Clinical trials: PreTerm Neonate
Chorioamnionitis
Selective Use of Antibiotics in Neonates Born to Mothers With Suspected Chorioamnionitis
Retrospective Chart Review to determine the selective use of antibiotics in neonates born to mothers with suspected chorioamnionitis
- Trial name
- Chorio (NCT03576560)
- Testing
- Retrospective Chart Review
- Where
- United States
- Volunteers
- 768 people
- Sponsor
- Pediatrix
Patent Ductus Arteriosus, Congenital Heart Disease
PDA for Kidneys Study
The goal of this observational study is to gather more information on kidney oxygen levels in babies with a patent ductus arteriosus (PDA), and evaluate the relationships between kidney oxygen levels, PDA status and kidney…
- Trial name
- PDA4K (NCT06658496)
- Testing
- Near Infrared Spectroscopy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Wisconsin, Madison
Chronic Lung Disease of Prematurity, Bronchopulmonary Dysplasia
Relationship Between EIT and Respiratory Status in Very Preterm Infants
Electrical Impedance Tomography (EIT) is a non-invasive imaging technique that can measure lung function in real time. This study will follow premature infants to see if EIT can help predict which infants will be successful in…
- Conditions
- Chronic Lung Disease of Prematurity, Bronchopulmonary Dysplasia, Premature Lungs
- Trial name
- NCT06609135
- Testing
- Sentec LuMon Device (EIT system), Sentec Digital Monitoring System (transcutaneous CO2 monitor)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Lawrence Rhein
Hyper Bilirubinemia, Premature Infant
Cycled Phototherapy
Cycled phototherapy (PT) is likely to increase survival over that with continuous PT among extremely premature infants (< 750 g BW or <27 weeks GA).
- Trial name
- NCT03927833
- Testing
- Phototherapy lights
- Where
- 19 sites in United States
- Volunteers
- 1,700 people
- Sponsor
- NICHD Neonatal Research Network
Hyaline Membrane Disease, Preterm Infant
Evaluation of the Neonatal Autonomic Stress During Intubations Under Propofol in a Population of Premature Infants Under 33 w'GA
Hyaline membrane disease is one of the leading causes of morbidity and mortality in premature newborns in industrialized countries.
- Trial name
- PROPOSURF (NCT03721640)
- Testing
- electrocardiogram
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Retinopathy of Prematurity, Mydriasis
The Effects of Mydriatic Eye Drops in Retinopathy of Prematurity Examinations
Retinopathy of prematurity (ROP) is a retinal disorder of preterm neonates and a potential cause of blindness. As early diagnosis and treatment preserve vision, very low birth weight infants must be screened for ROP.
- Conditions
- Retinopathy of Prematurity, Mydriasis, Neonatal Disease, Analgesic Adverse Reaction
- Trial name
- NCT05880433
- Testing
- NIRS(INVOS 5100; Covidien Somanetics, Troy, MI
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Istanbul Training and Research Hospital
Neonatal Respiratory Distress Related Conditions, Neonatal Respiratory Failure
Automated Versus Manual Control Of Oxygen For Preterm Infants On Continuous Positive Airway Pressure In Nigeria
One in ten babies are born preterm (<37 weeks gestation) globally. Complications of prematurity are the leading cause of death in children under 5 years, with the highest mortality rate in Sub-Saharan Africa (SSA).
- Conditions
- Neonatal Respiratory Distress Related Conditions, Neonatal Respiratory Failure, Prematurity, Oxygen Toxicity
- Trial name
- NCT05508308
- Testing
- OxyMate, Manual oxygen control
- Where
- 2 sites in Nigeria
- Volunteers
- 49 people
- Sponsor
- Murdoch Childrens Research Institute
Infant, Premature, Diseases
Study the Safety and Efficacy of Probiotics Use in Premature Infants
Prophylactic enteral probiotics may enhance clinical markers and biomarkers of preterm infants' health, and may also play a role in reducing NEC and associated morbidity.
- Trial name
- NCT01891604
- Testing
- breast milk with Bifidobacterium Longum subp. Infantis R0033, breast milk
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Manitoba
Premature; Infant, Light-for-dates, Enteral Feeding Intolerance
Exclusive Enteral Nutrition in Preterm Neonates
To test the hypothesis that early exclusive enteral nutrition with the minimal use of parenteral nutrition will improve preterm infants' nutritional outcomes when compared to delayed progression of enteral nutrition and prolonged…
- Trial name
- ENACT (NCT04337710)
- Testing
- Exclusive Enteral Nutrition, Progressive Enteral Nutrition
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Alabama at Birmingham
Malnutrition, Infant, Enteral Feeding Intolerance
Efficacy and Safety of Numeta G13%E Compared to Compounded Parenteral Nutrition in Preterm Neonates
Preterm (PT, born before 37 weeks of gestation) birth complications are the leading causes of death among children aged under 5 years globally, with nearly one million infant deaths reported in 2013.
