Clinical trials: Postoperative Neurocognitive Disorder
Emergence Delirium
Emergence Agitation of Sevoflurane in Pediatric
Low dose nalbuphine versus dexmedetomidine on prevention of emergence agitation in children
- Trial name
- NCT06830564
- Testing
- we will give the patient 0.1 mg nalbuphine 15 min before the end of the procedure, we will give the patient 0.5 mg dexmedetomidine 15 min before the end of the procedure
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Emergence Agitation, Pain
Emergence Agitation and Pain Scores in Pediatrics When Comparing Single-modal vs Multi-modal Analgesia for ENT Surgery
The purpose of this study is to compare the incidence of EA in pediatric patients undergoing minor ENT surgery under Sevoflurane and compare opioid-only based intra-operative analgesia to multi-modal analgesia consisting of…
- Trial name
- NCT03062488
- Testing
- IV acetaminophen, Fentanyl, PO acetaminophen
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Preoperative Care, Anxiety
Perioperative Effects of Operating Room Virtual Tour
Preoperative anxiety is associated with adverse consequences such as emergence delirium, and postoperative behavioral changes. According to previous studies, providing information of anesthetic procedures helps to lessen…
- Conditions
- Preoperative Care, Anxiety, Emergence Delirium, Postoperative Complications
- Trial name
- NCT03172182
- Testing
- a 360-degree VR video tour
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Seoul National University Bundang Hospital
Delirium
Effect of Preoperative Intervention With Folic Acid and Vitamin B12 on Postoperative Neurobehavioral Changes in Children
Comparison of preoperative folic acid and VitB12 intervention on postoperative delirium and long-term neurobehavioral changes in children under general anesthesia
- Trial name
- NCT04456985
- Testing
- Folic acid and vitamin B12, brown sugar aqueous
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Sevoflurane Anaesthesia
Effect of Animated Cartoon for Prevention of Emergence Agitation in Children Aged 1.5 - 5 yr After General Anesthesia
Emergence agitation (EA) in children early after sevoflurane anaesthesia is a common postoperative problem, with incidence ranging up to 80%.
- Trial name
- NCT01880138
- Testing
- watching animated cartoon before general anesthesia, not watching animated cartoon beofre general anaesthesia
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Emergence Delirium, Postoperative Complications
Epigenetics in PostOperative Pediatric Emergence Delirium
Emergence delirium (ED) infers the occurrence of behavior and cognition changes during the early postoperative period. Main signs and symptoms of ED are the disturbances of consciousness and awareness of the environment, with…
- Conditions
- Emergence Delirium, Postoperative Complications, DNA Methylation
- Trial name
- EPOPED (NCT03787849)
- Testing
- Sevoflurane, Propofol
- Where
- Brazil
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Strabismus, Delirium on Emergence
Efficacy of Single-Shot Dexmedetomidine Versus Placebo in Preventing Pediatric Emergence Delirium in Strabismus Surgery
This study is trying to see if using precedex pre-operatively prevents emergence delirium in pediatric (ages 1-7) patients undergoing strabismus surgery.
- Conditions
- Strabismus, Delirium on Emergence, Pediatric Disorders
- Trial name
- NCT01901588
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- NYU Langone Health
Atrial Septal Defect (ASD), Dexmedetomidine
Effect of Dexmedetomidine Supplementation to General Anaesthesia in Paediatric Transcatheter Closure of Atrial Septal Defect
The aim of this randomized trial is to determine efficacy of dexmedetomidine in improving quality of recovery in pediatric patients undergoing interventional catheter closure of ASD while maintaining the hemodynamic parameters.
- Conditions
- Atrial Septal Defect (ASD), Dexmedetomidine, Delirium - Postoperative, Stress Response
- Trial name
- NCT06631534
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Postoperative Agitation, Emergence Delirium, Anesthesia
Impact of Neuromonitoring on Postoperative Agitation in Pediatric General Anesthesia
Postoperative agitation is frequently observed in the pediatric patient group following general anesthesia. The exact cause of this agitation has not been clearly determined; however, it may be associated with various factors…
- Trial name
- NCT07243990
- Testing
- dsa intervention group, Traditional Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sakarya University
Emergence Delirium
Effect of Ketamine/Midazolam Premedication Versus Pre-extubation Ketofol on Recovery Profile in Pediatrics Undergoing Adenotonsillectomy.
