Clinical trials: Respiratory Function
Respiratory Distress Syndrome, Newborn
Randomized Controlled Trial of Surfactant Administration by Laryngeal Mask Airway (LMA)
In this protocol we will conduct a randomized controlled trial where babies with respiratory distress syndrome (RDS) who have not yet reached criteria for intubation, will be randomized to receive surfactant by LMA or to continue…
- Trial name
- NCT00599651
- Testing
- Surfactant administered via Laryngeal Mask Airway (LMA), standard of care (nasal CPAP and supplemental oxygen)
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- University of Virginia
COVID-19, COVID-19 Respiratory Infection
Low-field Magnetic Resonance Imaging in Pediatric Post Covid-19
SARS-CoV-2 (Severe acute respiratory syndrome coronavirus type 2) is a new coronavirus and identified causative agent of COVID-19 disease.
- Conditions
- COVID-19, COVID-19 Respiratory Infection, Long COVID
- Trial name
- FASCINATE (NCT05445531)
- Testing
- Low-field magnetic resonance imaging, Nailfold capillaroscopy, Spiroergometry
- Where
- Germany
- Volunteers
- 111 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Chronic Cough
French Linguistic and Metric Validations of Parent-proxy QOL Chronic Cough Specific Questionnaire (PC-QOL)
Cough is one of the most common reasons for consultation. Even if cough is a non-specific symptom, it can be the first sign of a chronic pathology.
- Trial name
- PC-QOL (NCT01865422)
- Testing
- parent-proxy QoL chronic cough specific questionnaire (PC-QOL)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Respiratory Distress
The Smell of Breast Milk and Therapeutic Positions in Comfort
Before starting the data collection process, a pilot study was conducted with 10 preterm newborns, five in the safe swaddling group and five in the control group, to evaluate the comprehensibility of the questionnaire form and…
- Trial name
- NCT06826053
- Testing
- Therapeutic position, Therapeutic position + smell breast milk
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Karamanoğlu Mehmetbey University
Respiratory Depression
Effect of Propofol Versus Remimazolam Intravenous Anesthesia on Respiratory Depression
General anesthesia is the preferred choice for pediatric patients, but the induction of volatile anesthetics via face mask may cause preoperative anxiety and postoperative delirium.
- Trial name
- NCT06816173
- Testing
- Propofol group, Remimazolam group
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Respiratory Failure
PCO2 ELSO (Extracorporeal Life Support Organization)
Investigation of the association between PaCO2 change after extra corporeal membrane oxygenation (ECMO) initiation and neurological outcome and mortality in neonates treated by ECMO for respiratory failure.
- Trial name
- NCT04798794
- Testing
- ECMO for neonates
- Where
- France
- Volunteers
- 4,072 people
- Sponsor
- Nantes University Hospital
Noninvasive Ventilation for Respiratory Distress Syndrome
Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants
The investigators aimed to compare the efficacy of nasal intermittent mandatory ventilation (IMV) and nasal continuous positive airway pressure (CPAP) in early rescue surfactant treatment in preterm infants.
- Trial name
- NCT01741129
- Testing
- Nasal CPAP (SLE), Nasal IMV (SLE)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Mehmet Yekta
Mechanical Ventilation Complication
Cross-sectional, Observational, Prospective and Analytical Study:MECHANICAL POWER DAY (MPDay)
Recently the new concept of "mechanical power" has been proposed. It refers to the amount of energy per minute that is transferred to the lung by the ventilator.
- Trial name
- MPDay (NCT03936231)
- Testing
- NO Intervention
- Where
- Spain
- Volunteers
- 2,000 people
- Sponsor
- Hospital Universitario Marqués de Valdecilla
Hematopoietic Stem Cell Transplantation
Effectiveness Rehabilitation Hematopoietic Transplantation (ovERsHOT)
The objective of the study is to evaluate the benefits and costs of a comprehensive rehabilitation program (physical, psychological, social and educational) for patients receiving hematopoietic stem cell transplantation (HSCT).
- Trial name
- ovERsHOT (NCT03324620)
- Testing
- Specific program functional and respiratory rehabilitation
- Where
- Spain
- Volunteers
- 190 people
- Sponsor
- Hospital Clinic of Barcelona
Newborns
The Effect of Mother's Voice on the Levels of Pain and Comfort in Newborns
This study was conducted in a randomized controlled experimental type to determine the effect of maternal voice during care on pain and comfort level in term newborns receiving mechanical ventilation.
