Clinical trials: Randomised Controlled Trial
Adult
Communicating Evidence From Systematic Reviews to the Public
The purpose of this randomised controlled trial is to compare a new standardised summary format for presentation of synthesised evidence from systematic reviews for the public (a new plain language summary format) to the current…
- Trial name
- PLSRCT (NCT01939925)
- Testing
- New plain language summary format, Current plain language summary format
- Where
- 5 sites in Argentina, Canada and 3 more
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Norwegian Knowledge Centre for the Health Services
Prematurity
Automatic Oxygen Control for Reducing Extremes of Oxygen Saturation (AreOS): A Randomised Control Trial
Oxygen treatment is common in babies born early (preterm) and requiring intensive care. Having too much or too little oxygen can increase the risk of damage to the eyes and lungs, and contribute to death or disability.
- Trial name
- AreOS (NCT04223258)
- Testing
- Automatic Oxygen control, Manual Oxygen Control
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Schizophrenia, Prodrome
Indicated Prevention With Omega-3 Fatty Acids in Adolescents With 'At-Risk-Mental-State' for Psychosis
Early intervention in psychosis might be associated with better outcomes. However, intervention in the pre-psychotic phase has been questioned as, using current criteria, only 20-50% of individuals classified as prodromal develop…
- Trial name
- NCT00396643
- Testing
- Omega 3 fatty acids
- Where
- Austria
- Volunteers
- 81 people
- Sponsor
- Medical University of Vienna
Dengue, Zika Virus Infection
Applying Wolbachia to Eliminate Dengue
This cluster randomised trial will evaluate the efficacy of Wolbachia-infected Aedes aegytpi mosquitoes in reducing dengue cases in Yogyakarta City, Indonesia
- Conditions
- Dengue, Zika Virus Infection, Chikungunya Fever
- Trial name
- AWED (NCT03055585)
- Testing
- Wolbachia-infected Aedes aegypti mosquitoes, standard practice dengue control
- Where
- Indonesia
- Volunteers
- 8,173 people
- Sponsor
- Gadjah Mada University
Total Abdominal Hysterectomy
Are Sutures Required in Total Abdominal Hysterectomy? A Randomised Control Trial
The Hypothesis of this study is that performing total abdominal hysterectomy using the newer electrocoagulation forceps, specifically, the gyrus open seal forceps, curved, compared to the traditional clamp \& suture technique…
- Trial name
- NCT00484835
- Testing
- Performing abdominal hysterectomy using gyrus electrocoagulation forceps
- Where
- 3 sites in Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Southern Health
Tuberculosis Infection, Tuberculosis
BCG Revaccination in Children and Adolescents
Bacille Calmette Guerin (BCG) vaccine is one of the most used vaccines of the world, to reduce the risks of natural tuberculous infection.
- Trial name
- BRiC (NCT05330884)
- Testing
- BCG vaccine, Oral Chemoprophylaxis
- Where
- India
- Volunteers
- 9,200 people, healthy volunteers welcome
- Sponsor
- Tuberculosis Research Centre, India
Early Childhood Caries (ECC)
Aesthetic and Functional Evaluation of a Universal One-Shade Composite in Primary Maxillary Incisors
Use of tooth-coloured fillings is an essential part of Pediatric dentistry as most patients desire fillings which look like natural teeth.
- Trial name
- NCT07716033
- Testing
- Tokuyama Palfique Omnichroma composite restoration, 3M Filtek Z350 composite restoration
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Goa Dental College
Human Immunodeficiency Virus, HIV
Europe-Africa Research Network for Evaluation of Second-line Therapy
The trial aim is to ascertain what, if anything, needs to be combined with a boosted protease inhibitor (bPI) backbone in second-line therapy in order to maximize the chance of a good clinical outcome following WHO-defined…
- Trial name
- EARNEST (NCT00988039)
- Testing
- Aluvia + 2NRTIs, Aluvia + raltegravir, Aluvia monotherapy
- Where
- 14 sites in Kenya, Malawi and 3 more
- Volunteers
- 1,277 people
- Sponsor
- Justine Boles
Peritoneal Inflammation
Humidification in Laparoscopic Colonic Surgery
Laparoscopic surgery allows surgeons to remove bowel via small incisions. To allow insertion of a camera and instruments, cold and dry gas is blown into the abdominal cavity.
- Trial name
- NCT00642005
- Testing
- Fisher and Paykel Humidifier (MR860), Standard insufflation
- Where
- 3 sites in New Zealand
- Volunteers
- 82 people
- Sponsor
- University of Auckland, New Zealand
Obesity
Effects of Group Vs. Home-Based Combined Exercise-Diet Program In Childhood Obesity: A Randomised Controlled Trial
The aim of this study was to compare the effect of a hospital group-based vs. home-based combined exercise-diet program for the treatment of childhood obesity.
- Trial name
- NCT01503281
- Testing
- Circuit training
- Where
- Spain
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Allergic Rhinitis, Allergic Rhinoconjunctivitis
Specific Immunotherapy With Mannan-Conjugated Allergoids for HDM-Allergic Rhinitis/Rhinoconjunctivitis_MM09-SIT-063.
