, with a high incidence of emergence delerium in the recovery room. A combination of intravenous ketamine/dexmedetomidine, or ketodex, has been previously shown to reduce…
- Trial name
- NCT03779282
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Postoperative Delirium, Strabismus
Does Preoperative Sleep Quality Affect the Postoperative Emergence Delirium in Children Undergoing Strabismus Surgery
Sleep is important in maintaining the physiological function of the human body. Recently several studies have reported that preoperative sleep quality is associated with postoperative emergence delirium (ED) The ED is a common in…
- Conditions
- Postoperative Delirium, Strabismus, Sleep Disorder
- Trial name
- NCT03332407
- Where
- South Korea
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital