Clinical trials: Pre-term Delivery
Prenatal Care, Premature Birth
Biological Markers of Disease in the Prediction of Preterm Delivery, Preeclampsia and Intra-Uterine Growth Retardation: A Longtitudinal Study
Preterm delivery, preeclampsia and intrauterine growth restriction are leading causes of perinatal morbidity and mortality. Efforts to treat these syndromes have not been effective, most likely becuase these obstetric…
- Trial name
- NCT00340899
- Where
- Chile
- Volunteers
- 19,134 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Placental Transfusion
Delivery Room Assistance With the Placental Circulation Intact
Preterm newborns receiving placental transfusion at birth (a volume of blood coming from the placenta towards the newborn till the cord is left unclamped) have better neonatal outcomes (in particular reduction of intraventricular…
- Trial name
- PCI-T (NCT02671305)
- Testing
- placental circulation intact, cord milking
- Where
- 8 sites in Italy
- Volunteers
- 212 people
- Sponsor
- University of Florence
Small for Gestational Age at Delivery, Low Birth Weight
Effect of a Fortified Balanced Energy-Protein Supplement on Birth Outcome and Child Growth in Houndé District, Burkina Faso.
The 2016 WHO antenatal care guidelines stated that pregnant women in undernourished populations should receive fortified balanced energy-protein (BEP) supplements to reduce the risk of stillbirth and small-for-gestational-age…
- Conditions
- Small for Gestational Age at Delivery, Low Birth Weight, Prematurity, Infant Malnutrition
- Trial name
- MISAME-3 (NCT03533712)
- Testing
- Fortified balanced energy-protein (BEP) supplement, Fe and folic acid supplement
- Where
- Burkina Faso
- Volunteers
- 1,788 people, healthy volunteers welcome
- Sponsor
- University Ghent
Respiratory Distress Syndrome in Premature Infant
Pressure HIgh or LOw DElivered to Preterm Newborns in the Delivery ROOM
The aim of this randomized pilot clinical trial of preterm infants requiring noninvasive respiratory support for respiratory distress syndrome (RDS) at birth is to improve short-term respiratory outcomes.
- Trial name
- PHILODENDROOM (NCT06123845)
- Testing
- static CPAP 8 cmH2O, static CPAP 5 cmH2O
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- ASST Fatebenefratelli Sacco
Sepsis, Pre-Term
Olive Oil Massage Effect for Reduction of Preterm Sepsis (OMEPS)
The OMEPS trial is a randomized clinical trial in the western region of Saudi Arabia. Conducted to assess the safety and feasibility of olive oil as massage for preterm infants and if associated with reduced risk of Late-Onset…
- Conditions
- Sepsis, Pre-Term, Late-Onset Neonatal Sepsis
- Trial name
- OMEPS (NCT04717037)
- Testing
- Olive Oil Massage
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 300 people
- Sponsor
- King Abdullah International Medical Research Center
Preterm Infant
Acoustics as a Metric of Airway Pressure in Premature Infants Using Bubble Continuous Positive Airway Pressure
This is an observational, proof-of-concept, feasibility study where 30 preterm infants on bubble CPAP with gestational age < 32+0 weeks will be recruited from the neonatal intensive care unit (NICU) at the Montreal Children's…
- Trial name
- Bubble CPAP (NCT07060833)
- Testing
- External pressure transducer, Standard microphone, Wireless acoustic sensor
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pre-Term
MusicHyperBrain Study With Preterm Infants and Their Parents
Inter-personal brain coupling between preterm infants, their parents and a musician during Creative Music Therapy using functional near-infrared imaging (fNIRI) hyperscanning and systemic physiology measurements
- Trial name
- NCT05383586
- Testing
- Creative Music Therapy
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Respiratory Distress Syndrome in Premature Infant, Non-invasive Ventilation
Open Lung Strategy During Non-Invasive Respiratory Support of Very Preterm Infants in the Delivery Room
The opening and aeration of the lung is critical for a successful transition from fetal to neonatal life. Early nasal CPAP in the delivery room in spontaneously breathing premature babies with a gestational age of 30 weeks or…
- Conditions
- Respiratory Distress Syndrome in Premature Infant, Non-invasive Ventilation, Lung Injury
- Trial name
- OpenCPAP-DR (NCT05031650)
- Testing
- openCPAP, standardCPAP
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 145 people
- Sponsor
- Dokuz Eylul University
Preterm Birth, Preterm Premature Rupture of Membrane
Cerclage After Full Dilatation Caesarean Section
CRAFT-OBS: Observational Study; To evaluate subsequent pregnancy risk of preterm birth in women with a history of previous caesarean in established labour.
- Conditions
- Preterm Birth, Preterm Premature Rupture of Membrane, Preterm Spontaneous Labor With Preterm Delivery
- Trial name
- CRAFT (NCT04110704)
- Testing
- Insertion of transvaginal cerclage
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Prematurity Complications, NICU Infants
A Pilot Study Comparing Telehealth and In-Person Therapy Service Delivery Following NICU Discharge
20 high-risk parent-infant dyads hospitalized in a 58-bed level IV NICU will be randomized to either receive Telehealth or in-person Baby Bridge services.
