Clinical trials: Pre-term Delivery
Neonatal Sepsis
Distribution of Haptoglobin Phenotype in Septic and Non Septic Pre-term Neonates (PTSH)
The Haptoglobin (Hp) gene locus at chromosome 16q22 is polymorphic with two alleles denoted 1 and 2 .The gene product exists in three phenotypes: 1-1, 2-1, and 2-2.
- Trial name
- NCT00800449
- Where
- Israel
- Volunteers
- 133 people
- Sponsor
- Irina Kessel
Pre-Term, Respiratory Distress Syndrome, Newborn
NeO2Matic-Pilot Trial
The main goal of this trial is to test if: automated adjustment of supplemental oxygen to preterm infants in noninvasive respiratory support based on feedback from a measurement of blood-oxygen saturation results in more stable…
- Conditions
- Pre-Term, Respiratory Distress Syndrome, Newborn, Retinopathy of Prematurity, Bronchopulmonary Dysplasia
- Trial name
- NEO2MATIC (NCT05629910)
- Testing
- O2Matic
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Respiratory Distress Syndrome
Caffeine Treatment in in the Delivery Room
Background. In recent years, particular attention has been paid to all interventions that could help reduce the need for mechanical ventilation MV and, therefore, the risk of BPD.
- Trial name
- CAFROOM (NCT04044976)
- Testing
- Caffeine Citrate
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- University of Florence
Preterm Infant
Acoustics as a Metric of Airway Pressure in Premature Infants Using Bubble Continuous Positive Airway Pressure
This is an observational, proof-of-concept, feasibility study where 30 preterm infants on bubble CPAP with gestational age < 32+0 weeks will be recruited from the neonatal intensive care unit (NICU) at the Montreal Children's…
- Trial name
- Bubble CPAP (NCT07060833)
- Testing
- External pressure transducer, Standard microphone, Wireless acoustic sensor
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Ventilator Lung; Newborn
Comparing Intubation Rates in the Delivery Room by Interface
Although the majority of premature neonates < 30 weeks gestion require positive pressure ventilation (PPV) at birth, the optimal interface to provide PPV has not been determined.
- Trial name
- NCT05609773
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Illinois College of Medicine at Peoria
Premature Delivery
Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island
Prematurity is the leading cause of mortality and perinatal morbidity. Despite the many preventive measures and use of tocolytic therapy, the incidence of premature births has not decreased in recent decades.
- Trial name
- PARTOSURE-OI (NCT02904070)
- Testing
- Vaginal swabbing
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Resuscitation
Co2 Monitoring at Preterm Delivery-Observational Study
CO2 data, serving as a proxy marker for tidal volume, might enable titration of tidal volume/pressure thereby providing optimal ventilation during neonatal resuscitation.
- Trial name
- COSTA (NCT04699708)
- Testing
- Carbon dioxide monitoring
- Where
- 2 sites in United Kingdom
- Volunteers
- 150 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Cesarean Delivery Affecting Fetus, Preterm Labor
Baby Smell Visual Stimulus Program Cortical and Breast Oxygenation Milk Amount Mother-Infant Attachment
In this study, the effect of infant odor and visual stimulus program applied to mothers who had delivered by cesarean section and whose babies were taken to the NICU on cortical and breast oxygenation (rSO2), amount of breast…
- Trial name
- NCT06058208
- Testing
- Olfactory stimulation, Visual stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Prematurity
Effects of Massage Therapy and Kinesthetic Stimulation on Pre-Term Infants
The purpose of this study was to determine whether massage with or without physical exercise impacted weight gain or length of hospital stay for premature infants.
- Trial name
- NCT00661791
- Testing
- Massage therapy without exercise, Massage therapy with exercise
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- George Washington University
Pre-Term
I-InTERACT Preterm
Open pilot of a brief online parenting-skills intervention for young children ages 3-8 who were born very preterm (< 32 weeks gestational age).
- Trial name
- NCT05282628
- Testing
- Building Better Brains and Behavior program (B4 Preterm)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Transient Tachypnea
Prophylactic Continuous Positive Airway Pressure (CPAP) in Delivery Room, in the Prevention of Transient Tachypnea of Newborn (TTN): A Randomized Controlled Trial
Transient Tachypnea of the Newborn (TTN) is a disorder of delayed clearance of lung liquid and a common cause of admission of full term infants and late pre term infants (34 to 36 weeks) to Neonatal Intensive Care Units (NICU).
