Clinical trials: Randomised Controlled Trial
Pediculosis
A Randomised, Assessor-Blind, Comparative Efficacy Clinical Trial of 3 Pediculicides.
Objective To compare the cure rates (defined as the complete absence of live lice, adults or nymphs, as diagnosed by wet-combing of three Australian approved head lice products for the treatment of primary school children with…
- Trial name
- NCT00381082
- Testing
- 1) MOOV Head Lice Treatment (Ego Pharmaceutical)., Banlice Mousse Aerosol (Pfizer, Australia), 3) KP24 Medicated Foam (Nelson Laboratories)
- Where
- Australia
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Uniquest Pty Ltd
Pain
Analgesic Effect of Oral 25% Glucose Versus Oral 24% Sucrose for Pain Relief During Heel Lance in Preterm Neonates
RESEARCH HYPOTHESIS-In preterm neonates during heel lance oral 25% glucose is more efficacious in reducing pain as compared to oral 24% sucrose when assessed by PIPP(Premature infant pain profile)
- Trial name
- NCT01931020
- Testing
- Sucrose, Glucose
- Where
- India
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Lady Hardinge Medical College
Malaria,Falciparum
Safety, Immunogenicity and Efficacy of R21 Matrix-M in 5-17 Month Old Children in Nanoro, Burkina Faso
This is a double blind randomised controlled clinical trial to evaluate the efficacy of R21 adjuvanted with Matrix-M in healthy 5-17 month old children in a malaria endemic area.
- Trial name
- NCT03896724
- Testing
- R21 adjuvanted with 25mcg Matrix-M, Rabies Vaccine, R21 adjuvanted with 50mcg Matrix-M
- Where
- Burkina Faso
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Lung Diseases, Interstitial
A Study to Find Out How Nintedanib is Taken up in the Body and How Well it is Tolerated in Children and Adolescents With Interstitial Lung Disease (ILD)
The main objective of the study is to evaluate dose-exposure and safety of nintedanib in children and adolescents with fibrosing Interstitial Lung Disease (ILD).
- Trial name
- InPedILD® (NCT04093024)
- Testing
- Nintedanib
- Where
- 43 sites in United States, Argentina and 19 more
- Volunteers
- 39 people
- Sponsor
- Boehringer Ingelheim
Tobacco Industry, Denormalisation
A Cluster RCT on TID
The brief intervention comprised the main intervention (tobacco industry denormalisation [TID] video, TID worksheet and sugar-sweetened beverages [SSB] worksheet) and booster intervention (worksheets where key contents in the…
- Trial name
- NCT05403957
- Testing
- TID video, TID worksheet, SSB worksheet
- Where
- Hong Kong
- Volunteers
- 2,881 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Child Behavior Disorders, Parenting
RCT of Brief Universal Parenting Program to Prevent Child Behavioural and Emotional Difficulties in Greece
This study investigates the impact of a Triple P Seminar Series on positive parenting for universal prevention of behavioural and emotional difficulties in a general Greek sample of parents with children aged 2 to 12.
- Trial name
- NCT02030730
- Testing
- Triple P Seminar Series
- Where
- United Kingdom
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Hypoxic-Ischemic Encephalopathy
PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns
Double-blind, placebo controlled Phase III trial of erythropoietin for hypoxic ischaemic encephalopathy in infants receiving hypothermia.
- Trial name
- PAEAN (NCT03079167)
- Testing
- Epoetin Alfa, Normal saline
- Where
- 24 sites in Australia, New Zealand and 1 more
- Volunteers
- 313 people
- Sponsor
- University of Sydney
Crohn Disease
Comparing Hand-sewn (END-TO-END or Kono-S) to Stapled Anastomosis in Ileocolic Resection for Crohn's Disease
The aim of this multicenter randomised controlled trial is to compare the handsewn (end-to-end and Kono-S) to the stapled side-to-side ileocolic anastomosis after ileocolic resection for Crohn's disease with respect to 6 months…
- Trial name
- END2END (NCT05578235)
- Testing
- stapled side-to-side anastomosis, Handsewn anastomosis
- Where
- Netherlands
- Volunteers
- 165 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
COPD (Chronic Obstructive Pulmonary Disease), COPD
Balance Training Following Pulmonary Rehabilitation on Balance in People With Chronic Obstructive Pulmonary Disease (COPD)
This study aims to see if a co-designed balance training programme called Sport4Steadiness (S4S), is acceptable to people with COPD and if the study procedures, including recruitment and the collection of outcomes, is feasible.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD, Balance Exercise, Falls, Intervention
- Trial name
- B-PuRe (NCT07750821)
- Testing
- Sport4Steadiness
- Where
- 3 sites in United Kingdom
- Volunteers
- 77 people
- Sponsor
- Samantha Harrison
Bone Resorption, Diabetes
Application of Information-Motivation-Behavioral Model-based Continuity of Care on the Peri-implantitis Recovery in Diabetic Implant Overdenture Patients
The investigators recruited 32 diabetic IOD patients with a total of 110 problematic implants who had completed the treatment for peri-implantitis between January 2021 and March 2023 as research subjects.
