Clinical trials: Randomized-controlled Trial
Labor Pain
Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor
This randomized, double-blind, placebo-controlled trial aims to compare the analgesic efficacy and obstetric effects of tramadol (100 mg IV) versus paracetamol (1 g IV) versus placebo (saline solution) in nulliparous women during…
- Trial name
- TRAMPA (NCT07440069)
- Testing
- Tramadol Hydrochloride, Paracetamol (acetaminophen)
- Where
- 2 sites in Honduras
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Honduras
Dysmenorrhea
Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring (MK-8342B) in the Treatment of Women With Primary Dysmenorrhea (MK-8342B-060)
The purpose of this study was to evaluate the efficacy of the etonogestrel (ENG) + 17β-estradiol (E2) (MK-8342B) vaginal ring compared to placebo vaginal ring in the treatment of dysmenorrhea at Treatment Cycle 2.
- Trial name
- NCT02668822
- Testing
- ENG 125 μg + E2 300 μg vaginal ring (MK-8342B), Ibuprofen
- Volunteers
- 18 people
- Sponsor
- Organon and Co
Diphtheria, Tetanus
Phase I Clinical Trial of Diphtheria-Tetanus-acellular Pertussis Component Combined Vaccine
This study is a randomized, blinded, active-controlled phase I clinical trial to evaluate the safety and preliminary immunogenicity of the Diphtheria-Tetanus-acellular Pertussis Component Combined Vaccine (DTacP) in subjects…
- Conditions
- Diphtheria, Tetanus, Pertussis
- Trial name
- NCT06184542
- Testing
- DTacP (one-dose booster), DTacP (three-dose primary vaccination), DT (one-dose booster)
- Where
- 3 sites in China
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
Endometrial Cancer
OSNA Versus Ultrastaging to Detect Sentinel Lymph Node Metastasis in Endometrial Cancer
Patients enrolled in the study will be randomized before surgery: in one study arm, the search for lymph node metastases in surgically removed sentinel lymph nodes will occur using the ultrastaging method (standard), while in the…
- Trial name
- SENT-OSNA (NCT06935305)
- Testing
- OSNA, Ultrastaging
- Where
- Italy
- Volunteers
- 1,922 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Obstructive Sleep Apnea, Alzheimer Disease
ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing
Obstructive sleep apnea (OSA), which causes abnormal pauses in breathing during sleep, is common in patients with vascular cognitive impairment (VCI) and Alzheimer's disease (AD), and exacerbates the cognitive deficits seen in…
- Conditions
- Obstructive Sleep Apnea, Alzheimer Disease, Vascular Dementia, Mild Cognitive Impairment
- Trial name
- ENCHANT (NCT04335994)
- Testing
- In-laboratory polysomnography, Home Sleep Apnea Test
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
PCOS
Clomiphene Citrate Versus Tamoxifen for Ovulation Induction in PCOs
Comparison between Clomiphene citrate and Tamoxifen for induction of ovulation in women with PCOS.
- Trial name
- NCT02479256
- Testing
- Clomiphene citrate, Tamoxifen
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Late Onset Neonatal Sepsis
Bolus Versus Prolonged Infusion of Meropenem in Newborn With Late Onset Sepsis
Newborns in the neonatal intensive care unit (NICU), especially premature ones with immature organ systems, frequently suffer nosocomial infections caused by microorganisms resistant to narrow-spectrum antibiotics like ampicillin…
- Trial name
- BVPIMNBLOS (NCT02503761)
- Testing
- Meropenem.
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Group B Streptococcus Infections
Trial To Evaluate The Safety, Tolerability, And Immunogenicity Of A Multivalent Group B Streptococcus Vaccine In Healthy Nonpregnant Women And Pregnant Women And Their Infants
Phase 1/2, randomized, placebo-controlled, observer-blinded study will evaluate the safety, tolerability and immunogenicity of the investigational multivalent group B streptococcus vaccine administered at one dose level (various…
- Trial name
- NCT03765073
- Testing
- Multivalent Group B streptococcus vaccine
- Where
- 35 sites in United States, South Africa and 1 more
- Volunteers
- 1,208 people, healthy volunteers welcome
- Sponsor
- Pfizer
Epistaxis
Effect of Practical Demonstration to Use Nasal Spray and Apply Intranasal Ointment on Epistaxis
To compare the result of verbally educating the parents about method of intranasal antiseptic cream application versus practically educating and demonstrating how to apply cream intra nasally.
- Trial name
- NCT04217941
- Testing
- Health education with practical demonstration of nasal ointment, Health Education and practical demonstration of Nasal spray and intranasal ointment
- Where
- Pakistan
- Volunteers
- 300 people
- Sponsor
- Combined Military Hospital, Pakistan
Educational Problems, Augmented Reality
Augmented Reality Serious Game Design for Promoting Children's Science Education Cognition
Background：The process of constructing knowledge in the context of children's science education plays a significant role in fostering the development of early scientific literacy.
