Clinical trials: Randomised Controlled Trial
Asthma
Efficacy and Safety of 2 Doses of Tiotropium Respimat® Compared to Placebo in Children With Moderate Persistent Asthma
The overall purpose of the trial is to evaluate efficacy and safety of tiotropium inhalation solution delivered via Respimat® inhaler (2.5 mcg and 5 mcg once daily in the evening) over 48 weeks, compared to placebo, in children…
- Trial name
- NCT01634139
- Testing
- Tiotropium low dose QD, Tiotropium high dose QD
- Where
- 79 sites in United States, Bulgaria and 14 more
- Volunteers
- 403 people
- Sponsor
- Boehringer Ingelheim
Infant Formula, Growth
Lower Protein Intake and Long-term Risk of Obesity and Cardiovascular Disease
The primary objective of this study is to investigate if consumption of lower protein formula can slow the rate of weight gain of formula-fed infants between 3 and 12 months of age.
- Trial name
- BabyGrowth (NCT03456934)
- Testing
- Modified infant formula, Standard infant formula
- Where
- United Kingdom
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Hemophilia A With Inhibitors
International Immune Tolerance Study
The purpose of this study is to see if a low-dose arm or a high dose-arm of immune tolerance is more effective in eliminating inhibitors in patients with hemophilia A.
- Trial name
- NCT00212472
- Testing
- Factor VIII concentrates, Low-dose treatment, High-dose treatment
- Where
- 39 sites in United States
- Volunteers
- 134 people
- Sponsor
- New York Presbyterian Hospital
Body Dysmorphic Disorders
Internet-delivered Cognitive-behaviour Therapy for Child and Adolescent Body Dysmorphic Disorder
The purpose of this trial is to evaluate the clinical efficacy, the cost-effectiveness and the 6-month durability of a therapist-guided, Internet-delivered cognitive-behavior therapy programme for children and adolescents with…
- Trial name
- NCT06262412
- Testing
- Internet-delivered cognitive-behaviour therapy (ICBT), Internet-delivered relaxation treatment (IRT)
- Where
- 3 sites in Sweden
- Volunteers
- 154 people
- Sponsor
- Karolinska Institutet
Anterior Cruciate Ligament Rupture
Cross Bracing Protocol Versus Surgery for Acute Anterior Cruciate Ligament Rupture
The aim of the EMBRACE clinical trial is to compare outcomes (knee pain, symptoms, function and quality of life) between people with anterior cruciate ligament (ACL) rupture who are managed with either a novel bracing protocol…
- Trial name
- EMBRACE (NCT06956339)
- Testing
- Early anterior cruciate ligament surgery, Novel bracing protocol
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- University of Melbourne
Pelvic Organ Prolapse
PEssary Plus Physiotherapy for Pelvic Organ Prolapse (PEPPY)
1. To determine the feasibility of conducting a randomised controlled trial (RCT) of the effectiveness of a PFMT intervention in conjunction with vaginal pessary management versus vaginal pessary management alone for women with…
- Trial name
- PEPPY (NCT01136889)
- Testing
- PFMT
- Where
- 4 sites in United Kingdom
- Volunteers
- 16 people
- Sponsor
- Glasgow Caledonian University
HIV Infections
Safety and Efficacy of Reduced Versus Standard Dose Efavirenz (EFV) Plus Two Nucleotides in Antiretroviral-naïve Adults.
Clinical data suggests that the standard dose of the anti-HIV medication, efavirenz (EFV), could be reduced without compromising its effectiveness.
- Trial name
- ENCORE1 (NCT01011413)
- Testing
- Efavirenz 600mg, Efavirenz 400mg
- Where
- Australia
- Volunteers
- 636 people
- Sponsor
- Kirby Institute
Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant
Optimising Breathing Support at Extubation in Very Preterm Infants: A Clinical Study
Many babies born very preterm (<32 weeks of pregnancy) require support to breathe from a breathing machine (mechanical ventilator) via a breathing tube. Although this keeps babies alive, it can damage their lungs.
- Trial name
- PrePAP (NCT07251790)
- Testing
- Pre-extubation continuous positive airway pressure
- Where
- 3 sites in Australia
- Volunteers
- 134 people
- Sponsor
- Murdoch Childrens Research Institute
Gastroenteritis
Oral Nitazoxanide in Acute Gastroenteritis in Australian Indigenous Children
This is a multi-centre (RDH and ASH), phase IV, double-blind, randomised, placebo-controlled Bayesian adaptive trial of oral NTZ for the treatment of acute gastroenteritis requiring admission to hospital.
- Trial name
- NICEGUT (NCT02165813)
- Testing
- Nitazoxanide
- Where
- 2 sites in Australia
- Volunteers
- 216 people
- Sponsor
- Telethon Kids Institute
Acute Appendicitis
TAP Block for Laparoscopic Appendicectomy in Adults
Laparoscopic (key-hole) appendicectomy is a minimally invasive procedure when compared to open large bowel resection, but is still associated with a significant amount of pain and discomfort.
- Trial name
- NCT03252561
- Testing
- Ultrasound guided Transversus Abdominis Plane (TAP) bock, Local anaesthetic infiltration of laparoscopic port sites
- Where
- United Kingdom
- Sponsor
- Oxford University Hospitals NHS Trust
Newborn Resuscitation
PEEP Resuscitation Trial
Each year, almost 3 million newborn babies die within their first month of life, often as a consequence of labour complications. Approximately 5% of newborns will not start breathing at birth and need immediate help.
