Clinical trials: Randomised Controlled Trial
Endotracheal Extubation
Endotracheal Extubation With Suctioning Versus Positive Pressure in Children After General Anaesthesia.
Comparing extubation of endotracheal tube in children after general anaesthesia by applying suctioning to the endotracheal tube versus applying positive pressure to the endotracheal tube.
- Trial name
- NCT05489809
- Testing
- Endotracheal extubation with suctioning, Endotracheal extubation with positive pressure
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Pakistan Navy Station Shifa Hospital
Forearm Fracture
Biodegradable Versus Titanium Nailing in Forearm Shaft Fractures in Children
There are disadvantages in Elastic Stable Intramedullary Nailing (ESIN) of forearm shaft fractures, such as soft tissue irritation and the need of implant removal.
- Trial name
- NCT03474900
- Testing
- PLGA implant, Bioretec ltd. Finland, Titanium elastic stable nail
- Where
- Finland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Jaakko Sinikumpu
Pain
Epidural Morphine Following Vaginal Delivery
The investigators believe that pain management following a vaginal delivery can be improved. Many women receive epidural medication during labor and delivery, and the investigators felt that using the epidural following delivery…
- Trial name
- NCT00803114
- Testing
- Preservative-free epidural morphine
- Where
- Canada
- Volunteers
- 228 people
- Sponsor
- Mount Sinai Hospital, Canada
Infant Sleep Problems, Circadian Rhythm
Chrononutrition in Preterm Infants: a Randomised Controlled Trial of Time-matched Breast Milk Feeding and Its Effects on Sleep and Circadian Development
This study investigates whether the timing of feeding expressed breast milk influences infant sleep and circadian (day-night) development in preterm infants.
- Conditions
- Infant Sleep Problems, Circadian Rhythm, Neurodevelopment
- Trial name
- NCT07533578
- Testing
- Chronobiologically Timed Feeding of Expressed Breast Milk, Usual Feeding Practice (Untimed Expressed Breast Milk)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Luzerner Kantonsspital
HIV Infections
Safety and Efficacy of Reduced Versus Standard Dose Efavirenz (EFV) Plus Two Nucleotides in Antiretroviral-naïve Adults.
Clinical data suggests that the standard dose of the anti-HIV medication, efavirenz (EFV), could be reduced without compromising its effectiveness.
- Trial name
- ENCORE1 (NCT01011413)
- Testing
- Efavirenz 600mg, Efavirenz 400mg
- Where
- Australia
- Volunteers
- 636 people
- Sponsor
- Kirby Institute
Arterial Puncture
Ultrasound Guided Arterial Puncture
The main purpose of the study is to evaluate whether the routine use of ultrasound guided arterial puncture can increase the proportion of patients who only needs one puncture attempt in order to successfully extract enough blood…
- Trial name
- NCT01660724
- Testing
- Ultrasound guided arterial puncture, Conventional arterial puncture technique
- Where
- Denmark
- Volunteers
- 238 people
- Sponsor
- Odense University Hospital
Virtual Reality, Anxiety
Effect of VR and Music on Fetal Well-Being and Anxiety During Nonstress Test
Music and virtual reality (VR) have been utilized in the medical field and are known to reduce anxiety and stress. However, a limited number of studies have investigated the effects of music and VR on women undergoing non-stress…
- Conditions
- Virtual Reality, Anxiety, Pregnancy, Randomised Controlled Trial
- Trial name
- NCT07082790
- Testing
- Music intervention, Virtual Reality Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bilecik Seyh Edebali Universitesi
Attention-Deficit/Hyperactivity Disorder
Social VR Based Intervention on Enhancing Social Interaction Skills in Children With AD/HD
The study targets children with diagnosed ADHD and aims to (1) develop a social virtual reality based (SocVR) intervention and (2) investigate its effects on improving the social skills and executive functioning of inhibitions…
- Trial name
- NCT05568446
- Testing
- Social virtual reality, Traditional social skills
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Anxiety, Anxiety Disorders
A Single-session Growth Mindset Intervention for Children and Young People With Mental Health Difficulties
The present study aims to evaluate whether an online, self-administered, single session intervention (SSI) increases children and adolescents' perceptions of control over external threats and their emotional experience and…
- Conditions
- Anxiety, Anxiety Disorders, Depression, Low Mood
- Trial name
- NCT04652362
- Testing
- Growth Mindset Online Single-Session Intervention, Supportive Therapy Online Single-Session Intervention (Control)
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Royal Holloway University
Healthy Participants
Educational VR Game Intervention to Enhance Hygiene Practices in Primary School Children
The goal of this observational study is to investigate if VR game-based educational intervention can enhance primary schoolchildren's compliance with hygiene practices to prevent the transmission of SARS-CoV-2 and other upper…
- Trial name
- NCT07168759
- Testing
- VR game -based education program
- Where
- China
- Volunteers
- 2,160 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Responses to Infant Immunisations
A Trial Comparing Two Pertussis-containing Vaccines in Pregnancy and Vaccine Responses in UK Mothers and Their Infants
Due to an unexpectedly high number of infant deaths from whooping cough in 2012, the Department of Health acted to protect newborns between birth and completion of primary immunisations, the period with greatest risk of disease.