- Conditions
- Educational Problems, Augmented Reality, Serious Game
- Trial name
- NCT06184022
- Testing
- Augmented reality serious game design for promoting children's science education cognition:
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Cerebral Palsy
GO-PLAY - Early Family-Centered Intervention for Infants With High-Risk of Cerebral Palsy
Background. Early diagnosis of cerebral palsy (CP) is important to enable appropriate intervention at a time when neuroplasticity is at its highest.
- Trial name
- GO-PLAY (NCT05883969)
- Testing
- GO-PLAY, Usual care
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Molar Incisor Hypomineralization
Antimicrobial Photodynamic Therapy on Teeth With Molar Incisor Hypomineralization
Molar Incisor Hypomineralization (MIH) is a change in the formation of dental enamel of systemic origin that affects at least one of the first four permanent molars and usually affects incisors.
- Trial name
- NCT03904641
- Testing
- aPDT, ART
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Anemia During Pregnancy
The Effect Of Pumpkin Seed Extract Capsules On Nutritional Status and Haemoglobin Level in Pregnant Women.
The goal of this to measure the effect of supplementation of Yellow Pumpkin Seed Extract Capsules in pregnant women on hemoglobin levels and nutritional status of pregnant women.
- Trial name
- NCT05657821
- Testing
- Pumpkin seeds extract capsules
- Where
- Indonesia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Dr. Rosdiana Syakur
Dental Caries, Dental Occlusion
Occlusal Impact of Hall Crowns in Primary Molars
Hall Technique is a non-invasive restorative approach for managing carious primary molars, increasingly used in pediatric dentistry due to its simplicity and patient tolerance.
- Conditions
- Dental Caries, Dental Occlusion, Pediatric Dentistry
- Trial name
- NCT07134114
- Testing
- Hall Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Well-being
The Effectiveness of Engagement-based Personalization of a Digital Mental Health Intervention
This study will investigate the effectiveness of an engagement-based personalized 2-week mobile wellbeing intervention, vs the effectiveness of a non-personalized 2-week mobile wellbeing intervention.
- Trial name
- NCT05300906
- Testing
- personalized 2-week mobile wellbeing intervention, non-personalized 2-week mobile wellbeing intervention
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Twente
HPV, Vaccination Hesitancy
A Bio-Psycho-Social Medical Model-Based Study on Adolescent Female HPV Vaccination Behavior and Comprehensive Intervention
Based on the biopsychosocial (BPS) medical model, this study focuses on HPV vaccination behavior among adolescent females. It aims to explore the influence of multidimensional factors-including biological characteristics…
- Conditions
- HPV, Vaccination Hesitancy, Biopsychosocial Model
- Trial name
- NCT07562984
- Testing
- the BPS-based comprehensive intervention
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Thyroid Disease, Pregnancy
Thyroid Disease in Pregnancy: Case Finding Versus Universal Screening
The purpose of this study is to determine whether treatment of thyroid disease during pregnancy decrease the incidence of adverse outcome, and to compare the impact of Universal Screening versus case Finding strategy in detecting…
- Trial name
- NCT00846755
- Testing
- Levothyroxine, Propylthiouracile
- Where
- Italy
- Volunteers
- 4,657 people, healthy volunteers welcome
- Sponsor
- Ospedale V. Fazzi
Anxiety, GAD
Transcranial Direct Current Stimulation (tDCS) and Immersive Virtual Reality Meditation (IVRM) for the Treatment of Anxiety Disorders
The goal of this RCT is to evaluate the post-intervention (week 2) and 1-month post-intervention (week 6) of a 2-week intervention (12 sessions) of combined tDCS (a non-invasive brain stimulation method, with anodal stimulation…
- Trial name
- NCT07299916
- Testing
- tDCS +IVRM (Active stimulation)
- Where
- Hong Kong
- Volunteers
- 52 people
- Sponsor
- The University of Hong Kong
Pain, Postoperative, Developmental Dysplasia of the Hip
Postoperative Analgesic Effect of Two Peripheral Nerve Blocks for Hip Surgery in Pediatrics
Hip joint surgery for developmental dysplasia of the hip (DDH) in children is extremely painful and associated with considerable postoperative pain despite the use of systemic opioids.
- Conditions
- Pain, Postoperative, Developmental Dysplasia of the Hip, Regional Anesthesia Morbidity
- Trial name
- NCT05348421
- Testing
- FTPB, PENG Block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Class IV Dental Caries
Comparative Evaluation of Shade Matching Using a Digital Spectrophotometer in Monochromatic Versus Polychromatic Layering Techniques for Restoring Fractured Incisal Angles of Maxillary Incisors - Invivo Study
The color and appearance of a tooth is complex phenomenon which is related to many factors such as color stability, The Blending Effect, color Induction, color assimilation effect of resin composite materials which are all fall…
- Trial name
- Shade Matching (NCT06827847)
- Testing
- Traditional polychromatic layering dental composite technique, Contemporary monochromatic single shade dental composite technique
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Badr University
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