An optimum recovery profile after AT includes a rapid, smooth awakening without emergence agitation (EA), stable vital signs and oxygenation, reduced postoperative nausea and vomiting (PONV), controlled postoperative pain, and…
- Trial name
- NCT06010927
- Testing
- ketamine/midazolam, Ketofol
- Where
- 2 sites in Egypt
- Volunteers
- 140 people
- Sponsor
- Cairo University
Postoperative Delirium, Postoperative Pain
Effect of Electroencephalography Guided General Anesthesia on Postoperative Delirium in Children
Participants aged 4-10 years (92 patients), who came to the Hospital Operating Room at the University Faculty of Dentistry with an indication for dental treatment under general anesthesia due to lack of cooperation, will be…
- Trial name
- NCT06400706
- Testing
- EEG guided general anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Emergence Agitation
The Effect of Depth of Anesthesia as Measured by Bispectral Index (BIS) on Emergence Agitation in Children
The purpose of this study is to determine whether depth of anesthesia has an effect on emergence agitation (EA) in children age 2 - 8 years old.
- Trial name
- NCT00990769
- Testing
- Depth of anesthesia
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Pain, Postoperative
Transversus Abdominis Plane Block in Iliac Crest harvest-is it Beneficial?
The purpose of this study is to determine whether a supplemental Transversus Abdominis Plane block administered intraoperatively improves the postoperative parameters in patients undergoing Alveolar bone grafting with iliac crest…
- Trial name
- NCT02997124
- Testing
- local infiltration and TAP block, local infiltration only
- Volunteers
- 143 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Electroencephalogram, Postoperative Delirium
Correlation of Electroencephalogram With Postoperative Delirium During Cardiac Surgery
The purpose of this study is to explore characteristic changes of EEG epileptiform discharges in patients under CPB and correlation with POD
- Trial name
- NCT04943939
- Where
- China
- Volunteers
- 60 people
- Sponsor
- General Hospital of Ningxia Medical University
Agitation, Child
Effects of Preoperative Using of Eye Patches on Prevention of Emergence Agitation After Cataract Surgery
This study is a single-center, prospective, randomized, controlled trial. To investigate if preoperative using of eye patch will decrease emergence agitation, and to provide a better method of decreasing emergence agitation to…
- Conditions
- Agitation, Child, Anesthesia
- Trial name
- NCT02590744
- Testing
- eye patch, non-eye patch
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Xiaoliang Gan
Tonsillectomy
Dexmedetomidine as a Rapid Bolus in Children for Emergence Agitation
To Determine The Efficacy of a Rapid Bolus Injection of Dexmedetomidine on the Incidence of Emergence Agitation in Anesthetized Children and the Cardiovascular Profile of a Rapid Bolus Injection of Dexmedetomidine.
- Trial name
- NCT01528891
- Testing
- Dexmedetomidine
- Where
- 2 sites in United States
- Volunteers
- 418 people
- Sponsor
- Peter Davis
Anxiety State, Child Behavior
The Effect of Child Choice With Accompanying Parent on Postoperative Delirium During Induction of Anesthesia
Induction of anesthesia can be distressing both for children and their parents. Nonpharmacological behavioral interventions can reduce the anxiety of children without significant adverse effects as seen with sedative drugs.
- Conditions
- Anxiety State, Child Behavior, Postoperative Delirium
- Trial name
- NCT05931770
- Testing
- Selection of parent(mother or father) according to children preference, Parent (mother or father) selection according to parents' preference
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Preoperative Anxiety, Emergence Agitation
Association of Inflammatory Markers With Preoperative Anxiety and Agitation
This study was planned as a prospective, observational study. The study will include pediatric patients aged 3-12 who will undergo surgery.
- Trial name
- NCT06648122
- Testing
- laboratory results
- Where
- Turkey (Türkiye)
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Tonsillitis, Post-operative Nausea and Vomiting (PONV)
Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery
This is a prospective, randomized, controlled, non-inferiority study of patients undergoing tonsil surgeries at Boston Children's Hospital Waltham.
- Conditions
- Tonsillitis, Post-operative Nausea and Vomiting (PONV), Emergence Delirium, Opioid Analgesic Adverse Reaction
- Trial name
- NCT06326983
- Testing
- Dexmedetomidine, Acetaminophen, Ketorolac
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Boston Children's Hospital
Anesthesia, General
Recorded Maternal Voice on the Emergence of General Anesthesia on Pediatric Patients
Mother spend a large amount of time with their children. It is assumed that mother contributes to their neurological development not only with visual stimuli, but also with auditory stimuli.
- Trial name
- Maternal voice (NCT02955680)
- Testing
- recorded maternal voice, recorded stranger's voice
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Daegu Catholic University Medical Center