Clinical trials: Out-of Hospital Cardiac Arrest
Out-Of-Hospital Cardiac Arrest, Pediatric Disorder
Etiology, Incidence and Survival of Pediatric Out-of-hospital Cardiac Arrests: a Four-year Danish Analysis
Background: OHCA is a rare condition for children and young adults. Overall incidence rates are reported as 3.3-5.97 per 100.000 inhabitants.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Pediatric Disorder, Cardiopulmonary Arrest
- Trial name
- Child-OHCA (NCT04275856)
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Cardiac Arrest, Sudden Cardiac Death
Epidemiological Study of Out-of-hospital Cardiac Arrest in Guangzhou
Aim This was a population-based retrospective cohort study of OHCA. This study intends to retrospectively analyze the data of pre-hospital emergency system in Guangzhou for 10 years, explore the incidence trend of OHCA in…
- Trial name
- NCT06448156
- Testing
- "cardiac arrest" and "sudden death"
- Where
- China
- Volunteers
- 44,375 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cardiac Arrest
Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-OH [Out of Hospital] Trial
Cardiac arrest is a sudden, unexpected loss of heart function. Therapeutic hypothermia, in which the body's temperature is lowered and maintained several degrees below normal for a period of time, has been used to successfully…
- Trial name
- THAPCA-OH (NCT00878644)
- Testing
- Therapeutic Hypothermia, Therapeutic Normothermia
- Where
- 34 sites in United States, Canada
- Volunteers
- 295 people
- Sponsor
- University of Michigan
Drowning, Out-Of-Hospital Cardiac Arrest
Drowning-related OHCA in Denmark: A Six-year Registry-based Study
Within a six-year period from 2016-2021, this retrospective cohort study aims to: 1) report the national incidence of drowning related OHCA's among cases attended by the Danish Emergency Medical Services (EMS), 2) assess survival…
- Trial name
- NCT05323097
- Testing
- Drowning-related OHCA
- Where
- Denmark
- Volunteers
- 31,200 people
- Sponsor
- Prehospital Center, Region Zealand
out-of Hospital Cardiac Arrest
Pre-Hospital Cerebral Oxygenation and End-Tidal CO2 During Cardiopulmonary Resuscitation (CPR)
Cerebral saturation will be measured pre-hospital during an out-of hospital cardiac arrest with O3TM regional oximetry for Root® (Masimo®).
- Trial name
- CopernicusIb (NCT02850237)
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Hasselt University
Out-Of-Hospital Cardiac Arrest
International Termination of Resuscitation Practices
Neither the international nor the interregional variation in survival following OHCA is fully understood, but may rely on multiple factors such as: organization of the Emergency Medical Service (EMS) system bystander…
- Trial name
- NCT05029180
- Testing
- Termination of resuscitation
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Heart Arrest, Out-Of-Hospital, Wounds and Injuries
Pediatric Prehospital Airway Resuscitation Trial
This study is a Phase 3, multi-center, Bayesian Adaptive Sequential Platform Trial testing the effectiveness of different prehospital airway management strategies in the care of critically ill children.
- Conditions
- Heart Arrest, Out-Of-Hospital, Wounds and Injuries, Respiratory Insufficiency in Children, Child, Only
- Trial name
- Pedi-PART (NCT06364280)
- Testing
- BVM, SGA, ETI
- Where
- 10 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Ohio State University
Ventricular Fibrillation, Cardiac Arrest
SmartCPR Trial: An Analysis of a Waveform-Based Automated External Defibrillation (AED) Algorithm on Survival From Out-of-Hospital Ventricular Fibrillation
This study is designed to examine the impact of an available technology within an automated external defibrillator (AEDs) to improve survival following out-of-hospital cardiac arrest for patients presenting in ventricular…
- Trial name
- SmartCPR (NCT00535106)
- Testing
- Automated external defibrillator (Philips FR2+ AED), SmartCPR, Delayed defibrillation
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 900 people
- Sponsor
- New York City Fire Department
Out-Of-Hospital Cardiac Arrest
Cardiac Arrest Registry of the Lombardia Region (Lombardia CARe)
The registry enroll all the patients who suffered an out-of-hospital cardiac arrest in the Lombardia Region with a follow-up up to ten years after the event.
- Trial name
- Lombardia CARe (NCT03197142)
- Where
- 21 sites in Italy
- Volunteers
- 15,000 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Out of Hospital Cardiac Arrest
Dispatcher-Activated Neighborhood Access Defibrillation and Cardiopulmonary Resuscitation
The hypothesis of this study is Dispatcher-Activated Neighborhood Access Defibrillation and Cardiopulmonary Resuscitation (NAD-CPR) would improve survival of out-of-hospital cardiac arrest (OHCA).