- Trial name
- Newborn (NCT06387888)
- Testing
- Listening to mother's voice
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Obstructive Sleep Apnea
Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome
-Intranasal budesonide therapy may lead to improved symptoms and sleep study findings in children with mild obstructive sleep apnea with and without allergic rhinitis that would not be treated with T\&A.
- Trial name
- NCT00560586
- Testing
- Budesonide
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Louisville
Cystic Fibrosis
Investigation of Relationship Between Vascular Functions, Exercise Capacity, and Respiratory Functions in CF
In the literature, there is no study that evaluates the endothelial function and arterial stiffness together and investigates its relationship with exercise capacity and respiratory functions in children with CF of different…
- Trial name
- NCT04259983
- Testing
- Maximal exercise test, Endothelial dysfunction assessment, Arterial stiffness assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Pulmonary Langerhans Cell Histiocytosis
Evaluation of Outcome of Adult Pulmonary Langerhans Cell Histiocytosis Based on Lung HRCT and Lung Function
this is a multicenter retrospective study on patients with pulmonary LCH who were sequentially evaluated by concomitant lung HRCT and lung function testing.
- Trial name
- HLP (NCT01651507)
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstructive Sleep Apnea (OSA)
CPAP vs High-Flow Nasal Cannula for Treating Sleep Apnea in Children
This study is looking at two different treatments for obstructive sleep apnea (OSA) in children. OSA is a sleep condition where breathing repeatedly stops and starts during sleep, which can affect a child's health, behavior…
- Trial name
- CHOSA (NCT07600333)
- Testing
- High Flow Nasal Cannula, Continuous Positive Airway Pressure
- Where
- Canada
- Volunteers
- 258 people
- Sponsor
- The Hospital for Sick Children
Bronchiolitis
Non-Invasive Ventilation Versus Neurally-Adjusted Ventilatory Assistance (NAVA) for the Treatment of Bronchiolitis
This project aims to answer whether the use of a Neurally-Adjusted Ventilatory Assistance mode for non-invasive ventilation in pediatric patients with bronchiolitis results in improved comfort and reduced escalations in therapy…
- Trial name
- NCT06053684
- Testing
- Standard Non-Invasive Mechanical Servo Ventilation, Neurally-Adjusted Ventilatory Assistance (NAVA) Non-Invasive Mechanical Servo Ventilation
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Montefiore Medical Center
Neonatal Respiratory Distress Syndrome
Flow-cycled Ventilation in Preterm Infants
This short pilot study is to assess the tolerance of preterm infants, born below 32 weeks gestation with respiratory distress syndrome, to flow-cycle ventilation, and see if infants require less overall pressure from the…
- Trial name
- FLIPI (NCT02522455)
- Testing
- Flow-cycle ventilation, Time-cycle ventilation mode
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Manchester University NHS Foundation Trust
Abdominal Cancer, Heart Diseases
Survey Of Mobilisation and Breathing Exercises After Thoracic and Abdominal Surgery
Background Thoracic or abdominal surgeries are followed by a shorter or longer period of immobilization and after major surgery there is a higher risk of developing cardiorespiratory complications.
- Trial name
- SOMBATA (NCT04729634)
- Testing
- Mobilization
- Where
- Sweden
- Volunteers
- 1,492 people
- Sponsor
- Göteborg University
Respiratory Infections, Diarrhea
High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM
Vitamin A deficiency is an important health problem globally including Bangladesh. The problem is greater among under-five children, particularly in malnourished.
- Conditions
- Respiratory Infections, Diarrhea, Malnutrition
- Trial name
- NCT00388921
- Testing
- Vitamin A
- Where
- Bangladesh
- Volunteers
- 260 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Preterm Labor, Respiratory Distress Syndrome
The Relationship of Fetal Lung Elastography Values With the Development of Respiratory Distress in Cases of Preterm Labor
The aim of this study was to compare fetal lung elastography (FAE) values between groups with and without Respiratory Distress Syndrome (RDS) in preterm neonates and to evaluate the potential of FAE to predict the risk of…
- Trial name
- NCT06168149
- Testing
- fetal lung elastography measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Heart Disease
Evaluation of Cardiac Function With Cardio-respiratory Synchronized MRI
The purpose of this investigation is to evaluate newer methods of performing cardiovascular MRI (CMR) that will provide new kinds of information related to the interplay between the cardiac and the respiratory cycles, such as the…
- Trial name
- NCT02728284
- Testing
- cardiovascular MRI (CMR), Conventional Cardiologic Evaluation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
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