- Trial name
- NCT06103799
- Testing
- IMB model-based continuity of care
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
HIV Infection
The Efavirenz (EFV) Central Nervous System Exposure Sub-study of Encore1
Persistent HIV infection in the central nervous system (CNS) compartment may put subjects at risk of developing HIV-related brain disease.
- Trial name
- ENCORE1-CNS (NCT01451333)
- Testing
- Efavirenz
- Where
- 5 sites in Germany, Thailand and 1 more
- Volunteers
- 32 people
- Sponsor
- Kirby Institute
Child Development Disorders, Specific, Developmental Communication Disorders
Improvised Music to Enhance Intensive Interaction Version 1
The project will investigate the effectiveness of a specialised musical-clinical approach used as an adjunct to an established non-musical intervention in the enhancement of interpersonal interaction.
- Trial name
- NCT03188016
- Testing
- Intensive Interaction with Music, Standard Intensive Interaction
- Where
- United Kingdom
- Sponsor
- Beacon Hill Academy
Seasonal Allergic Rhinitis
Acupuncture for Seasonal Allergic Rhinitis
Acupuncture is widely use by patients with seasonal allergic rhinitis (SAR), although there is only limited evidence of its effectiveness.
- Trial name
- ACUSAR (NCT00610584)
- Testing
- acupuncture, cetirizine dihydrochloride (rescue medication)
- Where
- Germany
- Volunteers
- 422 people
- Sponsor
- Charite University, Berlin, Germany
Oral Health
Interactive Video- and Game-Based Oral Health Education for 11-Year-Old Schoolchildren
The goal of this cluster randomised controlled trial is to learn if an interactive video- and game-based oral health education intervention helps improve oral health outcomes among 11-year-old schoolchildren in Pulau Pinang…
- Trial name
- NCT07097324
- Testing
- Video- and Game-Based Oral Health Education, Conventional Oral Health Talk
- Where
- Malaysia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Dental Caries in Children
SDF for the Management of Dental Caries in Children in Primary Dental Care: Protocol for a Feasibility Study
Dental caries remains a significant health problem in England, effecting 11% of 3-year-olds and 23% of 5-year- olds. Children with dental caries suffer pain, infection and poor oral health-related quality of life.
- Trial name
- NCT06092151
- Testing
- Silver diamine fluoride, Usual dental care
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Necrotizing Enterocolitis
Primary Anastomosis Versus Enterostomy in the Surgical Treatment of Necrotising Enterocolitis
Necrotizing enterocolitis (NEC) is a devastating disease that affects the intestine of premature infants and is the most common surgical emergency in newborns.
- Trial name
- NCT04912453
- Testing
- Primary anastomosis, Enterostomy
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Frequent Attenders
Effectiveness of the "7H" Intervention to Reduce Frequent Attendance in Primary Care
The main objective is to measure the effectiveness of a new intervention to decrease use of services of primary care frequent attenders (FA).Among the secondary objectives are to evaluate the cost-effectiveness and cost utility…
- Trial name
- "7H" (NCT01151969)
- Testing
- New multicomponent "7H" intervention
- Where
- Spain
- Volunteers
- 527 people
- Sponsor
- The Mediterranean Institute for the Advance of Biotechnology and Health Research
Insomnia
Effects of Group-based and Digitally Delivered CBT-I in Youth
Adolescence is a critical transitional stage characterised by a cascade of developmental changes in biological, cognitive, and psychological functioning.
- Trial name
- NCT05270369
- Testing
- digital CBTI, group CBTI
- Where
- Hong Kong
- Volunteers
- 159 people
- Sponsor
- The University of Hong Kong
Malaria
A Trial of Intermittent Treatment in the Prevention of Malaria in Senegalese Children
In countries of the Sahel and sub-Sahel, malaria transmission is highly seasonal with nearly all infections occurring during a few months of the year.
- Trial name
- NCT00132561
- Testing
- Sulfadoxine/pyrimethamine and artesunate
- Where
- Senegal
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Mental Health Impairment, Mental Health Disorder
The MILESTONE Study: Improving Transition From Child to Adult Mental Health Care
This study evaluates the longitudinal health and social outcomes of adolescent mental health service users who are at the transition boundary of their child and adolescent mental health service, and whether the implementation of…
- Trial name
- MILESTONE (NCT03013595)
- Testing
- TRAM feedback
- Where
- 10 sites in Belgium, Croatia and 6 more
- Volunteers
- 1,000 people
- Sponsor
- University of Warwick
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