- Trial name
- iMAP2 (NCT02145624)
- Testing
- Repevax, Boostrix-IPV
- Where
- 3 sites in United Kingdom
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Public Health England
Pneumonia
Amoxicillin Versus Benzyl Penicillin for Treatment of Children Hospitalised With Severe Pneumonia
This study seeks to determine whether clinical outcome following initial treatment of severe pneumonia with oral amoxicillin is as effective as the current standard benzyl penicillin.
- Trial name
- NCT01399723
- Testing
- Amoxicillin, Benzyl penicillin
- Where
- 6 sites in Kenya
- Volunteers
- 561 people
- Sponsor
- KEMRI-Wellcome Trust Collaborative Research Program
Early Childhood Caries (ECC)
Aesthetic and Functional Evaluation of a Universal One-Shade Composite in Primary Maxillary Incisors
Use of tooth-coloured fillings is an essential part of Pediatric dentistry as most patients desire fillings which look like natural teeth.
- Trial name
- NCT07716033
- Testing
- Tokuyama Palfique Omnichroma composite restoration, 3M Filtek Z350 composite restoration
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Goa Dental College
Pes Planus
Orthotics for Treatment of Symptomatic Flat Feet in Children
Update 13.12.2021 To mitigate the effects the COVID-19 pandemic, and due to difficulties in sites setting up the custom orthoses arm of the protocol an amendment was approved to change the design of the study from a 3 to a 2 arm…
- Trial name
- OSTRICH (NCT04104555)
- Testing
- Birthday card, Prefabricated orthoses, Signposting to multimedia
- Where
- 16 sites in United Kingdom
- Volunteers
- 134 people
- Sponsor
- University of York
Early Childhood Caries (ECC), Dental Caries
Effect Of Three Remineralizing Agents On Early Childhood Caries
Early Childhood Caries (ECC) remains a global public health concern, necessitating minimally invasive, fluoride-based alternatives to conventional restorative therapy.
- Trial name
- SDF (NCT07371117)
- Testing
- Silver Diamine Fluoride (SDF, 38%), Sodium Fluoride with CPP-ACP, Acidulated phospahate fluoride gel 1.23%
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- University of Jazan
Scabies
Ivermectin Safety in Small Children
This trial will evaluate the safety, pharmacokinetics, and efficacy of ivermectin in scabies infected children weighing 5 to less than 15kg.
- Trial name
- ISSC (NCT04332068)
- Testing
- Oral ivermectin, Permethrin Cream
- Where
- 3 sites in Brazil, Kenya and 1 more
- Volunteers
- 240 people
- Sponsor
- University of Oxford
Depression in Adolescence, Depressive Disorder
Clinical Effectiveness of TARA Compared to Standard Treatment for Adolescents and Young Adults With Depression
Depressive Disorders constitute an increasing global health concern and available treatments for young people have not been sufficiently effective in haltering this trend.
- Conditions
- Depression in Adolescence, Depressive Disorder, Dysthymia and Chronic Depression
- Trial name
- TARA (NCT04747340)
- Testing
- Training for Awareness Resilience and Action (TARA), Standard treatment
- Where
- 3 sites in Sweden
- Volunteers
- 136 people
- Sponsor
- Umeå University
Allergic Rhinitis Due to Dust Mite
Safety and Efficacy Study of Sublingual Immunotherapy (SLIT) to Treat House Dust Mite Allergic Rhinitis in Adolescents and Children
The purpose of this study is to assess the efficacy of one dose of sublingual immunotherapy (SLIT) administered to children and adolescents as allergen-based tablets once daily over a period of 24 months over 3 years compared to…
- Trial name
- NCT01199133
- Testing
- 300 IR house dust mites allergen extract tablet
- Volunteers
- 471 people
- Sponsor
- Stallergenes Greer
Herpes Genitalis, HIV Infection
Randomised Controlled Trial Assessing the Impact of Genital Herpes Suppressive Therapy on HIV Shedding
Genital herpes is a long-life sexually transmitted diseases which infects a large proportion of women in Africa. Its clinical symptoms are painful sores on the genitals, which heals after a few days.
- Trial name
- NCT00158509
- Testing
- Valacyclovir
- Where
- Burkina Faso
- Volunteers
- 215 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Knee Osteoarthritis
Bespoke vs Standard Instrumentation in TKR
Total knee replacement (TKR) is an established treatment for knee osteoarthritis and leads to a satisfactory outcome in over 75% of patients.
- Trial name
- NCT02845206
- Testing
- Patient specific cutting blocks, Conventional cutting blocks
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- NHS Lothian
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.