Clinical trials: Preterm Neonates
Transient Tachypnea of the Newborn
Inhaled Beta-2 Agonist Versus Epinephrine For Treatment of Transient Tachypnea of Newborn (TTN)
Inhaled Beta-2 Agonist Versus Epinephrine For Treatment of Transient Tachypnea of Newborn: Randomized controlled trial to assess:
- Trial name
- NCT05006235
- Testing
- Epinephrine Inhalation Solution, Salbutamol, Saline Inhalants
- Volunteers
- 135 people
- Sponsor
- Ahmed Noaman
Risky Baby, Premature Birth of Newborn
Synchronous vs. Asynchronous Telerehabilitation for High-Risk Infants
Premature birth, low birth weight, and a history of neonatal intensive care history are significant risk factors associated with long-term neurodevelopmental adverse outcomes in infants.
- Conditions
- Risky Baby, Premature Birth of Newborn, Motor Delay
- Trial name
- NCT07499843
- Testing
- Synchronous Telerehabilitation Group, Asynchronous Telerehabilitation Group
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Biruni University
Feeding; Difficult, Newborn
Source of Human Milk Fortifier and Intestinal Oxygenation in Preterm Infants <30 Weeks Gestation
Preterm infants require higher nutritional intakes during the neonatal phase than they do at any other stage of their development. Standard volumes of human milk alone do not offer sufficient nourishment to these infants.
- Trial name
- NCT06336668
- Testing
- Human milk-based HMF
- Volunteers
- 18 people
- Sponsor
- University of Calgary
Patent Ductus Arteriosus
Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI)
Very premature infants with a large ductus, selected by an early echocardiogram, will receive either ibuprofen or placebo before 12 hours of life.
- Trial name
- TRIOCAPI (NCT01630278)
- Testing
- Ibuprofen
- Where
- 11 sites in France
- Volunteers
- 363 people
- Sponsor
- Nantes University Hospital
Lymphedema, Premature Birth
Infant Massage for Lymphedema and Comfort in Preterm Newborns
This randomized controlled trial investigates the effectiveness of infant massage in reducing symptoms of immobilization-related lymphedema and improving comfort in preterm newborns hospitalized in the Neonatal Intensive Care…
- Conditions
- Lymphedema, Premature Birth, Edema, Immobilization
- Trial name
- NCT07418814
- Testing
- Infant Massage Group
- Volunteers
- 40 people
- Sponsor
- Erzurum Technical University
Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant
Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting
The purpose of this study is to analyze the gastric fluid aspirated from the stomachs of neonates receiving routine post-delivery care to predict the need for prolonged respiratory support (>6 hours of life).
- Conditions
- Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant, Transient Tachypnea of the Newborn, Meconium Aspiration Syndrome
- Trial name
- NCT07344714
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pain
Comparison of Two Methods in Pain Caused by Orogastric Tube Placement in Preterm Newborns
Aim : This study will be conducted to determine the effect of breast milk and knitted octopus in reducing pain caused by routine orogastric tube insertion in preterm newborns.
- Trial name
- NCT06438731
- Testing
- BREAST MILK, KNITTED OCTOPUS
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Pamukkale University
Respiratory Distress Syndrome, Newborn, Infant, Premature, Diseases
Airway Flow of RAM Cannula With BCPAP in Infants
The RAM Cannula interface is used as routine interface for newborn infants receiving CPAP treatment for respiratory distress. Compared to the standard systems that have been used for more than 50 years, the interface has high…
- Conditions
- Respiratory Distress Syndrome, Newborn, Infant, Premature, Diseases, Infant, Newborn, Diseases
- Trial name
- NCT06697912
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Retinopathy of Prematurity (ROP), Intraventricular Hemorrhage
Safety and Efficacy Outcomes Following Previously Administered Short-Term Treatment With SHP607 in Extremely Premature Infants
The purpose of this study is to evaluate long-term safety and efficacy outcomes following previously administered short-term exposure to SHP607, as compared to a standard neonatal care group.
- Conditions
- Retinopathy of Prematurity (ROP), Intraventricular Hemorrhage, Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity
- Trial name
- NCT04506619
- Testing
- No Intervention
- Where
- 8 sites in United States, Italy and 1 more
- Volunteers
- 26 people
- Sponsor
- Oak Hill Bio Ltd
Premature Birth
Neonatal Pulse Oximetry Sensor Study
To validate the SpO2 accuracy, bias, and precision of Medline's reprocessed pulse oximetry sensors as compared to SaO2 in arterial blood samples as assessed by CO-oximetry in neonates.
