Clinical trials: Pain Tolerance
Hematological Malignancies
Impact of Child Positioning on Pain During a Lumbar Puncture
This protocol is a pilot study on standard care. The main goal is to assess the impact of positioning on lumbar puncture process especially on pain sensitivity in children.
- Trial name
- PHIPA-PEPL (NCT02834156)
- Testing
- LP in a seated position then LP in a lying position, LP in a lying position then LP in a seated position
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Intellectual Disability
Characterization of Nociception Phenotype in Individuals With Intellectual Disability
Background: People with intellectual disability (ID) often have physical disabilities as well. These physical problems can affect their bones, muscles, nerves, and gastrointestinal tracts. All of these issues can also cause pain.
- Trial name
- NCT05473429
- Testing
- TSA2 Thermosensory Stimulator
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cervicogenic Headache
The Effect of Myofascial Release in Patients With Cervicogenic Headache
Cervicogenic headache (CeH) is a secondary and often unilateral that is known by referring pain from soft or hard cervical structures to occipital, temporal, frontal and sometimes pre-orbital regions.
- Trial name
- RCT (NCT03113357)
- Testing
- Myofascial release technique, conventional exercise therapy
- Where
- Iran
- Volunteers
- 34 people
- Sponsor
- University of Social Welfare and Rehabilitation Science
Electroencephalography, Anesthesia, General
Validity of Pain Threshold Index in Children
Comparison of total infused dose of remifentanil between pain threshold index monitoring group and control group
- Trial name
- NCT03622242
- Testing
- Pain threshold index, Wavelet index
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Seoul National University Hospital
Dysmenorrhea Primary
Effect of Aquatic Exercise Versus Aerobic Exercise on Primary Dysmenorrhea and Quality of Life in Adolescent Females
This study was conducted to determine the difference between impact of aerobic and aquatic exercise on primary dysmenorrhea and quality of life in adolescent girls.
- Trial name
- NCT06129708
- Testing
- Aquatic Exercise, Aerobic Exercise
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Cancer
Therapeutic Play on Pain Tolerance and Emotion Regulation in Children
The research is a randomized controlled experimental study. The population of the research will consist of 10-18 year old children who were diagnosed with acute lymphoblastic leukemia and received chemotherapy, who were admitted…
- Trial name
- NCT06368947
- Testing
- Therapeutic Play
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Childhood Cancer
Pain, Body Composition and Physical Activity in Childhood Cancer.
Comparing baseline assessments of children with cancer and their parents with baseline assessments of healthy children and their parents in a case-control study will allow the investigators to make the comparison in terms of…
- Trial name
- NCT04004455
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Neck Pain
Acute Effects of Action Observation on Neck Pain
This study aims to assess the immediate effects of action observation therapy on the cervical muscles' strength, pain intensity, tactile acuity and pain pressure threshold in individuals with chronic nonspecific neck pain.
- Trial name
- NCT05078489
- Testing
- Action-observation therapy
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Aveiro University
Tennis Elbow, Health Adult Subjects
Assessment of Pressure Pain Threshold (PPT) and Conditioned Pain Modulation (CPM) After Effect in Patients With and Without Tennis Elbow (TE)
This study at Hashemite University looks at how people with and without tennis elbow (AKA lateral elbow tendinopathy) feel pressure pain and how their bodies briefly "turn down" pain after a cold stimulus.
- Conditions
- Tennis Elbow, Health Adult Subjects, Lateral Elbow Tendinopathy (Tennis Elbow), Pressure Pain Threshold (PPT)
- Trial name
- NCT07178288
- Testing
- Physiological/measurement-validation study
- Where
- Jordan
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- The Hashemite University
Primary Dysmenorrhea
Effect of High Intensity Aerobic Exercise on Pain Threshold and Blood Pressure in Females With Primary Dysmenorrhea
Primary dysmenorrhea is common among females of reproductive age and is characterized by painful menstrual cramps without an underlying pelvic disease.
