Clinical trials: Skin Burn
Sunburn
Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Lotion) in the Relief of Sunburn Related Symptoms
Topical antihistamines can be used to promote relief of sunburn related symptoms (erythema, itch and burning sensations). Dexchlorpheniramine maleate 1% cream is a topical antihistamine formulation approved by ANVISA in Brazil…
- Trial name
- NCT01085851
- Testing
- Dexchlorpheniramine 1% lotion, Dexchlorpheniramine 1% cream
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Mantecorp Industria Quimica e Farmaceutica Ltd.
Burns
Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial-Partial Thickness Wounds
This study aims to evaluate the efficacy of Nile tilapia skin as a xenograft for the treatment of partial-thickness burn wounds in children.
- Trial name
- NCT04391582
- Testing
- Tilapia skin, silver sulfadiazine cream 1%
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara
Wounds
Study of Donated Amnion, Fetal Placental Membrane, as Skin Substitute for Burn Patients
Is the use of fetal membrane (human amnion) as a transient wound coverage in wound repair safe and efficacious. Will the incorporation of liposomal gene constructs to amnion enhance the functionality of human amnion and improve…
- Trial name
- Amnion (NCT00592189)
- Testing
- blood draw
- Where
- United States
- Volunteers
- 1,164 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Healthy Volunteers, Fungal Infections
A Pilot of Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity
This study will examine the phototoxicity, a reaction to light that is like exaggerated sunburn, which occurs in people who take medications such as voriconazole, a medication used to fight fungus.
- Conditions
- Healthy Volunteers, Fungal Infections, Bacterial Infections
- Trial name
- NCT00353158
- Testing
- Doxycycline, Voriconazole
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Burns
Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Children
This phase IIb trial aims to evaluate the efficacy and safety of EHSG-KF (synonym denovoSkin) in comparison to meshed STSG in children with partial deep dermal and full thickness burns.
- Trial name
- NCT03229564
- Testing
- EHSG-KF, STSG
- Where
- 4 sites in Italy, Netherlands and 1 more
- Volunteers
- 12 people
- Sponsor
- CUTISS AG
Breast Neoplasms
A Clinical Trial to Reduce Skin Burn Induced by Breast Radiotherapy Using Intensity Modulated Radiation Therapy (IMRT)
The purpose of this study is to determine whether the use of a 3D missing tissue compensation radiation technique during a standard adjuvant breast radiotherapy delivering a dose of 50Gy in 25 treatments could reduce…
- Trial name
- NCT00187343
- Testing
- Breast IMRT
- Where
- 2 sites in Canada
- Volunteers
- 340 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sunburn
Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Gel) in the Relief of Sunburn Related Symptoms
Topical antihistamines can be used to promote relief of sunburn related symptoms (erythema, itch and burning sensations). Dexchlorpheniramine maleate 1% cream is a topical antihistamine formulation approved by ANVISA in Brazil…
- Trial name
- NCT01237925
- Testing
- Dexchlorpheniramine 1% gel, Dexchlorpheniramine 1% cream
- Where
- Brazil
- Volunteers
- 124 people
- Sponsor
- Mantecorp Industria Quimica e Farmaceutica Ltd.
Blood Loss, Surgical
Safety and Immunogenicity Study of Recombinant Thrombin (rThrombin) in Pediatric Participants
The objective of this study is to assess the safety and immunogenicity of recombinant thrombin (rThrombin) administered as an aid to hemostasis during burn wound excision and skin grafting in pediatric patients, newborn through…
- Trial name
- NCT00859547
- Testing
- rThrombin, 1000 IU/mL
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- ZymoGenetics
Deep Partial or Full Thickness Wounds
Safety and Efficacy Study of FS 4 IU VH S/D (Fibrin Sealant With 4IU/mL Thrombin, Vapor Heated, Solvent/Detergent Treated) to Adhere Split Thickness Skin Grafts and Improve Wound Healing in Burn Patients
The primary objective of this study is to evaluate skin graft adherence and wound healing in burn patients to evaluate whether FS 4IU VH S/D is equivalent or superior to the current standard of care (staples).
- Trial name
- NCT00157131
- Testing
- Fibrin Sealant, ARTISS 4IU/ml VH SD, Staples
- Where
- 17 sites in United States
- Volunteers
- 150 people
- Sponsor
- Baxter Healthcare Corporation
Skin Burn Multiple
Ability of Modulated Imaging and Laser Speckle Imaging to Determine Burn Wound Severity and Healing Potential
According to the National Burn Repository 2007, the most common type of burn injury is a partial thickness burns. The current standard of care for partial thickness burns is two weeks of topical therapy and wound care.