- Trial name
- PEEPrest (NCT02971553)
- Testing
- Upright Resuscitator with PEEP, Upright Resuscitator
- Where
- Tanzania
- Volunteers
- 330 people
- Sponsor
- Helse Stavanger HF
Hypoxemia
Capnography Monitoring During Intravenous Conscious Sedation Sedation With Midazolam for Oral Surgery
Dentists use sedation to help patients accept difficult procedures and to relieve anxiety. During sedation, the well-being of the patient is monitored by the dental team.
- Trial name
- NCT01949012
- Testing
- Capnography
- Where
- Ireland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University College Cork
Hand Hygiene
Randomised Controlled Trial (RCT) of 6 Versus 3 Steps for Hand Hygiene
The aim is to compare the effectiveness of the 6 step hand rub technique versus 3 step hand rub technique in hand coverage and in reducing bacterial contamination on the hands of healthcare workers in practice.
- Trial name
- SHoRT (NCT02396836)
- Testing
- 6 step technique, 3 step technique
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Glasgow Caledonian University
Diabetes, Diabetes Mellitus, Type 2
A Trial Investigating the Efficacy and Safety of Insulin Detemir Versus Insulin NPH in Combination With Metformin and Diet/Exercise in Children and Adolescents With Type 2 Diabetes Insufficiently Controlled on Metformin With or Without Other Oral Antidiabetic Drug(s) With or Without Basal Insulin
This trial is conducted globally. The aim of the trial is to investigate the efficacy and safety of insulin detemir versus insulin Neutral Protamine Hagedorn (NPH) in combination with the maximum tolerated dose of metformin and…
- Trial name
- iDEAt2 (NCT02131272)
- Testing
- Insulin detemir, Insulin NPH, Diet/exercise
- Where
- 82 sites in United States, Argentina and 22 more
- Volunteers
- 42 people
- Sponsor
- Novo Nordisk A/S
Healthy
The Effect of Different Financial Competing Interest Statements on Readers' Perceptions of Clinical Educational Articles
Financial ties with industry are common among doctors, academics and institutions. This trial aims to investigate the influence of different types of industry-linked activities on readers' perceptions of clinical reviews.
- Trial name
- NCT02548312
- Testing
- Variations of financial competing interest statements
- Volunteers
- 1,065 people, healthy volunteers welcome
- Sponsor
- The BMJ
Uncomplicated Plasmodium Falciparum Malaria
A Study to Find Out if a Combination of 3 Medicines for the Treatment of Malaria Works as Well and is as Safe and Tolerable as Combinations of 2 Medicines
The goal of this open-label randomised, controlled, non-inferiority trial is to assess and compare the efficacy, tolerability and safety of a fixed dose TACT artemether-lumefantrine-amodiaquine (ALAQ) to the ACTs…
- Trial name
- FD-TACT (NCT05951595)
- Testing
- Artemether-Lumefantrine-Amodiaquine (ALAQ), Artemether-Lumefantrine (AL), Artesunate-Amodiaquine (ASAQ)
- Where
- Rwanda
- Volunteers
- 1,680 people
- Sponsor
- University of Oxford
Acute and Chronic Wounds
Is Pressurized Irrigation an Effective Alternative to Swabbing for Wound Cleansing?
The study is to examine the effectiveness of cleansing wound with pressurized irrigation method compared with conventional practice of swabbing on the wound healing and infection of acute and chronic wound, and to evaluate the…
- Trial name
- NCT01885273
- Testing
- Pressurized irrigation method, Swabbing wound cleansing method
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Insomnia, Autism Spectrum Disorder (ASD)
Sleep Intervention in Children With ASD
The goal of this randomised controlled trial is to examine the following research questions: 1) whether digitally delivered parent-based behavioural sleep intervention with or without personalised support is effective in…
- Trial name
- NCT07398183
- Testing
- App-based CBT-I with personalised telephone support, App-based CBT-I without personalised telephone support
- Where
- Hong Kong
- Volunteers
- 195 people
- Sponsor
- The University of Hong Kong
Obesity, Growth
Prevention of Overweight in Infancy
Obesity is one of the biggest threats to health in the 21st century. Rapid weight gain in the first year of life tends to lead to overweight in children, which in turn leads to overweight in adults.
- Conditions
- Obesity, Growth, Sleep
- Trial name
- POInz (NCT00892983)
- Testing
- FAB, Sleep
- Where
- New Zealand
- Volunteers
- 802 people, healthy volunteers welcome
- Sponsor
- University of Otago
Upper Respiratory Tract Infections, Virus
Edinburgh and Lothian Virus Intervention Study in Kids
ELVIS Kids is a parallel, open label, randomised controlled trial (RCT) of Hypertonic Saline (HS) nose drops (~2.6% NaCl) vs. standard care in children <7 years of age with symptoms of an Upper Respiratory Tract Infection (URTI).
- Conditions
- Upper Respiratory Tract Infections, Virus, Virus Shedding, Pediatric ALL
- Trial name
- ELVIS Kids (NCT03463694)
- Testing
- Na Cl solution
- Where
- United Kingdom
- Volunteers
- 407 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
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