Clinical trials: Pulmonary Atelectasis
Shock, Preterm Birth Complication
Early Hydrocortisone Versus Regular Treatment in Shock in Extremely Preterm Neonates - an Open Randomized Controlled Trial
The goal of this clinical trial is to determine the effectiveness of early use of hydrocortisone (since the diagnosis of shock) for its resolution within the first 72 hours in premature infants under 1,500 g.
- Conditions
- Shock, Preterm Birth Complication, Preterm Intraventricular Hemorrhage, Asphyxia Perinatal
- Trial name
- NCT07248761
- Testing
- Intravascular Hydrocortisone (stress dosage): 1 mg/k/dose each 8 hours for 5 days, Vasoactive drug therapies
- Where
- Mexico
- Volunteers
- 76 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Atelectasis, Pulmonary Infection
Bi-PAP vs Sham Bi-PAP on Pulmonary Function in Morbidly Obese Patients After Bariatric Surgery
The effect of biphasic positive airway pressure (Bi-PAP) at individualized pressures on the postoperative pulmonary recovery of morbidly obese patients (MOP) undergoing open bariatric surgery (OBS) and possible placebo…
- Conditions
- Atelectasis, Pulmonary Infection, Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Disease
- Trial name
- NCT03438383
- Testing
- Bi-PAP
- Volunteers
- 48 people
- Sponsor
- Evangelismos Hospital
Anesthesia
Evaluation of Atelectasis Formation With Electrical Impedance Tomography During Anesthesia for MRI in Children
This study investigates under controlled conditions the variation of poorly ventilated lung units (silent spaces) in children between 1 and 6 years of age measured by electrical impedance tomography during intravenous anaesthesia…
- Trial name
- ATLANTIS (NCT04507581)
- Testing
- electrical impedance tomography during anaesthesia
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Respiratory Distress of Newborn
Feasibility of Using the Neovent in Low-Resource Settings
Breathing problems are a leading cause of newborn death/sickness worldwide but most of deaths are in low resources areas. Over 99% of newborn death is in countries with limited healthcare resources like Nigeria and Nepal.
- Trial name
- Neovent (NCT06697951)
- Testing
- bilevel ventilation with the Neovent
- Where
- 2 sites in Nepal, Nigeria
- Volunteers
- 70 people
- Sponsor
- Tina Slusher
Atelectasis, Atelectasis, Postoperative Pulmonary
Pediatric Bronchoscopy and LUS
Rigid bronchoscopy is commonly used for diagnosing and treating lung and airway diseases, including foreign body removal. Patients often experience atelectasis post-procedure, which lung ultrasound (LUS) can effectively detect.
- Trial name
- NCT06658613
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Pregnancy Complications, Atelectasis
Effect of Epidural Analgesia on Regional Lung Ventilation in Parturient Women as Assessed by Thoracic Impedance
The goal of this observational study is to learn more about the effect of obstetric epidural anesthesia on regional lung ventilation in healthy parturient women.
- Trial name
- NCT06195774
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Erasme University Hospital
Surfactant Deficiency Syndrome Neonatal
deMISTify: The Impact of Ventilator Pressure Levels During Minimally Invasive Surfactant Therapy on Lung Aeration in Preterm Infants
Infants born preterm (before 36 weeks' gestation age) have immature lungs and struggle to breathe on their own. They are supported via respiratory machines like ventilators, as well as pharmaceutical aids like surfactant…
- Trial name
- deMISTify (NCT07522346)
- Testing
- Lung Recruitment Manoeuvre prior to Minimally Invasive Surfactant Therapy, Control (Minimally Invasive Surfactant Therapy)
- Where
- Australia
- Volunteers
- 36 people
- Sponsor
- Murdoch Childrens Research Institute
Respiratory Distress Syndrome (Neonatal), Surfactant Deficiency Syndrome Neonatal
Video vs. Direct Laryngoscopy for Less Invasive Surfactant Administration
Many preterm babies born between 22-28+6 weeks' estimated gestational age (EGA) need surfactant, a medicine that helps the lungs.
- Trial name
- VID LISA (NCT07426016)
- Testing
- Video Laryngoscopy, Direct Laryngoscopy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Texas Southwestern Medical Center
Anesthesia Induced Atelectasis
Evaluation of the Effect of Lung Recruitment and Positive End- Expiratory Pressure (PEEP) on Anesthesia Induced Atelectasis Using Lung Ultrasound
Atelectasis is a side effect of general anesthesia which can be found in all types of interventions and patients of all ages.1-3 The reported incidence of anesthesia- induced atelectasis in children varies, ranging from 12 to 42%…
- Trial name
- NCT03069157
- Testing
- lung recruitment maneuver
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Pulmonary Atelectasis
Fraction of Inspired Oxygen and Atelectasis in Children
Investigators hypothesized that maintaining low fraction of inspired oxygen would be beneficial to prevent anesthesia-induced atelectasis in mechanically ventilated children undergoing general anesthesia.
