Clinical trials: Palliative Radiotherapy
Pediatric Malignant Brain Tumor -Diffuse Intrinsic Pontine Glioma
Palliative Re-irradiation for Progressive Diffuse Intrinsic Pontine Glioma (DIPG) in Children
Although DIPG is not curable, re-irradiation with a modest total dose and short treatment time provides good palliation of symptoms, improves quality of life, delays disease progression and has minimal and manageable toxicity.
- Trial name
- NCT01777633
- Testing
- Palliative re-irradiation for progressive DIPG in children
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Hadassah Medical Organization
Metastases, Metastatic Cancer
Trial Comparing LATTICE Radiotherapy vs Moderately Dose-escalated Palliative Radiation for Patients With Metastases.
Unblinded, randomized study of 5-fraction LATTICE radiotherapy (20 Gy with an SIB to 66.7 Gy in 5 fractions) versus moderately dose-escalated palliative radiation (25 Gy in 5 fractions)
- Trial name
- NCT07594431
- Testing
- LATTICE Radiotherapy, Standard radiotherapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stanford University
Metastatic Malignant Solid Neoplasm, Unresectable Malignant Solid Neoplasm
Adding Spatially Fractionated Radiation Therapy to Standard Palliative Radiation for Improving Disease-Related Symptoms in Patients With Unresectable Solid Tumors
This clinical trial evaluates whether adding spatially fractionated radiation therapy (SFRT) to standard palliative external beam radiation therapy (EBRT) improves disease-related symptoms in patients with solid tumors that…
- Conditions
- Metastatic Malignant Solid Neoplasm, Unresectable Malignant Solid Neoplasm, Unresectable Solid Tumor, Malignant Tumor
- Trial name
- NCT07856394
- Testing
- Electronic Health Record Review, External Beam Radiation Therapy, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Malignant Neoplasm, Metastatic Malignant Neoplasm in the Bone
Palliative Radiation Therapy in Reducing Pain in Patients With Bone Metastasis
This randomized phase II trial studies how well palliative radiation therapy works in reducing pain in patients with cancer that has spread from the original (primary) tumor to the bone (bone metastasis).
- Conditions
- Malignant Neoplasm, Metastatic Malignant Neoplasm in the Bone, Pain
- Trial name
- NCT02699697
- Testing
- External Beam Radiation Therapy, Palliative Radiation Therapy, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Wake Forest University Health Sciences
Oesophageal Cancer
ROCS (Radiotherapy After Oesophageal Cancer Stenting) Study
The single most distressing symptom for more than 70% of patients with oesophageal cancer is difficulty in swallowing (dysphagia) caused by blockage of the gullet by a tumour.
- Trial name
- ROCS (NCT01915693)
- Testing
- Radiotherapy
- Where
- 17 sites in United Kingdom
- Volunteers
- 220 people
- Sponsor
- Lisette Nixon
Palliative Radiotherapy
Advanced Techniques For Single-fraction Palliative Radiotherapy Versus Standard Multi Fraction Radiation
The aim of the study is to determine if single fraction dose escalated palliative radiotherapy results in a prolonged duration of benefit for patients otherwise suitable for Multifraction (5-10#) palliative radiation.
- Trial name
- ASPIRE_Multi (NCT04649125)
- Testing
- dose escalation
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Royal North Shore Hospital
Sarcoma
Radiation Therapy as Palliative Treatment of GIST
Gastrointestinal stromal tumors (GISTs) are generally considered resistant to radiation, but no prospective trials addressing efficacy and tolerability of radiation therapy have been carried out.
- Trial name
- GIST-RT (NCT00515931)
- Testing
- Radiation therapy (external beam photons)
- Where
- Finland
- Volunteers
- 25 people
- Sponsor
- Heikki Joensuu
Rectal Neoplasms
Palliative Short-Course Radiotherapy in Rectal Cancer
Radiotherapy (RT) is a potentially effective method in the treatment of symptoms of rectal carcinomas. Nevertheless, almost all the evidences about palliative RT in rectal cancer have been published more than two decades ago and…
- Trial name
- NCT02639403
- Testing
- Conformal three-dimensional Radiotherapy
- Volunteers
- 18 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Radiodermatitis; Acute, Radiotherapy Side Effect
The Use of Photobiomodulation in the Management of Radiodermatitis in Patients in Palliative Care. A Prospective Study.
It is estimated that there will be 670,000 new cases of cancer worldwide in 2020-2022 and it is known that the most commonly instituted treatments in cancer are chemotherapy, radiotherapy and surgery.
- Conditions
- Radiodermatitis; Acute, Radiotherapy Side Effect, Cancer Patients, Palliative Care
- Trial name
- NCT05561803
- Testing
- Photobiomodulation Therapy
- Where
- Brazil
- Sponsor
- University of Nove de Julho
Bone Metastases, Radiotherapy
Pain Relief in Symptomatic Bone Metastases With Adjuvant Hyperthermia MR Guided HIFU
Metastatic disease to the bone is a common cause of pain. External beam radiation therapy (EBRT) is the standard palliative treatment BUT pain improvement is observed in 60% to 80%.