- Trial name
- NCT01166893
- Testing
- Modulated Imaging and Laser Speckle Imaging
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, Irvine
Herpes Virus Infection
Comparison of Prophylactic Acyclovir and Placebo in Prevention of Eczema Herpeticum in Pediatric Burns
Introduction: Early detection is important in treating patients with Eczema Herpeticum (EH), which may arise in paediatric burn patients.
- Trial name
- childburn (NCT06380647)
- Testing
- Intravenous Acyclovir
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- King Edward Medical University
Burn Injury, Skin Graft
A Soft Silicone Wound Contact Layer Containing Silver in the Treatment of Skin Grafts in Surgical Burn Patients.
Part A The primary objective of Part A will be to verify performance and safety of Mepitel® Ag, a meshed, non- adherent soft silicone wound contact layer containing silver in the treatment of skin grafts in surgical burn…
- Trial name
- MpTAg03 (NCT02210208)
- Testing
- Mepitel® Ag, Mepilex® Transfer Ag
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Molnlycke Health Care AB
Burns
Comparison Between Burn Dressing Using Tilapia-Fish Skin Versus Regular Dressing
The aim of this study is to evaluate the use of tilapia fish skin as a healing dressing in burn patients and its clinical outcome and compare it with regular dressing.
- Trial name
- NCT07142824
- Testing
- burn dressing using Tilapia-Fish Skin, burn dressing using regular dressing
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Hypertrophic Scars
Laser Induced Bioengineered Remodeling of Thermally Injured Skin Trial
This study will evaluate the efficacy of pulsed dye laser (PDL) and carbon dioxide (CO2) laser in conjunction with usual care (MED) for the treatment of hypertrophic burn scars and will determine the optimal sequence and timing…
- Trial name
- LIBERTI (NCT02655211)
- Testing
- CO2 laser treatment, PDL laser treatment, Usual care
- Sponsor
- University of North Carolina, Chapel Hill
Amputation Stump, Burn Injury
Hypertrophic Scar Prosthetic Pressure in Burn Amputee
Amputation following burn injury is rare but complex, affecting predominantly younger individuals with extensive burns, particularly electrical injuries, and often resulting in residual limbs characterized by scarring…
- Conditions
- Amputation Stump, Burn Injury, Pressure Distribution, Pressure Injuries
- Trial name
- NCT07850557
- Testing
- Skin assessment of prothesis interface and control area, Interface pressure
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Skin Burn
Evaluation of Platelet Rich Plasma in Skin Graft Take for Patients With Post Burn Raw Areas
1. To evaluate the effect of the platelet rich plasma on the take of split thickness skin graft and its early and late results in resurfacing of post burn raw areas. 2.
- Trial name
- NCT05996614
- Testing
- PRP in skin grafts, conventional methods in skin grafts
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Burns
Safety and Efficacy Study of Fibrin Sealant (FS 4IU) for Skin Graft Fixation and Wound Healing in Subjects With Burn Wounds
The purpose of this study is to assess if Fibrin Sealant 4IU is as safe and efficacious as staples (the current standard of care) to achieve fixation of skin grafts and wound healing in subjects with burn wounds.
- Trial name
- NCT00161759
- Testing
- Sheet skin grafts affixed with Fibrin Sealant (lyophilized) with 4 IU/mL Thrombin
- Where
- 12 sites in United States
- Volunteers
- 40 people
- Sponsor
- Baxter Healthcare Corporation
Pruritus
Gabapentin for the Treatment of Pruritus Caused by Burn Injuries in Children
Children with healing burns often suffer from pruritus that may continue for many months. Pruritus can be very distressing to the child and can interfere with sleep, activities of daily living, and rehabilitation therapy.
- Trial name
- NCT01092520
- Testing
- Gabapentin
- Where
- Canada
- Sponsor
- The Hospital for Sick Children
Burns
Children Severe Traumatic Skin Lesions and Functional Outcome
Traumatic skin lesions require an adapted and early patient care management
- Trial name
- NCT02804607
- Testing
- questionnaire
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Human Herpes Virus, Herpes Simplex Virus
Review of Human Herpes Viruses in Burns
Herpes simplex virus, cytomegalovirus and varicella zoster virus infection are purported to play a pivotal role in morbidity and mortality in burns.
- Conditions
- Human Herpes Virus, Herpes Simplex Virus, Varicella-zoster Virus, Chickenpox
- Trial name
- NCT02452229
- Testing
- Review of the Literature for Human Herpes Virus infections
- Volunteers
- 10,267 people
- Sponsor
- The University of Texas Medical Branch, Galveston