The goal of this clinical trial is to learn whether EP-088_MM09 works to treat house dust mite allergy. It will also assess the treatment's safety.
- Conditions
- Allergic Rhinitis, Allergic Rhinoconjunctivitis, Allergic Asthma
- Trial name
- NCT07904195
- Testing
- EP-088_MM09
- Where
- 16 sites in Portugal, Spain
- Volunteers
- 250 people
- Sponsor
- Inmunotek S.L.
Uncomplicated Acute Appendicitis in Children
Early vs Conventional Enteral Nutrition After Uncomplicated Paediatric Open Appendectomy
This clinical trial is conducted to see if after surgery of appendix(open appendectomy) in children giving oral nutrition within 6hours of surgery instead of older method of starting oral nutrition after 24hours of surgery…
- Trial name
- NCT07016919
- Testing
- early enteral nutrition, Conventional enteral nutrition
- Where
- Pakistan
- Volunteers
- 88 people
- Sponsor
- Shaikh Zayed Hospital, Lahore
Giant Cell Arteritis, Takayasu Arteritis
Biologics in Refractory Vasculitis: A Trial of Biologic Therapy for Refractory Primary Non-ANCA Associated Vasculitis
Vasculitis occur when the body's immune system, rather than protecting the body, attacks blood vessels, causing injury to the vessel and the part of the body it supplies with blood.
- Conditions
- Giant Cell Arteritis, Takayasu Arteritis, Cogan Syndrome, Relapsing Polychondritis
- Trial name
- BIOVAS (NCT05168475)
- Testing
- Rituximab, Infliximab, Tocilizumab
- Where
- 5 sites in United Kingdom
- Volunteers
- 22 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Eczema, Asthma
The PEBBLES Study - Testing a Strategy for Preventing Eczema and Food Allergy in High Risk Infants
This is a phase III, single blind (outcome assessor is blinded), randomised controlled multicentre trial of the effect of EpiCeram emollient for improving and maintaining skin barrier function and reducing incidence of eczema and…
- Conditions
- Eczema, Asthma, Allergy;Food
- Trial name
- PEBBLES (NCT03667651)
- Testing
- EpiCeram
- Where
- 4 sites in Australia
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Diabetes, Diabetes Mellitus, Type 2
A Trial Investigating the Efficacy and Safety of Insulin Detemir Versus Insulin NPH in Combination With Metformin and Diet/Exercise in Children and Adolescents With Type 2 Diabetes Insufficiently Controlled on Metformin With or Without Other Oral Antidiabetic Drug(s) With or Without Basal Insulin
This trial is conducted globally. The aim of the trial is to investigate the efficacy and safety of insulin detemir versus insulin Neutral Protamine Hagedorn (NPH) in combination with the maximum tolerated dose of metformin and…
- Trial name
- iDEAt2 (NCT02131272)
- Testing
- Insulin detemir, Insulin NPH, Diet/exercise
- Where
- 82 sites in United States, Argentina and 22 more
- Volunteers
- 42 people
- Sponsor
- Novo Nordisk A/S
Physical Violence, Educational Achievement
Good Schools Study
The purpose of this study is to determine whether use of the Good Schools Toolkit is effective in reducing violence against children in primary schools.
- Conditions
- Physical Violence, Educational Achievement, Mental Health, Sexual Violence
- Trial name
- GSS (NCT01678846)
- Testing
- Good School Toolkit
- Where
- Uganda
- Volunteers
- 3,820 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Tobacco Prevention
Effectiveness of an Online Quiz in Promoting Tobacco-Related Knowledge, Attitudes, and Behaviours Among Primary Students
The goal of this modified pilot RCT is to evaluate the effects of the intervention (online platform) on tobacco-related knowledge, attitudes and intentions on smoking among local primary 5-6 school students.
- Trial name
- NCT06913166
- Testing
- Online quiz competition
- Where
- Hong Kong
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dietary Deficiency
Fish Consumption and Dietary Diversity in Timor-Leste
A one-year, cluster-randomized, partially masked, controlled trial to test and compare the effects of fish aggregating devices and social and behaviour change communication on the frequency and volume of household fish…
- Trial name
- NCT04729829
- Testing
- Social and behaviour change communication, Fish aggregating device
- Where
- Timor-Leste
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- WorldFish
Necrotizing Enterocolitis
Primary Anastomosis Versus Enterostomy in the Surgical Treatment of Necrotising Enterocolitis
Necrotizing enterocolitis (NEC) is a devastating disease that affects the intestine of premature infants and is the most common surgical emergency in newborns.
- Trial name
- NCT04912453
- Testing
- Primary anastomosis, Enterostomy
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Resilience, Well-being
Efficacy of Mountain Craft Training at Enhancing the Resilience and Physio-psychological Well-being of Children From Low-income Families
It is imperative to offer adequate community resources and psychosocial support, with a particular focus on enhancing resilience for children from low-income families.
- Conditions
- Resilience, Well-being, Children
- Trial name
- NCT06286787
- Testing
- Intervention
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
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