- Conditions
- Prematurity Complications, NICU Infants, Early Intervention, Telehealth
- Trial name
- BabyBridge (NCT06893003)
- Testing
- Baby Bridge
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Preterm, Iron Metabolism
Iron Metabolism in Small Pre Term Newborns
Iron is an essential micronutrient that plays an important role in cellular functions of all microorganisms. Both iron deficiency and iron excess during the early weeks of life can have severe effects on neurodevelopment that may…
- Conditions
- Preterm, Iron Metabolism, Iron Overload
- Trial name
- NCT01443195
- Testing
- Iron preparation
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- HaEmek Medical Center, Israel
Extreme Prematurity, Respiratory Distress Syndrome
LISA in the Delivery Room for Extremely Preterm Infants
The purpose of this study is to evaluate the effect of LISA used in the delivery room (DR) in decreasing the intubation rates in preterm infants at 22-25 weeks gestational age (GA), during first 72 hours compared to the standard…
- Trial name
- DRLISA (NCT04715373)
- Testing
- LISA
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Anemia, Low Birth Weight
Dietary Diversity is Associated With Maternal Anemia and Key Prenatal Outcomes in Ethiopia
Background: Maternal and child under-nutrition is the underlying cause of death for millions across the globe. Anemia during pregnancy is among the leading nutritional disorders with serious short and long term consequences to…
- Conditions
- Anemia, Low Birth Weight, Pre-Term Birth, Still Birth
- Trial name
- NCT02620943
- Where
- Ethiopia
- Volunteers
- 374 people
- Sponsor
- Dilla University
Sleep Problem, Neurobehavioral Manifestations
NapBiome: Targeting Gut Microbiota and Sleep Rhythm to Improve Developmental and Behavioral Outcomes in Early Childhood
The gut-brain axis plays a crucial role in the regulation and development of psychological and physical processes. The first year of life is a critical period for the development of the gut microbiome, which parallels important…
- Trial name
- NapBiome (NCT06396689)
- Testing
- Synbiotic
- Where
- 2 sites in Switzerland
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Petra Zimmermann
Preterm Birth, Neonatal Respiratory Distress
Tandem: Skin-to-skin Transfer From the Delivery Room to the Neonatal Unit
Immediate skin-to-skin contact (SSC) is already standard care for healthy term newborns, but its use for term or preterm newborns requiring admission to neonatal unit (NICU) with or without respiratory support is challenging.
- Conditions
- Preterm Birth, Neonatal Respiratory Distress, Mother-Infant Interaction
- Trial name
- Tandem (NCT06198478)
- Where
- Belgium
- Volunteers
- 73 people
- Sponsor
- Erasme University Hospital
Prematurity, Histologic Chorioamnionitis
Infant Immune Response to Bacterial Infection
This study will examine the response of white blood cells to bacterial infection in blood taken from the umbilical cords of newly delivered infants.
- Trial name
- NCT00546195
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Extreme Prematurity, Enteral Nutrition
High-energy Human Milk Diets in the First Two Weeks After Birth to Reduce BPD in Extremely Preterm Infants
This Phase II, parallel-group, masked, randomized clinical trial aims to evaluate whether a DHA/ARA-enriched, fortified human milk diet administered during the first 14 days of life reduces respiratory morbidity and improves lung…
- Conditions
- Extreme Prematurity, Enteral Nutrition, Bronchopulmonary Dysplasia
- Trial name
- MEND-BPD (NCT07307612)
- Testing
- High-energy group, Standard-energy group
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Alabama at Birmingham
Prematurity
Milking the Umbilical Cord Versus Immediate Clamping in Pre-term Infants < 33 Weeks
Anemia in preterm neonates is a significant problem encountered frequently in the neonatal intensive care unit. Most preterm neonates born at less than 33 weeks gestation will require at least one blood transfusion during their…
- Trial name
- NCT01819532
- Testing
- Milking group, Immediate cord clamping
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Johns Hopkins University
Pre-Term, Respiratory Disease
Closed-loop Oxygen Control in Ventilated Infants Born at or Near Term
Ventilated neonates frequently require supplementary oxygen to allow for adequate oxygen delivery to the tissues and normal cell metabolism.
- Trial name
- NCT05017727
- Testing
- Closed-loop automated oxygen control with Oxygenie Auto-O2 software (SLE6000)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- King's College Hospital NHS Trust
Ventilator Lung; Newborn
Comparing Intubation Rates in the Delivery Room by Interface
Although the majority of premature neonates < 30 weeks gestion require positive pressure ventilation (PPV) at birth, the optimal interface to provide PPV has not been determined.
- Trial name
- NCT05609773
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Illinois College of Medicine at Peoria