Clinical trials: Prophylaxis
Surgical Wound Infection
Duration of Postoperative Antibiotic Prophylaxis in Facial Fractures
Facial fractures make up a significant proportion of injuries in trauma patients. Treatment of these fractures often results in standard surgical interventions.
- Trial name
- NCT01583062
- Testing
- Amoxicillin/clavulanic acid
- Where
- Switzerland
- Volunteers
- 217 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Migraine
A Trial to Test if Fremanezumab is Effective in Preventing Migraine in Children and Adolescents
The primary objective of the study is to evaluate the long-term safety and tolerability of subcutaneous fremanezumab in the preventive treatment of migraine in pediatric participants 6 to 17 years of age (inclusive at enrollment…
- Trial name
- NCT04530110
- Testing
- Fremanezumab
- Where
- 70 sites in United States, Canada and 7 more
- Volunteers
- 499 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D LLC
COVID-19, SARS-CoV-2
Parent Study: Study Understanding Pre-Exposure pRophylaxis of NOvel Anitbodies (SUPERNOVA) Sub-study: Study Understanding Pre-Exposure pRophylaxis of NOvel Anitbodies (SUPERNOVA Sub-study)
AZD3152, a single mAb, is being developed to have broad neutralizing activity across known SARS-CoV-2 variants of concern for pre-exposure prophylaxis of COVID-19.
- Trial name
- SUPERNOVA (NCT05648110)
- Testing
- AZD5156 (Parent study Sentinel Safety Cohort), EVUSHELD™ (Parent study Main Cohort), AZD3152 (Parent study Main Cohort)
- Where
- 215 sites in United States, Australia and 16 more
- Volunteers
- 3,882 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Ventilator Associated Pneumonia
Role of Lactoferrin in Prevention of Ventilator Associated Pneumonia in Neonates.
The aim of the study is to 1. Evaluate the preventive value of Lactoferrin on VAP among ventilated neonates. 2. Evaluate the Primary outcome of Lactoferrin on: Sepsis, Feeding intolerance, Vomiting, Constipation or diarrhea 3.
- Trial name
- NCT07255742
- Testing
- Lactoferrin in prevention of VAP, Control
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Dalia Mohamed Salah
Suicidal Ideations, Suicidal Behaviors
Technology-assisted Methods to Advance Suicide Prevention Among Youth in Colombia
This study will investigate a multi-level approach that applies technology-assisted methods to reduce suicidal thoughts and behaviors (SIB) and promote mental health among Colombian youth: (a) digital platform for youth; (b)…
- Conditions
- Suicidal Ideations, Suicidal Behaviors, Depression, Anxiety, Well-being
- Trial name
- NCT06651554
- Testing
- Digital Platform Intervention
- Where
- Colombia
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Brown University
Diabetes
Preventing Hypoglycemia
The purpose of the project is to improve in-patient safety by lowering the risk of severe hypoglycemia (low blood sugar) for patients with diabetes on insulin therapy and to improve communication between healthcare providers.
- Trial name
- NCT01923688
- Testing
- Informatics Alert/Nurse/physician responders
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Head and Neck Cancers
Collection Of Tissue, Blood, and Other Specimens From Patients With Head and Neck Tumors To Study the Causes, Diagnosis, Prevention and Treatment of Cancers
This is a protocol to collect tissues, blood, and other specimens from patients with malignant or nonmalignant diseases of the head and neck.
- Trial name
- NCT00580203
- Where
- United States
- Volunteers
- 1,468 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
5 Year Old Children Born Prematurely
Early Detection of Developmental Abnormalities of Preterm Infants at 5 Years of Age
The project is a national, prospective, multicenter, interventional pilot project focused on the follow up of 5 year old children that were born prematurely.
- Trial name
- NCT07391527
- Testing
- Pediatric check-up
- Where
- 4 sites in Czechia
- Volunteers
- 210 people
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
Pre-Exposure Prophylaxis, HIV Infections
PrEPARE: PrEP in Pregnancy, Accelerating Reach and Efficiency
This study tests strategies for improving PrEP implementation in maternal and child health clinics using a difference-in-difference approach.