- Conditions
- Bone Metastases, Radiotherapy, Pain, MRI
- Trial name
- BM-RT-HIFU (NCT05167669)
- Testing
- HIFU-MRI guided
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Sana Boudabbous
Bone Metastases in Subjects With Advanced Cancer, Radiotherapy
Timely Integration of Palliative Care in Oncology Care for Patients Referred for Palliative Radiotherapy on Bone Metastases: A Randomized Trial
Rationale: With improvements in systemic tumour-directed treatments for primary tumours, survival rates for patients with bone metastases are improving.
- Trial name
- TIPZO-RT (NCT06805396)
- Testing
- Palliative Care Consult
- Where
- 5 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Roxanne Gal
Ewing Sarcoma, Rhabdomyosarcoma
Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma, Rhabdomyosarcoma, and Wilms Tumors
This research study is studying stereotactic body radiotherapy (SBRT) as a possible treatment for lung relapse of Ewing sarcoma, rhabdomyosarcoma, osteosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, Wilms tumor or other…
- Conditions
- Ewing Sarcoma, Rhabdomyosarcoma, Wilms Tumor, Osteosarcoma
- Trial name
- NCT02581384
- Testing
- Stereotactic Body Radiotherapy (SBRT)
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Dana-Farber Cancer Institute
Head and Neck Cancer
Review of Palliative Radiotherapy in the Management of Advanced Head and Neck Cancer
To describe the charactersitics of patients with advanced head and neck cancer treated with palliative intent and determine outcome in terms of symptom control and toxicity
- Trial name
- NCT00280891
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Alberta Health services
Carcinoma, Non-Small-Cell Lung
Combination of Weekly Chest Radiotherapy and Oral Navelbine for the Palliation of Advanced Non Small Cell Lung Cancer: A Phase I Study
The study is designed for subjects whose cancer is too advanced and therefore cannot be operated with the goal of completely removing the cancer.
- Trial name
- NCT00256815
- Testing
- chemotherapy, Radiation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Clinical Oncology Research Associates
Neoplasms
Increasing Patient Comfort in Palliative Radiotherapy With a Newly Developed Mattress - A Prospective Clinical Study
The goal of this research is to determine if a new radiotherapy mattress is more comfortable for patients than the standard mattress. The table of the CT scanner and the radiation machine is flat and hard.
- Trial name
- RTCOMFORT (NCT06903507)
- Testing
- RT-Comfort Mattress
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Erasmus Medical Center
Cancer
Prognosis of Inpatients Evaluated for Palliative Radiotherapy
Understanding patient's prognosis is of utmost importance to determine radiotherapy's indication and dose/ fractionation. The investigators plan to conduct an observational study of prognosis of inpatients evaluated for…
- Trial name
- PROGRAD (NCT02312791)
- Where
- Brazil
- Volunteers
- 362 people
- Sponsor
- University of Sao Paulo
Metastatic Cancer Rectum
The Role of Short Course of Palliative Radiation in Metastatic Cancer Rectum
Short-course radiotherapy (SCRT), which allows the delivery of 25 Gy in five daily fractions, has emerged as an attractive strategy for rectal cancer treatment.
- Trial name
- NCT06521827
- Testing
- short course radiotherapy
- Volunteers
- 49 people
- Sponsor
- Assiut University
Metastatic Cancer, Prostate Cancer
Strontium Compared With Radiation Therapy in Treating Patients With Hormone-Refractory Prostate Cancer With Painful Bone Metastases
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. This may be an effective treatment for prostate cancer.
- Trial name
- NCT00002503
- Testing
- strontium chloride Sr 89
- Where
- 21 sites in Belgium, Denmark and 7 more
- Volunteers
- 204 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Fatigue, Lung Cancer
Radiation Therapy to Relieve Symptoms in Patients With Non-small Cell Lung Cancer
RATIONALE: Radiation therapy may relieve symptoms in patients with non-small cell lung cancer. It is not yet known which regimen of radiation therapy is most effective in relieving symptoms in patients with non-small cell lung…
- Conditions
- Fatigue, Lung Cancer, Nausea and Vomiting, Pain
- Trial name
- NCT00003685
- Testing
- fatigue assessment and management, nausea and vomiting therapy, pain therapy
- Where
- 21 sites in Canada
- Volunteers
- 230 people
- Sponsor
- NCIC Clinical Trials Group
Oesophageal Cancer
Role of Radiotherapy Following Oesophageal Stenting in Cancer
To assess the benefits of oesophageal stenting and external beam radiotherapy over oesophageal stenting alone in patients with inoperable oesophageal cancer
- Trial name
- NCT01179074
- Testing
- oesophageal stenting with self expandable metal stent, Oesophageal stent followed by external beam radiotherapy
- Where
- India
- Volunteers
- 84 people
- Sponsor
- All India Institute of Medical Sciences