- Trial name
- NCT02010151
- Testing
- NAD-CPR
- Where
- South Korea
- Volunteers
- 3,194 people
- Sponsor
- Seoul National University Hospital
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
AutoPulse Compared With Manual Technique for OHCA Patients on Outcome and CPR Process.
The AutoPulse Resuscitation System Model 100 (ZOLL Medical Corporation, Chelmsford, MA, US) ZOLL has been used as a standard treatment for a number of subjects in this trial and granted CE marking for Europe in November of 2003.
- Trial name
- NCT04663009
- Testing
- AutoPulse
- Where
- Norway
- Volunteers
- 3,250 people
- Sponsor
- Lars Wik
Cardiac Arrest, Cardiopulmonary Arrest
Use of a Feedback Device to Limit Too Shallow Compressions Associated With the Use of an I-gel® Device
Airway management in out-of-hospital cardiac arrest is still debated. Several options exist: bag-valve-mask ventilation, supraglottic devices and endotracheal intubation.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest, Resuscitation, Emergency Medicine
- Trial name
- NCT05709613
- Testing
- Use of a chest compressions' feedback device
- Where
- 4 sites in Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Geneve TEAM Ambulances
Resuscitation, Outcome, Fatal
Outcome After Out of Hospital Cardiac Arrest in Bern, Switzerland
Sudden cardiac arrests is one of the most frequent causes of death. In Switzerland every year 8000-10.000 people suffer from a cardiac arrest.
- Conditions
- Resuscitation, Outcome, Fatal, Out-Of-Hospital Cardiac Arrest
- Trial name
- NCT03759210
- Where
- Switzerland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pediatric Out-of-Hospital Cardiac Arrest
POHCA Resuscitation: Evaluation of IM Epinephrine
This is a pragmatic, two-arm, open-label, prospective stepped-wedge cluster quasi randomized control trial (SW-CRCT) looking to evaluate early intramuscular (IM) epinephrine in the management of pediatric out-of-hospital cardiac…
- Trial name
- PRIME (NCT05166343)
- Testing
- Epinephrine Injection
- Where
- Canada
- Volunteers
- 284 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cardiac Arrest
Effect of Pre-imaging on Cardiopulmonary Resuscitation (CPR) Pause
Patients presenting following out of hospital cardiac arrest will undergo bedside ultrasound as per the hospital clinical practice.
- Trial name
- NCT04248985
- Testing
- Pre-Imaging - an ultrasound technique of acquiring images
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Massachusetts, Worcester
Resuscitation
Incidence of the Out- and in Hospital Cardiac Arrest at a Tertiary Hospital in Germany
Incidence of the background information, incidence and special characteristics of out- and in-hospital cardiac arrest at a tertiary hospital in Germany.
- Trial name
- ProseCPR (NCT05709665)
- Testing
- Time to Decision for eCPR
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Johannes Gutenberg University Mainz
Out-Of-Hospital Cardiac Arrest After Initial Successful Resuscitation, Out of Hospital Cardiac Arrest
RESTORE-ZG: Return of Effective Spontaneous Circulation Resuscitation Evaluation Canton of Zug
This study looked at cardiac arrest that happens outside a hospital. Cardiac arrest means the heart suddenly stops pumping blood. When this happens, a person collapses and needs help right away.
- Conditions
- Out-Of-Hospital Cardiac Arrest After Initial Successful Resuscitation, Out of Hospital Cardiac Arrest, Out of Hospital Setting, Defibrillation
- Trial name
- RESTORE-ZG (NCT07750119)
- Testing
- Prehospital resuscitation care
- Where
- Switzerland
- Volunteers
- 240 people
- Sponsor
- Felix Brinkmann
Cardiac Arrest (CA)
Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest…
- Trial name
- LUCASVP (NCT06824961)
- Testing
- 5-second ventilation pause duration during mechanical CPR, 3-second ventilation pause duration during mechanical CPR
- Where
- 2 sites in Netherlands
- Volunteers
- 692 people
- Sponsor
- Amsterdam UMC, location VUmc
Out-Of-Hospital Cardiac Arrest
Differential Diagnosis and Cause-specific Treatment During OHCA
Differential diagnosis: ultrasound, blood gas analyse combined with examination of the patient and environment is used during Out Of Hospital Cardiac Arrest (OHCA) to screen possible underlying cause of cardiac arrest.
- Trial name
- NCT04670354
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Helsinki University Central Hospital
BLS, Out-Of-Hospital Cardiac Arrest
Geographical Association Between Basic Life Support Courses, Bystander Cardiopulmonary Resuscitation and Survival
Background Since 2001 when the Danish Cardiac Arrest Registry was first established several large-scale interventions aimed at the entire Danish population from all ages have been initiated.
- Trial name
- Geodata-BLS (NCT04353089)
- Testing
- Basic life support courses
- Where
- Denmark
- Volunteers
- 900,000 people, healthy volunteers welcome
- Sponsor
- Emergency Medical Services, Capital Region, Denmark