- Trial name
- NCT06894446
- Testing
- Numeta G13%E, Compounded Parenteral Nutrition (cPN) solution
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Neonatal Intensive Care, Preterm
The Effect of Simulated Intrauterine Sound Applied to Preterms
Preterm infants lack intrauterine sounds suitable for their development as they are born early. In addition, they are exposed to many unfamiliar sounds for weeks or months in the neonatal intensive care unit (NICU) where their…
- Trial name
- NCT05806320
- Testing
- Intrauterine Sound Listening Group 1, Intrauterine Sound Listening Group 2
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Retinopathy of Prematurity, Myopia
Prematurity and Ophthalmological Changes
Ophthalmological differences in school-aged children with and without a history of retinopathy of prematurity
- Trial name
- NCT06452524
- Testing
- axial length (AU) and anterior chamber depth (ACD), optical coherence tomography (OCT)
- Where
- Turkey (Türkiye)
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Respiratory Distress Syndrome
Sustained Lung Inflation in the Delivery Room in Preterm Infants at High Risk of Respiratory Distress Syndrome
BACKGROUND. Sustained lung inflation (SLI) associated to an adequate PEEP may help the efficacy of the respiratory effort in lung of preterm infants at risk for respiratory distress syndrome (RDS) and reduce need of mechanical…
- Trial name
- SLIS (NCT01440868)
- Testing
- Sustained lung inflation
- Where
- Italy
- Volunteers
- 276 people
- Sponsor
- University of Florence
Neonatal Intensive Care
NeoSHARK: Anatomical Versus Round Facemasks for Breathing Support in Preterm and Term Newborn Infants
When babies can't breathe effectively, we can use a facemask to give them breaths and oxygen. There are various types of facemasks that can be used, including round and anatomical (triangular) masks, depending on the preference…
- Trial name
- NeoSHARK (NCT07524517)
- Testing
- Intervention: Anatomical facemask, Control: Round facemask
- Where
- Ireland
- Volunteers
- 50 people
- Sponsor
- University College Dublin
Respiratory Distress Syndrome
Trial To Assess The Safety And Tolerability Of Lucinactant For Inhalation In Preterm Neonates 26 to 28 Weeks PMA
This study is to evaluate the safety and tolerability of lucinactant for inhalation, administered as an aerosol in up to four escalating doses to preterm neonates 26 to 28 weeks gestational age who are receiving nCPAP for RDS…
- Trial name
- NCT02528318
- Testing
- Lucinactant for inhalation, nCPAP alone
- Where
- 20 sites in United States, Canada and 2 more
- Volunteers
- 48 people
- Sponsor
- Windtree Therapeutics
Respiratory Distress Syndrome of Newborn
Modified Intubation-surfactant-extubation (InSurE) Technique in Preterm Neonates With Respiratory Distress Syndrome
This study evaluates the less invasive surfactant administration (LISA) combined with synchronized nasal intermittent positive pressure ventilation (SNIPPV) technique in the treatment of respiratory distress syndrome (RDS) of…
- Trial name
- NCT03989960
- Testing
- LISA+SNIPPV, traditional InSurE
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Preterm, Small Gestational Age (SGA)
A National Multicenter Survey on Small Vulnerable Newborns
The goal of this nationwide multicenter observational study is to comprehensively investigate the severity of Small Vulnerable Newborns (SVN) issues across China and to propose further preventive and intervention measures.
- Trial name
- NCT07143825
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Hearing Loss, Mental Retardation
Postnatal HCMV Infection in Very Preterm Infants. Implications, Morbidity, Growth and Neurodevelopmental Outcomes.
The aim of this study is to investigate short and long term consequences from early postnatal HCMV infection transmitted via human milk in very preterm infants (birth weight < 1500 g or gestational age < 32 weeks).
- Conditions
- Hearing Loss, Mental Retardation, Microcephaly, Chorioretinitis
- Trial name
- NCT01151462
- Where
- Norway
- Sponsor
- Oslo University Hospital
Bronchopulmonary Dysplasia
Pilot Study of Topical Steroid for Prevention of Chronic Lung Disease in Extremely Premature Infants.
A Pilot study to evaluate the safety and the efficacy of endotracheal instillation of pulmonary surfactant, with or without topical steroid (Budesonide), as a prophylactic treatment for Bronchopulmonary Dysplasia (a form of…
- Trial name
- NCT01268215
- Testing
- Infasurf, Pulmicort
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- East Carolina University
Newborn Preterm
The Effect of Bed Head Height During Feeding With Orogastric Catheter on Neonatal Growth
Aim:The study was planned as a randomised controlled experimental study to determine the effect of bed head height applied during feeding with orogastric catheter on growth parameters and feeding tolerance of preterm newborns.
- Trial name
- NCT07079878
- Testing
- Group with Bed Head Height 30°, Group with Bed Head Height 45°
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Tarsus University
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