- Trial name
- NCT07891143
- Testing
- High Intensity Aerobic Exercise
- Where
- Malaysia
- Volunteers
- 110 people
- Sponsor
- Lincoln University College
Peripheral Arterial Disease
Heat Therapy to Reduce Pain and Improve Walking Tolerance
The purpose of this study is to investigate whether exposure to heat therapy improves calf muscle oxygenation and enhances walking tolerance in patients with symptomatic Peripheral Arterial Disease (PAD).
- Trial name
- NCT03435835
- Testing
- Heat Therapy (HT)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Indiana University
Post-operative Pain, Acute, Pain Threshold
Cold Press Test and Post Operative Pain Relationship
The goal of this clinical trial is to investigate whether it is possible to get a preliminary idea about the postoperative pain in the patient with the results of a practical cold press test applied to American Society of…
- Trial name
- NCT05904873
- Testing
- Mandibular Third Molar Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sinem Büşra Kıraç Can
Autism Spectrum Disorder
Participant(s) With Autism and High Pain Tolerance Treated With High Dose Naltrexone
High dose naltrexone with response gauged by pain tolerance as measured by the cold pressor test may help treat autism.
- Trial name
- NCT05100563
- Testing
- 50 mg naltrexone
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Healthy, Hyperalgesia
Influence of Genetics in Pain Sensitivity
The purpose of this study is to learn more about the role of genetics in pain sensitivity. Pain perception varies widely among individuals, and information gained from this trial may lead to better methods of preventing and…
- Conditions
- Healthy, Hyperalgesia, Pain
- Trial name
- NCT00001956
- Testing
- Blood draw, Oral surgery, Tissue biopsy
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Migraine
Puberty, Sex Hormones and Pain Sensitivity in Adolescents With Migraine
The purpose of this research study is to investigate the relationships between sex hormone levels and experimental pain sensitivity and migraine severity will be examined.
- Trial name
- IHS (NCT05738213)
- Testing
- Thermal stimuli, Pressure stimuli, Pain ratings
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Knee Osteoarthritis
Pain Compared Between the First and the Second Surgery in Staged BTKA
postoperative pain and analgesic consumption between the first and the second surgery would be compared in patients undergoing staged bilateral total knee arthroplasty (BTKA).
- Trial name
- NCT01457313
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Seoul National University Bundang Hospital
Widespread Chronic Pain
Chronic Widespread Pain and White Blood Cell Activation
Our goal is to conduct a proof-of-concept trial to test the efficacy of KF treatment in adolescents with severe CWP not responding to the standard of care (SOC) treatment program in a multidisciplinary tertiary care chronic pain…
- Trial name
- NCT02984397
- Testing
- Ketotifen Fumarate, Standard of Care
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Shoulder Impingement Syndrome
The Immediate Effect of Mulligan's Mobilization With Movement on Shoulder Girdle' Pain, Range of Motion and Muscle Activity, in Subjects With Shoulder Impingement Syndrome
The aim of present study was to evaluate the immediate effect of Mulligan's mobilization with movement on shoulder girdle' pain, range of motion (ROM) and muscle activity, in subjects with shoulder impingement syndrome
- Trial name
- NCT06953895
- Testing
- Mulligan's Mobilization With Movement, Active Mobilization
- Where
- Portugal
- Volunteers
- 24 people
- Sponsor
- Escola Superior de Tecnologia da Saúde do Porto
Opioid Tolerance, Pain
Safety and Efficacy of a Low Dose Naloxone Infusion in NICU Patients
When narcotic pain medicine, like fentanyl or morphine, is given to adults and children for several days, they often develop a tolerance to the medicine.
- Trial name
- NCT00669175
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Children's Mercy Hospital Kansas City
Somatosensory Disorders
Somatosensory Evoked Potentials and Pain Thresholds in Term and Preterm-Born Adolescents After Early Exposure to Pain; a Quantitative Study
Background: Several studies have indicated that infants who had undergone postnatal painful procedures appear to be hypersensitive to pain, with a lower threshold to tactile stimulations later on life.
- Trial name
- NCT00503100
- Testing
- Thermal stimulation
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Soroka University Medical Center