- Conditions
- Pre-Exposure Prophylaxis, HIV Infections, Pregnancy Related
- Trial name
- NCT04712994
- Testing
- PrEP Optimization Interventions
- Where
- 8 sites in Kenya
- Volunteers
- 1,958 people, healthy volunteers welcome
- Sponsor
- University of Washington
SARS-CoV-2, COVID-19
eVusheld Assessment reaL wORld Effectiveness in Israel Clalit Health Services
An AstraZeneca-sponsored observational, electronic healthcare record (EHR)-embedded retrospective cohort study to assess the real-world effectiveness of EVUSHELD against SARS-CoV-2 infection, COVID-19-related hospitalization, and…
- Trial name
- VALOR C19 IL (NCT05712096)
- Testing
- EVUSHELD
- Where
- Israel
- Volunteers
- 4,000 people
- Sponsor
- AstraZeneca
HIV CDC Category A1
A Community-based Implementation Model for HIV Prevention and Testing in Malawi
This implementation study is testing whether community members can use a 3-step model (prepare, roll-out and sustain) to implement an efficacious peer group HIV prevention intervention with fidelity and effectiveness in a single…
- Trial name
- NCT02765659
- Testing
- Mzake ndi Mzake T1, Mzake ndi Mzake T2, Mzake ndi Mzake T3
- Where
- Malawi
- Volunteers
- 1,353 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Knowledge, Attitudes, Practice, Post-exposure Prophylaxis
Comic Intervention for Sexual Violence Prevention and Post-rape Care
In humanitarian settings, sexual and gender-based violence disproportionately impacts women and children. However, there continues to be a lack of evidence regarding both sexual violence prevention and post-rape care…
- Trial name
- NCT04656522
- Testing
- Participatory Comic Intervention
- Where
- 2 sites in Canada, Uganda
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Prediabetes, Type 1 Diabetes
Diabetes Prevention - Immune Tolerance
A double-blind, randomized investigator-initiated study to determine the safety and the effect of Diamyd® on the progression to type 1 diabetes in children with multiple islet cell autoantibodies Eligible children are 4 years or…
- Trial name
- DIAPREV-IT (NCT01122446)
- Testing
- Diamyd
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Lund University
Neoplasms
Implementation of a Program Based on Adapted Physical Activity and Recommendations for Second Cancers Prevention for TYACs
About 700 new cases of cancer are recorded each year among TYAC aged 15 to 25 years old in Rhône-Alpes region (France); more than 200 are treated and supported within the TYAC Department of the Institute of Hematology and…
- Trial name
- PREVAPAJA (NCT03336905)
- Testing
- Physical activity program and prevention after cancer
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Leon Berard
Hiv, Adolescent Behavior
A Pragmatic Trial of An Adaptive eHealth HIV Prevention Program for Diverse Adolescent MSM
This pragmatic trial of an HIV prevention program focuses on HIV risk-reduction in men who have sex with men (MSM) ages 13-18. The design is a three-tiered, internet-based HIV prevention intervention series that uses a sequential…
- Conditions
- Hiv, Adolescent Behavior, Sex, Safe
- Trial name
- SMART (NCT03511131)
- Testing
- Queer Sex Ed, Keep It Up, Keep It Up-Control
- Where
- United States
- Volunteers
- 1,306 people, healthy volunteers welcome
- Sponsor
- Northwestern University
HIV, Sexually Transmitted Diseases
HIV/STI Prevention for Adolescents With Substance Use Disorders in Treatment
Adolescents with substance use disorders (SUD) are at substantial risk for contracting HIV/STIs compared to their counterparts without SUD, yet few HIV/STI sexual risk reduction interventions have been developed to meet their…
- Trial name
- STYLEnS (NCT01383837)
- Testing
- STYLEnS, Health Promotion
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- New York State Psychiatric Institute
Problematic Behavior in Children
Prevention and Intervention of Externalizing Problem Behavior in School: Development and Evaluation of a Teacher Coaching.
Children with externalizing problem behaviour are at risk of developing educational impairment, because of their problems in rule following, social behaviour and attention. This behaviour represents a great challenge for teacher.
- Trial name
- NCT02116088
- Testing
- Teacher Coaching
- Where
- Germany
- Volunteers
- 53 people
- Sponsor
- University of Cologne
Respiratory Infections, Gastrointestinal Diseases
A Randomized Controlled Trial of a School Disinfection and Hand Hygiene Program
The objective of the trial is to assess the impact of a disinfection and hand hygiene program on absenteeism in elementary school classrooms.
- Trial name
- NCT00514670
- Testing
- Alcohol-based hand sanitizer & quaternary ammonium wipes
- Where
- United States
- Volunteers
- 285 people
- Sponsor
- Boston Children's Hospital
Bronchopulmonary Dysplasia, Premature
Autologous Cord Blood Mononuclear Cells for Bronchopulmonary Dysplasia in Very Preterm Neonates
Rationale: Pre-clinical animal studies provide robust evidence regarding the beneficial effect of cord blood-derived mononuclear cells (MNCs) for experimental bronchopulmonary dysplasia (BPD).
- Conditions
- Bronchopulmonary Dysplasia, Premature, Neonatal Death
- Trial name
- NCT02999373
- Testing
- Autologous Umbilical Cord Blood Mononuclear Cells Therapy
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Guangdong Women and Children Hospital
Obesity
Family Exergaming: A Research Study Testing a Videogame Intervention to Increase Physical Activity for Families
The purpose of this study is to determine if an interactive game (Dance Dance Revolution/DDR) can promote healthy physical activity for the health of all family members
- Trial name
- NCT00889122
- Testing
- Exergame (DDR)
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- MaineHealth
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