Clinical trials: Oxygen Therapy
Work of Breathing, Term Infant
Work of Breathing in Term Infants
This is a prospective observational cohort study conducted in the mother-baby unit at ChristianaCare. The study is designed to assess work of breathing indices and oxygen saturation stability at discharge in full-term infants.
- Trial name
- NCT05209269
- Testing
- Work of breathing observation
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Christiana Care Health Services
Preterm Birth
Oxygen Assist Module in Preterm Infants on High Flow Nasal Cannula Support.
Oxygen treatment is common in babies born early (preterm) and requiring intensive care. Having too much or too little oxygen can increase the risk of damage to the eyes and lungs, and contribute to death or disability.
- Trial name
- ROAM (NCT04687618)
- Testing
- High Flow Nasal Cannula withAutomatic control of FiO2 using OAM, High Flow Nasal Cannula with manual control of FiO2
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Cardiac Output
Comparison of Techniques for Assessing Cardiac Output and Preload in Critically Ill Pediatric Patients
The ability to measure cardiac output (CO) accurately and reproducibly at frequent intervals remains elusive to the clinician caring for critically ill pediatric patients even though a large proportion of these children are known…
- Trial name
- GCH (NCT00853437)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Transonic Systems Inc.
Term Delivery With Preterm Labor, Third Trimester, Term Delivery With Preterm Labor, Unspecified Trimester
Tidal Neonatal NO, Vitamins A and D, and Infant Lung Disease - The AD-ON Study
Children born prematurely are of greater risk of developing chronic lung disease (Bronchopulmonary Dysplasia). With an increase in the amount of premature children, we expect an increasing number of children with BPD.
- Conditions
- Term Delivery With Preterm Labor, Third Trimester, Term Delivery With Preterm Labor, Unspecified Trimester, Bronchopulmonary Dysplasia
- Trial name
- NCT01722760
- Testing
- measurements
- Where
- 2 sites in Denmark
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Hillerod Hospital, Denmark
Obstructive Sleep Apnea (OSA), Down Syndrome
Endotype DIrected Treatment for OSA in Down Syndrome
Down syndrome is the most common genetic cause of intellectual disability. People with Down syndrome often have obstructive sleep apnea (OSA), a condition where people have difficulties with breathing while asleep.
- Trial name
- EDIT OSA (NCT07280468)
- Testing
- ato-oxy, Oxygen
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Arizona
Bronchiolitis
Monitoring OXYgen in Infants Hospitalized With Bronchiolitis: A Best Practices Trial (The MOXY Trial)
In infants hospitalized with bronchiolitis, a common infection in the lungs caused by a virus, it is uncertain on how to best monitor their oxygen levels.
- Trial name
- NCT01646606
- Testing
- Intermittent oxygen monitoring, Continuous oxygen monitoring
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- The Hospital for Sick Children
Children, Congenital Heart Surgery
The Relationship Between Oxygen Reserve Index and PaO2
Oxygen Reserve Index (ORI) is a new parameter for noninvasive monitoring of oxygen reserve using oximetry sensor. In this study, the investigators evaluate the correlation between ORI and the partial pressure of arterial blood…
- Trial name
- NCT03130023
- Testing
- Pulse Oximeter with ORI
- Where
- South Korea
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Neonates, White Noise
Effects of White Noise and Lullaby on Vital Signs of Term Newborns in Neonatal Intensive Care
This clinical study aims to evaluate how two types of gentle sounds - white noise and a traditional Turkish lullaby ("Dandini Dandini Dastana") - affect the vital signs of term newborns cared for in the Neonatal Intensive Care…
- Conditions
- Neonates, White Noise, Non-Pharmacological Interventions, Auditory
- Trial name
- NCT07590479
- Testing
- White Noise Exposure, Lullaby Listening
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Heart Defects, Congenital
Mixed Venous Oxygen Saturation From Central Venous Line, Venous Side of Heart Lung Machine and the Pulmonary Artery
This study was designed to examine if venous saturations from the central venous line and from the venous side of the heart lung machine are interchangeable or not with mixed venous saturation from the pulmonary artery in…
- Trial name
- NCT02498626
- Testing
- venous saturations
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Preterm
Automated Versus Manual Oxygen Control in Preterm Babies on Respiratory Support
Babies admitted in the NICU (neonatal intensive care unit) frequently need supplemental oxygen to keep their oxygen saturation (SpO2) in target range (TR).