- Trial name
- NCT02870842
- Testing
- Lung ultrasound, Respiratory management
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Seoul National University Hospital
Postoperative Pulmonary Atelectasis
Evaluation of Perioperative Lung Ultrasound Scores in Laparoscopic Pediatric Surgeries
Laparoscopic surgeries require carbon-dioxide into the abdomen which may occasionally lead to atelectasis. The extent of this atelectasis is not well documented in peri-operative period although it has been extensively researched…
- Trial name
- NCT06072885
- Testing
- Lung Ultrasound Scoring
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Pulmonary Atelectasis, Postoperative, Atelectasis, Compression
Postoperative Atelectasis in Pediatric Patients With Prone Position
This study evaluates the incidence of postoperative atelectasis after general anesthesia with prone position using lung ultrasound in children age < 3 years.
- Trial name
- NCT03486847
- Testing
- Repetitive recruitment with PEEP, One recruitment with PEEP
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Seoul National University Hospital
Pediatric Lung Atelectasis
Effectiveness of Ultrasound-guided Lung Ventilation in Determining the Optimum Inspiratory Pressure in Pediatric Patients
This study aimed to show the Effectiveness of Ultrasound-guided Lung Ventilation to determine the appropriate level of inspiratory pressure sufficient to provide adequate pulmonary ventilation with the resolution of the…
- Trial name
- NCT06188169
- Testing
- Increasing the inspiratory pressure if atelectasis detected by US
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Infant Respiratory Distress Syndrome, Acute Bronchiolitis
Continuous Regional Analysis Device for Neonate Lung
The purpose of the study is to assess whether Electrical Impedance Tomography (EIT) has the potential to optimize the ventilator therapy, validate the effectiveness, efficacy and safety of nursing and medical interventions…
- Conditions
- Infant Respiratory Distress Syndrome, Acute Bronchiolitis, Acute Respiratory Distress Syndrome
- Trial name
- CRADL (NCT02962505)
- Where
- 4 sites in Cyprus, Finland and 1 more
- Volunteers
- 200 people
- Sponsor
- University Hospital Schleswig-Holstein
Pre-Term, Respiratory Distress of Newborn
Predictive Value of Lung Ultrasound for Respiratory Decompensation in Late Preterm Neonates
Respiratory morbidity presents a significant clinical challenge in the neonatal period, and an individual patient's clinical course is often difficult to predict.
- Conditions
- Pre-Term, Respiratory Distress of Newborn, Premature
- Trial name
- NCT07216053
- Testing
- Point of care lung ultrasound
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Hackensack Meridian Health
Respiratory Distress Syndrome (Neonatal), Intubation Complication
InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS
The purpose of this clinical study is to determine the effectiveness and safety of Infasurf® administered through the InfasurfAero™, a novel oral airway delivery device specifically designed to give Infasurf in a less complicated…
- Conditions
- Respiratory Distress Syndrome (Neonatal), Intubation Complication, Death; Neonatal
- Trial name
- Aero-05 (NCT05960929)
- Testing
- Infasurf Aero™
- Where
- 10 sites in United States
- Volunteers
- 220 people
- Sponsor
- ONY
Respiratory Distress of Newborn
Comparison of Continuous Positive Airway Pressure and Non Invasive Positive Pressure Ventilation
The objective of the study is to compare the effectiveness of treatment with Non Invasive Positive Pressure Ventilation (NIPPV) and continuous positive airway pressure (CPAP) in decreasing the requirement for endotracheal…
- Trial name
- NCT03347136
- Testing
- CPAP, NIPPV
- Where
- Sri Lanka
- Volunteers
- 80 people
- Sponsor
- Ministry of Health, Sri Lanka
Respiratory Distress Syndrome, Newborn
Intrapulmonary Percussive Ventilation (IPV) Versus Nasal Continuous Positive Airway Pressure Ventilation (nCPAP) in Transient Respiratory Distress of the Newborn
During caesarean section, transient respiratory distress which occurs frequently (3%) with possible complications are at present managed by non invasive nasal continuous positive airway pressure ventilation (nCPAP) associated…
- Trial name
- HFPV (NCT00556738)
- Testing
- Nasal Continuous Positive Airway Pressure ventilation, Intrapulmonary Percussive Ventilation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Infants Aged 0 Days to 13 Months Scheduled for Elective Surgery
Effect of Pressure Support Ventilation During Anesthetic Emergence on Postoperative Atelectasis in Infant
Atelectasis occurs in patients of all ages who receive mechanical ventilation under general anesthesia, and although fatal cases are rare, it is known as a cause of postoperative hypoxia or fever.
- Trial name
- NCT05373589
- Testing
- conventional ventilation, group C, pressure support, group PS
- Where
- South Korea
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Neonatal Respiratory Distress
The Association Between LPCAT1 Genetic Polymorphism and Stress Biomarkers in Neonatal Respiratory Distress Syndrome
Aims of the Research Primary: 1. Measure the levels of stress biomarkers in full and preterm neonates with normal and complicated pregnancies and to study the influence of delivery mode on their cord blood concentrations. 2.
- Trial name
- NCT04947215
- Testing
- stress biomarkers
- Where
- 2 sites in Egypt
- Volunteers
- 160 people
- Sponsor
- Assiut University