- Trial name
- NCT01082900
- Testing
- Prophylactic CPAP Administration
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- New York Hospital Queens
Prematurity
Human Milk Cream as a Caloric Supplement in Pre-Term Infants
Human milk is commonly considered to have 20 calories per ounce (kcal/oz). However, studies show that up to 65% of human milk may be less than the expected 20 kcal/oz which can greatly affect an infant's growth.
- Trial name
- NCT01487928
- Testing
- Human Milk Cream
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Baylor College of Medicine
Premature Birth
Interpregnancy Care Project-Mississippi (IPC-M)
The IPC program will enroll women who deliver Very Low Birth Weight babies (stillborn or liveborn) at University of Mississippi Medical Center and women who have Very Low Birth Weight babies that receive treatment in the Neonatal…
- Trial name
- IPC-M (NCT00852319)
- Testing
- Interpregnancy Care
- Where
- 3 sites in United States
- Volunteers
- 264 people
- Sponsor
- University of Mississippi Medical Center
Preterm Birth
The Contribution of Internal Maternal Resources to Creation of Motherhood. Comparison Among Mothers to Twins and Singleton
Delivery of twins or preterm infant is a very stressful episode to mothers. The purpose of this study is to characterize maternal psychological resources in dealing with this situation and compare it to mothers giving birth to…
- Trial name
- NCT00353236
- Where
- Israel
- Sponsor
- Sheba Medical Center
Parenting, Problem Behavior
Parent Training for Parents of Toddlers Born Very Premature:
The purpose of the study is to test the effects of the ezParent (web-based parent training program) intervention and telephone coaching calls (coach) on parent and child outcomes after 3-, 6-, and 12-months.
- Conditions
- Parenting, Problem Behavior, Premature Birth, Parenting Intervention
- Trial name
- ezParent (NCT05217615)
- Testing
- ezParent, Coaching calls, Active Control
- Where
- 3 sites in United States
- Volunteers
- 452 people
- Sponsor
- Ohio State University
Preterm Birth, Infant, Premature, Diseases
Multi Modal Stimulations in Pre-term Neonates
A total of 56 neonates with LBW will recruited by the convenience sampling to participate in this two group pre-test post-test, single blinded randomized clinical study.
- Trial name
- NCT04247308
- Testing
- Sensory Stimulation, Movement therapy, Routine hospital care
- Where
- India
- Volunteers
- 56 people
- Sponsor
- Asir John Samuel
Fetal Membranes, Premature Rupture
Safety and Efficacy Study of Intentional Delivery in Women With Preterm and Prelabour Rupture of the Membranes
Two-year multicentre randomized controlled parallel trial to compare intentional delivery and conservative management in pregnant women with preterm and prelabour rupture of membranes between 32 and 35 weeks.
- Trial name
- NCT00259519
- Testing
- Induction of delivery
- Where
- 11 sites in Canada
- Volunteers
- 152 people
- Sponsor
- University of Alberta
Pre-oxygenation in Term Pregnant Women
Clinical Trial of Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Oxygen in Women Having Planned Caesarean Delivery
Clinical Trial of Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Oxygen in Women having Planned Caesarean Delivery.
- Trial name
- THRIVEN90 (NCT04229745)
- Testing
- THRIVE pre-oxygenation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- SABA AL-SULTTAN
Neonatal Pain, Retinopathy of Prematurity (ROP)
Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants
The goal of this clinical trial is to learn whether intranasal fentanyl (a pain medicine given as a nasal spray) can reduce pain and is safe to use during routine eye examinations for retinopathy of prematurity (ROP) in preterm…
- Conditions
- Neonatal Pain, Retinopathy of Prematurity (ROP), Pain Management, Infant, Premature
- Trial name
- FIREFLY (NCT07112430)
- Testing
- Fentanyl Citrate (Intranasal)
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Marsha Campbell-Yeo
Pre-Term
Optos Versus Indirect Ophthalmoscopy for ROP Screening Examination (Optos vs BIO Study)
ROP is a preventable cause of blindness in premature infants. It is routinely screened for by using an indirect ophthalmoscope, a scleral depressor, and a condensing lens.
- Trial name
- NCT04292015
- Testing
- Optos ultra-widefield retinal imaging (Optos California)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust