Clinical trials: Randomised Controlled Trial
Preterm Birth
Brief Delay in Cord Clamping and Neurobehaviour in Preterms
RESEARCH HYPOTHESIS Brief delay(>30 sec to <60 sec ) in cord clamping as compared to early cord clamping (< 20 sec) leads to a better short term neurobehavioural outcome in preterm (34-36 wks) neonates when assessed by…
- Trial name
- NCT01753843
- Testing
- early cord clamping, Brief Delay in cord clamping
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lady Hardinge Medical College
Neuromuscular Diseases
Efficacy of Intermittent Abdominal Pressure Ventilation in Neuromuscular Patients
Non-Invasive Ventilation (NIV) is an established treatment to manage respiratory muscles dysfunction in neuromuscular disease, preventing the progression of respiratory failure to intubation and/or a tracheotomy.
- Trial name
- IAPV (NCT05346263)
- Testing
- Intermittent Abdominal Pressure Ventilation, Usual ventilation
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Patent Ductus Arteriosus
Echocardiographically Guided Versus Standard Ibuprofen Treatment for Patent Ductus Arteriosus
Patent ductus arteriosus (PDA) is a very common condition in immature newborn babies and it has been associated to morbidity and mortality.
- Trial name
- NCT01593163
- Testing
- Ibuprofen EchoG, Standard ibuprofen treatment
- Where
- Spain
- Volunteers
- 49 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz
Recurrent Urinary Tract Infection, Genitourinary Syndrome of Menopause
RCT Comparing Intravaginal Laser Therapy to Sham in Post-menopausal Women with Recurrent Urinary Tract Infections
Recurrent urinary tract infection (rUTI) is a common and difficult to treat problem with limited treatment option; postmenopausal women are disproportionately affected.
- Trial name
- UTIEXTERMINATE (NCT06124820)
- Testing
- Deka SmartXide Touch C60 (MonaLisa Touch)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- King's College Hospital NHS Trust
Perforated Appendicitis
Surgical Site Infection in Perforated Appendicitis After Peritoneal Lavage With Super-oxidised Solution
This study is to evaluate the effectiveness of peritoneal lavage with super-oxidised solution in reducing surgical site infection after open surgery for perforated appendicitis.
- Trial name
- PLaSSo (NCT04512196)
- Testing
- Superoxidized Water, Normal Saline
- Where
- Malaysia
- Volunteers
- 102 people
- Sponsor
- Hospital Queen Elizabeth, Malaysia
Chronic Pelvic Pain
Treatment of Ilioinguinal Entrapment Syndrome - an Often Overlooked Cause of Chronic Pelvic Pain
Neuralgic pain caused by entrapment of peripheral nerves is an often overlooked cause of chronic pelvic pain. The objective of the present study was to assess pain and quality of life in women with pain caused by entrapment of…
- Trial name
- NCT01020162
- Testing
- Amitryptiline, gabapentin, Resection of the ilioinguinal nerve
- Where
- Sweden
- Volunteers
- 19 people
- Sponsor
- Göteborg University
Breastfeeding
A Randomised Controlled Trial to Compare Antenatal Preparation and Postnatal Counseling
This is a randomised controlled trial to compare antenatal preparation and postnatal counseling strategies for improving breastfeeding rates. The objectives are: 1.
- Trial name
- NCT00270920
- Testing
- Lactation counseling
- Where
- Singapore
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Bronchopulmonary Dysplasia
OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP
Trial question: Does administration of exogenous surfactant using a minimally-invasive technique improve outcome in preterm infants 25-28 weeks gestation treated with continuous positive airway pressure (CPAP)? Trial hypothesis…
- Trial name
- OPTIMIST-A (NCT02140580)
- Testing
- Minimally invasive surfactant therapy, Continuation on CPAP
- Where
- 16 sites in United States, Australia and 4 more
- Volunteers
- 486 people
- Sponsor
- Menzies Institute for Medical Research
Surgical Simulation Education
Development and Evaluation of Low-Cost Non-Animal Biological Simulation Models for Undergraduate Surgical Training in Trauma Tissue Reconstruction
This study evaluated two low-cost, non-animal biological simulation models for teaching basic surgical skills to undergraduate medical students.
- Trial name
- NCT07820345
- Testing
- Suturing Simulation Training, Tendon Repair Simulation Training
- Where
- India
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Balanitis Xerotica Obliterans (BXO)
Circumcision Versus Preputioplasty for BXO in Children
Traditionally, BXO is managed with circumcision (surgical removal of the foreskin) and this approach has long been held as the 'gold standard.
- Trial name
- BXO (NCT02854995)
- Testing
- circumcision, preputioplasty with intralesional injection of triamcinolone:
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Chronic Lung Disease of Prematurity, Bronchopulmonary Dysplasia
Continuous Versus Intermittent Bolus Feeding in Very Preterm Infants - Effect on Respiratory Morbidity
Chronic Lung Disease (CLD) of Prematurity is a common yet challenging co-morbidity affecting extremely premature newborns. Multifactorial influences leading to this co-morbidity is known and targeted in various research studies.
- Trial name
- CONFER (NCT03961139)
- Testing
- Method of feeding; continuous feeding OR bolus feeding
- Where
- 2 sites in Malaysia, Singapore
- Volunteers
- 150 people
- Sponsor
- National University Hospital, Singapore
Malaria,Falciparum
A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 With Matrix-M in Combination With R21/Matrix-M
This is a Phase IIb randomised controlled trial of the safety, immunogenicity and efficacy of the malaria vaccine candidates R78C with Matrix-M™, and the combination of RH5.1 and R21 with Matrix-M™, in children aged 5-36 months…
- Trial name
- VAC087 (NCT07183371)
- Testing
- R21, RH5.1, R78C
- Where
- Burkina Faso
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cerebrovascular Accident, Transient Ischemic Attack
The Post Stroke Preventive Trial (PREVENT). A RCT Nested in a Cohort Study
Patients with a diagnosis of stroke or TIA, who are already included in the RIALTO-cohort study are asked to participate in a RCT after discharge from hospital.
- Conditions
- Cerebrovascular Accident, Transient Ischemic Attack, Myocardial Infarction
- Trial name
- PREVENT (NCT00253097)
- Testing
- Intervention
- Where
- 2 sites in Denmark
- Volunteers
- 353 people
- Sponsor
- Hvidovre University Hospital
Poliomyelitis
IPV Clinical Trial - The Gambia
The overall goal of this study is to identify interference between intramuscular Inactivated Polio Vaccine (IPV) and other vaccines (Measles Rubella and Yellow Fever) co-administered at nine months of age and to confirm the…
- Trial name
- IPV (NCT01847872)
- Testing
- IPV IM Needle, IPV ID Needle, IPV IM Device
- Where
- The Gambia
- Volunteers
- 1,504 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Friedreich Ataxia
Micronised Resveratrol as a Treatment for Friedreich Ataxia
The aim of this study is to assess the efficacy of micronised resveratrol as a treatment for FRDA, in terms of reducing the severity of ataxia symptoms at 24 weeks, through a randomised blinded, placebo controlled crossover trial.
- Trial name
- NCT03933163
- Testing
- Resveratrol
- Where
- 4 sites in Australia
- Volunteers
- 25 people
- Sponsor
- Murdoch Childrens Research Institute
Acute Myeloid Leukemia, Acute Lymphoid Leukemia
G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor
The purpose of this study is to explore the effect of G-CSF combination with GM-CSF on prevention and treatment of infection in children with malignant tumor.
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoid Leukemia, Lymphoma, Neuroblastoma
- Trial name
- NCT02933333
- Testing
- GM-CSF, G-CSF, GM-CSF and G-CSF
- Where
- 7 sites in China
- Volunteers
- 405 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Pregnancy, Labor
Hypnosis Antenatal Training for Childbirth (HATCh): a Randomised Controlled Trial
Antenatal hypnosis is associated with a reduced need for pharmacological interventions during childbirth. This trial seeks to determine the efficacy or otherwise of antenatal group hypnosis preparation for childbirth in late…
- Trial name
- NCT00282204
- Testing
- antenatal hypnosis + audio compact disc on hypnosis, Audio compact disc on hypnosis
- Where
- Australia
- Volunteers
- 448 people
- Sponsor
- Women's and Children's Hospital, Australia
Autism
Autism - Children's Improvisational Music Therapy Evaluation
The goal of this clinical trial is to evaluate the effectiveness of individual sessions of improvisational music therapy for autistic children aged 7 - 11.
- Trial name
- CHIME (NCT06016621)
- Testing
- Improvisational Music Therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 240 people
- Sponsor
- Prof Simon Baron-Cohen
Child Abuse, Parental Burnout
ACT-Based Training for Parental Burnout and Child Well-being
The purpose of the proposed randomized controlled trial is to evaluate the feasibility, acceptability, and potential effectiveness of Acceptance and Commitment Therapy (ACT) in reducing parental burnout and improving children's…
- Trial name
- NCT07047378
- Testing
- ACT Intervention Group, control group
- Where
- 2 sites in Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Depression, Anhedonia
Imagine a Brighter Future: An Intervention to Improve Positive Emotions in Young People
Depression is a common mental health problem that often begins during adolescence. Onset during adolescence can be disruptive to schoolwork and social relationships and if left untreated can lead to recurrence during adulthood…
- Trial name
- IMAGINE-P (NCT05507385)
- Testing
- IMAGINE-POSITIVE, Control
- Where
- United Kingdom
- Sponsor
- King's College London
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