- Trial name
- NCT06622161
- Testing
- automated oxygen vs manual oxygen
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Embryo Development
The Clinical Outcome of Ultra-low Oxygen Tension on Post Thawed Human Blastocyst
The clinical outcome of Ultra-low oxygen tension on post thawed human blastocyst
- Trial name
- NCT03817671
- Testing
- 5% O2, 2% O2
- Where
- Egypt
- Volunteers
- 168 people
- Sponsor
- Ganin Fertility Center
Neonatal Respiratory Distress Syndrome
To Investigate the Effect of Pulmonary Surfactant With Different Inspired Oxygen Concentrations on the Clinical Outcomes of Very Preterm Infants Under Non-invasive Assisted Ventilation
A prospective multicenter randomized controlled study was conducted. Eligible very preterm infants with a gestational age of <32 weeks were enrolled.
- Trial name
- NCT07235345
- Testing
- According to the FiO2 threshold of PS application corresponding to randomization, PS treatment was given when FiO2 reached the threshold
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xu Falin
Neuroendocrine Cell Hyperplasia of Infancy
Efficacy of Methylprednisolone Pulses in Neuroendocrine Celles Hyperplasia of Infancy : An Early Phase Study
Childhood interstitial lung diseases (chILD) are a heterogeneous group of rare and severe disorders with an estimated prevalence of 1/100,000.
- Trial name
- CORTICONEHI (NCT06471556)
- Testing
- IV Methylprednisolone pulses
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Paediatric Asthma
Design, Development and Evaluation of a Digital Health Assistant for Paediatric Asthma
This study is to evaluate the efficacy of the digital health assistant (DHA) "Alex" in improving asthma control in asthmatic children and adolescents aged 10 to 19 compared to their baseline values.
- Trial name
- ALEX (NCT07472283)
- Testing
- Phase I (months 1-3): DHA core functionality, Phase II (months 3-6): platform augmentation, Embedded qualitative study
- Where
- 5 sites in Romania
- Volunteers
- 42 people
- Sponsor
- University Children's Hospital Basel
Anesthesia, Airway Complication of Anesthesia
Apnoeic Oxygenation During Pediatric Tracheal Intubation
The goal of this randomized, controlled, single-blinded clinical trial is to evaluate the effectiveness of apnoeic Oxygenation in pediatric anesthesia.
- Conditions
- Anesthesia, Airway Complication of Anesthesia, Anesthesia; Adverse Effect
- Trial name
- NCT06576596
- Testing
- apnoeic Oxygenation
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Heidelberg
Cerebral Necrosis
Adverse Radiation Effects After Gamma Knife Radio Surgery and Hyperbaric Oxygen Therapy
Evaluation of clinical improvement and the reduction of edema lesion documented by magnetic resonance imaging (MRI) in patients with cerebral radiation necrosis post gamma knife surgery (GKS) by treatment with hyperbaric oxygen…
- Trial name
- GKSHBO (NCT02714465)
- Testing
- hyperbaric oxygen therapy
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Niguarda Hospital
Cyanotic Congenital Heart Disease, Right Ventricular Outflow Tract Obstruction
RVOT Stenting Versus Surgical RV-PA Conduit in Cyanotic Adults
This prospective observational cohort study aims to compare clinical and hemodynamic outcomes of percutaneous right ventricular outflow tract stenting versus surgical right ventricle-to-pulmonary artery conduit placement in…
- Trial name
- NCT07866911
- Volunteers
- 30 people
- Sponsor
- Assiut University
Resuscitation
Pilot Study to Assess Safety and Feasibility of Resuscitation of Preterm Infants With Controlled Volume of Air/Oxygen
QUESTION: Is controlled tidal volume delivery during the resuscitation of preterm infants < 28 weeks' gestation safe and feasible? BACKGROUND AND RATIONALE: Current resuscitation of preterm neonates follows the Neonatal…
- Trial name
- NCT00157989
- Testing
- Controlled tidal volume resuscitation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Mount Sinai Hospital, Canada
Apgar; 0-3 at 1 Minute, Metabolic Acidosis
Autologous Stem Cells in Newborns With Oxygen Deprivation
The purpose of this study is to determine whether the plasticity of autologous intravenous application of cord blood stem cells would improve the clinical course of asphyxiated newborns.
- Conditions
- Apgar; 0-3 at 1 Minute, Metabolic Acidosis, Hypoxia, Brain, Multiple Organ Failure
- Trial name
- NCT01506258
- Testing
- Application of Stem Cells, Observation
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Hyperbaric Oxygen Therapy, Neuroprotective
Hyperbaric Oxygen Therapy as a Neuroprotective Intervention in Pediatric Acquired Brain Injury With Cognitive Disability
This research aimed to investigate the effectiveness of hyperbaric oxygen therapy as a neuroprotective strategy for improving neurological outcomes in pediatric patients who have sustained acquired brain injury.
- Conditions
- Hyperbaric Oxygen Therapy, Neuroprotective, Pediatric, Acquired Brain Injury
- Trial name
- NCT06954376
- Testing
- Hyperbaric oxygen therapy, Conventional rehabilitation
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Kafrelsheikh University