- Trial name
- NCT05250102
- Testing
- Pulse oximeter sensors
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Medline Industries
Formula Milk, Breast Milk Collection
Metabolomic Profile in Breastfed Late Preterm Infants
Exclusive breast milk is recommended from birth to 6 months of life to promote the development of a balanced intestinal microbiota.
- Conditions
- Formula Milk, Breast Milk Collection, Postbiotic Supplemented Formula Milk
- Trial name
- NCT06052592
- Testing
- Milk
- Where
- 2 sites in Italy
- Volunteers
- 54 people
- Sponsor
- Ospedale Buon Consiglio Fatebenefratelli
Premature Infant, Hypoxia
Measuring Oxygenation of Newborn Infants in Targeted Oxygen Ranges
The investigators aim to measure the effect of targeting premature babies to a slightly higher oxygen saturation target range (92-97%) than routinely used, for a brief period, to plan a future larger study of the effect of this…
- Conditions
- Premature Infant, Hypoxia, Hyperoxia
- Trial name
- MONITOR (NCT03360292)
- Testing
- Higher target range
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Preterm Birth Complication
Prediction of Adverse Outcome Using Fetal MRI in Pregnancies at Risk of Preterm Birth
1.4% of babies have a very premature birth (PTB) (less than 32 weeks of pregnancy). This can result in severe life-long complications including cerebral palsy, learning and behavioural difficulties and breathing problems.
- Trial name
- NCT05164432
- Testing
- MRI scan
- Where
- United Kingdom
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- King's College London
Retinopathy of Prematurity
Oral Propranolol Versus Placebo for Early Stages of Retinopathy of Prematurity: A Randomized and Prospective Study
In premature infants, propranolol (Prop) treatment might suppress continuing neo-vascularization (NV) and decelerate the progression of retinopathy of prematurity (ROP) towards its severe stages (III-V), thus avoiding the need of…
- Trial name
- NCT01238471
- Testing
- propranolol, sucrose 5%
- Where
- 4 sites in Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Adrenal Insufficiency
Relative Adrenal Insufficiency in Preterm Very Low Birth Weight Infants With Shock
The objective of this study is to estimate the prevalence of relative adrenal insufficiency in preterm very low birth weight infants with and without shock.
- Trial name
- NCT00974337
- Where
- India
- Volunteers
- 39 people
- Sponsor
- All India Institute of Medical Sciences
Bronchopulmonary Dysplasia (BPD)
Steroids and Surfactant in Extremely Low Gestation Age Infants Dose Escalation Trial
This is a phase I/II open-label study to determine the lowest, safe, effective dose of budesonide given with calfactant as the vehicle.
- Trial name
- SASSIE (NCT02907593)
- Testing
- Budesonide in Calfactant
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- Cynthia McEvoy
Infant, Newborn, Infant, Low Birth Weight
Early-Onset Sepsis Surveillance Study
In this observational study, the NICHD Neonatal Research Network (NRN) is conducting surveillance of all infants born at NRN centers to identify all newborns who are diagnosed with early-onset sepsis (EOS) and/or meningitis.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- EOS (NCT00874367)
- Where
- 19 sites in United States
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Prematurity, Nutrition
Nutritional Content of Breast Milk From Mothers of Premies
The purpose of this study is to determine the correlation, if any, between the nutritional content of breast milk pumped by the mothers of very low birth weight (VLBW) infants in the neonatal intensive care unit (NICU) and the…
- Trial name
- NCT01050192
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pediatrix
Retinopathy of Prematurity
Antiangiogenic Therapy With Bevacizumab in Retinopathy of Prematurity. Structural Outcome
Purpose:Retinopathy of prematurity (ROP) continues tobe a major cause of blindness in children. Although ablation of the retina with laser or cryotherapy reduces the incidence of blindness by suppressing the neovascular phase of…
- Trial name
- NCT00346814
- Testing
- intravitreal injection
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Neonatal Thrombocytopenia, Intraventricular Hemorrhage
PRedicting OutcomeS in Preterm nEonates With thromboCyTopenia
Preterm neonates often receive platelet transfusions when their platelet count is low to prevent bleeding. However, it is currently unclear which infants benefit from such transfusions.
- Conditions
- Neonatal Thrombocytopenia, Intraventricular Hemorrhage, Platelet Transfusion
- Trial name
- PROSPECT (NCT06043050)
- Testing
- Platelets
- Where
- 12 sites in Germany, Netherlands and 1 more
- Volunteers
- 1,042 people
- Sponsor
- Leiden University Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.